A novel mechanism of FTO modulating the progression of endometriosis through mediating the m6A methylation of GEF-H1 in a YTHDF1-dependent manner by Xin-Yu Ding, Hua-Ying Zhang, Jia-Hao Chen, Meng-Jie Yang, Zhi-Xiong Huang, Yi-Hong Lei, Qin-Kun Sun, Jian-Bin Bai, Dian-Chao Lin, Jian-Fa Lan, Lu-Lu Ren, Zheng-Yi Chen, Wei-Dong Zhou, Qiong-Hua Chen

“…Subsequent experiments revealed that GEF-H1 mediates the effects of FTO in promoting migration and invasion. …”
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Assessment of Biodegradation Mechanisms of Ceftiofur Sodium by <i>Escherichia</i> sp. CS-1 and Insights from Transcriptomic Analysis by Meng-Yang Yan, Cai-Hong Zhao, Jie Wu, Adil Mohammad, Yi-Tao Li, Liang-Bo Liu, Yi-Bo Cao, Xing-Mei Deng, Jia Guo, Hui Zhang, Hong-Su He, Zhi-Hua Sun

“…Furthermore, the differentially expressed genes (DEGs) of <i>E. coli</i> CS-1 were functionally annotated using a combination of genomics and bioinformatics approaches. …”
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Bridging Data Silos in Oncology with Modular Software for Federated Analysis on Fast Healthcare Interoperability Resources: Multisite Implementation Study by Jasmin Ziegler, Marcel Pascal Erpenbeck, Timo Fuchs, Anna Saibold, Paul-Christian Volkmer, Guenter Schmidt, Johanna Eicher, Peter Pallaoro, Renata De Souza Falguera, Fabio Aubele, Marlien Hagedorn, Ekaterina Vansovich, Johannes Raffler, Stephan Ringshandl, Alexander Kerscher, Julia Karolin Maurer, Brigitte Kühnel, Gerhard Schenkirsch, Marvin Kampf, Lorenz A Kapsner, Hadieh Ghanbarian, Helmut Spengler, Iñaki Soto-Rey, Fady Albashiti, Dirk Hellwig, Maximilian Ertl, Georg Fette, Detlef Kraska, Martin Boeker, Hans-Ulrich Prokosch, Christian Gulden

“…MethodsTo harness RWD effectively, we designed a pipeline to convert the oncological basic dataset (oBDS) into HL7 FHIR format and prepare it for FA. …”
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Genetic evolution, epidemic trends, and recombination dynamics of PRRSV-1 in China by Chengzhen Weng, Chengzhen Weng, Chengzhen Weng, Xinxin Huang, Xinxin Huang, Xinxin Huang, Zhian Chen, Zhian Chen, Minjia He, Minjia He, Minjia He, Beiwen Zhang, Beiwen Zhang, Beiwen Zhang, Hongxi Li, Hongxi Li, Hongxi Li, Jingrui Xie, Jingrui Xie, Meichun Chen, Meichun Chen, Meichun Chen, Longxin Qiu, Longxin Qiu, Xiaobing Li, Xiaobing Li, Chong Cao, Chong Cao, Hongbo Chen, Hongbo Chen

“…The results indicated that mutations had occurred at amino acid sites within the antigenic epitopes and functional domains of GP5. Additionally, the prediction of potential N-glycosylation sites identified five locations in GP5: positions 35, 37, 38, 46, and 53. …”
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IL-28A/IL-10Rβ axis promotes angiogenesis via eNOS/AKT signaling and AP-1/NF-κB/MMP-2 network by regulating HSP70-1 expression by Jun-Hui Song, Byungdoo Hwang, Sung Lyea Park, Hoon Kim, Soontag Jung, Changsun Choi, Hwan Myung Lee, Seok-Joong Yun, Yung Hyun Choi, Eun-Jong Cha, Cam Patterson, Wun-Jae Kim, Sung-Kwon Moon

“…Gene expression changes in HUVECs following IL-28A treatment were analyzed by NGS. The functional role of HSP70-1 and IL-10Rβ in IL-28A-induced angiogenic responses was evaluated using PCR and siRNA knockdown. …”
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Autoinducer-2 enhances the defense of Vibrio furnissii against oxidative stress and DNA damage by modulation of c-di-GMP signaling via a two-component system by Heng Zhang, Wenjin Zhao, Wenguang Yang, Huimin Zhang, Xinyu Qian, Kai Sun, Qiao Yang, Xihui Shen, Lei Zhang

“…However, unknown AI-2 receptors in bacteria may be more than what has been discovered so far, and there are still many unknown functions for this signal waiting to be explored. Here, we have identified a membrane-bound histidine kinase of the pathogenic bacterium Vibrio furnissii, AsrK, as a receptor that specifically detects AI-2 under low boron conditions. …”
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Development of a core patient-centred outcome set for adults living with obesity: a modified delphi-based international consensusResearch in context by Teferi Mekonnen, Leanne Staniford, Spencer Connell, Zofia Das-Gupta, Umanga DeSilva, Yasmine Saoud, Isabel Miller, Mohapradeep Mohan, Simon Nienhuijs, Megha Poddar, Vaishali Chetan Deshmukh, Marli Conradie-Smit, Soo Huat Teoh, Sanjeev Sockalingam, Emilia Huvinen, Paolo Sbraccia, Ronald Liem, Michael Vallis, Kenneth Clare, Tracy Zvenyach, Karen Coulman, Marianela Aguirre Ackermann, Verónica Vázquez-Velázquez, Yudith Preiss Contreras, Josep Vidal, Agbo Urudinachi, María Fernanda Tejeda-Muñoz, Ian Patton, T Alafia Samuels, Morgan Emile Gabriel Salmon Leguede, Georgia Rigas, Ximena Ramos Salas, Michael Crotty, Bruno Halpern, Daniel Bessesen, Laura Pizzi, Omniyat Mohammed Al Hajeri, Arya M. Sharma

“…These span domains including physical health, psychosocial well-being, health behaviours, body functioning, and adverse events. Specific measures were also developed for bariatric surgery and female reproductive health (both pregnant and non-pregnant individuals). …”
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Genome-wide association study of post COVID-19 syndrome in a population-based cohort in Germany by Anne-Kathrin Ruß, Stefan Schreiber, Wolfgang Lieb, J. Janne Vehreschild, Peter U. Heuschmann, Thomas Illig, Katharina S. Appel, Maria J. G. T. Vehreschild, Dagmar Krefting, Lennart Reinke, Alin Viebke, Susanne Poick, Stefan Störk, Jens-Peter Reese, Thomas Zoller, Lilian Krist, David Ellinghaus, Bärbel U. Foesel, Christian Gieger, Bettina Lorenz-Depiereux, Martin Witzenrath, Gabriele Anton, Michael Krawczak, Jan Heyckendorf, Thomas Bahmer

“…The SNP is located in a region including the NEK6, PSMB7 and ADGRD2 genes which, however, does not immediately suggest an etiological connection to PCS. As regards functional plausibility, variants of a possible effect mapped to the olfactory receptor gene region (lead SNP rs10893121 at position chr11:123,854,744; p = 2.5 × 10− 6). …”
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Geographic variation in secondary metabolites contents and their relationship with soil mineral elements in Pleuropterus multiflorum Thunb. from different regions by Yaling Yang, Siman Wang, Ruibin Bai, Feng Xiong, Yan Jin, Hanwei Liu, Ziyi Wang, Chengyuan Yang, Yi Yu, Apu Chowdhury, Chuanzhi Kang, Jian Yang, Lanping Guo

“…Among these, 2 important functional compounds including physcion and 2,3,5,4′-tetrahydroxystilbene-2-O-(6″-O-acetyl)-glucoside (THSG-5) are the most abundant in HSW samples from Deqing, a geographical indicative production region. …”
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Cloud-scale Gas Properties, Depletion Times, and Star Formation Efficiency per Freefall Time in PHANGS–ALMA by Adam K. Leroy, Jiayi Sun, Sharon Meidt, Oscar Agertz, I-Da Chiang, Jindra Gensior, Simon C. O. Glover, Oleg Y. Gnedin, Annie Hughes, Eva Schinnerer, Ashley T. Barnes, Frank Bigiel, Alberto D. Bolatto, Dario Colombo, Jakob den Brok, Mélanie Chevance, Ryan Chown, Cosima Eibensteiner, Damian R. Gleis, Kathryn Grasha, Jonathan D. Henshaw, Ralf S. Klessen, Eric W. Koch, Elias K. Oakes, Hsi-An Pan, Miguel Querejeta, Erik Rosolowsky, Toshiki Saito, Karin Sandstrom, Sumit K. Sarbadhicary, Yu-Hsuan Teng, Antonio Usero, Dyas Utomo, Thomas G. Williams

“…Our results depend sensitively on the adopted CO-to-H _2 conversion factor, with corrections for excitation and emissivity effects in inner galaxies playing an important role. …”
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Investigating the molecular mechanisms and clinical potential of APO+ endothelial cells associated with PANoptosis in the tumor microenvironment of hepatocellular carcinoma using s... by Zhaorui Cheng, Xiangyu Yang, Yi Ren, Huimin Wang, Qi Zhang, Sailing Lin, Wenhao Wu, Xiaolu Yang, Jiahan Zheng, Xinzhu Liu, Xin Tao, Xiaoyong Chen, Yuxin Qian, Xiushen Li

“…Despite its significance, the specific functions and mechanisms of PANoptosis within the tumor microenvironment (TME) of hepatocellular carcinoma (HCC) remain unclear. …”
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Optimization of synthesis conditions of hydrochar and pyrohydrochar from fish bones for their use in the adsorption of fluoride from water by Sergio Armando Cruz Briano, Nahum Andrés Medellín Castillo, Juan Carlos Moreno Piraján, Liliana Giraldo Gutiérrez, Guillermo Javier Castro Larragoitia, Pablo Delgado Sánchez, Alfredo Israel Flores Rojas, Hilda Guadalupe Cisneros Ontiveros

“…The effect of pH on the adsorption capacity of HC1 and PHC5 fluorides was also investigated, revealing an increase of this capacity with decreasing solution pH due to electrostatic forces.…”
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Association of Muscle Radiodensity and Muscle Mass With Thoracic Aortic Calcification Progression in Dialysis Patients by Xiao‐xu Wang, Jing‐yuan Cao, Yao Wang, Min Li, Shi‐mei Hou, Zhen Zhao, Min Yang, Ping‐ping Ju, Yu‐jia Jiang, Jing‐jie Xiao, Ri‐ring Tang, Hong Liu, Bi‐cheng Liu, Xiao‐liang Zhang, Bin Wang

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Fermented strawberry pomace enhances carcass characteristics and meat quality by regulating plasma biochemical indices and antioxidant capacity in aged laying hens by Wei Lan, Wei Lan, Wei Lan, Ting Chen, Ting Chen, Binghua Qin, Binghua Qin, Md. Abul Kalam Azad, Md. Abul Kalam Azad, Zhihua Li, Yadong Cui, Yadong Cui, Xiangfeng Kong, Xiangfeng Kong, Xiangfeng Kong

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إدارة الأزمة ومكونات المنظمة - دراسة حالة في واقعة الطف by علي عبد الحسين الفضل, غسان رشاد دوش

“…The highlights of the research objectives were: 1. highlight the role for some administrative groups that formed in the light of the behind-Husseini and the reference to the most important roles and functions entrusted to each group. 2. Determine the role of coherent components of the organization, which has led to a typical overcome the crisis, which hinder the achievement of important objectives. …”
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The Role of Heat in the Lifestyle of the People of Iran during the Safavid Era by Javad Alipoor silab

“…In hot climates, buildings were designed to mitigate the effects of heat. Local materials were used as thermal insulators, and buildings were constructed to protect inhabitants from the intense heat. …”
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STAT2/SLC27A3/PINK1-Mediated Mitophagy Remodeling Lipid Metabolism Contributes to Pazopanib Resistance in Clear Cell Renal Cell Carcinoma by Dingheng Lu, Yuxiao Li, Xinyang Niu, Jiazhu Sun, Weitao Zhan, Yuchen Shi, Kai Yu, Suyuelin Huang, Xiaoyan Liu, Liping Xie, Xueyou Ma, Ben Liu

“…The differential expression of SLC27A3 and its effect on drug resistance of ccRCC tumor were detected in vitro and in vivo. …”
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Validación de una encuesta de opinión sobre la eficacia de la simulación para participantes by Aida Camps-Gómez, Anna González-Fernández, Jennifer Morata-Serrano, Katherina M. Faundez-Inostroza, Carmen Gomar-Sancho, Marina Mateu-Capell

“…The survey is valid for students and professionals to assess the effectiveness of training simulation sessions, and to detect opportunities for improve them.…”
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Legal Challenges of Marine Insurance Laws in the Use of Unmanned Ships by Mahsa Bahadoran- Baghbaderani, Masoud Shirani, Reza Soltani

“…Furthermore, standardizing the design and functionality of unmanned ships and issuing certifications for software and systems are vital steps in minimizing risks and fostering trust among insurers and operators. …”
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Transkingdom mechanism of MAMP generation by chitotriosidase feeds oligomeric chitin from fungal pathogens and allergens into TLR2-mediated innate immune sensing by Tzu-Hsuan Chang, Yamel Cardona Gloria, Margareta J. Hellmann, Timmy Richardo, Carsten Leo Greve, Didier Le Roy, Thierry Roger, Francesca Bork, Stefanie Bugl, Johanna Jakob, Johannes Sonnberger, Lydia Kasper, Bernhard Hube, Bernhard Hube, Stefan Pusch, Neil A. R. Gow, Morten Sørlie, Anne Tøndervik, Bruno M. Moerschbacher, Alexander N. R. Weber, Alexander N. R. Weber, Alexander N. R. Weber, Alexander N. R. Weber

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