The importance of different preoperative factors in the prognosis of functional results of uncomplicated surgery for idiopathic epimacular membranes by S. G. Toropygin, S. V. Nazarova, A. N. Maslov

“…Purpose: to estimate the cumulative effect of different preoperative predictors on the functional results of the removal of idiopathic epimacular membranes (EMMs) 12 months after the surgery. …”
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Meaningful to whom? Minimal clinically important differences and the priorities of individuals living with dementia for everyday function by Andrea Gilmore‐Bykovskyi, Kayla Dillon, Beth Fields, Clark Benson, Dorothy Farrar Edwards

“…Highlights Alzheimer's disease and Alzheimer's disease related dementias (AD/ADRD) have a significant impact on an individual’ functional cognitive abilities, of which changes in these abilities are measured through detection of minimally clinically important difference (MCID) thresholds to determine the effectiveness of AD/ADRD clinical trials. …”
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Robot-assisted exercise improves gait and physical function in older adults: a usability study by Su-Hyun Lee, Eunmi Kim, Jinuk Kim, Hwang-Jae Lee, Yun-Hee Kim

“…The purpose of this study was to investigate the usability of Bot Fit after task-specific physical activities and functional gait training, as well as to examine the effects of a wearable hip exoskeleton, Bot Fit, on gait, physical function, and muscle strength in older adults living in residential care facilities. …”
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Development and mechanism study of functional fermentation media for reducing alkaloid content in cigar tobacco leaves by Wanrong Hu, Li Liu, Jiabao Zhang, Quanwei Zhou, Zhongrong Jiang, Yun Jia, Qianying Zhang, Dongliang Li

“…Fermentation is a well-recognized strategy to reduce alkaloid content. However, its effectiveness is influenced by the choice of fermentation media. …”
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[Comment] Intravenous lidocaine for gut function recovery in colonic surgery: a randomized clinical trial by Huo Zhikui, Li Jiannan

“…[Objective] To evaluate the effect of 2% perioperative intravenous lidocaine infusion on return of gut function after elective minimally invasive colon resection. …”
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Dynamics of Vascular Stiffness and Endothelial Function in Combination Therapy of Heart Failure with Preserved Ejection Fraction by Z. M. Akhilgova, I. I. Almazova, N. K. Gabitova, E. A. Kotaeva, A. G. Avtandilov

“…Aim. To assess the effect of combination therapy (perindopril, indapamide, amlodipine) on vascular stiffness and endothelial function in patients with heart failure with preserved ejection fraction (HFpEF).Material and methods. …”
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Esketamine modulates cerebral function variations between S1 and BLA in rats with chronic pain and anxiety by Yuanyuan Fang, Xiaokai Sui, Danhao Zheng, Jiahui Sun, Ting Chen, Junke Jia, Jing Yao, Jie Wang, Chang Chen, Zongze Zhang

“…Background: The comorbidity of chronic pain and anxiety exerts a profound impact on neurological functions. This study aims to investigate the alterations in brain metabolism and functional connectivity that arise from the interaction between chronic pain and anxiety in rats. …”
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Chemical-functional characterization of Ascophyllum nodosum and Phymatolithon calcareum and dietary supplementation in post-weaning pigs by Sara Frazzini, Serena Reggi, Matteo Dell’Anno, Anna Paola Fifi, Elena Scaglia, Elena Scaglia, Irene Ferri, Luciana Rossi

“…IntroductionAs the livestock industry grapples with the need for sustainable land, maintaining production systems, and reducing antimicrobial resistance, the application of functional nutrition emerges as a potential solution.AimIn line with the One Health principles, this study aims to evaluate functional properties of Ascophyllum nodosum and Phymatolithon calcareum, and assess the effects of their dietary supplementation on piglets’ health.Materials and methodsA chemical-functional characterization was conducted before and after in vitro digestion. …”
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Linking Immunological Parameters and Recovery of Patient’s Motor and Cognitive Functions In The Acute Period of Ischemic Stroke by A. M. Tynterova, N. N. Shusharina, A. M. Golubev, E. M. Moiseeva, L. S. Litvinova

“…Although obtained results demonstrate negative effect of increased MPIF-1/CCL23, Gro-a/CXCL1, IL-16 and Eotaxin-2/CCL24 concentrations on the improvement of motor and cognitive impairments, further studies are needed to verify the CXC and CC subfamilies chemokines as prognostic markers of patient’s functional outcome in the acute period of ischemic stroke.…”
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Novel Trimethoprim-Based Metal Complexes and Nanoparticle Functionalization: Synthesis, Structural Analysis, and Anticancer Properties by Abbas M. Abbas, Hossam H. Nasrallah, A. Aboelmagd, W. Christopher Boyd, Haitham Kalil, Adel S. Orabi

“…We then prepared metal complexes of this derivative with Cu(II), Co(II), Ni(II), Ag(I), and Zn(II) and functionalized them with ZnO and Au nanoparticles. Their structures were confirmed through ¹H NMR, mass spectrometry, FTIR, conductivity, thermal analysis, magnetic susceptibility, X-ray diffraction, UV-Vis spectroscopy, and TEM, revealing octahedral geometries for all complexes. …”
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Executive Functions, Anxiety, Social Participation and Quality of Life in Children with Migraine During COVID-19 by Jacob Genizi, Hila Samet, Hussein Zaitoon, Uriel Elimelech, Nogah C. Kerem, Aharon Kessel, Adel Shalata, Keren Nathan, Batya Engel-Yeger

“…Objective: We aimed to compare executive functions (EF), anxiety, social participation, and quality of life (QoL) between children with migraine and healthy controls during the COVID-19 pandemic, and to examine these parameters in children in each group who did vs. did not contract COVID-19. …”
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Highly efficient generation of mature megakaryocytes and functional platelets from human embryonic stem cells by Chuxin Chen, Ning Wang, Xueyan Zhang, Yingjie Fu, Zhiyong Zhong, Haibin Wu, Yaming Wei, Yuyou Duan

“…Furthermore, 95% of platelets showed CD42b+CD62p+ phenotype upon the stimulation with ADP and TRAP-6, while 50% of platelets exhibited the ability to bind PAC-1, indicating that hESC-derived platelets possessed the in vitro functionality. In mice models of thrombocytopenia, hESC-derived platelets effectively restored hemostasis in a manner comparable to human blood-derived platelets. …”
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SPOP-mediated ubiquitination and degradation of PDK1 suppresses AKT kinase activity and oncogenic functions by Qiwei Jiang, Nana Zheng, Lang Bu, Xiaomei Zhang, Xiaoling Zhang, Yuanzhong Wu, Yaqing Su, Lei Wang, Xiaomin Zhang, Shancheng Ren, Xiangpeng Dai, Depei Wu, Wei Xie, Wenyi Wei, Yasheng Zhu, Jianping Guo

“…Conclusions Our results not only reveal a physiological regulation of PDK1 by E3 ligase SPOP, but also highlight the oncogenic roles of loss-of-function mutations of SPOP or gain-of-function mutations of PDK1 in tumorigenesis through activating the AKT kinase.…”
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An Approach to, and Tool for, Predicting the Time Course of an Infectious Disease Outbreak as a Function of Behavioral Interventions by Abebe HT, Siraj A, Berhane K, Siraj D, Van Breukelen GJ

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Temporal evolution and factors influencing visual function and RNFL thickness in ethambutol-associated optic neuropathy by Taimin Guo, Yue Fu, Xiaoyu Xu, Xiaoning Liu, Yurong Zhang, Hui Yang

“…Comprehensive ophthalmologic assessments, including best corrected visual acuity (BCVA), visual field (VF), optical coherence tomography (OCT), and magnetic resonance imaging (MRI), were conducted to evaluate visual function and optic nerve structure. Statistical analyses including multiple linear regression and comparative analyses (independent t-tests/Mann–Whitney U tests) were performed to identify factors influencing recovery, with effect sizes calculated using Cohen’s d. …”
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Structural and functional changes of the heart in patients with chronic ischemic heart failure, associated with renal dysfunction by D. A. Lashkul

“…The effects of CKD on other left ventricular and myocardial parameters, however, have been less characterized. …”
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Integrated multi-omics analysis reveals the functional signature of microbes and metabolomics in pre-diabetes individuals by Yanmin Liu, Qinwei Qiu, Yang Chen, Yusheng Deng, Wei Huang, Chen Sun, Xiaoxiao Shang, Xinyan Chen, Chengrui Wang, Lijuan Han, Shiyan Chen, Jiamin Yuan, Fuping Xu, Zhimin Yang, Xiaodong Fang, Li Huang

“…Using an integrated analysis of human microbiota and metabolomics data, we seek to identify the functional signature associated with PD and gain insights into potential mechanisms driving its progression to type 2 diabetes. …”
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The impact of kidney function on Alzheimer’s disease blood biomarkers: implications for predicting amyloid-β positivity by Burak Arslan, Wagner S. Brum, Ilaria Pola, Joseph Therriault, Nesrine Rahmouni, Jenna Stevenson, Stijn Servaes, Kübra Tan, Paolo Vitali, Maxime Montembeault, Jesse Klostranec, Arthur C. Macedo, Cecile Tissot, Serge Gauthier, Juan Lantero-Rodriguez, Eduardo R. Zimmer, Kaj Blennow, Henrik Zetterberg, Pedro Rosa-Neto, Andrea L. Benedet, Nicholas J. Ashton

“…Abstract Background Impaired kidney function has a potential confounding effect on blood biomarker levels, including biomarkers for Alzheimer’s disease (AD). …”
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Randomised control trial of virtual reality in cognitive rehabilitation: effectiveness and near-transfer effect for stroke patients by Jovita Janavičiūtė-Pužauskė, Raimonda Petrolienė, Loreta Zajančkauskaitė-Staskevičienė, Andrius Paulauskas, Liuda Šinkariova

“…Additionally, it seeks to examine whether egocentric perspective-based training enhances the near transfer effect, resulting in improved other cognitive functions compared to allocentric perspective-based training and conventional rehabilitation. …”
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Long-term impact on cardiopulmonary function and quality of life among patients recovered from SARS-CoV-2 infection in a 6-month follow-up period in Lima, Peru: FUNCTION cohort stu... by Carlos Seas, Larissa Otero, Eduardo Gotuzzo, Fernando Mejia, Rodrigo Cachay, Takashi Watanabe-Tejada, Katiuska Cuno, Marcela Gil-Zacarias, Carolina Coombes, Isabel Ballena, Felix Medina, Oscar Gayoso

“…Primary outcomes are defined as abnormal pulmonary function test considered as DLco <80%, abnormal cardiovascular function considered as left ventricular ejection fraction <50% and abnormal quality of life considered as a <40 score for each sphere in the RAND-36-Item Short Form Health Survey.Ethics and dissemination The study protocol was approved by the Institutional Ethics Committee of the Universidad Peruana Cayetano Heredia (SIDISI 203725) and the Ethics Committee of the Hospital Cayetano Heredia (042-2021). …”
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