Resistance to recombinant human erythropoietin therapy in haemodialysis patients by Elísio Costa, Margarida Lima, Susana Rocha, Petronila Rocha-Pereira, Flávio Reis, Elisabeth Castro, Frederico Teixeira, Vasco Miranda, Maria do Sameiro Faria, Alfredo Loureiro, Alexandre Quintanilha, Luís Belo, Alice Santos-Silva

“…We also showed that resistance to rhEPO therapy is associated with “functional” iron deficiency, lymphopenia and CD4+ lymphopenia, higher elastase plasma levels, increased interleukin-7 serum levels, and alterations in erythrocyte membrane protein structure and in band 3 profile. …”
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Reliability and responsiveness of the D12 and validity of its scores as a measure of dyspnoea severity in patients with rheumatoid arthritis-related interstitial lung disease by Jeffrey J Swigris, Sonye Danoff, Paul F Dellaripa, Joshua J Solomon, Tracy J Doyle

“…George’s Respiratory Questionnaire (SGRQ) Activity score ≥50 vs <50, 9.36 (1.27) points, p<0.0001, with a large effect size=1.7) and physiological impairment at baseline. …”
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An FPGA-Based SiNW-FET Biosensing System for Real-Time Viral Detection: Hardware Amplification and 1D CNN for Adaptive Noise Reduction by Ahmed Hadded, Mossaad Ben Ayed, Shaya A. Alshaya

“…The SiNW-FET biosensor, functionalized with antibodies specific to viral antigens, detects impedance shifts caused by antibody–antigen interactions, providing a highly sensitive platform for viral detection. …”
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Diseño de un Controlador por Convergencia de Estado para un Sistema Teleoperado no Lineal con Retardo de Comunicación by Julio C. Tafur, Cecilia E. García, Rafael Aracil, Roque Saltarén

“…Abstract: This article presents a novel control scheme for bilateral teleoperation of n degree-of-freedom (DOF) nonlinear robotic systems with time-varying communication delay.The bilateral control of the teleoperator system considers the case were the human operator applies a constant force on the local manipulator and when the interaction of the remote manipulator with the environment is considered passive.The stability analysis was performed using Lyapunov-Krasovskii functionals, and it showed that using a control scheme by state convergence for the cases with variant time delay resulted inasymptotically stable local and remote nonlinear teleoperation systems.The proposed control strategies are independent of parameter uncertainties in the robot models, the human operator and the remote environment.It is also shown that, in the case of reliable communication protocols, the proposed scheme guarantees that the local-remote position coordination is achieved.The experimental results are presented to show the effectiveness of the main results. …”
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Exploration of the multiomics-based mechanisms of Gancao Nourishing-Yin decoction in regulating mitochondrial metabolic genes CYB5R3 and PICK1 to influence glioma progression by Yufeng Chen, Anjing Zhang, Li Lei, Kangping Xiao, Wenchao Mao

“…Colocalisation analysis, validation using the TCGA database, survival analysis, and functional annotations of mitochondrial energy pathways were performed to explore the mechanisms of action. …”
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Single-cell RNA sequencing reveals palmitoylation-driven cellular heterogeneity and prognostic biomarkers in lung adenocarcinoma by Taibo Huang, Lijie Kou, Qianqian Zhang, Xueya Liu, Xingang Hu

“…Conclusions: Our single-cell analysis focused on palmitoylation reveals new dimensions of tumor diversity in LUAD and establishes a validated 12-gene risk signature. Functional studies highlight ASPH as a promising candidate for therapeutic targeting. …”
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<i>Bacillus tropicus</i> YJ33 and <i>Medicago sativa</i> L. Synergistically Enhance Soil Aggregate Stability in Saline–Alkali Environments by Jingjing Li, Yajuan Che, Shiyang Chen, Mengge Liu, Mengmeng Diao, Chao Yang, Wenke Jia

“…Soil salinization represents a significant global environmental challenge, necessitating the urgent amelioration of saline–alkali lands. As a critical functional component of the soil system, soil aggregates play a pivotal role in enhancing soil structure and are essential for nutrient cycling and plant growth. …”
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Hypoxia‐induced PGK1 expression promotes esophageal squamous cell carcinoma progression via stimulating MYH9‐mediated GSK3β/β‐catenin signalling by Jia‐cheng Xu, Lin‐feng Wu, Tian‐yin Chen, Yan‐bo Liu, Yi‐fei Zhang, Ping‐hong Zhou, Yi‐qun Zhang

“…Abstract Background Phosphoglycerate kinase 1 (PGK1) serves as a critical metabolic enzyme in the process of glycolysis and has many nonmetabolic functions in tumour progression. One of the most prevalent malignant tumours is still esophageal squamous cell carcinoma (ESCC), with high recurrence rates, high probabilities of metastasis, and poor prognoses. …”
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Identification of components in scorpion and centipede traditional Chinese medicine formulations with potentially beneficial actions in asthma: network pharmacology and molecular d... by Yi-Ren Chen, Ya-Da Zhang, Wei Zhang, Bin-Qing Tang

“…The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis and gene ontology (GO) functional enrichment analysis were carried out on the targets associated with scorpion and centipede-derived TCM components. …”
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Exploring alternative paramedic roles: a multinational mixed-methods survey by Fintan Feerick, Eoin Coughlan, Shane Knox, Adrian Murphy, Ivan Grady, Conor Deasy

“…Quantitative data were analysed using Microsoft Excel’s statistical functions, with results presented as frequencies, percentages, and numerical summaries. …”
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Microbial diversity in active and abandoned desert kangaroo rat burrows and from proximal surface sand by Duygu Aydin, Janice M. Parks, Sera Tirkes, Clint E. Collins, Idil Deniz Akin, Maren L. Friesen, Douglas R. Call, Haluk Beyenal

“…Following DNA extraction from samples, 16S rRNA gene sequencing was performed, and functional predictions were made and assessed for each characterized bacterial community. …”
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Exploring corrosion behavior, antimicrobial evaluation, molecular docking and DFT calculation of thiosemicarbazone ligand and its metal complexes by Howida S. Mandour, Lobna A. Khorshed, Amr M. Abdou, Basma Ghazal

“…To obtain a good relation that supports and explains the interactions between the molecules of the studied compounds and the metal surface and with the antibacterial activity; the theoretical study in detail was applied using density functional theory (DFT) and molecular docking. The parameters such as, energy level (ΔE), the highest HOMO (EH), and the lowest occupied LUMO (EL), molecular orbital and the binding energy are deducted and discussed. …”
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BLACK HUMOUR: ORIGIN DESCRIPTION AND AN ATTEMPT OF IDENTIFICATION by Iryna A. Blynova.

“…The compositional and speech means of organising black humour is based on opposition, antonymy of lexical units, contrast. The functioning of hyperbole, verbal and situational irony, and paradox are frequent at the lexical and semantic level. …”
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Research on Quantitative Analysis Method of Infrared Spectroscopy for Coal Mine Gases by Feng Zhang, Yuchen Zhu, Lin Li, Suping Zhao, Xiaoyan Zhang, Chaobo Chen

“…Spline fitting, polynomial fitting, and other curve fitting methods are used to establish a functional relationship between characteristic parameters and gas concentration. …”
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Pengembangan Aplikasi Berlatih Membaca Cepat Berbahasa Inggris Berbasis Progressive Web App dengan Metode Prototyping by Muhammad Fajar Alfath, Lutfi Fanani, Agi Putra Kharisma

“…Evaluation tests demonstrated the application's compatibility with mobile devices and its cross-browser functionality. Each feature achieved a 100% validity rate in effectiveness testing. …”
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Genome-wide association study for feed efficiency indicator traits in Nellore cattle considering genotype-by-environment interactions by João B. Silva Neto, João B. Silva Neto, Luiz F. Brito, Lucio Flavio M. Mota, Claudio U. Magnabosco, Fernando Baldi

“…Furthermore, the magnitude and direction of SNP effects varied across environmental gradients, reinforcing the relevance of G×E. …”
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5-Item Modified Frailty Index Score is Associated with Increased Postoperative Complications Following Ankle Fracture ORIF by Ronit Kulkarni BS, Alexander S. Guareshi BS, Nikhil Vallabhaneni BA, Joshua L. Morningstar BS, Daniel J. Scott MBA, MD, Christopher E. Gross MD

“…This study aims to analyze the effect of preoperative mFI-5 on 30-day complication, readmission, reoperation, and mortality rates following ankle fracture procedures. …”
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Assessing international alcohol consumption patterns during isolation from the COVID-19 pandemic using an online survey: highlighting negative emotionality mechanisms by Henrietta Bowden-Jones, Valerie Voon, Samantha N Sallie, Valentin Ritou

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LncRNA H19 acts as a ceRNA to promote glioblastoma malignancy by sponging miR-19b-3p and upregulating SERPINE1 by Wonyi Jang, Mijung Im, Goeun Yoon, Jungwook Roh, Wanyeon Kim

“…Cell viability and motility assays were performed to assess the effects of modulating H19/miR-19b-3p/SERPINE1 expression on cell survival, migration, and invasion. …”
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Exploring the mechanism of Bu Zhong Yi Qi Tang in the treatment of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) based on network pharmacology and molecular docking by Pengfei Zhou, Yang Xuan, Zaisheng Zhu, Han Wu, Yang Hu, Liangyou Chen, Qianya Zhou

“…Key targets were further subjected to Gene Ontology (GO) functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. …”
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