Orthosis Followed by Trapeziectomy for Thumb Base Osteoarthritis: A Cohort Pilot Study on Pain and Function by Kati Jaatinen, M.Sc, Jenni Pajari, MD, Eero Waris, MD, PhD, Jarkko Jokihaara, MD, PhD, Simo Taimela, MD, PhD, Teppo L.N. Järvinen, MD, PhD, Teemu Karjalainen, MD, PhD

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Analysis of the prognostic efficacy of syndecan-1 for patients with ACLF and its functional role in liver regeneration by Yingli He, Xiaoli Zhang, Yichen Yao, Juan Li, Shan Fu, Yali Feng, Tianzhi Ni, Ruojing Wang, Qiao Zhang, Yushan Liu, Zhijun Liu, Jinfeng Liu, Yuan Yang, Yingren Zhao, Yalei Zhao

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Aqueous extracts of Portulaca oleracea L. alleviate atopic dermatitis by restoring skin barrier function by Haobin Wei, Zhang Chen, Zhang Chen, Wenjie Lai, Wenjie Lai, Wenxian Wang, Xiqing Bian, Xiqing Bian, Limin Zhang, Xinzhi Li, Xinzhi Li

“…The PO hydrogel promoted the expression of caspase-14 and filaggrin, thereby helping restore skin barrier function in AD. The PO hydrogel and/or aurantiamide acetate inhibited the enzymatic activity of JAK1 and downstream (STAT)3/STAT6 signaling pathways in vitro and in vivo.ConclusionPO significantly ameliorated skin lesions and restored epidermal barrier function in AD mice. …”
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Structural and functional changes of the heart and electrical disorders in patients with coronary artery disease with concomitant anemia by M. O. Konovalova, N. S. Mikhailovskaya

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TRIM21 functions as an oncogene in glioblastoma by transactivating FOSL1 and promoting the ubiquitination of p27 by Vanajothi Ramar, Rajveer Singh Sidhu, Osei Pako, Cheyenne R. Cisse, Alyssa A. Guo, Jason Li, Kelcey Stapleton, Shanchun Guo, Guangdi Wang, Mingli Liu

“…TRIM21 functions as an oncogene in GBM by degrading the tumor suppressor p27 and promoting FOSL1 transactivation. …”
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The Two Sides of Placebo Analgesia: Differential Functional Connectivity Reveals Mechanisms of Placebo Analgesic Response by Bush NJ, Cushnie AK, Boissoneault J, Aghabeigi S, Alexander C, Staud R, Robinson ME

“…One cluster was identified where greater increases in functional connectivity were associated with non-responders compared to responders in regions associated with attention and motor processing.Conclusion: Our results provide evidence that responders and non-responders have differential behavioral and functional responses to acute pain during a placebo analgesic task.Keywords: placebo analgesia, placebo, responder, placebo non-responder, pain, functional connectivity…”
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Exploring the impact of pregnancy on cognitive function: a comparative study in a low-income setting by Syed Aman Ali, Muhammad Sualeh, Ghana Raza, Mohammad Sabeeh ul haq, Laiba Hissan, Duaa Zafar, Muhammad Adnan, Syed Kauser Ali

“…Higher education was associated with better cognitive function while increasing gestational age correlated with a decline in cognitive function. …”
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Efficacy of Action Observation Therapy on Cognitive Function in Stroke: A Systematic Review and Meta‐Analysis by Xuewei Guan, Meijuan Lan, Leiwen Tang, Hongyan Yang, Yuanyuan Chen, Lan Ge, Yumei Zhong

“…This review will examine the efficacy of AOT on clinical cognitive function in stroke. Methods: Randomized controlled trials (RCTs) comparing AOT with non‐AOT interventions in cognitive function were included. …”
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Accurate prediction of protein–ligand interactions by combining physical energy functions and graph-neural networks by Yiyu Hong, Junsu Ha, Jaemin Sim, Chae Jo Lim, Kwang-Seok Oh, Ramakrishnan Chandrasekaran, Bomin Kim, Jieun Choi, Junsu Ko, Woong-Hee Shin, Juyong Lee

“…We trained the model to account for both deviations in experimental and predicted binding affinities and pose prediction uncertainties. By effectively integrating the outputs of the triplet neural networks with a physics-based scoring function, our model showed a significantly improved performance in hit identification. …”
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Resting-State Functional MRI Reveals Altered Seed-Based Connectivity in Diabetic Osteoporosis Patients by Li J, Liu M, Qin J, An Y, Zheng X, Mohamad NS, Ramli I

“…These alterations correlated with deficits in visual processing, working memory, and executive function.Conclusion: Distinct FC reorganization in DOP patients reflects synergistic effects of metabolic and skeletal pathologies on neural networks, potentially mediating cognitive decline through visual pathway disruption and prefrontal-default mode network decoupling. …”
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Functional efficiency of pancreatic cell-engineered construct in an animal experimental model for type I diabetes by N. V. Baranova, A. S. Ponomareva, L. A. Kirsanova, A. O. Nikolskaya, G. N. Bubentsova, Yu. B. Basok, V. I. Sevastianov

“…In T1D rats, CEPC has a more potent antidiabetic effect than islets of Langerhans. Thus, it has been shown that a tissue-specific scaffold may be used to create bioartificial pancreas in order to increase the functional efficiency of islets.…”
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Function over form: The benefits of aspen as surrogate brood‐rearing habitat for greater sage‐grouse by Michel T. Kohl, Charles P. Sandford, Paul C. Rogers, Renee Chi, Terry A. Messmer, David K. Dahlgren

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eVIP2: Expression-based variant impact phenotyping to predict the function of gene variants. by Alexis M Thornton, Lishan Fang, April Lo, Maria McSharry, David Haan, Casey O'Brien, Alice H Berger, Marios Giannakis, Angela N Brooks

“…To validate these predictions, we performed reporter assays and found that each pathway activated by expression of RNF43 G659fs, but not expression of RNF43 WT, was identified as impacted by eVIP2, supporting that RNF43 G659fs is a change-of-function mutation and its effect on the identified pathways. …”
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Clinical and functional state of the retina after adequately performed laser coagulation of peripheral vitreochorioretinal dystrophies by V. V. Neroev, G. Yu. Zakharova, T. D. Okhotsimskaya, I. V. Tsapenko, M. V. Zueva, M. A. Arakelyan, B. M. Magamadov

“…Перенести в английский вариант   Purpose.  To assess the effect of adequate laser coagulation (LC) of peripheral vitreochorioretinal dystrophy (PVCRD) on the clinical and functional state of the retina and the microcirculation of the macular region.     …”
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Tuning Transmission Properties of Two-Dimensional Photonic Crystal Waveguides Using Functional Dielectric Cavities by Siqi Zhang, Feng Yang, Wenying Zhang, Wei Zhao, Luhe Yang, Hong Li

“…The waveguide consists of circular <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>K</mi><mi>N</mi><mi>b</mi><msub><mi>O</mi><mn>3</mn></msub></mrow></semantics></math></inline-formula> and functional dielectric cylinders embedded in air. The dielectric constant of a functional medium cylinder is spatially dependent, which is realized through the electro-optic and Kerr effects. …”
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Functional characteristics of sleep monitoring devices in China: A real-world cross-sectional study by Le Yang, Bingtao Weng, Xingyan Xu, Zhi Huang, Run Ding, Miaomiao Si, Yingxin Fu, Yurui Zhu, Yu Jiang, Beibei Rao, Xinyi Zhang, Qingwei Zhou, Shenglan Lin, Yansong Guo, XiaoXu Xie

“…This study investigates the functional characteristics of existing sleep monitoring devices in the Chinese market and delves into population preferences. …”
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α-synuclein expression in glioblastoma restores tumor suppressor function and rescues temozolomide drug resistance by Eric Duplan, Aurore Bernardin, Thomas Goiran, Nathalie Leroudier, Mathew Casimiro, Richard Pestell, Shinya Tanaka, Celine Malleval, Jerome Honnorat, Ahmed Idbaih, Lucie Martin, Hélène Castel, Frédéric Checler, Cristine Alves da Costa

“…Overall, our data reveals a new role of α-syn as an oligodendroglioma biomarker and as a glioblastoma tumor suppressor capable of either potentiate TMZ effect or avoid TMZ-associated resistance.…”
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Functional Liver Imaging Score to Predict Clinically Significant PHLF for Hepatocellular Carcinoma After Resection by Zheng X, Zhang Y, Huang H, Luo N

“…In both cohorts, overall survival rate was significantly lower among patients whom the model placed at high risk of clinically significant PHLF than among those at low risk.Conclusion: The combination of FLIS and other easily acquired clinical data may reliably predict clinically significant PHLF and mortality in hepatocellular carcinoma.Plain Language Summary: Functional liver imaging score derived from gadoxetic acid-enhanced MRI can effectively and conveniently evaluate liver function. …”
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The Neuromusculoskeletal Modeling Pipeline: MATLAB-based model personalization and treatment optimization functionality for OpenSim by Claire V. Hammond, Spencer T. Williams, Marleny M. Vega, Di Ao, Geng Li, Robert M. Salati, Kayla M. Pariser, Mohammad S. Shourijeh, Ayman W. Habib, Carolynn Patten, Benjamin J. Fregly

“…Standardized interventions have produced suboptimal functional outcomes due to the unique treatment needs of each patient. …”
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Coenzyme Q10 and rikkunshito prevent age-related changes in mouse otolith morphology and function by Keita Ueda, Takao Imai, Tadao Okayasu, Tatsuhide Tanaka, Kouko Tatsumi, Akio Wanaka, Tadashi Kitahara

“…In recent years, the herbal medicine rikkunshito (RKT) and the antioxidant coenzyme Q10 (CoQ10) have been studied for their anti-aging properties; however, their effects on otoliths remain unknown. Therefore, we aimed to investigate whether RKT and CoQ10 can prevent age-related functional and morphological changes in otoliths. …”
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