LLT1 overexpression renders allogeneic-NK resistance and facilitates the generation of enhanced universal CAR-T cells by Shuxian Zhu, Shiyu Zuo, Chuo Li, Xingjie You, Erlie Jiang, Xiaoming Feng, Yuechen Luo

“…We performed cytotoxicity, proliferation, and cytokine assays to evaluate the functionality of universal chimeric antigen receptor-T cell (UCAR-T) cells and conducted in vitro and in vivo assays, including allogeneic responses and RNA sequencing, to assess their resistance to allogeneic T and NK cells, anti-leukemia efficacy, and persistence in treating hematologic malignancies. …”
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Plasma testosterone concentration is correlated with circulating immune cell abundance in transgender young people on gender-affirming hormone treatment by Alice A. White, Alice A. White, Thomas Pearce, Thomas Pearce, Isabelle Coenen, Xander Bickendorf, Xander Bickendorf, Julia K. Moore, Julia K. Moore, Penelope Strauss, Liz A. Saunders, Liz A. Saunders, Georgia Chaplyn, Aris Siafarikas, Aris Siafarikas, Aris Siafarikas, Ashleigh Lin, Martyn French, Martyn French, Christian Tjiam, Christian Tjiam, Deborah Strickland, Jonatan Leffler

“…This cross-sectional observational study of young trans individuals suggests that testosterone treatment may have immune modulatory effects, which should be investigated further, including functional studies. …”
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YY1 drives PARP1 expression essential for PARylation of NONO in mRNA maturation during neuroblastoma progression by Chunhui Yang, Jiaying Qu, Yang Cheng, Minxiu Tian, Zhijie Wang, Xiaolin Wang, Xinyue Li, Shunchen Zhou, Bosen Zhao, Yanhua Guo, Liduan Zheng, Qiangsong Tong

“…Poly(ADP-ribose) polymerase 1 (PARP1), a key enzyme catalyzing polyADP-ribosylation (PARylation), plays critical roles in various cellular processes, and contributes to tumorigenesis and aggressiveness. However, the functions and regulatory mechanisms of PARP1 in NB progression still remain to be determined. …”
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High expression of SOX10 is correlated with poor prognosis and immune infiltrates in skin cutaneous melanoma by Xu Sun, Yi-ming Cheng, Meng-wei Sun, Xu-dong Zhang, Xiao-yu Yu, Hai-bo Wang, Yi-fei Wang, Ning Li

“…Kaplan-Meier method was conducted to assess the effect of SOX10 on survival. Additionally, the clinical significance of SOX10 in SKCM was figured out by LASSO and prognostic nomogram model. …”
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The cold immunological landscape of ATM-deficient cancers by Fresia Pareja, Stephen Morris, Sonali Sinha, Lorenzo Galluzzi, Fatemeh Derakhshan, Jennifer Ma, Jorge Reis-Filho, Nadeem Riaz, Shu Yazaki, Victor Ng, Ardijana Novaj, Yingjei Zhu, Xin Pei, Jeremy Setton, Flavie Naulin, Manuel Beltrán-Visiedo, Ethan Shin, Ana Leda F Longhini, Rui Gardner, Kevin Ma, Anne Roulston, Maria Koehler, Simon Powell, Ezra Rosen, Atif Khan

“…Background Mutations in genes encoding DNA repair factors, which facilitate mismatch repair, homologous recombination, or DNA polymerase functions, are known to enhance tumor immunogenicity. …”
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IQUB mutation induces radial spoke 1 deficiency causing asthenozoospermia with normal sperm morphology in humans and mice by Tingwenyi Hu, Xiangrong Tang, Tiechao Ruan, Shunhua Long, Guicen Liu, Jing Ma, Xueqi Li, Ruoxuan Zhang, Guoning Huang, Ying Shen, Tingting Lin

“…To date, many components of RSs and their functions in human sperm flagella remain unclear. Methods We recruited a cohort of 323 infertile males with ASZ between August 2019 and June 2024. …”
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Integrating proteomics and machine learning reveals characteristics and risks of lymph node-independent distant metastasis in colorectal cancer by Chenxiao Zheng, Baiwang Zhu, Yanyu Chen, Numan Shahid, Yiwang Hu, Hajar Mansoor Ahmed Ali Husain, Binbin Ou, Qiongying Zhang, Haobo Jin, Yating Zheng, Peng Li, Yifei Pan, Xiaodong Zhang, Xiaodong Zhang

“…Tumor Mutation Burden (TMB), Microsatellite Instability (MSI) score, immune functions and immune checkpoint gene expression were analyzed to evaluate immunotherapy response. …”
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Human menstrual blood-derived stem cells secreted ECM1 directly interacts with LRP1α to ameliorate hepatic fibrosis through FoxO1 and mTOR signaling pathway by Yangxin Fang, Lin Chen, Yin Yuan, Sining Zhou, Jiamin Fu, Qi Zhang, Ning Zhang, Yuqi Huang, Yifei Li, Li Yuan, Lijun Chen, Charlie Xiang

“…Previous studies found that MenSC-derived secretomes exert protective effects against liver fibrosis. However, the underlying mechanisms of these observations remain unclear. …”
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Anticholinergic burden and behavioral and psychological symptoms in older patients with cognitive impairment by Sabrina Pistorio, Gianluca Scotto di Tella, Vittoria Canzanella, Raffaella Merenda, Gianluigi Cuomo, Paola Iacotucci, Vincenzo Carnovale, Leonardo Bencivenga, Maria Vargas, Annalaura Manes, Mauro Cataldi, Giuseppe Rengo, Giuseppe Rengo, Michela Zanetti, Grazia Daniela Femminella, Grazia Daniela Femminella

“…Screening tests for cognitive impairment (MMSE) and functional status (ADL, IADL) were performed. BPSD were evaluated with the Neuropsychiatric Inventory (NPI). …”
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Deciphering the anticoccidial mechanism of Qinghao Changshan formula through network pharmacology and molecular docking by Dong Tian, Hui Fu, Hongxia Tao, Miaolan Li, Qinghua Zhang, Weidong Deng

“…These findings provide mechanistic insights into the therapeutic effects of QHCS and lay a theoretical foundation for its broader application in veterinary parasitology.…”
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SwinDAF3D: Pyramid Swin Transformers with Deep Attentive Features for Automated Finger Joint Segmentation in 3D Ultrasound Images for Rheumatoid Arthritis Assessment by Jianwei Qiu, Grigorios M. Karageorgos, Xiaorui Peng, Soumya Ghose, Zhaoyuan Yang, Aaron Dentinger, Zhanpeng Xu, Janggun Jo, Siddarth Ragupathi, Guan Xu, Nada Abdulaziz, Girish Gandikota, Xueding Wang, David Mills

“…Rheumatoid arthritis (RA) is a chronic autoimmune disease that can cause severe joint damage and functional impairment. Ultrasound imaging has shown promise in providing real-time assessment of synovium inflammation associated with the early stages of RA. …”
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Cancer-associated foam cells hamper protective T cell immunity and favor tumor progression in human colon carcinogenesis by Barbara Vergani, Massimo Milione, Marco Vitellaro, Giulio Ferrero, Veronica Huber, Luca Lalli, Agata Cova, Paola Frati, Flavio Arienti, Licia Rivoltini, Simonetta Guarrera, Laura Cattaneo, Luca Sorrentino, Elena Daveri, Elena Casiraghi, Marta Zorza, Manuela Gariboldi, Patrizia Pasanisi, Daniele Morelli, Paola A Corsetto, Angela M Rizzo, Martina Stroscia, Vincenzo Lagano, Giovanna Sabella, Biagio E Leone

“…FChigh tumors exhibited reduced CD8+ T cells and increased regulatory T cells (Tregs). Functional transcriptional profiling depicted an immunosuppressed milieu characterized by reduced interferon gamma, memory CD8+ T cells, and activated macrophages mirrored by increased T-cell exhaustion and Treg enrichment. …”
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Objectively measured activity behaviours using the ActivPAL accelerometer following robotic and manually performed total knee arthroplasty: a feasibility study from a randomized co... by Nick D. Clement, Bola Ajekigbe, Jayasree Ramaskandhan, Steven Galloway, Karen Smith, David J. Weir, David J. Deehan

“…There were no differences in activity with small effect sizes (≤ 0.2) between the raTKA and mTKA groups, despite differences in subjective knee pain. …”
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Toll-like receptor 3 activation enhances antitumor immune response in lung adenocarcinoma through NF-κB signaling pathway by Ang Li, Ang Li, Ang Li, Man Luo, Xiyao Liu, Hongjiao Wu, Hongjiao Wu, Hongjiao Wu, Xiaoguang Liu, Zhi Zhang, Xuemei Zhang, Xuemei Zhang, Xuemei Zhang

“…BackgroundToll-like receptor 3 (TLR3) is a pattern recognition receptor known to play a crucial role in the immune response to cancer. However, its effect on the efficacy of immunotherapy in lung adenocarcinoma (LUAD) remains unclear. …”
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Development of an innovative duplex digital PCR assay for circulating MiRNA ratio quantification in metastatic melanoma by Alex De Gregorio, Andrea Sacconi, Chiara Mandoj, Fabio Valenti, Valentina De Pascale, Gabriele Madonna, Mariaelena Capone, Teresa Meinardi, Francesca Guerresi, Irene Terrenato, Giovanni Cigliana, Michelangelo Russillo, Virginia Ferraresi, Maurizio Fanciulli, Giovanni Blandino, Paolo Antonio Ascierto, Gennaro Ciliberto, Rita Mancini, Luigi Fattore

“…Their stability in biological fluids, tissue-specific expression, and functional roles in tumor biology make them particularly suitable for liquid biopsy approaches. …”
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Macrophage GSK3β-deficiency inhibits the progression of hepatocellular carcinoma and enhances the sensitivity of anti-PD1 immunotherapy by Li Liu, Jie Zhao, Jinyu Zhang, Guoqiang Sun, Yongxiang Xia, Xuehao Wang, Hanyuan Liu, Siqi Zhao, Zihao Zhang, Tian Huang, Xiangyi Kong, Weiwei Tang, Guangshun Sun, Hengsong Cao, Dawei Rong, Qinghua Ji

“…However, the biological functions of GSK3β in tumor-associated macrophages (TAMs) in cancers including hepatocellular carcinoma (HCC) remain unclear.Methods The enrichment of GSK3β in tumor tissues was assessed by Gene Expression Omnibus (GEO) database. …”
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Exploring the gut microbiota associated with peripheral nerve invasion in colorectal cancer patients and constructing predictive models by Chuanbin Chen, Qingmin Chen, Shenghai Liu, Guoxi Li, Jiawei Zhao, Jingting Huang, Tianyi Ye, Xinting Yang, Zigui Huang, Zhen Wang, Fuhai He, Mingjian Qin, Chenyan Long, Binzhe Tang, Yongqi Huang, Weizhong Tang, Jungang Liu, Xiaoliang Huang

“…Abstract Objective This study aims to explore the differences in composition, abundance, and biological functions of the gut microbiota between colorectal cancer (CRC) patients with peripheral nerve invasion (PNI) and those without peripheral nerve invasion (NPNI). …”
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Symptoms of anxiety, depression, and post-traumatic stress disorder 6 weeks and 6 months after ICU: Six out of 10 survivors affected by E van der Merwe, L Stroud, G Sharp, N van Vuuren, M Mosola, T Fodo, F Paruk

“…These conditions can have lasting consequences on their wellbeing, ability to return to their pre-illness level of functioning and health-related quality of life. There is a paucity of South African data in terms of the psychological aspects of the post-intensive care unit (ICU) syndrome. …”
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Tenecteplase thrombolytic therapy for acute ischaemic stroke in China: a real-world, multicentre, retrospective, controlled study by Peng Li, Qiang Dong, Anqi Zhang, Qiang Li, Hong Zhang, Yibin Fang, Ye Liu, Gang Li, Hui Luo, Xiaoyu Zhou, Chao Wu, Dan li, Yu Yao, Kun Fang, Xiangjun Li, Yin Liu, Jingyu Guo, Huaying Wang, Jianjun Tang, Xin Cheng, Jianhong Yang, Lan Hong, Guozhi Lu, Guang Wu, Rongbo Qu, Yongren Fang, ZhiJiao He, Lian Zuo, Jinchun Wang, Dongya Huang, Ge-Fei Li, Yanzhang Xiao, Zongyan Dang, Yeqiu Jiao, Yang Zhu, Yulei Deng, Linghao Cao

“…We aim to investigate the real-world evidence regarding its safety and effectiveness in China.Methods We conducted a retrospective study on patients receiving alteplase or TNK for acute ischaemic stroke (AIS) within 4.5 hours of onset between 1 March 2019 and 1 October 2023, from 18 stroke centres in China. …”
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Entrectinib can induce nerve cell damage by inhibiting PI3K-AKT and TGF-β signaling pathways by Qingshan Tang, Jiachen Dong, Feng Zhang, Dan Zhao, Qi Yang, Jiayu Wen, Yuhao Sun, Jifu Wei, Zhixian Liu

“…However, the precise mechanism of such CNS-related toxicities remains elusive.MethodsThe effect of entrectinib-induced nerve cell damage was evaluated by the nerve cells (PC12, HT22 and SK-N-SH) based in vitro models. …”
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