Hyaluronic acid: Function and location in the urothelial barrier for bladder pain syndrome/interstitial cystitis, an in vitro study. by Charlotte J van Ginkel, Cléo D M Baars, Dorien M Tiemessen, Cornelius F J Jansen, Frank M J Martens, Jack A Schalken, Dick A W Janssen

“…Immunohistochemistry was performed on human and porcine biopsies and on porcine cell cultures to evaluate the location of HA. Functional contribution was assessed through transepithelial electrical resistance measurements and the effects on gene expression in a differentiated primary porcine urothelial cell model. …”
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Nutritional supplement Youtianli regulates Treg function and gut immunity via SCFA-producing microbiota modulation by Hexiu Yuan, Yichun Xiao, Yubo Huang, Leming Huang

“…Fecal microbiota transplantation (FMT) demonstrated that immunoregulatory effects of YTL were microbiota-dependent. These findings suggest that YTL improves immune function by modulating gut microbiota and enhancing SCFA metabolism. …”
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Impact of ionizing radiation and low-energy electrons on DNA functionality: radioprotection and radiosensitization potential of natural products by Kouass Sahbani Saloua, Rayan M. Alansari

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Analytical and Computational Investigations of Stochastic Functional Integral Equations: Solution Existence and Euler–Karhunen–Loève Simulation by Manochehr Kazemi, AliReza Yaghoobnia, Behrouz Parsa Moghaddam, Alexandra Galhano

“…This paper presents a comprehensive investigation into the solution existence of stochastic functional integral equations within real separable Banach spaces, emphasizing the establishment of sufficient conditions. …”
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SIRT3 mediates CPT2 delactylation to enhance mitochondrial function and proliferation in goat granulosa cells by Shuaifei Song, Mingzhi Yang, Jiayue Li, Yaru Li, Lei Wang, Shiyi Yao, Zihan Wang, Qiuyan Li, Yanguo Han, Dejun Xu, Zhongquan Zhao

“…However, the specific effect of SIRT3 on the follicular development process remains unclear. …”
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Resveratrol Alleviates NEFA-Induced Oxidative Damage in Bovine Mammary Epithelial Cells by Restoring Mitochondrial Function by Longwei Sun, Junpeng Huang, Xiangyang Dou, Zhenyu Dong, Yuan Li, Shujing Tan, Ran Yu, Chengmin Li, Weiguo Zhao

“…Resveratrol (RES) is a polyphenolic compound with antioxidant, anti-inflammatory and multiple other physiological effects. However, its effect on oxidative damage triggered by NEFAs in bovine mammary epithelial cells is rarely reported. …”
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Influence of alprostadil on the dynamics of blood flow resistance index and renal graft function in the early postoperative period by P. A. Drozdov, I. V. Nesterenko, D. A. Makeev, O. S. Zhuravel, S. A. Astapovich, D. A. Solomatin, E. A. Lidzhieva

“…Aim. To evaluate the effect of continuous intravenous infusion of alprostadil solution on the dynamics of the peripheral resistance to arterial blood flow and renal graft function in the early postoperative period.Material and methods. …”
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Exploring the Influence of a Pomegranate Extract on the Functionality of Healthy and Diseased Human Gut Microbiota: An In Vitro Study by Daniele Giuseppe Buccato, Adriana Delgado-Osorio, Lorenza Francesca De Lellis, Maria Vittoria Morone, Hammad Ullah, Luana Izzo, Sonia Lombardi, Alessandro Di Minno, Costanza Valentina Riccioni, Dafni Moriki, José Ángel Rufián-Henares, Maria Daglia

“…The PE exerted a modulatory effect on gut microbiota functionality, as reflected by an increasing concentration of SCFAs, especially lactic acid. …”
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Exposure to polycyclic aromatic hydrocarbons and risk of abnormal liver function: The mediating role of C-reactive protein by Yating Wang, Enwei Zhu, Xiaoyan Zhu, Xiaoliang Li, Mei’an He, Rihong Zhai, Xuli Wu, Dongsheng Hu, Xu Han

“…These results enhanced our comprehension of the health effects of PAHs exposure on liver function as well as the underlying mechanism.…”
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Downregulation of AdipoR1 in the hippocampus impairs synaptic function and structure and causes depression-like behavior by Peilin Zhu, Yanmin Luo, Yue Li, Jing Tang, Li Liu, Yuhui Deng, Jing Li, Lin Jiang, Wenyu Yang, Qian Xiao, Shun Wang, Yuning Zhou, Fenglei Chao, Lei Zhang, Chunni Zhou, Yong Tang, Xin Liang

“…The adiponectin receptors (AdipoRs) AdipoR1 and AdipoR2, which serve as the main receptors for adiponectin in the central nervous system, mediate the downstream biological effects of this compound, which has been reported to have positive effects on synaptic plasticity. …”
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The functional influences of common ABCB1 genetic variants on the inhibition of P-glycoprotein by Antrodia cinnamomea extracts. by Ming-Jyh Sheu, Yu-Ning Teng, Ying-Yi Chen, Chin-Chuan Hung

“…Antrodia cinnamomea is a traditional healthy food that has been demonstrated to possess anti-inflammatory, antioxidative, and anticacer effects. The purpose of this study was to evaluate whether the ethanolic extract of A. cinnamomea (EEAC) can affect the efflux function of P-glycoprotein (P-gp) and the effect of ABCB1 genetic variants on the interaction between EEAC and P-gp. …”
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Comparison of Oral Diazepam and Baclofen on Hand Function in Spastic Cerebral Palsy: A Prospective Randomised Study by Vinay Goyal, Nonica Laisram

“…There are no studies comparing the effect of diazepam and baclofen on hand function in spastic CP. …”
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Double Sigmoid Activation Function for Fault Detection in Wind Turbine Generator using Artificial Neural Network by NOOR FAZLIANA FADZAIL, Samila Mat Zali, Ernie Che Mid

“…The ANN model was developed in different activation functions, namely linear and double sigmoid activation functions to evaluate the effectiveness of the proposed activation function. …”
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Investigating the cardiorespiratory fitness gene COX7A2L in cardiomyocytes: Viability and mitochondrial function. by Ada Nilsen Nordeidet, Gurdeep S A Marwarha, Øystein Røsand, Victoria Johansen, Karin Garten, Morten A Høydal, Mette Langaas, Anja Bye

“…For the mitochondrial function measurements, we stimulated the cells with isoproterenol to investigate if the effect of altering COX7A2L levels would be larger under simulated increased energy demand. …”
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Genetic and epigenetic factors regulating the expression and function of the vitamin D receptor in patients with coronary artery disease by Zh. I. Ionova, E. G. Sergeeva, O. A. Berkovich

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Intermittent fasting reduces alpha-synuclein pathology and functional decline in a mouse model of Parkinson’s disease by Éva M. Szegő, Lennart Höfs, Anna Antoniou, Elisabeth Dinter, Nadine Bernhardt, Anja Schneider, Donato A. Di Monte, Björn H. Falkenburger

“…This study investigates the therapeutic effects of intermittent fasting (IF) in an rAAV-aSyn mouse model of PD. …”
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Evaluation the correlation between Inulin and Cystatin C with kidney function tests and GFR in patients with renal disorders by Nawar Mohsin Abd-alaziz, Wasan Nazhan Hussein

“… Background: Kidneys are important organs in the human body because of their great importance in assisting the body to remove waste products that resulting from food metabolism through renal filtration of blood plasma from unwanted substances and excreted through diuresis and recover substances that body needs to the blood, relative effectiveness of the kidney can be estimated by measuring the efficiency of glomerular filteration rate (GRF), represented by amount of inulin filtrate into renal tubules for a specified period of time, any difference in normal value indicates the presence of a disorder in the kidney, which affects on performance of its functions and occurrence of imbalance in internal environment of the body, and leads to disrupting functions of other parts of the body, measuring rate of renal filtration is one of the best ways to know function of the kidneys and diagnose various kidney diseases and prevent their development. …”
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A Comprehensive Review of Bioactive Tannins in Foods and Beverages: Functional Properties, Health Benefits, and Sensory Qualities by Fernanda Cosme, Alfredo Aires, Teresa Pinto, Ivo Oliveira, Alice Vilela, Berta Gonçalves

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Contribution of depression and cardiometabolic diseases and the role of depression treatment in survival and functioning in older adultsResearch in context by Najmeh Davoodian, Malcolm Forbes, Michael Berk, Daniel Clayton-Chubb, Rachel R. Huxley, Crystal Man Ying Lee, Mojtaba Lotfaliany, John J. McNeil, Julie A. Pasco, Kevan R. Polkinghorne, Greg Roebuck, Joanne Ryan, Andrew M. Tonkin, Robyn L. Woods, Mohammadreza Mohebbi

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Interaction with IGF1 overrides ANXA2-mediated anti-inflammatory functions of IGFBP5 in vivo by Yan Fan, Yi-Jin Wu, Yi-Jin Wu, Kai Guo, Xia-Qing Zhou, Abulizi Abulaiti, Opeyemi Joshua Olatunji, Cong-Lan Ji, Jian Zuo, Jian Zuo

“…An IGF1R inhibitor picropodophyllin antagonized functions of IGF1/IGF1R too, but didn’t reinforce the effects of IGFBP5.ConclusionIGFBP5 eases inflammation by interacting with ANXA2, an activator of NF-κB; as an antagonist of IGF1/IGF1R, IGFBP5 may disrupt immune homeostasis in vivo, due to impairment of the latter’s anti-inflammatory functions; excessive IGFBP from adipocytes would be a pathogenic factor in certain diseases.…”
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