Empirical assessment of functional somatic disorder (FSD): frequency, applicability, and diagnostic refinement in a population-based sample by Abigail Smakowski, Judith Rosmalen, Bernd Löwe, Christopher Burton, Anne Toussaint

“…Kruskal–Wallis and chi-square tests with effect size estimates were used to investigate differences in the diagnostic subgroups regarding chronic diseases, functional comorbidities and psycho-behavioural features. …”
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Radiation-Based Multi-Modal Therapy Combining with Immunotherapy to Develop a Vaccine-Like Effective Treatment for Triple-Negative Breast Cancer by Dai M, Tian Z, Xu F, Yao B, Liang H, Li D, Wang J, Rong J, Liu T, Tang H, Lu H, Zhang W

“…The synergistic therapy exerts a powerful vaccine-like long-term immune memory function to prevent tumor recurrence with the elevated level of effector memory T (Tem) cells (from 12.8% to 33.3%, P < 0.05).Conclusion: Based on the 4T1 mouse model, developed an effective vaccine-like therapeutic strategy combining X-PDT with Anti-CTLA4, which can effectively ablate tumors, inhibit metastasis, and prevent tumor recurrence. …”
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Orally Administered Functional Polyphenol‐Nanozyme‐Armored Probiotics for Enhanced Amelioration of Intestinal Inflammation and Microbiota Dysbiosis by Yong Zhu, Ziqu Fang, Jie Bai, Longhui Wang, Jiaqing Chen, Zehua Zhang, Qiang Wang, Weiwei Sheng, Xueyin Pan, Zhenyuan Gao, Dengqiu Xu, Pengkai Wu, Beicheng Sun

“…Abstract Maintaining microbiota balance and enhancing the antioxidant performance of nanozyme‐based probiotic systems are crucial for effective inflammatory bowel disease (IBD) therapy. …”
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Aptamer-functionalized graphene quantum dots combined with artificial intelligence detect bacteria for urinary tract infections by Kun Li, Shiqiang Fang, Tangwei Wu, Chao Zheng, Yi Zeng, Jinrong He, Yingmiao Zhang, Yingmiao Zhang, Zhongxin Lu, Zhongxin Lu

“…And the result of detection system is in good agreement with MALDI-TOF MS.ConclusionsThe detection system is an accurate and effective way to detect bacteria in urinary tract infections.…”
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Selective retinoid X receptor agonism promotes functional recovery and myelin repair in experimental autoimmune encephalomyelitis by Gracious D. S. Kasheke, Basmah A. M. Hendy, Gabriel G. Dorighello, Nonthué A. Uccelli, Jean-David M. Gothié, Robyn J. Novorolsky, Madison J. Oulton, Jude Asainayagam, Adam I. Makarov, Kaitlyn S. Fraser, Vidyasagar Vuligonda, Martin E. Sanders, Timothy E. Kennedy, George S. Robertson

“…These results inform the discovery of restorative neural therapeutics for MS by demonstrating that selective RXR agonism is sufficient for effective myelin repair. Moreover, our findings support the therapeutic potential of IRX4204 to promote functional recovery in MS.…”
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Plant-Derived Exosomes: Carriers and Cargo of Natural Bioactive Compounds: Emerging Functions and Applications in Human Health by Sorur Yazdanpanah, Silvia Romano, Anna Valentino, Umberto Galderisi, Gianfranco Peluso, Anna Calarco

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Functional screening identifies kinesin spindle protein inhibitor filanesib as a potential treatment option for hepatoblastoma by Ruth Nousiainen, Katja Eloranta, Jani Saarela, Antti Hassinen, Tamara J. Luck, Stefano Cairo, Emilie Indersie, Swapnil Potdar, Michaela J. Feodoroff, Jouko Lohi, Lassi Paavolainen, David B. Wilson, Vilja Pietiäinen, Markku Heikinheimo, Marjut Pihlajoki

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Environmental gradients strongly affect functional composition and biomass C stocks within aquatic plant meadows by Roel Lammerant, Jenna Hölttä, Janina Pykäri, Nishant Nishant, Anna Villnäs, Sofia A. Wikström, Alf Norkko, Camilla Gustafsson

“…Abstract Ecological succession provides a critical framework to evaluate and predict the effects of successional dynamics within plant communities on ecosystem functions, which has become increasingly relevant in recent years as humans adapt to a world that is progressively shaped by anthropogenic disturbances. …”
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Synthesis of Diazepam-Imprinted Polymers with Two Functional Monomers in Chloroform Using a Bulk Polymerization Method by Aliya Nur Hasanah, Dang Soni, Rimadani Pratiwi, Driyanti Rahayu, Sandra Megantara, Mutakin

“…Diazepam is a benzodiazepine that has the potency to be misused because it is effective, easily obtained, and inexpensive. The misuse of diazepam is to replace illegal drugs and be a sedative. …”
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Development of the algal pigment-based salinity transfer function for lakes on the Tibetan Plateau and evaluation of the quantitative reconstruction by Xinyao Sun, Qi Lin, Chenliang Du, Shixin Huang, Ke Zhang, Ji Shen

“…Comparison with other paleoclimatic and meteorological records revealed that the lake salinity was mainly influenced by climate-mediated changes in regional precipitation and effective moisture. This study established a new algal pigment-based salinity transfer function, and provided a promising indicator and method to quantitatively reconstruct past lake environmental conditions on the Tibetan Plateau.…”
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Functionalized mesoporous silica nanoparticles templated by pyridinium ionic liquid for hydrophilic and hydrophobic drug release application by Nurul Syahira Zaharudin, Eleen Dayana Mohamed Isa, Haslina Ahmad, Mohd Basyaruddin Abdul Rahman, Khairulazhar Jumbri

“…Besides, by employing surface functionalization, the effectiveness of MSNs as drug delivery agent may also increase. …”
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Developing an early warning land degradation indicator based on geostatistical analysis of Ecosystem Functional Types dynamics by Cristina Domingo-Marimon, Małgorzata Jenerowicz-Sanikowska, Lluís Pesquer, Marek Ruciński, Michał Krupiński, Edyta Woźniak, Anna Foks-Ryznar, Mohammad Abdul Quader

“…This study evaluates the effectiveness of Ecosystem Functional Attributes (EFAs) and Ecosystem Functional Types (EFTs) as early warning indicators of ecosystem degradation. …”
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Silent changes in taxonomic, functional and phylogenetic diversity of birds in Qiyunshan National Nature Reserve, south China by Binqiang Li, Jian Lu, Xin Zhong, Daohan Li, Bailin Li, Nehafta Bibi, Kechuan Linghu, Shanjun Ma, Pinghua Zhong

“…However, the potential impact of these changes on functional diversity and phylogenetic diversity remains poorly understood. …”
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Lactiplantibacillus plantarum LZU-J-Q21 enhanced the functional metabolic profile and bioactivity of Cistanche deserticola by Kangkang Liu, Junxiang Li, Wenting Hao, Jingjing Li, Israr Khan, Yibo Liang, Haijuan Wang, Xiaofeng Li, Chunjiang Zhang

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Synthesis and evaluation of smart drugs with integrated functions for identifying and treating oxidative microenvironments associated with cellular ferroptosis by Yibo Zhang, Rui Cai, Yu Ding, Jiangye Zhang, Changxu Ning, Jiangcheng Zeng, Zhongxiang Zhou, Shisheng Wang, Yueqing Li, Xiuhan Guo

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Clinical and Functional Outcomes of Percutaneous Locking Plate as an External Fixator in Extra-Articular Proximal Tibia Fractures by Imran Manzoor, Rizwan Khan Lodhi, Muhammad Moeen, Jahanzeb Khan, Imanullah Riaz, Muhammad Omer Imran Elahi

“… Objective: To evaluate the clinical and functional outcomes of using a percutaneous locking plate as an external fixator in extra-articular proximal tibia fractures, with particular emphasis on pain reduction, fracture union, and progressive recovery of knee range of motion (ROM). …”
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Advances in gut microbiota functions in inflammatory bowel disease: Dysbiosis, management, cytotoxicity assessment, and therapeutic perspectives by Ivan Kushkevych, Michaela Dvořáková, Dani Dordevic, Bożena Futoma-Kołoch, Márió Gajdács, Lamiaa A. Al-Madboly, Mohamed Abd El-Salam

“…Despite advances in diagnosis, effective long-term therapeutic options remain limited, with many patients experiencing recurrent symptoms after treatment. …”
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Stability and Efficacy of Mucoadhesive Eye Drops Containing Olopatadine HCl: Physicochemical, Functional, and Preclinical In Vivo Assessment by Anđelka Račić, Veljko Krstonošić, Ana Micov, Uroš Pecikoza, Vladimir Dobričić, Erna Turković, Danina Krajišnik

“…<b>Background:</b> The incorporation of polymers into drug delivery vehicles has been shown to be an effective strategy to prolong the residence time of active ingredients in the precorneal tear film and to increase ocular bioavailability. …”
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Study on Large‐Scale Brain Network Abnormalities in Patients With Beta‐Thalassemia by Mingrui Yang, Guowei Chen, Peng Peng, Cheng Tang, Chaotian Luo, Fei Peng, Rong Kong, Chunxia Zhu, Jiatong Liang

“…Abstract Background Beta‐thalassemia major (β‐TM) is a hereditary blood disorder characterized by chronic anemia and hypoxia, which may have profound effects on brain function. This study systematically evaluates alterations in both intra‐brain network functional connectivity (FC) and inter‐network functional connectivity (FNC) in β‐TM patients using resting‐state functional magnetic resonance imaging (rs‐fMRI) and independent component analysis (ICA), aiming to uncover the potential mechanisms underlying their neurofunctional impairments. …”
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Electrostatic Self‐Assembly of Ag‐NPs Mediated by Eu3+ Complexes for Physically Unclonable Function Labels by Yao Kou, Yanan Guo, Lijuan Liang, Xue Li, Yifan Wang, Pingru Su, Chun‐Hua Yan, Yu Tang

“…ABSTRACT Physically unclonable functions (PUFs) are essential for anticounterfeiting. …”
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