Targeting Drp1 inhibits ESCC progression via the ROS-PGC1-α-Nrf1/2 pathway by Zhixiong Jiang, Yating Yang, Jinchi Zhou, Xin Li, Qingqing Meng, Xiangyi Yu, Yaxin Xue, Mengyu Li, Yichen Cai, Pengchun Han, Mingjun Jiang, Huizhen Wang, Congrong Liu, Jing Zhao, Lixin Wan, Dengke Bao

“…Methods This study utilized database analysis and immunohistochemistry to evaluate the expression of Drp1 in ESCC tissues. Functional cell experiments and mouse models were performed to elucidate the mechanisms by which Drp1 influences ESCC cell growth and metastasis. …”
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Elevation of ISG15 promotes diabetic kidney disease by modulating renal tubular epithelial cell pyroptosis by Lingzhi Huang, Xinyi Chen, Yawen Shao, Shujun Deng, Chen Wang, Jianqiao Chen, Yongsheng Xie, Siming Yuan, Liqin Tang

“…The deletion of ISG15 alleviated renal functional damage, fibrosis and inflammation, which correlated with reduced ISGylation levels. …”
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Liver specific transgenic expression of CYP7B1 attenuates early western diet-induced MASLD progression by Genta Kakiyama, Nanah Bai-Kamara, Daniel Rodriguez-Agudo, Hajime Takei, Kei Minowa, Michael Fuchs, Sudha Biddinger, Jolene J. Windle, Mark A. Subler, Tsuyoshi Murai, Mitsuyoshi Suzuki, Hiroshi Nittono, Arun Sanyal, William M. Pandak

“…Effect of liver specific oxysterol 7α-hydroxylase (CYP7B1) overexpression on the Western diet (WD)-induced metabolic dysfunction-associated steatotic liver disease (MASLD) progression was studied in mice. …”
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Cannabidiol-Loaded Retinal Organoid-Derived Extracellular Vesicles Protect Oxidatively Stressed ARPE-19 Cells by Peggy Arthur, Sangeetha Kandoi, Anil Kalvala, Breana Boirie, Aakash Nathani, Mounika Aare, Santanu Bhattacharya, Tanmay Kulkarni, Li Sun, Deepak A. Lamba, Yan Li, Mandip Singh

“…<b>Results:</b> Distinct miRNA cargo were identified in early and late retinal organoid-derived EVs, implicating their roles in retinal development, differentiation, and functionality. The therapeutic effects of CBD-loaded EVs on oxidative-stressed ARPE-19 cells showed greater viability, decreased ROS production, downregulated expression of inflammation- and apoptosis-related proteins, and upregulated expression of antioxidants by Western blot and immunocytochemistry. …”
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External negative pressure improves lung aeration in near-term rabbit kittens at risk of developing respiratory distress by C. Diedericks, C. Diedericks, K. J. Crossley, K. J. Crossley, D. Jurkschat, M. J. Wallace, M. J. Wallace, I. M. Davies, I. M. Davies, P. J. Riddington, P. J. Riddington, A. B. te Pas, M. J. Kitchen, M. J. Kitchen, S. B. Hooper, S. B. Hooper

“…IntroductionAs airway liquid is cleared into lung interstitial tissue after birth, the chest wall must expand to accommodate this liquid and the incoming air. We examined the effect of applying external positive and negative pressures to the chest wall on lung aeration in near-term rabbit kittens at risk of developing respiratory distress.MethodsRabbit kittens (30 days; term ∼31 days) were randomised into Control and Elevated Liquid (EL) groups. …”
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Improving the Theranostic Potential of Magnetic Nanoparticles by Coating with Natural Rubber Latex for Ultrasound, Photoacoustic Imaging, and Magnetic Hyperthermia: An In Vitro Stu... by Thiago T. Vicente, Saeideh Arsalani, Mateus S. Quiel, Guilherme S. P. Fernandes, Keteryne R. da Silva, Sandra Y. Fukada, Alexandre J. Gualdi, Éder J. Guidelli, Oswaldo Baffa, Antônio A. O. Carneiro, Ana Paula Ramos, Theo Z. Pavan

“…Surface coatings are essential for stabilizing MNPs, improving biocompatibility, and preventing oxidation that could compromise their functionality. Natural rubber latex (NRL) offers a promising coating alternative due to its biocompatibility and stability-enhancing properties. …”
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Short-term use of ceftriaxone sodium leads to intestinal barrier disruption and ultrastructural changes of kidney in SD rats by Wenli Zou, Yueming Liu, Wei Zhang, Bo Lin, Wei Shen, Yiwen Li, Qiang He, Juan Jin

“…Objective Antibiotic treatments are known to disturb gut microbiota, but their effects on the mucosal barrier and extraintestinal diseases are rarely discussed. …”
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Chemoresistant tumor cell secretome potentiates immune suppression in triple negative breast cancer by Eleni Skourti, Kotryna Seip, Nadia Mensali, Shakila Jabeen, Siri Juell, Inger Øynebråten, Solveig Pettersen, Olav Engebraaten, Alexandre Corthay, Else Marit Inderberg, Helmut Dolznig, Gunhild Mari Mælandsmo, Eivind Valen Egeland, Lina Prasmickaite

“…The immunomodulatory influence of the tumor cell secretome was investigated by exploring its effect on monocytes, macrophages (MΦs) and T cells derived from healthy blood donors. …”
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Regulations, biosecurity measures, and impact of COVID-19: A comprehensive mixed method study in traditional wet and live animal markets in Bangladesh by Sukanta Chowdhury, Tushar Kumar Das, Nurun Nahar Chisty, Sajal Kanti Biswas, Mohammed Ziaur Rahman, Jiaxin Ling, Mahmoud M. Naguib, Johanna F. Lindahl

“…Most markets (80 %, n = 8) lacked direct water supply lines for their shops, and 50 % had no functional drainage systems. A majority (55 %, n = 22) of the key informants reported not seeing any food inspectors at the market within the last three months. …”
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Insights into high-altitude adaptation and meat quality regulation by gastrointestinal metabolites in Tibetan and black pigs by Xue Bai, Xue Bai, Zhiying Huang, Helin Tan, Yiren Gu, Xun Wang, Long Jin, Peng Shang, Keren Long, Diyan Li, Mingzhou Li

“…Integrated multi-omics approaches linked stomach metabolism, particularly through bile secretion pathways influenced by acetylcholine, to muscle functionality, highlighting the important role played by the ATP1B4 gene in enabling muscle physiology in Tibetan pigs.DiscussionThis study highlights the importance of targeted dietary interventions in improving meat quality for specific pig breeds. …”
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Artificial intelligence analysis of thermal energy for convectively heated ternary nanofluid flow in radiated channel considering viscous dissipations aspects by Hamid Qureshi, Amjad Ali Pasha, Muhammad Asif Zahoor Raja, Zahoor Shah, Salem Algarni, Talal Alqahtani, Waqar Azeem Khan, Moinul Haq

“…This research works to establish the convective heat transfer coefficient (CHTC) of new improved ternary hybrid functionalized nanofluids with CuO, Fe2O3, and SiO2 nanoparticles in polymeric fluid. …”
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Symptom-specific gut microbial and metabolic profiles in ADHD reveal SCFA deficiency as a Key pathogenic mechanism by Xinyue Wang, Ning Wang, Teng Gao, Yunfan Zhang, Zhao Fu, Yilu Zhao, Yujingwen Huang, Xiangyu Zheng, Xuping Gao, Lin Lu, Li Yang

“…Imidazoleacetic acid partially mediated the effects between Lactobacillus sanfranciscensis and inattention (p = 0.012). …”
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Novel Lung Cell-Penetrating Peptide Targets Alveolar Epithelial Type II Cells, Basal Cells, and Ionocytes by Jin Wen, Gajalakshmi Singuru, Jeffrey Stiltner, Sanjay Mishra, Kyle S. Feldman, Kayla McCandless, Raymond Yurko, Kazi Islam, Ray Frizzell, Hisato Yagi, Jonathan M. Brown, Maliha Zahid

“…<b>Background:</b> Cell-penetrating peptides cross cell membrane barriers while carrying cargoes in a functional form. Our work identified two novel lung-targeting peptides, S7A and R11A. …”
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Membrane-associated ring–CH–type finger 2 protects against metabolic dysfunction-associated fatty liver disease by targeting fatty acid synthase by Dongsheng Ni, Zhaolai Qi, Shuang Ma, Yuefeng Wang, Dehuan Liang, Xiyue Zhang, Yong Man, Jingzhou Chen, Kefei Dou, Guoping Li

“…And liver-specific overexpression of MARCH2 by rAAV effectively reduces FASN levels and further ameliorates MAFLD in ob/ob mice. …”
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Enhancing Pacific white shrimp immunity against Vibrio parahaemolyticus through β-glucan supplementation from marine diatoms by Chettupon Pooljun, Pitchanee Jariyapong, Patcharapon Laksana-aut, Ikuo Hirono, Suwit Wuthisuthimethavee

“…Key immune-related DEGs were validated by quantitative reverse transcription polymerase chain reaction (qRT-PCR). Functional analysis of the lysozyme (Lyz) gene was conducted through RNA interference (RNAi), followed by V. parahaemolyticus challenge. …”
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The role of soil chemical properties and microbial communities on Dendrocalamus brandisii bamboo shoot quality, Yunnan Province, China by Qian Chen, Jianjie Cao, Manyun Zhang, Lei Guo, Lei Guo, Negar Omidvar, Zhihong Xu, Chaomao Hui, Weiyi Liu, Weiyi Liu

“…ObjectiveTo explore the effects of soil nutrients and microbial communities on the quality of Dendrocalamus brandisii shoots in different regions, providing a scientific basis for their development and utilization.MethodsUsing seven different geographic sources of D. brandisii from Yunnan Province as research subjects, this study employs chemical analysis and high-throughput sequencing to reveal the relationship between soil nutrients, microbial functional groups, and the nutritional quality of bamboo shoots.ResultsThe results indicate that there are significant differences in soil nutrient content among the regions (p &lt; 0.05), with bamboo shoots from Baoshan Changning (CN) exhibiting the best overall nutritional quality. …”
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Eurycomalactone switched hepatocellular carcinoma cells into quiescence through 5’tRFAla/DVL/β-catenin pathway inhibition by Zhipeng Zhang, Yanmei Wu, Wenqiang Liang, Zhifang Liao, Hongbo Liao, Xingxing Xing, Wenxin Yi, Zixuan Liu, Yicheng Li, Mengya Shi, Dongling Lin, Ting Gu, Biao Wu, Mingzhi Zou, Huilai Miao, Xin Wu

“…Abstract Although tsRNA has been demonstrated to modulate various physiological processes analogous to miRNA, the potential regulatory functions and mechanisms of tsRNAs related to the pharmacological effects of small molecule drugs remain unclear. …”
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A Regional Gravimetric and Hybrid Geoid Model in Northern Greece from Dedicated Gravity Campaigns by Georgios S. Vergos, Dimitrios A. Natsiopoulos, Elisavet G. Mamagiannou, Eleni A. Tzanou, Anastasia I. Triantafyllou, Ilias N. Tziavos, Dimitrios Ramnalis, Vassilios Polychronos

“…The low frequencies have been modeled based on the XGM2019e global geopotential model (GGM) and the topographic effects have been evaluated with the residual terrain model (RTM) reduction. …”
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Validity and Reliability of a Mobile Device Application for Assessing Motor Performance in the 30-Second Sit-to-Stand Test by Eduardo Candido Veloso Ferreira, Amelia Pasqual Marques, Szymon Kulis, Jan Gajewski, Anderson Antunes da Costa Moraes, Manuela Brito Duarte, Gizele Cristina da Silva Almeida, Enzo Gabriel da Rocha Santos, Gustavo Henrique Lima Pinto, Andre Dos Santos Cabral, Givago da Silva Souza, Anselmo De Athayde Costa E Silva, Bianca Callegari

“…Despite some limitations, the mobile application demonstrated partial effectiveness in observing CoM motor behavior during the proposed functional test.…”
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Enhancing nurses’ communication about psychosocial needs and changes in intimacy and sexuality in patients with advanced cancer: a mixed-method study by Susanne A.M. Arends, Corien M. Eeltink, Floortje K. Ploos van Amstel, Astrid W. Oosten, Donna C. Ruijter, Nelleke van der Loo, Barbara Harterink-Poker, Anneke L. Francke, Irene P. Jongerden

“…Conclusion: After the programme, more nurses felt competent in discussing psychosocial needs in patients with advanced cancer, especially with regard to changes in intimacy and sexual functioning. The training had little effect on nurses’ notes about psychosocial needs in patient records; the focus remained on physical aspects. …”
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