Genetic variants in HLA-DQA1/DQB1 genes modulate the risk of gestational diabetes mellitus in a southern Chinese population by Lijie Nie, Yan Sun, Ruiqi Li, Qiulian Liang, Guocun Deng, Xinyu He, Yifei Zeng, Hui Zheng, Xinhe Xiao, Xiaodong Ding, Jian Huang, Xiangyuan Yu, Xiangyuan Yu

“…A dose- accumulation effect was detected between the number of unfavorable genotypes and GDM risk (Ptrend=0.024). …”
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Innovative nomogram for cervical cancer prediction: integrating high-risk HPV infection, p53 genotype, and blood routine parameters by Cheng Sun, Jun Zhang, Lili Pan, Shuang Yao, Fenghua Zhang, Linjuan Ji, Miaomei Yu, Guanghua Luo, Guanghua Luo, Xiping Jiang

“…The p53 gene influences cellular response to DNA damage and has a functional polymorphism (rs1042522, p.Arg72Pro) that affects susceptibility to degradation by HPV E6 protein. …”
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In-silico analysis of deleterious non-synonymous SNPs in the human AVPR1a gene linked to autism by Md. Delowar Kobir Jibon, Md. Asadul Islam, Md. Eram Hosen, Md. Omar Faruqe, Rashed Zaman, Uzzal Kumar Acharjee, Biswanath Sikdar, Yewulsew Kebede Tiruneh, Md. Khalekuzzaman, Motasim Jawi, Magdi E. A. Zaki

“…We analyzed the consequences of high‑risk nsSNPs on active sites, post-translational modification (PTM) sites, and their functional effects on protein stability. 3D modeling, structure validation, protein-ligand binding affinity prediction, and Protein-protein docking were conducted to verify the presence of five significant substitutions (R284W, Y140S, P107L, R149C, and F207V) and explore the modifications induced due to these mutants. …”
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Impact of methyl Jasmonate on blueberry ripening fruits: assessment of cell wall thermal stability, nutritional parameters and antioxidant enzymatic activity by Carlos Vasquez-Rojas, Carlos Vasquez-Rojas, Marcelo Muñoz-Vera, Sebastián Flores, Mauricio Betancourt, Mauricio Betancourt, Ricardo I. Castro, Patricio Ramos, Patricio Ramos, Daniel Laporte, Carolina Parra-Palma, Luis Morales-Quintana

“…This work provides a preliminary framework for integrating MeJA into sustainable horticultural practices to meet consumer demand for high-quality functional fruits.…”
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Integrating network pharmacology, molecular docking and non-targeted serum metabolomics to illustrate pharmacodynamic ingredients and pharmacologic mechanism of Haizao Yuhu Decocti... by Wenbin Huang, Xiaoju Liu, Xingjia Li, Ruixiang Zhang, Guofang Chen, Guofang Chen, Xiaodong Mao, Shuhang Xu, Chao Liu, Chao Liu

“…A total of 185 signaling pathways enriched in the 214 common targets were associated with cell proliferation and angiogenesis.ConclusionHYD exerts a pharmacological effect on hyperthyroidism via inhibiting pathological angiogenesis in the thyroid and rebalancing immunity.…”
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Altered expression and potential role of N6-methyladenosine mRNA methylation in abdominal aortic aneurysm mouse model by Julin Wang, Tianyu Miao, Yanyun Wang, Tiehao Wang, Zhangyu He, Fei Xiong, Ding Yuan, Qiang Guo, Yi Yang, Zhichen Tang, Bin Huang, Jichun Zhao

“…This study aimed to explore the expression profile, potential functions and regulated mechanism of m6A RNA methylation in the abdominal aortic aneurysm mice model. …”
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Influences of electrode density on intracranial seizure localisation: a single-blinded randomised crossover studyResearch in context by Ebenezer O. Chinedu-Eneh, Sharon Chiang, John P. Andrews, Ehsan Tadayon, Joline M. Fan, Paul A. Garcia, Ernesto Gonzalez-Giraldo, Manu Hegde, Patrick Hullett, Vikram R. Rao, Robert C. Knowlton, Edward F. Chang, Jonathan K. Kleen

“…While further studies assessing surgical outcomes in more patients are needed, these results suggest higher densities of electrodes on already-implanted hardware may reveal sub-centimetre extensions and clearer functional contiguity of the SOZ(s) for better appraisals of pathophysiological margins in epilepsy surgery. …”
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AVATAR Virtual Reality Social therapy (AVATAR_VRSocial) for distressing voices and their interference in social everyday life in early psychosis: protocol of a single-blind paralle... by Tom K J Craig, Silvia Schneider, Philippa Garety, Thomas Ward, Mar Rus-Calafell, Melina Luker, Maren Marzinzik, Phuong-Mi Nguyen, Tobias Teismann, Nils Ehrbar, Ekincan Tas, Xiao Chi Zhang, Clementine Edwards, Mark Huckvale

“…Introduction Around 70% of people with psychosis experience auditory verbal hallucinations (AVHs), which can cause distress and impair the social functioning of the individual. AVATAR therapy works by facilitating a ‘face-to-face’ dialogue between the person and a digital representation (avatar) of their persecutory voice. …”
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Human urine stem cells protect against cyclophosphamide-induced premature ovarian failure by inhibiting SLC1A4-mediated outflux of intracellular serine in ovarian granulosa cells by Hao-Cheng Gu, Ling-Fang Wang, Yu-Wei Zhang, You-Qiong Zhuo, Zhou-Hang Zhang, Xing-Yu Wei, Quan-Wen Liu, Ke-Yu Deng, Hong-Bo Xin

“…Morphological, histological, and functional alternations were examined using multiple approaches. …”
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Lnc MSTRG 4701.7 targets miR-1786/RORa to competitively regulate proliferation and apoptosis in chicken follicular granulosa cells by Chang Ma, Chang Ma, Hengsong Wu, Hengsong Wu, Chunchi Yan, Chunchi Yan, Simushi Liswaniso, Simushi Liswaniso, Xue Sun, Xue Sun, Ning Qin, Ning Qin, Rifu Xu, Rifu Xu

“…RORa was also identified as a functional target of miR-1786 in GCs, and as a competitive endogenous RNA, MSTRG.4701.7 regulated RORa expression by sponging miR-1786, thereby playing a regulatory role in GCs. …”
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Contribution of Human Resources for Health competence and skill mix on compliance with healthcare quality standards among Primary Healthcare Facilities in Tanzania: evidence from d... by Syabo M. Mwaisengela, Patricia A. Materu, Chrisogone J. German, Issa I. Mmbaga, Danny J. Temba, Raymond R. Kiwesa, Martin S. Mapunda, Erick S. Kinyenje, Nathanael Sirili, Pankras W. Luoga, Simon P. Ernest, Joseph M. Burra, Joseph C. Hokororo, Godfrey Kacholi, Ntuli A. Kapologwe, Mackfallen G. Anasel, Claud J. Kumalija, Michael Habtu, Grace E. Saguti, Janeth S. Masuma, Talhiya A. Yahya, Eliudi S. Eliakimu

“…Inadequate numbers with poor skill mix compromise health system functioning that negatively affect delivery of quality healthcare services. …”
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Identification and validation of DNA methylation-driven gene OSR1 as a novel tumor suppressor for the diagnosis and prognosis of breast cancer by Jian Xu, Biao Yang, Ling Cheng, Chen Gan, Runze Huang, Anlong Li, Han Ge, Longyu Hu, Meiwen Ling, Xinyi Zheng, Bao Zhao, Mingjun Zhang, Huaidong Cheng, Huaidong Cheng

“…Low OSR1 expression was significantly associated with M stage, HER2 status, PAM50 subtypes, and histological classification, and linked to poorer overall survival outcomes. Functional enrichment implicated OSR1 in pathways related to peptide hormone secretion, peptide transport, metal ion response, and forebrain development. …”
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Identification of a novel prognostic marker ADGRG6 in pancreatic adenocarcinoma: multi-omics analysis and experimental validation by Han Wu, Han Wu, Jin Shang, Yuanyan Bao, Huajie Liu, Haoran Zhang, Yaosheng Xiao, Yangtaobo Li, Zhaozhang Huang, Xiaolei Cheng, Zixuan Ma, Wenqing Zhang, Pingli Mo, Daxuan Wang, Mingqing Zhang, Yanyan Zhan

“…In vitro cell assays demonstrated that ADGRG6 promoted the proliferation, metastatic potential and immune marker expression of PAAD cells by increasing protein level of mutated p53 (mutp53), which activated a spectrum of gain-of-functions to promote cancer progression via the EGFR, AMPK and NF-κB signaling cascades. …”
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Anisotropic flexible stress sensors based on Loofah/CN/MWCNTs by 刘璐, 贾晓丽, 黄书童, 张景龙, 李守宝, 柯燎亮

“…Consequently, the loofah skeleton and conductive coating were compressed and released simultaneously, effectively functioning as a variable resistor. As applied stress increased, the loofah framework became more compact, gradually increasing the contact area between carbon-based materials of different sizes, thereby generating new current pathways. …”
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Regulation of behavioral responses to single prolonged stress in male and female rats: Role of PACAP by Marissa A. Smail, Evelin M. Cotella, Susan E. Martelle, James B. Chambers, Ria K. Parikh, Christine E. Moore, Ben A. Packard, Nawshaba Nawreen, Rachel D. Moloney, James P. Herman

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Carminic acid/ferric ion self assembled multienzyme mimetic nanodrug with concurrent photothermal/anti-inflammatory activity to prevent breast cancer metastasis by Mingcheng Wang, Huixi Yi, Qibao Zheng, Muhammad Adnan Younis, Liyou Guo, Zhixiong Zhan, Muhammad Rizwan Younis, Chengzhi Jin, Dong-Yang Zhang

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Mechanism of exogenous methyl jasmonate mediated AsA-GSH cycle in Summer Black grape against low temperature stress by ZHANG Shaowei, ZHU Qianyan, ZHAO Xiaogai, ZHOU Bing, LI Peng, LI Guirong

“…At each treatment time point, three grape plants were randomly selected from the normal temperature control group and the low temperature stress treatment group, and their functional leaves (the third to fifth fully expanded leaves from the top of the plant) were collected for the determination of various indicators. …”
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Chronic stress is associated with altered gut microbiota profile and relevant metabolites in adolescents by Li Ying, Wang Yuhao, He Yafang, Lan Jiao, Dang Lina, Song Qinze, Yang Chenghai, Zhao Shaoxiong, Gu Yuexi, Shen Mingwang, Cai Zelin, Wang Chuangchuang, Guo Zihan, Liu Xin, Ma Lu, Zhang Lei

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Comprehensive characterization of tobacco-induced changes in enamel surface topography by Tamanna Kaur, Ramya Ramadoss, Nitya Krishnasamy, Sandhya Sundar, Suganya Panneer Selvam, Hema Shree K

“…These alterations not only affect the aesthetic appearance of teeth but also have potential implications for enamel functionality and long-term oral health.…”
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Melatonin Enhances the Low-Calcium Stress Tolerance by Regulating Brassinosteroids and Auxin Signals in Wax Gourd by Jingjing Chang, Xuemei Zhu, Yixuan Lian, Jing Li, Xiao Chen, Zhao Song, Lei Chen, Dasen Xie, Baige Zhang

“…Melatonin is a biologically active and multi-functional hormone that plays an important role in improving nutrient use efficiency. …”
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