Promoting the Integration of Public Perspective into Urban Design Decision-Making Based on Crowdsourced Visual Perception Method by Lu HUANG, Takuya (JPN) OKI

“…Examining urban perception reveals authentic public needs — though lacking professional design expertise to propose specific solutions, the public’s sensory experiences and perceptual feedback effectively highlight real demands, providing critical input for design decisions. …”
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Dietary Probiotic <i>Bacillus subtilis</i> AAHM-BS2360 and Its Postbiotic Metabolites Enhance Growth, Immunity, and Resistance to Edwardsiellosis in <i>Pangasianodon hypophthalmus<... by Nugroho Wiratama, Pakapon Meachasompop, Benchawan Kumwan, Yosapon Adisornprasert, Prapansak Srisapoome, Phornphan Phrompanya, Patcharapong Thangsunan, Pattanapong Thangsunan, Kanokporn Saenphet, Supap Saenphet, Wararut Buncharoen, Anurak Uchuwittayakul

“…This study investigates the effects of probiotic <i data-eusoft-scrollable-element="1">Bacillus subtilis</i> AAHM-BS2360 and its postbiotic metabolites on growth performance, immune responses, antioxidative activity, and disease resistance against <i data-eusoft-scrollable-element="1">E. tarda</i> infection. …”
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TGF-&amp;beta; Decreases NK Cell Mobility and Cytotoxic Efficacy in Complex in vitro Models of the Leukemia Microenvironment by Švubová V, Janstová L, Jedlička M, Mašínová E, Szabová J, Feglarová T, Kuglerová K, Bosáková V, Brodská B, Boráková K, Kundrát D, Trsová I, Böhmová M, Kuželová K, Hrdý J, Gašová Z, Vydra J, Dostálová Merkerová M, Hortová-Kohoutková M, Frič J

“…RNA sequencing revealed that TGF-β altered key gene pathways associated with NK cell cytotoxicity, adhesion, and migration, supporting its immunosuppressive role. In functional assays, TGF-β exposure significantly reduced NK cell-mediated cytotoxicity in a time-dependent manner and impaired NK cell infiltration into 3D spheroids, particularly in models incorporating MSCs. …”
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Comprehensive Analysis of Differences in N6-Methyladenosine RNA Methylation Groups in CVB3-Induced Viral Myocarditis and Identification of the Anti-Apoptotic Role of RBM15B by Hu Y, Lin J, Yi L, Cheng S, You G, Chang H, Liu H, Yang Z, Chen S

“…However, the potential effects of CVB3 infection on m6A methylation within the myocardium remain unexplored. …”
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Prohibition of Discrimination Based on Sexual Orientation: Analysis of CJEU and ECtHR Case Law Concerning Human Rights by Monika Patrycja Bator-Bryła

“…This necessitates the adoption of comprehensive legal solutions to effectively combat discrimination in a practical dimension.     …”
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OsHemA gene, encoding glutamyl-tRNA reductase (GluTR) is essential for chlorophyll biosynthesis in rice (Oryza sativa) by Zhao-qiong ZENG, Tian-zi LIN, Jie-yu ZHAO, Tian-hui ZHENG, Le-feng XU, Yi-hua WANG, Ling-long LIU, Ling JIANG, Sai-hua CHEN, Jian-min WAN

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Cholangiocarcinoma-derived secreted products and growth arrest-specific 2-like 3 enhance migratory and invasive abilities of fibroblasts by Natnicha Paungpan, Kulthida Vaeteewoottacharn, Paweena Dana, Saowaluk Saisomboon, Sittiruk Roytrakul, Wiphawi Hipkaeo, Yada Polsan, Kanlayanee Sawanyawisuth, Sukanya Luang, Worachart Lert-itthiporn, Vor Luvira, Chawalit Pairojkul, Yaovalux Chamgramol, Sopit Wongkham, Seiji Okada

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Cation-self-shielding strategy promises high-voltage all-Prussian-blue-based aqueous K-ion batteries by Qiubo Guo, Shuai Han, Yaxiang Lu, Ruijuan Xiao, Jin Li, Qingli Hao, Xiaohui Rong, Suting Weng, Yaoshen Niu, Feixiang Ding, Yang Yang, Hui Xia, Xuefeng Wang, Fei Xie, Lin Zhou, Xueyan Hou, Hong Li, Xuejie Huang, Liquan Chen, Yong-Sheng Hu

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Elevating larval source management as a key strategy for controlling malaria and other vector-borne diseases in Africa by Fredros Okumu, Sarah J. Moore, Prashanth Selvaraj, Arnon Houri Yafin, Elijah O. Juma, GloriaSalome G. Shirima, Silas Majambere, Andy Hardy, Bart G. J. Knols, Betwel J. Msugupakulya, Marceline Finda, Najat Kahamba, Edward Thomsen, Ayman Ahmed, Sarah Zohdy, Prosper Chaki, Peter DeChant, Kimberly Fornace, Nicodem Govella, Steven Gowelo, Emmanuel Hakizimana, Busiku Hamainza, Jasper N. Ijumba, William Jany, Hmooda Toto Kafy, Emmanuel W. Kaindoa, Lenson Kariuki, Samson Kiware, Eliningaya J. Kweka, Neil F. Lobo, Dulcisária Marrenjo, Damaris Matoke-Muhia, Charles Mbogo, Robert S. McCann, April Monroe, Bryson Alberto Ndenga, Halfan S. Ngowo, Eric Ochomo, Mercy Opiyo, Richard Reithinger, Chadwick Haadezu Sikaala, Allison Tatarsky, David Takudzwa, Fedra Trujillano, Ellie Sherrard-Smith

“…In this paper, we argue that the heavy reliance on large-scale cluster-randomized controlled trials (CRTs) to generate evidence on epidemiological endpoints restricts the recommendation of approaches to only those interventions that can be measured by functional units and deliver relatively uniform impact and, therefore, are more likely to receive financial support for conducting these trials. …”
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Challenges in the preclinical design and assessment of CAR-T cells by Radu Tomai, Radu Tomai, Javier De Las Rivas, Bogdan Fetica, Bogdan Fetica, Rui Bergantim, Rui Bergantim, Rui Bergantim, Rui Bergantim, Brankica Filipic, Zarko Gagic, Katarina Nikolic, Diana Gulei, Diana Gulei, David Kegyes, David Kegyes, Madalina Nistor, Madalina Nistor, Ximena Maria Muresan, Ximena Maria Muresan, Diana Cenariu, Diana Cenariu, Richard Feder, Richard Feder, Mariana Pavel-Tanasa, Andrei Cianga, Adrian Bogdan Tigu, Adrian Bogdan Tigu, Raluca Munteanu, Raluca Munteanu, Alina Tanase, Hermann Einsele, Hermann Einsele, Hermann Einsele, Ciprian Tomuleasa, Ciprian Tomuleasa

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Clinical, electromyographic, and biophysical characterization of the rare Nav1.4 channel mutation SCN4A L1436P by François Charles Wang, François Charles Wang, Olivier Bouquiaux, Olivier Bouquiaux, Isabelle Lievens, Bernard Lakaye, Laura Vandries, Margaux Poleur, Samira Abdou Ide, Nurcan Inci, Vincent Seutin

“…IntroductionOur aims were to provide an integrated clinical and biophysical characterization of the rare variant NM_000334.4(SCN4A) c.4307T&gt;C (p.Leu1436Pro; L1436P), affecting the skeletal muscle sodium channel Nav1.4, and to compare its functional consequences with both wild-type (WT) channels and the well-established pathogenic variant p.Arg1448His (R1448H).MethodsWe retrospectively analyzed nine unrelated patients carrying the heterozygous L1436P variant. …”
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Phenol solutions recovery as water pollutants with eugenol cross-linked diallyl phthalate using supported liquid membrane by A.A. Kiswandono, N. Ningsih, A.V. Sindiani, Rinawati ., H.I. Qudus

“…Furthermore, it aims to assess the effectiveness of phenol transport and separation using this membrane technique. …”
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Targeting the <i>ZMYM2-ANXA9</i> Axis with <i>FLT3</i> Inhibitor G749 Overcomes Oxaliplatin Resistance in Colorectal Cancer by Dezheng Lin, Yucheng Xu, Huanmiao Zhan, Yufan Liang, Riyun Liu, Jun Liu, Dandong Luo, Xiaochuan Chen, Jiawei Cai, Yifeng Zou

“…<i>FLT3</i> inhibition by G749 effectively downregulates <i>ANXA9</i> and sensitizes tumors to chemotherapy, highlighting a novel therapeutic approach for chemoresistant CRC.…”
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Decentralized biobanking platform for organoid research networks by Marielle Gross, Marielle Gross, Ananya Dewan, Mario Macis, Mario Macis, Eve Budd, M. Eifler, Olayinka Odeniran, Jeff Kahn, Jeff Kahn, Jeff Kahn, Robert Clell Miller, Robert Clell Miller, William Sanchez

“…IntroductionOrganoids are living, patient-derived tumor models that are revolutionizing precision medicine and drug development, however current privacy practices strip identifiers, thereby undermining ethics, efficiency, and effectiveness for patients and research enterprises alike. …”
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Isolation andfunctional characterization of HO-hMSCs as NK-supportive cells derived from hematopoietic organoids by TANG Shili, LIN Bixuan, HUANG Enxia, HE Ying, XUE Yuan, ZHANG Yonggang

“…Flow-cytometric phenotyping and bulk RNA-sequencing were performed to compare HO-hMSCs with umbilical cord-derived MSCs (UC-hMSCs). The effect of HO-hMSCs on NK cell differentiation efficiency (CD3-CD56+) and effector maturation (CD16 expression) were assessed by co-culture experiments, using UC-hMSCs as control. …”
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POLYMORPHISM OF THE TP53 GENE IN PATIENTS WITH GASTRIC CANCER IN PROSPECTIVE AND CLINICAL CASE-CONTROL STUDIES by A. V. Belkovets, S. A. Kurilovich, V. N. Maksimov, Yu. I. Ragino, L. V. Scherbakova, O. V. Cheremisina, N. V. Cherdyntseva, M. V. Parulikova, M. I. Voevoda

“…Background. A functionally significant TP53Arg72Pro polymorphism can contribute to the development of gastric cancer (GC).The aim: to study the associations of genotypes and alleles of the TP53Arg72Pro 4 polymorphism with GC and biomarkers of gastric ucosal atrophy in population-based prospective and case-control clinical trials among the population of Siberia.Material and methods. …”
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Isolation and characterization of a novel lytic bacteriophage Pv27 with biocontrol potential against Vibrio parahaemolyticus infections in shrimp by Vu Thi Hien, Pham Thi Lanh, Thao Thi Phuong Pham, Khang Nam Tran, Nguyen Dinh Duy, Nguyen Thi Hoa, Nguyen Xuan Canh, Quang Huy Nguyen, Seil Kim, Dong Van Quyen

“…Finally, genomic analysis of Pv27 was conducted through whole-genome sequencing, followed by functional annotation of open reading frames (ORFs) and phylogenetic analysis. …”
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Targeting GPR84 to alleviate acute immune-mediated liver injury by Yanan Zheng, Yumeng Wang, Yujie Xu, Shanshan Shen, Haozhe Xu, Chao Hu, Yongzhen Chen, Fengmeng Teng, Jinshun Pan, Shuqian Zheng, Junqi Wang, Zhongping Su, Qiang You

“…GPR84 gene knockout mice were employed to evaluate the receptor’s functional role. Bone marrow chimeric mice were created to determine the involvement of hematopoietic cells. …”
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Development of in vitro laboratory models of the tumor immune microenvironment to evaluate quality parameters and specific efficacy of the dendritic cell vaccine by T. L. Nekhaeva, A. B. Danilova, E. I. Fedoros, N. A. Efremova, N. V. Emelyanova, M. L. Blokhina, M. N. Yurova, M. L. Tyndyk, I. A. Baldueva

“…Requirements for the quality of personalized autologous DCs, including control of immunophenotypic characteristics were developed, and functional activity of Tlymphocytes during induction of mature vaccine DCs was evaluated. …”
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Repetitive prefrontal tDCS activates VTA dopaminergic neurons, resulting in attenuation of Alzheimer’s Disease-like deficits in Tg2576 mice by Maria Luisa De Paolis, Gilda Loffredo, Paraskevi Krashia, Livia La Barbera, Annalisa Nobili, Emma Cauzzi, Lucy Babicola, Matteo Di Segni, Roberto Coccurello, Stefano Puglisi-Allegra, Emanuele Claudio Latagliata, Marcello D’Amelio

“…Moreover, decreased midbrain volume and functional VTA disconnection are identified as predictors of accelerated progression from Mild Cognitive Impairment to AD-dementia in clinical populations. …”
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