Exploring the Mechanism of Lianqiao Jinbei Decoction Inhibiting HER2-Positive Breast Cancer Based on Network Pharmacology and Experimental Verification by Li D, Liu X, Fan H, Dong J, Wei L, Guo N, Wang Z, Du Z, Liu J, Zhao X, Tian X, Han C, Yao X

“…Dehui Li,1,* Xukuo Liu,2,* Huanfang Fan,3 Jingfei Dong,4 Liying Wei,3 Na Guo,3 Zhengrong Wang,3 Zhihua Du,3 Jiao Liu,2 Xiaohui Zhao,2 Xiaotong Tian,2 Changhui Han,3 Xujiong Yao5 1Department of Oncology II, The First Affiliated Hospital of Hebei University of Chinese Medicine (Hebei Province Hospital of Chinese Medicine), Key Laboratory of Integrated Chinese and Western Medicine for Gastroenterology Research, Hebei Industrial Technology Institute for Traditional Chinese Medicine Preparation, Shijiazhuang, Hebei Province, People’s Republic of China; 2Graduate School, Hebei University of Chinese Medicine, Shijiazhuang, Hebei Province, People’s Republic of China; 3Department of Oncology II, The First Affiliated Hospital of Hebei University of Chinese Medicine (Hebei Province Hospital of Chinese Medicine), Shijiazhuang, Hebei Province, People’s Republic of China; 4Department of Medical Laboratory, The First Affiliated Hospital of Hebei University of Chinese Medicine (Hebei Province Hospital of Chinese Medicine), Shijiazhuang, Hebei Province, People’s Republic of China; 5Department of Pathology, The First Affiliated Hospital of Hebei University of Chinese Medicine (Hebei Province Hospital of Chinese Medicine), Shijiazhuang, Hebei Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Dehui Li, Department of Oncology II, The First Affiliated Hospital of Hebei University of Chinese Medicine (Hebei Province Hospital of Chinese Medicine), Key Laboratory of Integrated Chinese and Western Medicine for Gastroenterology Research, Hebei Industrial Technology Institute for Traditional Chinese Medicine Preparation, 389 Zhongshan East Road, Shijiazhuang, Hebei Province, 050000, People’s Republic of China, Email 258289951@qq.comPurpose: Through network pharmacological prediction and in vitro experimental verification, the mechanism of action of Lianqiao Jinbei Decoction (LJD) in inhibiting HER2-positive breast cancer cells was clarified, providing experimental evidence for its treatment of HER2-positive breast cancer.Methods: Network pharmacology method was used to construct the potential target network of LJD in the treatment of HER2+ breast cancer. …”
Get full text

Quality of Care and Outcomes of Inpatients with COPD: A Multi-Center Study in China by Wang F, Wang M, Chen X, Song A, Zeng H, Chen J, Wang L, Jiang W, Jiang M, Shi W, Li Y, Zhong H, Chen R, Liang Z

“…This study aimed to evaluate the quality of care and outcomes among inpatients with COPD and to identify prognostic factors relate to healthcare quality indicators.Methods: A multi-center, retrospective longitudinal study was conducted. …”
Get full text

Prediction of methylphenidate treatment response for ADHD using conventional and radiomics T1 and DTI features: Secondary analysis of a randomized clinical trial by Mingshi Chen, Zarah van der Pal, Maarten G. Poirot, Anouk Schrantee, Marco Bottelier, Sandra J.J. Kooij, Henk A. Marquering, Liesbeth Reneman, Matthan W.A. Caan

“…Methods: We performed a secondary analysis of a randomized clinical trial (ePOD-MPH), involving 47 stimulant-naive ADHD participants (23 boys aged 11.4 ± 0.4 years, 24 men aged 28.1 ± 4.3 years) who underwent 16 weeks of treatment with MPH. …”
Get full text

Advanced Characterization of Vitreous Hyperreflective Dots via OCT-Derived Metrics: A Cross-Sectional Study by William Rojas-Carabali, Jinghan Lin, Paola Saboya-Galindo, Eunice Jin Hui Goh, Joewee Boon, Carlos Cifuentes-González, Rupesh Agrawal

“…Abstract Introduction The use of optical coherence tomography (OCT) as a potential tool for the measurement of vitreous inflammation has been previously described as a more objective and reproducible method when compared to historically known subjective scales. …”
Get full text

A Randomized-Controlled Trial Using Point of Care Ultrasound to Evaluate Volunteer Patients in the Emergency Department Versus a Manikin Simulator for Improving Knowledge and Confi... by Patel B, Dobiesz VA, Goldsmith AJ, Montgomery MW, Osman NY, Pelletier SR, Miller MS, Shields HM

“…The primary end point was assessment of student knowledge and confidence at the 3-month longitudinal time period.Results: At the 3-month longitudinal survey, there was no statistical difference in the primary end point of questions correctly answered by students in the experimental group compared to those in the control group (88% vs 86.5%, p = 0.713, NS), and no statistical difference in reported confidence between students in the experimental group from those in the control group (4.22 vs 4.10, p = 0.846, NS).Conclusion: In this randomized-controlled trial using POCUS to assess hypotension and shock, there were no significant differences in learner knowledge and confidence between students in the ED experimental group learning from volunteer patients versus the control group learning from a manikin simulator indicating that the methods may be equally effective in teaching POCUS.Keywords: simulation, medical education, point of care ultrasound, volunteer patients…”
Get full text

Women’s Suffrage: A Cinematic Study by Suzanne Bouclin

“…These assumptions guide my case study of the women’s suffrage movement in the United States and the conflicting conceptualizations of women’s equality in which that movement was embedded. Drawing on methods from feminist jurisprudence, intersectionality namely, I locate Katja von Garnier’s film Iron Jawed Angels (2004) in its historical, legal and discursive contexts to suggest how it constitutes meaning about the solidarities and divergences within the American women’s movement at the turn of the 20th century. …”
Get full text

Enhanced Estimation of the Unit Lindley Distribution Parameter via Ranked Set Sampling with Real-Data Application by Sid Ahmed Benchiha, Amer Ibrahim Al-Omari, Ghadah Alomani

“…This paper investigates various estimation methods for the parameters of the unit Lindley distribution (U-LD) under both ranked set sampling (RSS) and simple random sampling (SRS) designs. …”
Get full text

Gender pedagogical practices in Moroccan schools: awareness, implementing, and attitudes by Said Ouabou, Hassan Achraouaou, Rachid Akhsay, Ahmed Outalb M’hand

“…This study examines the integration of Gender Pedagogical Practices (GPPs) to address these issues and foster inclusive, equitable education.MethodsA mixed-methods study was conducted with 188 teacher trainees at the Teacher Training Center in Souss-Massa (Morocco). …”
Get full text

Evaluating active mobility: enhancing the framework for social sustainability by Giuseppe Rainieri, Martina Carra, Anna Richiedei, Michele Pezzagno

“…A Rapid Evident Assessment method was employed in this research in two databases: PsycINFO and Scopus. …”
Get full text

Stability and Reusability of Tungsten Catalyst on Structured Support in Catalytic Ozonation of Textile Wastewater by Aleksandra Kędzierska-Sar, Maciej Fronczak, Marta Gmurek, Lucyna Bilińska

“…Plasma-enhanced chemical vapor deposition (PECVD) is a method of thin-layer deposition that is useful in catalyst production on structured supports. …”
Get full text

Driving Behavior and Tourist Experience: A Study of the Bandung Metropolitan Area by R. Rina Novianty Ariawaty, Layyinaturrobaniyah Layyinaturrobaniyah, Egi Arvian Firmansyah, Hilmiana Hilmiana, Kurniawan Saefullah

“…A total of 300 respondents, consisting equally of drivers and tourists, participated through an online questionnaire administered via Google Forms across West Bandung Regency, Bandung Regency, Cimahi City, and selected areas of Sumedang Regency in West Java Province, a method particularly effective during the COVID-19 pandemic. …”
Get full text

Four-quadrant modelling of carbon inequality in international trade and accounting for carbon compensation by Hao Chen, Erdan Wang, Tao Song, Yu Wang, Zulin Ye

“…On this basis, we use the four-quadrant analysis method to classify the carbon inequality in international trade, and construct the carbon inequality index to quantify the carbon inequality situation in bilateral trade. …”
Get full text

Vaccination in childhood: health education video for parents and guardians by Viviane Nogueira Borges Trajano, Paola Cristina de Castro, Silvia Matumoto, Tauani Zampieri Fermino, Luciana Mara Monti Fonseca, Gloria Lúcia Alves Figueiredo, Angelina Lettiere-Viana

“…ABSTRACT Objective: To develop, validate, and evaluate an educational video on childhood vaccination for parents and guardians. Method: Methodological study in three phases. Pre-production included: script, storyboard, recruitment and validation by experts. …”
Get full text

A meta-analysis on the effect of expertise on eye movements during music reading by Joris Perra, Alice Latimier, Bénédicte Poulin-Charronnat, Thierry Baccino, Véronique Drai-Zerbib

“…We used a variance estimation method to aggregate the effect sizes. The results support the robust finding of reduced fixation duration in expert musicians (Subset 1, g = -0.72). …”
Get full text

Evaluation of “Cyscope”, a novel fluorescence-based microscopy technique for the detection of malaria by Lovemore Gwanzura, Justin Mayini, Katherine Mabhanga, Joseph Chipinduro, Kansomba Mashamba, Menard Mutenherwa, Susan L Mutambu, Junior Mutsvangwa, Peter Robert Mason

“…Microscopic examination was done independently in two laboratories, with one performing the Giemsa stain and the other the Cyscope method.  After the tests were completed, the results were then matched and recorded without any alterations. …”
Get full text

Pemetaan Daerah Rawan Longsor di Kabupaten Bandung Barat menggunakan Metode Machine Learning dengan Teknik SVM by Afif Faadhilah, Hary Nugroho

“…This information is presented as a map obtained through the classification process of data contributing to landslides using the Support Vector Machine (SVM) method. The SVM method was chosen for its advantages in handling complex data and providing accurate predictions. …”
Get full text

Evaluation of MODIS and VIIRS BRDF Parameter Differences and Their Impacts on the Derived Indices by Chenxia Wang, Ziti Jiao, Yaowei Feng, Jing Guo, Zhilong Li, Ge Gao, Zheyou Tan, Fangwen Yang, Sizhe Chen, Xin Dong

“…Then, we analyzed the sensitivity of the BRDF parameters to variations in Normalized Difference Hotspot–Darkspot (NDHD) and examined the spatiotemporal distribution of zero-valued pixels in the BRDF parameter products generated by the constraint method in the Ross–Li model from both sensors, assessing their potential impact on NDHD derivation. …”
Get full text

Repair of aircraft engine parts made of heat-resistant nickel alloys using additive plasma technologies by Konstantin Balushok, Sergey Chigileychik

“…The article establishes that the use of additive technologies by the method of plasma surfacing in the repair of aircraft engine parts, such as turbine blades, sealing discs, NA parts, is very promising and will significantly increase the percentage of parts and assemblies restored after operation, which have a significant area of damage. …”
Get full text

Main directions of economic reintegration process of Sevastopol and Crimea into the Russian Federation by N. V. Alesina, B. A. Bukach, E. A. Posnaya

“…Identification of  the  main  stages  of  the  economic  reintegration  of  Crimea and  Sevastopol  into  the  Russian  Federation,  their composition,  analysis  of  the  level  of completion of each stage, identification of topical issues and development of ways to solve them. Materials and methods. Methods of financial analysis, statistical reporting data and legislation regulating the integration process were used. …”
Get full text

Integration of flexible corporate demographic policy tools into the personnel management system by Natalya V. Tonkikh, Marina V. Chudinovskikh, Svetlana V. Begicheva

“…Flexibilization theory in the context of corporate demographic policy constitutes the methodological basis of the study. The standard methods of structured personal interviews, frequency analysis with equality of proportions hypothesis test using a chi-square statistic, and comparison of mean values based on the Kruskal Wallis test were applied. …”
Get full text