A Microfluidic Device Integrating a Glucose Sensor and Calibration Function for Cell-Based Assays by Laner Chen, Kenta Shinha, Hiroko Nakamura, Kikuo Komori, Hiroshi Kimura

“…We have integrated a calibration function that corrects sensor drift, ensuring accurate and prolonged short-term measurement stability. …”
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Activation of the Rat P2X7 Receptor by Functionally Different ATP Activation Sites by Fritz Markwardt, Malte Berthold, Sanaria Hawro Yakoob, Günther Schmalzing

“…We conclude that the binding of one ATP⁴⁻ is sufficient for partial activation of the rP2X7R and that allosteric effects occur when all three ATP⁴⁻ binding sites are occupied, leading to distinct functional activation sites.…”
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Alterations in Human Hippocampus Subregions across the Lifespan: Reflections on White Matter Structure and Functional Connectivity by Jianling Tan, Zhongyan Wang, Yi Tang, Yin Tian

“…However, age-related changes of hippocampus subregions on structure and function are still unclear. Here, we investigated age-related structural and functional characteristics of 106 participants (7-85 years old) in resting state based on fractional anisotropy (FA) and functional connectivity (FC) in aHipp and pHipp in the lifespan. …”
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The mediating role of anxiety and depression in the relationship between alexithymia, somatosensory amplification, and functional impairment in fibromyalgia by Arda Kazim Demirkan, Gizem Gerdan

“…Participants completed self-report measures assessing alexithymia, anxiety, depression, SSA, and functional impairment. Statistical analyses included independent samples t-tests and multivariate analyses of covariance (MANCOVA) to compare groups, and mediation analyses to examine indirect effects of anxiety and depression.ResultsThe FMS group reported significantly higher levels of anxiety, depression, DIF, and SSA compared to controls. …”
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Pharmacological Blocking of Adiponectin Receptors Induces Alzheimer’s Disease-like Neuropathology and Impairs Hippocampal Function by Hui-Hui Guo, Hai-Ning Ou, Jia-Sui Yu, Suk-Yu Yau, Hector Wing-Hong Tsang

“…While AdipoRs are abundantly expressed in peripheral tissues, the effects of blocking these receptors in the peripheral tissues on the brain are unclear. …”
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Carpolobia lutea methanol root extract reinstates androgenesis and testicular function in cadmium- challenged rats by Ejike, Daniel Eze, Okpa, Precious Nwaka, Igbokwe, Ugochukwu Vincent, Moses, Dele Adams, Karimah, Mohammed Rabiu, Ayikobua, Emmanuel Tiyo

“…This study was intended to investigate the effects of Carpolobia lutea root extracts on testicular hormone function in cadmium-challenged male rats. 48 male Wistar rats (170-190 g) were divided into six groups, each containing eight rats. …”
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Exclusion of PD-1 from the immune synapse: A novel strategy to modulate T cell function by Luke Yi Hao, Shalom Lerrer, Matthieu Paiola, Emily K. Moore, Yevgeniya Gartshteyn, Ruijiang Song, Michael Goeckeritz, Matilda J. Black, Shoiab Bukhari, Xizi Hu, Adam Mor

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Investigating the potential of fish muscle-based gels as functional feed supplements for eco-friendly aquaculture by Jham Lal, Pradyut Biswas, Soibam Khogen Singh, Reshmi Debbarma, Anand Vaishnav, Gusheinzed Waikhom, N. Sureshchandra Singh, Dharmendra Kumar Meena

“…The study investigated the efficiency of a novel gel-based diet in promoting the growth, feed acceptance, and physiological function of an endemic ornamental fish, Pethia conchonius. …”
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Characteristics and function of the gut microbiota in patients with IgA nephropathy via metagenomic sequencing technology by Yang Deng, Zhiqiang Nong, Meiju Wei, Yuanshan Xu, Yuzhen Luo, Xiaohua Li, Ruobei Zhao, Zhenhua Yang, Ling Pan

“…We employed linear discriminant analysis effect size (LEfSe) analysis to identify significantly different bacterial microbiota and functional pathways. …”
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Research Progress on the Quality, Extraction Technology, Food Application, and Physiological Function of Rice Bran Oil by Wengong Huang, Baohai Liu, Dongmei Shi, Aihua Cheng, Guofeng Chen, Feng Liu, Jiannan Dong, Jing Lan, Bin Hong, Shan Zhang, Chuanying Ren

“…Rice bran oil has significant antioxidant, anti-inflammatory, anti-cancer, hypoglycemic, lipid-lowering, and neuroprotective effects. Further exploratory research on other unknown functions is required to lay a scientific basis for the application and development of rice bran oil.…”
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Improving functional capacity in haemophilia through adapted physical activity: a pilot study protocol by Giuseppe Barone, Erika Pinelli, Laura Bragonzoni, Maria Scoppolini Massini, Raffaele Zinno, Lelia Valdrè, Lydia Piscitelli, Giulio Senesi, Valentina Guarino, Isabella Diletta Cavalieri, Maria Grazia Benedetti, Giuseppina Mariagrazia Farella

“…These complications result in reduced functional capacity, muscle weakness and kinesiophobia, which further exacerbate physical inactivity and psychological distress. …”
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Adaptive evolution and functional significance of the PPARGC1A gene across diverse animal species by Seyed Mahdi Hosseini, Farman Ullah, Muhammad Zulfiqar Ahmad, Majid Pasandideh, Aixin Liang, Guohua Hua, Liguo Yang

“…The integration of mixed‐effect modeling (MEME) identified episodic diversifying selection, pinpointing codons that underwent selection episodes in certain lineages. …”
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Enhancing Functional Compounds in Sesame Oil through Acid-Soaking and Microwave-Heating of Sesame Seeds by Jitkunya Yuenyong, Suchintana Limkoey, Chonlathit Phuksuk, Thitima Winan, Chonlada Bennett, Sudarat Jiamyangyuen, Sugunya Mahatheeranont, Phumon Sookwong

“…This study investigated whether pre-treating sesame (<i>Sesamum indicum</i> L.) seeds with a combination of acid-soaking and microwave-heating could significantly enhance the quality of the resulting sesame oil, particularly by increasing its content of functional compounds such as lignans, tocopherol, phytosterol, and squalene. …”
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Functional diversity of soil macrofauna may contribute to microbial community stabilization under drought stress by Diana Morales-Fonseca, Diana Morales-Fonseca, Sandra Barantal, Sandra Barantal, François Buscot, Stephan Hättenschwiler, Alexandru Milcu, Alexandru Milcu, Johanne Nahmani, Emmanuel S. Gritti, Kezia Goldmann, Luis Daniel Prada-Salcedo

“…Overall, these findings highlight the importance of preserving soil biodiversity as a means to mitigate the effects of future droughts on soil functions and to enhance the resilience of terrestrial ecosystems in the face of ongoing climate change.…”
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Structural and functional insights of ZnT1 C-terminal domain as a regulator of zinc transport by Tomer Eli Ben Yosef, Itamar Kass, Anat Shahar, Ekaterina Eremenko, Alon Monsonego, Daniel Gitler, Arie Moran, Raz Zarivach

“…Abstract Zinc is an essential trace element vital for cellular function, and its homeostasis is tightly regulated. …”
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Functional connectivity of default mode network in non-hospitalized patients with post-COVID cognitive complaints by Derek Madden, Tressie M. Stephens, Jim Scott, Christen O’Neal Swann, Kiana Prather, Jordan Hoffmeister, Lei Ding, Lei Ding, Ian F. Dunn, Andrew K. Conner, Han Yuan, Han Yuan, Han Yuan

“…Additionally, we characterized the functional connectivity of the default mode network (DMN), which is known for cognitive functions including memory as well as the attention functions involved in normal aging and degenerative diseases.ResultsAlong with the retention of functional connectivity in the DMN, our results found the DMN to be associated with neurocognitive performance through region-of-interest and whole-brain analyses. …”
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Novel Fermented Plant-Based Functional Beverage: Biological Potential and Impact on the Human Gut Microbiota by Catarina Vila-Real, Célia Costa, Ana Pimenta-Martins, Samuel Mbugua, Sawadogo-Lingani Hagrétou, Kati Katina, Ndegwa H. Maina, Elisabete Pinto, Ana M. P. Gomes

“…In vitro digestion followed by in vitro faecal fermentation were used to study the impact of the fermented plant-based functional beverage (PBFB) on the human gut microbiota. …”
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Ferroportin 1 depletion in neural stem cells promotes hippocampal neurogenesis and cognitive function in mice by Yiqian Ding, Shanshan Yao, Shuxin Guo, Wei Meng, Jie Li, Fudi Wang, Jianhua Zhang, Yan-Zhong Chang, Guofen Gao

“…Notably, iron supplementation promoted the proliferation of primary NSCs dose-dependently, whereas the presence of ROS inhibitor abolished this effect. This study reveals that Fpn1 of NSCs and its regulated iron levels are key modulators of hippocampal neurogenesis through promoting the proliferation of NSCs and ultimately controlling hippocampal function. …”
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Techno-functional of peanut flour substituting on hybrid chicken meatball physico-chemical and nutritional qualities by Soklin Son, Sreymom Hun, Md Anisur Rahman Mazumder, Lutz Grossmann, Passakorn Kingwascharapong, Samart Sai-ut, Pittaya Chaikham, Young Hoon Jung, Saroat Rawdkuen

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Donor Smoking Negatively Affects Donor and Recipient Renal Function following Living Donor Nephrectomy by Jonathan Heldt, Robert Torrey, Daniel Han, Pedro Baron, Christopher Tenggardjaja, Justin McLarty, Tekisha Lindler, D. Duane Baldwin

“…While tobacco use by a renal transplant recipient has been shown to negatively affect graft and patient survival, the effect of smoking on the part of the kidney donor remains unknown. …”
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