LC-MS/MS based metabolomics reveals the mechanism of skeletal muscle regeneration by Lei Yi, Kaiming Wang, Sui Liufu, Wenwu Chen, Bohe Chen, Xiaolin Liu, Caihong Liu, Jingwen Liu, Xin Xu, Haiming Ma

“…Abstract Background Skeletal muscle possesses a robust regenerative capacity and can effectively repair itself following injury. However, research on the metabolic changes during skeletal muscle regeneration in large animals remains relatively limited. …”
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ETHIOPATHOGENETIC PARALLELS OF MORPHOLOGICAL CHANGES IN CHRONIC DENTAL CARIES AND ITS COMPLICATIONS by B.M. Fylenko

“…Dental plaque (biofilm) is resulted from structurally and functionally ordered colonization of microorganisms on the tooth surface. …”
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The clinical efficacy of hybrid surgery based on the Waveflex semi-rigid dynamic internal fixation system for the treatment of lumbar degenerative diseases: over three-year follow-... by Zhiwu Zhang, Jiashen Shao, Nan Su, Xiang Li, Qi Fei, Yong Yang, Hai Meng

“…Clinical efficacy was evaluated based on pain intensity (measured by the Visual Analogue Scale, VAS), functional disability (assessed via the Oswestry Disability Index, ODI), incidence of postoperative complications, and patient satisfaction level. …”
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LEGAL AND ECONOMIC PRINCIPLES OF THE FOREIGN POLICY OF INDEPENDENT AZERBAIJAN IN RELATION TO NEIGHBORING COUNTRIES by Katana Gafarova

“…The formal-legal method created the conditions for the formulation of conclusions on the effectiveness of measures defined by the international and national legislation in the field of construction of economic and legal principles of foreign policy of independent Azerbaijan in relation to the neighbouring countries. …”
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Diseño, validación y valoración de competencias del gestor de actividades físicas y deportivas (Design, validation and assessment of physical activity and sports manager competenci... by Daniel Carranza-Bautista, Manel Valcarce-Torrente

“…Organizations in the field of physical activity and sports management require people capable of performing effectively and efficiently in the positions they occupy. …”
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Benefícios da atenção domiciliar ao idoso portador de dano crônico: revisão sistemática da literatura [Benefits of home care to the elderly with chronic diseases: systematic litera... by Carolina Baltar Day, Lisiane Paskulin

“…Mortality was lower in patients receiving home care, meanwhile for hospitalizations, mean day of hospitalization, functional capacity and quality of were also similar among those receiving home care to those who received other care. …”
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CO35 | Bleeding phenotype characterization in patients with congenital bleeding disorders: a multigenic approach using next generation sequencing to identify coagulation-modulatin...

“…These results support a multigenic model influencing the bleeding phenotype in congenital bleeding disorders. Functional and segregation studies are warranted to clarify the role and clinical impact of the predisposing variants identified.   …”
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Building Energy Optimization Using an Improved Exponential Distribution Optimizer Based on Golden Sine Strategy Minimizing Energy Consumption Under Uncertainty by Mohammad Ali Karbasforoushha, Mohammad Khajehzadeh, Suraparb Keawsawasvong, Lapyote Prasittisopin, Thira Jearsiripongkul

“…The improved EDO (IEDO) effectiveness is evaluated in four cases including Case I: classical and CEC-2019 test functions, Case II: simplified and detailed building deterministic energy optimization (Without uncertainty), Case III: commercial, and residential complexes deterministic energy optimization, Case IV: simplified and detailed building stochastic energy optimization (With uncertainty), and Case V: commercial, and residential complexes stochastic energy optimization. …”
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GLUT1-mediated HMGB1 O-GlcNAcylation drives hyperglycemia-Induced neutrophil extracellular trap networks formation via TLR4 signaling and exacerbates fibroblast inflammation by Weijing Sun, Jinlong Xu, Shijie Li, Yue Zhao, Jiachen Fu, Lixia Di, Dezhi Han

“…Critically, high glucose elevated GLUT1 expression in MPBN (+ 1.2-fold), further amplified under co-culture conditions(+ 1.2-fold). Functional assays using GLUT1 knockdown confirmed that GLUT1 activity was essential for glucose uptake and subsequent O-GlcNAc modification of HMGB1, stabilizing its expression. …”
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Physicochemical stability, antioxidant and ACE-inhibitory activities of cryoprotected liposomes encapsulating stone fish-derived peptides by Shehu Muhammad Auwal, Chay Shyan Yea, Nazamid Saari

“…This study investigates the physicochemical stability, antioxidant activity, and ACE-inhibitory effects of cryoprotected liposomes encapsulating bifunctional peptides derived from stone fish, with unencapsulated peptides serving as a positive control. …”
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Feasibility of a Web-Based and Mobile-Supported Follow-Up Treatment Pathway for Adult Patients With Orthopedic Trauma in the Netherlands: Concurrent Mixed Methods Study by Gijs J A Willinge, Jelle F Spierings, Kim A G J Romijnders, Elke G E Mathijssen, Bas A Twigt, J Carel Goslings, Ruben N van Veen

“…These insights can guide clinicians and policy makers in effectively integrating similar tools into clinical practice.…”
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Does coenzyme Q10 improve semen quality and circulating testosterone level? a systematic review and meta-analysis of randomized controlled trials by Tunmise M. Akhigbe, Tunmise M. Akhigbe, Fabrael B. Fidelis, Fabrael B. Fidelis, Adebayo O. Adekunle, Adebayo O. Adekunle, Victory J. Ashonibare, Victory J. Ashonibare, Bolaji A. Akorede, Bolaji A. Akorede, Mansur S. Shuaibu, Mansur S. Shuaibu, Suliat A. Hassan, Cecilia A. Adegbola, Cecilia A. Adegbola, Precious J. Ashonibare, Precious J. Ashonibare, Opeyemi M. Oladapo, Opeyemi M. Oladapo, Adetomiwa E. Adeogun, Adetomiwa E. Adeogun, Adetomiwa E. Adeogun, Seun G. Bamidele, Seun G. Bamidele, Precious A. Oyedokun, Precious A. Oyedokun, Mungala Mukolokota, Mungala Mukolokota, Omotolani S. Kukoyi, Omotolani S. Kukoyi, Ayoola A. Oladipo, Ayoola A. Oladipo, Olayinka E. Adelowo, Olayinka E. Adelowo, Marvelous D. Akangbe, Marvelous D. Akangbe, Jennifer R. Hughes, Albert M. Ricken, Martine Culty, Maria C. W. Avellar, Roland E. Akhigbe, Roland E. Akhigbe

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A novel single-port robotic system in urology: A prospective multicenter single-arm clinical trial evaluating feasibility and efficacy of first 50 cases by Zheng Wang, Chao Zhang, Taile Jing, Yong Wei, Chengwu Xiao, Yang Wang, Yu Fang, Xiaofeng Wu, Shouyan Tang, Hong Xu, Yi Liu, Bo Yang, Shuo Wang, Bin Xu, Qingyi Zhu, Dan Xia, Zhenjie Wu, Xiaofeng Gao, Linhui Wang

“…Methods: In this prospective, multicenter clinical trial, we examined the effectiveness of the SHURUI single-port robotic surgical system in urological interventions. …”
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Click on Click: Click-Flavone Glycosides Encapsulated in Click-Functionalised Polymersomes for Glioblastoma Therapy by Nuno M. Saraiva, Ana Alves, Ana Isabel Barbosa, Andreia Marinho, Salette Reis, Marta Correia-da-Silva, Paulo C. Costa

“…To enhance therapeutic effect, improve local drug delivery, and overcome solubility issues of these high molecular weight compounds, the synthesised compounds were encapsulated in polymeric particles (polymersomes, PMs) composed of polylactic acid-polyethylene glycol (PEG-PLA) functionalized, once more by click chemistry, with 0.1 mol% transferrin mimetic (T7—HRPYIAH) peptide. …”
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The 3′ region of the ZPA regulatory sequence (ZRS) is required for activity and contains a critical E-box by Kathryn F. Ball, Kathryn F. Ball, Stephen Manu, Abbie K. Underhill, Jeanyoung Kim, Jessica C. Britton, Sarah R. Rudd, Madison M. Malone, Japhet Amoah, Allen Cooper, Charmaine Pira, Kerby C. Oberg

“…We hypothesized that the central E-box was required for activity, while the other E-boxes and Hoxd13 sites localize ZRS activity to the distal posterior limb mesoderm.MethodsTo identify the functional role of each subdomain, we generated three ZRS fragments (5′, central, and 3′) and combined fragment constructs to test subdomain collective contributions. …”
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Combatting environmental impacts and microbiological pollution risks in Potato cropping: Benefits of forage cultivation in a semi-arid region by Xudong Sun, Yousif Abdelrahman Yousif Abdellah, Guangyan Wang, Huasen Wang, Jishao Jiang, Yu Zhang, Caspar C.C. Chater, Yongping Yang, Yuanwen Duan, Fuqiang Yu, Dong Liu

“…The Mantel test further indicates that specific soil properties impact the abundance of certain microbial taxa and determine the expression of key functional genes, including those associated with antibiotic resistance. …”
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TEIPP-vaccination in checkpoint-resistant non-small cell lung cancer: a first-in-human phase I/II dose-escalation study by Mitchell Emmers, Marij J. P. Welters, Michelle V. Dietz, Saskia J. Santegoets, Sanne Boekesteijn, Anouk Stolk, Nikki M. Loof, Daphne W. Dumoulin, Annemarie L. Geel, Lauri C. Steinbusch, A. Rob P. M. Valentijn, Danielle Cohen, Noel F. C. C. de Miranda, Egbert F. Smit, Hans Gelderblom, Thorbald van Hall, Joachim G. Aerts, Sjoerd H. van der Burg

“…Abstract Functional loss of the intracellular peptide Transporter associated with Antigen Processing (TAP) fosters resistance to T-cell based immunotherapy. …”
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Rethinking timing residuals: advancing PET detectors with explicit TOF corrections by Stephan Naunheim, Stephan Naunheim, Luis Lopes de Paiva, Luis Lopes de Paiva, Vanessa Nadig, Yannick Kuhl, Yannick Kuhl, Stefan Gundacker, Stefan Gundacker, Florian Mueller, Volkmar Schulz, Volkmar Schulz, Volkmar Schulz, Volkmar Schulz

“…PET is a functional imaging method that can visualize metabolic processes and relies on the coincidence detection of emitted annihilation quanta. …”
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Neutrophil extracellular traps impede cancer metastatic seeding via protease-activated receptor 2-mediated downregulation of phagocytic checkpoint CD24 by Yu Liu, Xiaoli Zhang, Kun Chen, Hongying Wang, Junhu Yuan, Yiming Ma, Jianhui Ma, Fanyu Zhang, Bing-zhi Wang, Yinong Wang, Xinhua Zhao

“…Notably, PAR2 deficiency imitated the effect of NETs on phagocytosis and CD24. Mechanistic studies indicated that inhibiting PAR2 expression upregulated miR-34a and miR-146a and downregulated CD24 in cancer cells. …”
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Efficient Catalytic Reduction of Organic Pollutants Using Nanostructured CuO/TiO₂ Catalysts: Synthesis, Characterization, and Reusability by Mariyem Abouri, Abdellah Benzaouak, Fatima Zaaboul, Aicha Sifou, Mohammed Dahhou, Mohammed Alaoui El Belghiti, Khalil Azzaoui, Belkheir Hammouti, Larbi Rhazi, Rachid Sabbahi, Mohammed M. Alanazi, Adnane El Hamidi

“…The FTIR spectra confirmed the presence of all the functional groups in the prepared samples. SEM images revealed irregularly shaped copper oxide and agglomerated TiO₂ particles. …”
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