A novel loss-of-function variant in STAT1 causes Mendelian susceptibility to mycobacterial disease by Kunlun Lv, Zhuoqing Gong, Zhuoqing Gong, Yiting Fu, Sisi Zhao, Yinggai Song, Huijun Wang, Zhimiao Lin

“…AlphaFold3-based cluster analysis supported a loss-of-function effect of the mutant.DiscussionThis study expands the spectrum of STAT1 variants and microbial pathogens associated with MSMD.…”
Get full text

Comparative acetylome analysis reveals the potential mechanism of high fat diet function in allergic disease by Yanan Sun, Ning Liu, Huihui Wang, Taiqi Qu, Fazheng Ren, Yixuan Li

“…This study aimed to clarify the effects of a high-fat diet (HFD) on allergy risk and the underlying mechanisms. …”
Get full text

Building a Healthy Future: Functional Motor Skill Development in Precocious Prevention of Childhood Obesity by Debora Porri, Malgorzata Wasniewska, Giovanni Luppino, Letteria Anna Morabito, Elisa La Rosa, Giorgia Pepe, Domenico Corica, Mariella Valenzise, Maria Francesca Messina, Giuseppina Zirilli, Alessandra Li Pomi, Aurora Lanzafame, Valentina Arena, Angela Alibrandi, Debora Di Mauro, Tommaso Aversa

“…Early development of functional movement skills (FMS) is crucial for fostering active lifestyles and preventing CO. …”
Get full text

Design of a Dual-Function Autonomous Disinfection Robot with Safety Filter-Based Motion Control by Yuning Cao , Zehao Wu , I-Ming Chen , Qingsong Xu 

Get full text

Changes in bioactive compounds' stability and colour of functional plum spread during different storage conditions by Bajić Aleksandra R., Mastilović Jasna S., Cvetković Biljana R., Kovač Renata M., Ubiparip-Samek Dragana N., Djordjević Marijana Z., Djordjević Miljana Z., Dragojlović Danka M.

“…This study aimed to assess the effect of a storage period and temperature on the retention of phenolics, anthocyanins (total and monomeric) and the colour of functional plum spread enriched with plum pomace. …”
Get full text

Measurements of Serum Pituitary-Gonadal Hormones and Investigation of Sexual and Reproductive Functions in Kidney Transplant Recipients by Guang-chun Wang, Jun-hua Zheng, Long-gen Xu, Zhi-lian Min, You-hua Zhu, Jun Qi, Qiang-lin Duan

“…To investigate changes in serum pituitary-gonadal hormones and restoration of sexual and reproductive functions after successful kidney transplantation. …”
Get full text

Integrating a Fuzzy Fitness Function in Genetic Programming to Generate Breast Tissue Segmentation Models by Ingrid-Aurora Valencia-Hernandez, Carlos Alberto Reyes Garcia, Alicia Morales-Reyes, Gabriela del C. Lopez-Armas, Jose-Antonio Fuentes-Tomas, Efren Mezura-Montes

“…These results demonstrate the impact of fuzzy fitness functions in the evolution of segmentation models, highlighting the effectiveness of this approach in improving the segmentation and classification of medical images, in addition to the descriptive capabilities inherent to the fuzzy fitness function.…”
Get full text

Increased actin polymerization and stabilization interferes with neuronal function and survival in the AMPKγ mutant Loechrig. by Mandy Cook, Bonnie J Bolkan, Doris Kretzschmar

“…Together with the observed increase in SSH levels in the loe mutant, our experiments suggest that in mature neurons SSH may function as a stabilization factor for filamentous actin instead of promoting actin depolymerization.…”
Get full text

Functional Brain Network Disruptions in Parkinson’s Disease: Insights from Information Theory and Machine Learning by Ömer Akgüller, Mehmet Ali Balcı, Gabriela Cioca

“…<b>Objectives:</b> This study investigates disruptions in functional brain networks in Parkinson’s Disease (PD), using advanced modeling and machine learning. …”
Get full text

Testing the feasibility and utility of an executive function battery for use with primary school-aged students in Malawi. by Michael T Willoughby, Maclean Vokhiwa, Amanda C Wylie, Richard Reithinger, Lauren M Cohee

“…There is increasing evidence that malaria impacts student educational outcomes, in part through impairments in cognitive function. Currently, there is no consensus with regards to standardized tools or approaches to assess the extent and magnitude of this association. …”
Get full text

Correlation between fall experience and life functions among community-dwelling older adults in Japan by Koshi Sumigawa, Yuji Koike

“…Purpose: This study investigated the correlation between the risk of falls and life functions, including motor function, cognitive function, and urinary disorders, among older adults residing in small cities in the metropolitan areas of Japan and evaluated the contents of fall prevention instructions. …”
Get full text

Feasibility of Functional Electrical Stimulation-Assisted Neurorehabilitation following Stroke in India: A Case Series by Bhawna Khattar, Alakananda Banerjee, Rajsekhar Reddi, Anirban Dutta

“…Functional Electrical Stimulation (FES) facilitates ambulatory function after paralysis by electrically activating the muscles of the lower extremities. …”
Get full text

Recent advances in enrichment, regulation and the functional foods of γ-aminobutyric acid in germinated brown rice by JIN Guoming, CHEN Xiaoxiao, YAN Guowei, YU Jiahao, TONG Chuan

“…The potential biological functions of GABA in germinated brown rice and the development and application of functional foods such as germinated brown rice staple foods and beverages rich in GABA were discussed, and the future work on GABA in germinated brown rice was also prospected. …”
Get full text

Human stem cell-derived neurons: a system to study human tau function and dysfunction. by Mariangela Iovino, Rickie Patani, Colin Watts, Siddharthan Chandran, Maria Grazia Spillantini

“…Over expression of tau with 4 repeats affects tau cellular distribution and the short tau F3 fragment appears to increase tau phosphorylation but this effect does not appear to be toxic for the cell.<h4>Conclusions</h4>Our results indicate that human embryonic stem cell-derived neurons express all 6 tau isoforms and are a good model in which to study tau physiology and pathology.…”
Get full text

Predicting Injury in Collegiate Baseball and Softball Athletes Using Functional Testing: A Pilot Study by Alyse M. DePaola, Andrew R. Moore, Graeme J. Connolly, A. Maleah Holland-Winkler

“…The purpose of this pilot study was to use binomial logistic regression to identify injury-prone athletes with multiple pre-season functional measures and demographic information. Eighteen Division II baseball and softball athletes underwent pre-season functional testing including measures of manual muscle testing of the dominant shoulder muscles (MMT), the functional movement screen (FMS), and closed kinetic chain upper extremity stability (CKCUES). …”
Get full text

Genome-wide analysis in human populations reveals mitonuclear disequilibrium in genes related to neurological function by Eduardo González-Orozco, Christian E. Martínez-Guerrero, Rafael Montiel

“…The enriched GO terms were related to neurological function, highlighting the significant role and plasticity of neurological genes in the relatively rapid adaptation of mitochondrial function in human evolution.…”
Get full text

The Beta-Cell Function and Glucose Profile of Newly Diagnosed Acromegalic Patients with Normal Glucose Tolerance by Quanya Sun, Xiaoqing Li, Peili Chen, Lili Chen, Xiaolong Zhao

“…Untreated acromegaly is a nature model for unveiling the diabetogenic effects of GH. CGMS can uncover more glucose profile of acromegaly. …”
Get full text

The evolution of Indonesian SAI maturity: Oversight, insight, and foresight functions of health-themed performance audits by Nico Andrianto, J Basuki, R. Luki Karunia, Nurliah Nurdin

Get full text

The modern view of the idea of gamma-aminobutyric acid and its metabolite use to restore the motor function by А. G. Rodinskij, Т. V. Dемchenko, A. V. Моzgunov, К. V. Pysarevska

Get full text

A clinical and functional system for patients with accommodation disorders subjected to excimer laser correction of hypermetropia by O. S. Kuznetsova, S. V. Balalin

“…Purpose: to develop a clinical and functional rehabilitation system for patients with mild and moderate hyperopia and accommodation disorders before and after FemtoLASIK surgery and to assess its effectiveness.Material and methods. 234 patients (234 eyes) with the above conditions, aged 25 to 30 (mean age 27.9 ± 1.2 years) were divided into 2 groups. …”
Get full text