Protocol of the pilot study to test and evaluate the iCARE tool: a machine learning-based e-platform tool to make health prognoses and support decision-making for the care of older... by John P Hirdes, Hao Luo, Davide L Vetrano, Graziano Onder, Jonathan Chen, Violetta Kijowska, Katarzyna Szczerbińska, Johanna Edgren, Amaia Calderón-Larrañaga, George Heckman, Ron MC Herings, Johanna de Almeida Mello, Anja Declercq, Mark Hoogendoorn, Caitlin McArthur, Mari Aaltonen, Yi Chai, Karlijn J Joling, Micaela Jantzi, Rosa Liperoti, Melissa Northwood, Ilona Barańska, Agata Stodolska, Hein P J van Hout, Margaret Saari, Luca Mariotti, Emiel O Hoogendijk, Luke Turcotte, Louk Smalbil, Elizabeth P Howard, John N Morris, Daniela Fialová, Eline CM Kooijmans, Riikka-Leena Leskelä, Jokke Häsä, Georg Ruppe, Carmen Angioletti, Olena Antonenko, Shireen Aziz, Gustavo Betini, Jovana Brkič, Roberto Da Cas, Daniel Da Cunha Leme, Lu Dai, Cecilia Damiano, Natalia Drapała, Bonaventure Egbujie, Collin JC Exmann, Harriet Finne-Soveri, Charlene France, Tiziana Grisetti, Ira Haavisto, Sophie Hogeveen, Paweł Jagielski, Laurian Jongejan, Jet E Klunder, Ingrid Kummer, Anna Lukačišinová, Matti Mäkelä, Krista Mathias, Amanda Mofina, Reem Mulla, Mikko Nuutinen, Sandra Ochwat, Paula Pennanen, Jitka Pokladníková, Bregtje Proost, Ahmer Raza, Emanuele Rocco Villani, Jindra Reissigová, Erez Schachter, Katarzyna Sekulak, Chi-Ling Joanna Sinn, Andrea Vokálová, Adrianna Ziuziakowska, Mari Lahelma, Anna-Maria Hiltunen, Anna Salminen, Mor Alon, Collin Exmann, Wiebe Boorsma, Johanna de Almeida Mello, Hein PJ van Hout

“…Two pilot modalities—decision loop and non-decision loop—were implemented to assess the effect of the iCARE tool on clinical decisions. Descriptive statistics and bivariate and multivariate analysis will be conducted. …”
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Identification of novel molecular subtypes and construction of a prognostic signature via multi-omics analysis and machine learning in lung adenocarcinoma by Ke Ma, Jie Xu, Jie Xu, Congyue Wang, Congyue Wang, Xu Cao, Xu Cao, Wenjie Yu, Jingjing Xi, Xuan Zhang, Jiamin Zhan, Yang Liu, Aoyang Yu, Aoyang Yu, Shuhan Liu, Yanhua Liu, Yanhua Liu, Chong Chen, Chong Chen, Xiaoli Mai, Xiaoli Mai

“…We further confirmed the effects of ANLN knockdown and the expression of a domain-negative anillin protein (dnANLN) via western blotting, cell proliferation assays, flow cytometry, and transwell migration assays in vitro.ResultsOur analysis revealed that the novel molecular subtypes exhibited differences in prognoses, biological functions, and immune infiltration profiles in LUAD. …”
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History and development direction of iterative upgrading of deep coalbed methane reservoir reconstruction technology：Taking the Daji Block in the eastern margin of the Ordos Basin... by Fengyin XU, Huaibin ZHEN, Shuguang LI, Feng WANG, Lei ZHANG, Yubin WANG, Weichu YU, Weiping ZHU, Borui XU, Yun YANG, Haifeng ZHAO, Kunsen BAI

“…Four fracturing technologies—Volumetric acidizing, large-scale volumetric fracturing, ultra-large-scale volumetric fracturing, and integrated geological-engineering precision fracturing—are examined in terms of their implementation and effectiveness. Additionally, a brief analysis of the performance of corresponding fracturing fluid systems is provided.The technological progression evolved from pursuing matrix stimulation to achieving large-scale fracture networks, from maximizing stimulation volume to optimizing well-to-fracture network integration, and eventually to adopting innovative technologies and advanced concepts for reservoir stimulation. …”
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Significant differences in knee kinematics of healthy subjects with high and low anterior tibial laxity by Shiyang Chen, Shaohua Chen, Qingyang Kang, Fangzheng Lin, Fangzheng Lin, Fangzheng Lin, Shuting Zheng, Xixi Liu, Chunhong Guo, Chunhong Guo, Yongjin Li, Yongjin Li, Dingkun Lin, Dingkun Lin, Xiaolong Zeng

“…However, further research is needed to explore the clinical functional effects of knee laxity.…”
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Germline biomarkers predict toxicity to anti-PD1/PDL1 checkpoint therapy by Santosh Kesari, Jose Carrillo, Alexandra Drakaki, Joanne Weidhaas, Mark Scholz, Nicholas Marco, Aaron W Scheffler, Anusha Kalbasi, Kirk Wilenius, Emily Rietdorf, Jaya Gill, Mara Heilig, Caroline Desler, Robert K Chin, Tania Kaprealian, Susan McCloskey, Ann Raldow, Naga P Raja, Donatello Telesca

“…We tested the hypothesis that germline microRNA pathway functional variants, known to predict altered systemic stress responses to cancer therapies, would predict irAEs in patients across cancer types.Methods MicroRNA pathway variants were evaluated for an association with grade 2 or higher toxicity using four classifiers on 62 patients with melanoma, and then the panel’s performance was validated on 99 patients with other cancer types. …”
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Troxerutin suppresses the stemness of osteosarcoma via the CD155/SRC/β-catenin signaling axis by Junkai Chen, Hongbo Li, Qinglin Jin, Xiaoguang Li, Yiwen Zhang, Jingnan Shen, Gang Huang, Junqiang Yin, Changye Zou, Xinyu Li, Xin He, Xianbiao Xie, Tiao Lin

“…Additionally, in vivo animal models were utilized to assess the functional role of CD155 in a biological context. RNA-seq and co-immunoprecipitation methods were used to search for downstream target molecules and signaling pathways of CD155. …”
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Acute Coronary Syndrome in Patients With 2 Type Diabetes Mellitus (Review of Literature; Description of the Clinical Case) by Bilous Z., Abrahamovych О., Mazur N., Ryabokon S., Ilenkiv N., Bevza N.

“…The main mechanisms for the implementation of the effect of hyperglycemia include: activation of the polyolic pathway of glucose metabolism (sorbitol/aldose reductase); glycosylation of proteins; the effect of oxidative stress; increase of the role of diacylglycerols and activation of protein kinase isoforms as a result of enhanced formation of superoxide radical by inflammatory blood cells, smooth muscle cells, endothelial cells. …”
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Non-pharmacological interventions for temporomandibular disorders: A systematic review and meta-analysis by Qiu-yi CHEN, Quan MIAO, Fei-yu FU, Ying LIN, Chen-xi ZENG, Pei-yue PENG, Yi-xin ZHANG, Lu LIU, Bin LI

“…Objective: This study aimed to evaluate the clinical efficacy of non-pharmacological interventions for TMDs, focusing on their impact on pain relief, jaw mobility, and functional improvement. Specifically, we aimed to compare the effectiveness of four non-pharmacological interventions, including acupuncture, exercise, occlusal splinting, and laser therapy, for treating TMDs. …”
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Genome-Wide Identification of the HSP Gene Family in Penaeus japonicus and Their Expression Characteristics During Development Stages by Xueqiong BIAN, Xianyun REN, Junxia WANG, Shaoting JIA, Jianjun GUO, Kuangcheng ZHAO, Ping LIU, Jian LI, Jitao LI

“…Motif analysis showed that the hsp gene family was highly conserved; however, the functions of different families were quite different. …”
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Advanced strategy for cancer detection based on volatile organic compounds in breath by Ziqi Jia, Yiwen Jiang, Tongxuan Shang, Heng Cao, Jiayi Li, Lin Cong, Pengming Pu, Hengyi Xu, Yuchen Liu, Yansong Huang, Dongxu Ma, Jiang Wu, Ruijie Zhou, Xiang Wang, Chang bao Han, Jiaqi Liu

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Physiological mechanisms of 2,4-epibrassinolide treatment in enhancing salt-alkali stress tolerance in Corylus heterophylla × C. avellana hybrid seedlings by MA Chao, CHEN Weiqing, LIU Zaiguo, HAO Jing, ZHAO Mengjiong, LU Juan

“…These findings indicated that EBR played a role in modulating ion homeostasis, which was essential for maintaining cellular functions and reducing the toxic effects of sodium ions. …”
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大豆油在3种传统米面食品煎炸过程中的品质变化Quality changes of soybean oil during frying of three traditional rice and flour foods by 何雪梅1，黄晨昕1，李红丽1，陈文杰2，李琪1，于修烛1 HE Xuemei1, HUANG Chenxin1, LI Hongli1,CHEN Wenjie2, LI Qi1, YU Xiuzhu1

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eCBT-I dialogue system: a comparative evaluation of large language models and adaptation strategies for insomnia treatment by Xueying Bao, Xingyu Zhu, Dongren Yang, Hao Lou, Ruoyun Wang, Yutong Wu, Wenhui Li, Yu Xia, Li Zeng, Yingying Pan, Xiqin Wang, Xian Zhang, Cheng Ling, Youhui Ling, Yan Zhang, Qi Zhao, Mei Yang

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Genomic insights into population dynamics and adaptive strategies of the endangered dipterocarp, Hopea chinensis by Wei-Min Xiang, Yu-Ting Jiang, Jie Zou, Yan Deng, Kai Jiang, Kai-Jian Zhang, Xin-Yu Zhou, Kai-Xi Quan, Zi-Wen Han, Wei-Chao Liu, Liang Tang, Yuan-Yuan Li, Simon T. Segar, Yuan-Ye Zhang, Xing-Hua Hu, Rong Wang, Xiao-Yong Chen

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Environmental Levels and Degradation Behavior of Pharmaceuticals and Personal Care Products (PPCPs) in the Water Environment by Zhaohe ZHANG, Dian CHEN, Wei ZHAO, Guoli YUAN, Jun LI, Xingchun JIAO

“…In surface water, many PPCPs have avoided the strict biodegradation environment of wastewater treatment, and photochemistry may have a greater effect than the biodegradation under sunlight, in which antibiotics are mainly photodegraded in the water environment; ibuprofen, iopromide and caffeine are more prone to biodegradation; esters and amides are the most common functional groups that are easily hydrolyzed in PPCPs[63], and tetracycline can undergo hydrolysis reactions due to adsorption into sediments. …”
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Abrasion Resistance and Mechanism Analysis of Polyethylene Fiber-reinforced Cementitious Composite by ZI Jinjia, LI Weibin, WANG Jihong, WANG Zhiwen, LIU Yunjun, NONG Qingshun, LI Bixiong

“…PE fibers exerted multiple effects on the abrasion resistance of cement-based materials. …”
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Novel oxidative stress- and ferroptosis-related gene prognostic signature for erectile dysfunction by Meijun Liu, Maobin Yu, ZiYang Ma, Zilong Xu, Tao Zhang, Hongsen Zeng, Ze Li, XiYu Dang, Peihai Zhang

“…Abstract Background Studies have suggested that Guizhi Jia Longgu Muli decoction (GuiZhiJiaLongGuMuLiTang) has a therapeutic effect on erectile dysfunction (ED), even though how it works is still not fully understood. …”
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INVESTIGATION OF THE OPTICAL BONE DENSITY OF THE ALVEOLAR PROCESSES IN THE AREA OF DEFECTS OF DENTITION by S.A. German

“…To obtain a stable functioning implantation system, it is necessary to clearly define the amount of bone tissue to reveal the bone quality of the alveolar division of the jaw. …”
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A novel stemness-related lncRNA signature predicts prognosis, immune infiltration and drug sensitivity of clear cell renal cell carcinoma by Jia Liu, Lin Yao, Yong Yang, Jinchao Ma, Ruijian You, Ziyi Yu, Peng Du

“…Enrichment analysis was performed to explore the potential functions of SRmRNAs. Multiple machine learning algorithms were employed to construct a prognostic signature. …”
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Understanding the influence of precipitation and nitrogen depositions on the soil health and growth indices of invasive (Solidago canadensis L.) and native (Wedelia chinesis) assoc... by Ismail Khan, Muhammad Tariq, Faisal Nadeem, Muhammad Sadiq Khan, Sulaiman Ali Alharbi, Saleh Alfarraj, Sezai Ercisli, Ayse Usanmaz Bozhuyuk, Ping Zhuang

“…These factors have important implications for ecosystem functioning and biodiversity in the face of climate change. …”
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