Endoplasmic Reticulum-Targeted Phototherapy Remodels the Tumor Immunopeptidome to Enhance Immunogenic Cell Death and Adaptive Anti-Tumor Immunity by Weidong Xiao, Mingquan Gao, Banghui Mo, Xie Huang, Zaizhi Du, Shufeng Wang, Jianhong Chen, Shenglin Luo, Haiyan Xing

“…<b>Methods:</b> Laser activation of the ER-targeted photosensitizer ER-Cy-<i>po</i>NO₂ was performed to investigate its effects on tumor cell antigenicity. Transcriptomic analysis was carried out to assess gene expression changes. …”
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Sirt5 affects the metabolic remodeling of eosinophils by negatively regulating the level of succinylation modification of Pkm2 in eosinophilic chronic rhinosinusitis by Shun‐Yu Wu, Bo‐Yu Cai, Zhi‐Wen Cao, Tian‐Yu Wang, Cai‐Quan Liang, En‐Hong Xu, Hu Peng, Jianchun‐Liao, Huan‐Hai Liu

“…Inhibiting Sirt5 expression can effectively alleviate the abnormal activation of eosinophils and the resulting inflammatory response in eCRS‐affected nasal mucosa. …”
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Supramolecular Co-Assembled Fmoc-FRGDF/Hyaluronic Acid Hydrogel for Quercetin Delivery: Multifunctional Bioactive Platform by Xian-Ni Su, Yu-Yang Wang, Muhammed Fahad Khan, Li-Na Zhu, Zhong-Liang Chen, Zhuo Wang, Bing-Bing Song, Qiao-Li Zhao, Sai-Yi Zhong, Rui Li

“…<b>Background:</b> During food processing and storage, traditional protein-based delivery systems encounter significant challenges in maintaining the structural and functional integrity of bioactive compounds, primarily due to their temporal instability. …”
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Piezo1-specific Deletion in Macrophage Protects the Progression of Chronic Inflammatory Bowel Disease in MiceSummary by Yuman Wang, Tianjiao Chu, Chengzhen Meng, Yifei Bian, Jing Li

“…This study aimed to investigate the effect of Piezo1 channels in macrophage polarization and its associated functions in IBD. …”
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Machine learning–guided single-cell multiomics uncovers GDF15-driven immunosuppressive niches in NSCLC: A translational framework for overcoming anti-PD-1 resistance by Xianfei Zhang, Zhengxin Yin, Xueyu Chen, Nengchong Zhang, Shengjia Yu, Congcong Zhu, Lianggang Zhu, Liulan Shao, Bin Li, Runsen Jin, Hecheng Li

“…External validation using melanoma cohorts (GSE91061) confirmed the pan-cancer predictive relevance of GDF15 and its associated tumor cluster. Functional studies utilizing GDF15-knockdown Lewis lung carcinoma cells showed no significant effect on intrinsic tumor proliferation or growth under immune stress (both p>0.05). …”
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Improving recombinant protein secretion in Aspergillus nidulans by targeting the N-glycosylation machinery by Jaqueline Aline Gerhardt, Marcelo Ventura Rubio, Cesar Rafael Fanchini Terrasan, Natalia Sayuri Wassano, Aryadne Rodrigues, Fernanda Lopes de Figueiredo, Everton Paschoal Antoniel, Fabiano Jares Contesini, Artur Hermano Sampaio Dias, Uffe Hasbro Mortensen, Munir Salomão Skaf, André Damasio

“…N-glycosylation can significantly affect protein stability, production yield, and functionality. This study investigated the isolated and combined deletion of genes involved in N-glycan assembly on protein production in Aspergillus nidulans. …”
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Integrating multi-omics to unveil PSMD12 as a critical gene in promoting brain metastases of lung adenocarcinoma by Xin Li, Juxuan Zhang, Meng Zhang, Wenbin Jiang, Dexin Jia, Ruxiong Wang, Hao Li, Zhihui Wang, Yixin Liu, Lefan Tang, Jiaxing Deng, Wenyuan Zhao, Yan Yu, Shilong Liu, Lishuang Qi

“…Immunohistochemical results confirmed that patients exhibiting high PSMD12 protein expression had a significantly higher incidence of BM within 5 years and shorter progression-free survival. Functional experiments revealed that PSMD12 overexpression in A549 cells disrupted BBB integrity and enhanced tumor cell invasiveness, whereas PSMD12 knockdown attenuated these effects. …”
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MicroRNA-32-5p inhibits metastasis by directly targeting VPS4B and increases sensitivity to dihydroartemisinin in neuroblastoma by Lina Chen, Hui Liu, Zhongyuan Zheng, Shuiqing Qu, Yu Zhang, Shuoqiu Deng, Shuo Shen, Tuo Liu, Yue Dai, Yu Li, Honghua Cui, Yujie Li

“…The primary objective of the current investigation was to characterize a newly discovered microRNA, miR-32-5p, in terms of the functional role, underlying mechanism of action, and potential synergistic therapeutic impact in the context of NB metastasis. …”
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Indoleamine 2,3-dioxygenase 1-mediated immune suppressive status is positively associated with brain metastasis in patients with non-small cell lung cancer by Weiwei Chen, Li Yang, Victor Ho-fun Lee, Liangliang Xu, Lingyu Ma, Zhenghao Ye, Wanli Xu, Caining Zhao, Danyang Zheng, Karrie Mei-Yee Kiang, Stella Sun, Yuan Qu, Jiandong Zha, Dazhi Pang, Yan Zhang, Zhibing Liang, Wenchu Lin, Jinliang Zhang, Jitian Zhang, Min Luo, Zhiyuan Xu, Ding Li, Xiaoling Liang, Gilberto Ka-Kit Leung, Aya El Helali, Chiming Che, Feng-Ming (Spring) Kong

“…Here, we aimed to examine whether IDO1 activity is correlated with OS in NSCLC patients with brain metastasis (Bramet) and has negative effect on modulating the anti-tumor functions of immune cells. …”
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Safety and Efficacy in the Transcortical and Transsylvian Approach in Insular High-Grade Gliomas: A Comparative Series of 58 Patients by Alberto Morello, Francesca Rizzo, Andrea Gatto, Flavio Panico, Andrea Bianconi, Giulia Chiari, Daniele Armocida, Stefania Greco Crasto, Antonio Melcarne, Francesco Zenga, Roberta Rudà, Giovanni Morana, Diego Garbossa, Fabio Cofano

“…There are two main surgical approaches to address the complex vascular network and functional areas around the insula: the transsylvian approach and the transcortical approach. …”
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Genetic variations in the IDUA gene in Tunisian MPS I families: Identification of a novel microdeletion disrupting substrate binding and structural insights by Mariem Rebai, Yessine Amri, Chaima Sahli, Hajer Foddha, Taieb Messaoud, Hela Boudabous, Hassen Ben Abdennebi, Salima Ferchichi, Latifa Chkioua

“…This study aimed to identify genetic mutations in the IDUA gene among Tunisian families and assess their structural and functional implications. Patients and methods: Genomic DNA was extracted from blood samples of four patients including two siblings from three Tunisian families. …”
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Critical role of ROCK1 in AD pathogenesis via controlling lysosomal biogenesis and acidification by Chenghuan Song, Wanying Huang, Pingao Zhang, Jiyun Shi, Ting Yu, Jing Wang, Yongbo Hu, Lanxue Zhao, Rui Zhang, Gang Wang, Yongfang Zhang, Hongzhuan Chen, Hao Wang

“…Abstract Background Lysosomal homeostasis and functions are essential for the survival of neural cells. …”
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A systematic scoping review of mentoring support on professional identity formation by Lalit Kumar Radha Krishna, Hannah Yi Fang Kwok, Nila Ravindran, Xuan Yu Tan, Jasper Soh, Darius Wei Jun Wan, Varsha Rajalingam, Jun Kiat Lua, Elizabeth Yong Mei Leong, Tiat Yan Low, Aiden Wei-Jun Chan, Chong Jin Nicholas Lim, Yen Kit Ng, Arthena Anushka Thenpandiyan, Adele Yi Dawn Lim, Leia Ning Tse, Sriram PL, Sri Priyanka Rajanala, Jun Rey Leong, Elaine Li Ying Quah, Victoria Jia En Fam, Ranitha Govindasamy, Nur Amira Binte Abdul Hamid, Crystal Lim, Dorsett Shin Wei Sim, Eng Koon Ong, Stephen Mason, Nagavalli Somasundaram, Simon Yew Kuang Ong

“…Abstract Background Mentoring’s success in nurturing professional identity formation (PIF) has been attributed to its ability to build personalised and enduring mentoring relationships. However, beyond functioning as communities of practice (CoPs) supporting socialisation processes, how mentoring integrates programme values and instils a shared identity amongst mentees remains unclear. …”
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Quantitative Ultrasound Texture Analysis of Breast Tumors: A Comparison of a Cart-Based and a Wireless Ultrasound Scanner by David Alberico, Lakshmanan Sannachi, Maria Lourdes Anzola Pena, Joyce Yip, Laurentius O. Osapoetra, Schontal Halstead, Daniel DiCenzo, Sonal Gandhi, Frances Wright, Michael Oelze, Gregory J. Czarnota

“…The reference phantom technique was used to produce functional estimates of the normalized power spectra and backscatter coefficient for each image. …”
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Cortical thickness correlated with peripheral inflammatory cytokines in amyotrophic lateral sclerosis by Jing Yang, Jing Yang, Jing Yang, Wenyi Li, Wenyi Li, Wenyi Li, Mei Tian, Mei Tian, Mei Tian, Lei Zhang, Fengping Du, Fengping Du, Fengping Du, Xin Li, Xin Li, Xin Li, Qi Liu, Qi Liu, Qi Liu, Rui Li, Rui Li, Rui Li, Zhenzhong Li, Zhenzhong Li, Zhenzhong Li, Hui Dong, Hui Dong, Hui Dong, Yaling Liu, Yaling Liu, Yaling Liu

“…Current observational studies indicate the thinning of cortical thickness in patients with ALS is associated with rapid disease progression and cognitive changes. However, the effects of inflammatory cytokines on cortical thickness in patients with ALS are unclear. …”
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Genetically-engineered Salmonella typhimurium expressing FGF21 promotes neurological recovery in ischemic stroke via FGFR1/AMPK/mTOR pathway by Dongchen Xu, Min Wen, Bingwa Lebohang Anesu, Xijun Chen, Yuhao Chen, Wenqi Qian, Chenguang Yang, Jin Hai Zheng, Yinan Zhou, Haoqi Ni, Kunlin Jin, Qichuan Zhuge, Su Yang

“…Results S.t-ΔpGFGF21 selectively colonized peri-infarct regions and secreted functional FGF21, reducing neurologic deficits (48%) and infarct volume (46%) versus controls (p < 0.01). …”
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Predictive circulating biomarkers of the response to anti‐PD‐1 immunotherapy in advanced HER2 negative breast cancer by Yuhan Wei, Hewei Ge, Yalong Qi, Cheng Zeng, Xiaoying Sun, Hongnan Mo, Fei Ma

“…Patients were categorized as responders and non‐responders according to 6‐month progression‐free survival (PFS), followed by phenotypic and functional comparations to identify candidate predictive biomarkers. …”
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Early secretory antigen target of 6-kDa of Mycobacterium tuberculosis inhibits macrophage apoptosis and host defense via TLR2 by Lin Zhang, Fang Fang, Danrui Liu, Geman Xia, Tong Feng, Jingzhu Lv, Jinying Qi, Tengteng Li, Hui Liu, Tao Xu, Fengjiao Wu, Chuanwang Song, Wei Li, Xiaojing Wang, Xianyou Chang, Hongtao Wang, Ting Wang, Zhongqing Qian

“…To address this, we used cultured THP-1(A) macrophages to characterize the effects of secreted ESAT-6 on cellular host defenses and apoptosis. …”
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Orchard variable-rate spraying method integrating GNSS and wind-excited audio-conducted leaf area density by Hangxing Zhao, Hangxing Zhao, Hangxing Zhao, Shenghui Yang, Shenghui Yang, Shenghui Yang, Wenwei Li, Wenwei Li, Han Feng, Han Feng, Shijie Jiang, Shijie Jiang, Weihong Liu, Weihong Liu, Jingbin Li, Yongjun Zheng, Yongjun Zheng, Songchao Zhang

“…However, accurate and automated measurement of canopy leaf area density remains challenging due to leaf shading effects. As a result, few fully functional variable-rate spraying systems have been developed based on this parameter.MethodsThis study presents a variable-rate spraying method that integrates global navigation satellite system (GNSS) positioning with wind-excited audio-conducted estimation of canopy leaf area density. …”
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Physicochemical, Volatile Compound Profile, Antioxidant, and Cytotoxic Activities of Northeastern Thai Ethnic Ready-to-Serve Food Pastes Jaew Hon and Gang Om: A Comparative Study o... by Vijitra Luang-In, Worachot Saengha, Thipphiya Karirat, Piyathida Promjamorn, Nidthaya Seephua, Apichaya Bunyatratchata, Sudathip Inchuen, Kriangsak Banlue, Sarinthorn Suwannarong, Sirithon Siriamornpun

“…Overall, these findings suggest that industrially produced GO and JH pastes hold promise as functional foods, integrating traditional culinary practices with modern production techniques. …”
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