Comparative Cost-Effectiveness of Two Artificial Liver Therapies in Early-Stage Hepatitis B Virus-Related Acute-on-Chronic Liver Failure: A Retrospective Cohort Study by Chen J, Luo Q, Wang L, Zheng L, Zhang Y, Liu Y, Peng L, Xu W

“…Jia Chen,1,* Qiumin Luo,1,* Lu Wang,2,* Lihua Zheng,1 Yeqiong Zhang,1 Ying Liu,1 Liang Peng,1,3 Wenxiong Xu1 1Department of Infectious Diseases and Guangdong Key Laboratory of Liver Disease Research, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, People’s Republic of China; 2Department of Diagnostics, second School of Clinical Medicine, Binzhou Medical University, Yantai, Shandong, People’s Republic of China; 3Key Laboratory of Tropical Disease Control, Ministry of Education, Sun Yat-sen University, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wenxiong Xu, Department of Infectious Disease, Third Affiliated Hospital of Sun Yat-sen University, 600# Tianhe Road, Tianhe District, Guangzhou, Guangdong province, 510630, People’s Republic of China, Tel +8613760783281, Email xuwenx@mail.sysu.edu.cn Liang Peng, Department of Infectious Disease, Third Affiliated Hospital of Sun Yat-sen University, 600# Tianhe Road, Tianhe District, Guangzhou, Guangdong province, 510630, People’s Republic of China, Tel +8613533978874, Email pliang@mail.sysu.edu.cnPurpose: This study aimed to compare the cost-effectiveness of the double plasma molecular adsorption system sequential low-volume plasma exchange (DPMAS+LPE) versus conventional plasma exchange (PE) in treating early-stage hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF).Patients and Methods: A total of 215 early-stage HBV-ACLF patients were assigned to either DPMAS+LPE or conventional PE groups. …”
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Antimicrobial Effects of Thonningianin a (TA)-Loaded Chitosan Nanoparticles Encapsulated by a PF-127 hydrogel in Diabetic Wound Healing by Lin Q, Zhu F, Shiye A, Liu R, Wang X, Ye Z, Ding Y, Sun X, Ma Y

“…To promote diabetic wound healing, a composite of thonningianin A (TA)-loaded chitosan nanoparticles (CNPS) encapsulated by a Pluronic F-127 (PF-127) hydrogel (TA-CNPS-PF) was developed in this study.Methods: TA-CNPS was prepared by ionic gelation method and TA-CNPS was thoroughly dispersed into PF-127 hydrogel to prepare TA-CNPS-PF. …”
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Construction of Cationic Carbon Dots Carrying Survivin siRNA Delivery System and Its Active Targeting Therapy for Liver Cancer by Xue W, Du J, Wei Y, Zhou S, Wang S, Yang Y, Chen L, Yu S

“…Wenqiang Xue,1,* Jinglei Du,2,* Yingying Wei,2 Shizhao Zhou,2 Shicai Wang,4 Yongzhen Yang,3 Lin Chen,3 Shiping Yu2 1Department of Interventional Therapy, Shanxi Provincial People’s Hospital, Taiyuan, 030001, People’s Republic of China; 2Department of Interventional Therapy, Shanxi Province Cancer Hospital/ Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/ Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, 030001, People’s Republic of China; 3Key Laboratory of Interface Science and Engineering in Advanced Materials, Ministry of Education, Taiyuan University of Technology, Taiyuan, 030024, People’s Republic of China; 4Department of Interventional Therapy, Taiyuan Central Hospital, Taiyuan, 030001, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yongzhen Yang, Key Laboratory of Interface Science and Engineering in Advanced Materials, Ministry of Education, Taiyuan University of Technology, Taiyuan, 030024, People’s Republic of China, Email yangyongzhen@tyut.edu.cn Shiping Yu, Department of Interventional Therapy, Shanxi Province Cancer Hospital, Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences, Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, 030001, People’s Republic of China, Email yushiping@sxmu.edu.cnBackground: Small interfering RNA (siRNA) provides a new method for anti-tumor therapy by targeting Survivin gene in liver cancer. …”
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Hyper-Relapse Disease is a Special Pattern of Relapse of Hepatocellular Carcinoma After Curative Hepatectomy: A Retrospective Cohort Study by Yang ZL, Gan YX, Xu JX, Tang YH, Ouyang LY, Qi LN, Xu L

“…Hyper-relapse disease (HRD) is defined as tumor relapse within 6 months from surgery, multiple intrahepatic lesions, as well as macrovascular invasion and/or extrahepatic metastasis. Kaplan–Meier method and Cox regression model were used to analyze overall survival (OS). …”
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Opioid-Free Anesthesia Improved the Quality of Recovery After Thyroidectomy Through Pre-Emptive and Preventive Analgesia: A Randomized Controlled Trial by Zhang Y, Xian X, Wang F, Zhou B, Wang Y, Wang P, Li Y, Wu Y

“…Therefore, we examined the hypothesis that OFA enhances the early quality of recovery in patients undergoing thyroid surgery.Methods: In this randomized controlled trial, 204 adult patients undergoing thyroidectomy were randomly assigned to receive either OFA (esketamine, dexmedetomidine, and bilateral superficial cervical plexus blocks) or opioid-based anesthesia (OBA, sufentanil and remifentanil). …”
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Development of Solid Self-Nanoemulsifying Drug Delivery System of Rhein to Improve Biopharmaceutical Performance: Physiochemical Characterization, and Pharmacokinetic Evaluation by More SM, Rashid MA, Kharwade RS, Taha M, Alhamhoom Y, Elhassan GO, Gangane P, Asar TO, Pise A, Kaleem M, Mujtaba MA

“…Thus, this study aimed to develop a rhein-loaded self-nano emulsifying drug delivery system (RL-SNEDDS) to improve solubility and bioavailability.Methods: The RL-SNEDDS was prepared by aqueous titration method with eucalyptus oil (oil phase), tween 80 (surfactant), and PEG 400 (co-surfactant) and optimization was performed by 32 factorial design. …”
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Association Between Weight-Adjusted Waist Circumference Index and Metabolic Disease-Associated Fatty Liver Disease: A Retrospective Study by Tang T, Fan H, Yu Q, Rao X, Shi Y, Tong X, Feng L, Xu Z, Fu X, Chen J, Zhang X, Tang J, Wang H, Wang M

“…There is a need for a straightforward and effective method to screen for metabolic disease-associated fatty liver disease. …”
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MAGICAL REALISM IN THE CONTEXT OF POSTMODERN AESTHETICS: HERMANN KASACK’S “THE CITY BEYOND THE RIVER” AND MAX KIDRUK’S “DON’T LOOK BACK AND STAY QUIET” INTER- TEXTUAL CONNECTIONS... by Tetiana V. Bykova, Nina D. Osmak

“…To achieve the stated aim and solve the set tasks, historical-literary, hermeneutic, mythopoetic methods, as well as the method of intertextual analysis, were used. …”
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Associations Between Lifetime Histories of Iron Deficiency, Anxiety, Depression and Multiple Pain Conditions: An Observational Study Using a Large-Scale National Database by Champion D, Bui M, Aouad P, Teng A, Walters AS, Karroum EG, Tan AC, Yang Z, Joyce E, Jaaniste T

“…David Champion,1,2 Minh Bui,3 Phillip Aouad,2,* Arthur Teng,1,4,* Arthur S Walters,5,* Elias Georges Karroum,6,* Aidan Christopher Tan,1,2,* Zijing Yang,7,* Emily Joyce,8,* Tiina Jaaniste1,2 1School of Clinical Medicine, University of New South Wales, UNSW, Sydney, NSW, 2052, Australia; 2Department of Pain Medicine, Sydney Children`s Hospital, Randwick, NSW, 2031, Australia; 3Centre for Epidemiology and Biostatistics in the School of Population and Global Health, The University of Melbourne, Parkville, VIC, 3010, Australia; 4Department of Sleep Medicine, Sydney Children`s Hospital, Randwick, NSW, 2031, Australia; 5Department of Neurology, Sleep Division, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA; 6Department of Neurology, University of Virginia School of Medicine, Charlottesville, VA, 22903, USA; 7Department of Inflammation Biology, School of Immunology and Microbial Sciences, Centre for Rheumatic Diseases, King’s College, London Strand, London, WC2R 2LS, UK; 8Faculty of Science, University of Sydney, Sydney, NSW, 2006, Australia*These authors contributed equally to this workCorrespondence: David Champion, Department of Pain Medicine, Bright Alliance Building, Level 7, Sydney Children`s Hospital, Randwick, NSW, 2031, Australia, Tel +61 410405020, Email gdavidchampion@gmail.comPurpose: Our aims were to investigate in adults, as we have shown in three paediatric samples, associations between a history of iron deficiency (whenever acquired and treated) and history (> 3 months) of primary, overlapping and multisite chronic pain conditions, and to investigate associations between history of iron deficiency, anxiety, and depression.Participants and Methods: We recruited adult twins and their families from the Australian Twin Registry database. …”
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Determining the probability of spondyloarthritis in patients with uveitis by A. A. Godzenko, I. Yu. Razumova, S. I. Glukhova

“…SpA was diagnosed in 51/160 pts with unilateral uveitis and was not diagnosed in 109/160 (OR=2.028; 95% CI: 0.913–4.501; p=0.082); out of 48 pts with bilateral uveitis was 9 with SpA and 39 without SpA (OR=0.493; 95% CI: 0.222–1.095; p=0.082); among 149 pts with isolated AU – 55 with SpA and 94 without SpA (OR=6.319; 95% CI: 2.384–16.749; p=0.001); of 59 pts with panuveitis – 5 with SpA and 54 without SpA (OR=0.158; 95% CI: 0.060–0.419; p=0.001); among 159 HLA-B27-positive – 56 with SpA and 103 without SpA (OR=6.117; 95% CI: 2.091–17.888; p=0.001); the onset of uveitis at the age of ≤30 years was in 44/107 pts with SpA and in 63/107 – without SpA (OR=3.710; 95% CI: 1.921–7.168; p=0.001); SpA was confirmed in 39/79 male pts and was not confirmed in 40 (OR=5.014; 95% CI: 2.637–9.535; p=0.001).A formula to determine the probability of SpA in pts with uveitis was obtained by the method of multifactorial discriminant analysis: 1.972 × Х1 + 1.476 × Х2 + 1.418 × Х3 + 1.270 × Х4 + 0.668 × Х5 + 0.162 × Х6, where X1 – male; X2 – the onset of uveitis at the age of ≤30 years; X3 – HLA-B27; X4 – isolated anterior uveitis; X5 – unilateral uveitis; X6 – acute recurrent uveitis.If the amount is greater than 4.552, the probability of SpA is estimated as high, if the amount is less than or equal to 4.552, it is low.Conclusion. …”
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The effects of esketamine on postoperative delirium in older patients with fragile brain function during the non-acute phase following lung cancer surgery: a randomized controlled... by Honglin Fu, Jingna Hu, Xuewei Zhang, Kaiyun Xie, Lihong Hu

“…The Confusion Assessment Method (CAM) was used to evaluate the incidence(%) of POD at 24 h and 72 h post-surgery. …”
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Inflammatory Gene Signature Identified by Machine Algorithms Reveals Novel Biomarkers of Coronary Artery Disease by Liu X, Zhang Y, Wang Y, Xu Y, Xia W, Liu R, Xu S

“…The CIBERSORT algorithm and Wilcoxon test method were used to analyze the differences in immune cells between the CAD and normal samples. …”
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Effects of Xenon on Neuroinflammatory Markers: a Prospective Pilot Study by A. I. Shpichko, R. A. Cherpakov, A. K. Shabanov, A. K. Evseev, I. V. Goroncharovskaya, O. A. Grebenchikov

“…The concentration of S100 b protein during the entire observation period in both groups did not exceed 0.005 pg/ml.CONCLUSION Xenon inhalation according to the method proposed by the authors had a beneficial effect on the processes of neural tissue regeneration, however, with regard to neuroinflammation, its effects were not so pronounced.…”
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Efficacy and Safety of Transarterial Chemoembolization Combined with Hepatic Arterial Infusion Chemotherapy Plus Lenvatinib for Intermediate-Stage Hepatocellular Carcinoma Beyond U... by Zhong S, Zhang F, Zhang H, Hu H, Zeng Q, Li Y, Wei Q

“…Propensity score matching (PSM) and inverse probability weighting (IPTW) were applied to balance baseline differences. The Kaplan–Meier method was utilized for survival analysis. Cox regression-based multivariate analysis was used to identify survival-related risk factors. …”
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Diagnostic and Predictive Values of Soluble Triggering Receptor Expressed on Myeloid Cells-1 in Sepsis: A Multi-Center Prospective Clinical Study by Wang K, Zhang Y, Sang L, Hu Y, Su L, Xie S, Xiao K, Xu J, Wang J, Xie F, Zhu G, Fu S, Xie L

“…Kaifei Wang,1,* Youchen Zhang,2,* Lei Sang,3,* Ye Hu,1,* Longxiang Su,4 Sheling Xie,1 Kun Xiao,1 Jianqiao Xu,1 Jiang Wang,1 Fei Xie,1 Guangfa Zhu,5 Shihui Fu,6– 8 Lixin Xie1 1College of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital, Beijing, People’s Republic of China; 2Department of Pediatrics, Hainan Hospital of Chinese PLA General Hospital, Sanya, People’s Republic of China; 3Information Department, Hainan Hospital of Chinese PLA General Hospital, Sanya, People’s Republic of China; 4Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, People’s Republic of China; 5Department of Pulmonary and Critical Care Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, People’s Republic of China; 6Department of Cardiology, Hainan Hospital of Chinese PLA General Hospital, Hainan Geriatric Disease Clinical Medical Research Center, Hainan Branch of China Geriatric Disease Clinical Research Center, Sanya, People’s Republic of China; 7Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, People’s Republic of China; 8The Second School of Clinical Medicine, Southern Medical University, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shihui Fu, Department of Cardiology, Hainan Hospital of Chinese PLA General Hospital, Hainan Geriatric Disease Clinical Medical Research Center, Hainan Branch of China Geriatric Disease Clinical Research Center, Sanya, People’s Republic of China, Email xiaoxiao0915@126.com Lixin Xie, College of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital, Beijing, People’s Republic of China, Email xielx301@126.comObjective: To determine diagnostic values of serum and urine soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in sepsis including septic shock and their predictive values for clinical prognosis and sepsis-associated acute kidney injury (AKI).Methods: A multi-center prospective research method was used to enroll patients with sepsis.Results: A total of 586 cases were studied, including 238 patients with sepsis and 348 healthy individuals. …”
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Survival of retinoblastoma patients: a cohort study by two Russian medical centers by S. V. Saakyan, O. A. Ivanova, S. S. Tadevosyan, A. Yu. Tsygankov, L. V. Olkhova, T. L. Ushakova, V. G. Polyakov

“…To evaluate the overall, disease-specific, event-free, relapse-free survival of retinoblastoma (RB) patients and cumulative probability of eye survival in such patients.Material and methods. The study included 223 children with RB (126 male, 97 female). …”
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Electroacupuncture Prevent and Treat Perioperative Cognitive Impairment in Elderly Patients Undergoing Hip Surgery: A Protocol for a Randomized Controlled Trial by Fang Q, Xie J, Zheng S, Hou Y, Wu M, Chen Y, Yang Y, Wang G, Li J

“…However, the mechanism of electroacupuncture treatment for PND is comparatively unexplored.Methods/Design: This is a single-center clinical, prospective randomized controlled clinical trial protocol. 180 patients will be randomly divided into the treatment group and the control group in a ratio of 1:1. …”
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Impact of Pre-Interventional Observational Management Duration on Outcomes of Embolization for Splenic Injuries: Experience from Two Centers by Nguyen VT, Le TD, Pham HD, Tran QL

“…Van Thang Nguyen,1,2,* Thanh Dung Le,3,4,* Hong Duc Pham,1,5,* Quang Loc Tran3,4,* 1Radiology Department, Hanoi Medical University, Hanoi, Vietnam; 2Radiology Department, Hai Duong Medical Technical University, Hai Duong, Vietnam; 3Radiology Department, VNU University of Medicine and Pharmacy, Hanoi, Vietnam; 4Radiology Department, Viet Duc University Hospital, Hanoi, Vietnam; 5Radiology Department, Saint Paul Hospital, Hanoi, Vietnam*These authors contributed equally to this workCorrespondence: Van Thang Nguyen, Department of Radiology, Hai Duong Medical Technical University, Hai Duong, Vietnam, Email nguyenvanthang@hmtu.edu.vnObjective: To evaluate the clinical and technical success of splenic artery embolization (SAE) in the management of splenic trauma and factors affecting treatment outcomes.Materials and Methods: A retrospective and prospective study was conducted at two centers from December 2019 to December 2023, including 400 patients with splenic trauma (grade III–V according to the American Association for the Surgery of Trauma (AAST) - 2018 classification) and the Abbreviated Injury Scale (AIS) 2005 change from the AIS-1998. …”
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PHASE 2 MULTICENTER RANDOMIZED CLINICAL TRIAL: NEOADJUVANT CHEMORADIOTHERAPY FOLLOWED BY D2 GASTRECTOMY AND ADJUVANT CHEMOTHERAPY IN PATIENTS WITH LOCALLY ADVANCED GASTRIC CANCER by V. Yu. Skoropad, S. G. Afanasyev, S. V. Gamayunov, N. K. Silanteva, T. A. Agababyan, P. V. Sokolov, S. A. Ivanov, A. D. Kaprin

“…Additional objectives of the study were to assess the accuracy of preoperative staging of gastric cancer; tumor regression grade of the primary tumor and regional lymph node metastases according to CT findings; treatment outcomes according to the criteria of frequency and time to recurrence/metastasis; 1-, 2 -, and 3-year survival rates. Material and methods. The study included 70 patients with equal distribution between the treatment groups. …”
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AuNRs-PPARγmAb Induce Targeted Adipocyte Apoptosis Through Photothermal Effects for Effective Localized Fat Reduction by Hu Y, Xiao K, Chen Z, Ou S, Sima C, Wang H, Zhang J, Zhang Z, Li X

“…This targeted approach offers a promising method for non-surgical, localized fat reduction. …”
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