p53 enhances elesclomol-Cu-induced cuproptosis in hepatocellular carcinoma via FDXR-mediated FDX1 upregulation by Xiao Liu, Honglin Qu, Jingmin Li, Xuhong Sun, Zhenlin Wang, Dong Wang, Xianyong Bai, Xiaoyan Li

“…In mutant p53-R249S cells, CP-31398 functioned synergistically with elesclomol-Cu to suppress proliferation. …”
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The implementation, use and sustainability of a clinical decision support system for medication optimisation in primary care: A qualitative evaluation. by Mark Jeffries, Nde-Eshimuni Salema, Libby Laing, Azwa Shamsuddin, Aziz Sheikh, Anthony Avery, Antony Chuter, Justin Waring, Richard N Keers

“…Engagement between stakeholders was considered important for the intervention in ensuring prescribers continued to utilise its functionality. Sustained implementation might be enhanced by careful profile management of the suite of alerts in the system. …”
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Do Patients with Rheumatoid Arthritis Have an (In)Adequate Level of Physical Activity? A Latent Class Analysis Approach by Sretko Lukovic, Marko Baralic, Nina Tomonjic, Jovana Mihailovic, Aleksandra Neskovic, Marina Vujovic Sestakov, Ivana Pavlovic, Branko Barac, Tatjana Zivanovic Radnic, Predrag Ostojic

“…Introduction: Regular physical activity (PA) has a beneficial effect on joint pain, stiffness, strength, flexibility, and aerobic capacity in patients with rheumatoid arthritis (RA). …”
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Identification and therapeutic efficacy of Pleurotus djamor var fuscopruinosus by Monthien Phonemany, Phongeun Sysouphanthong, Narawadee Rujanapun, Satyajit D. Sarker, Lutfun Nahar, Panupong Puttarak, Poonsit Hiransai, Naritsada Thongklang, Rawiwan Charoensup

“…These results highlight P. djamor var. fuscopruinosus as a promising functional food with strong antioxidant, anticancer effects, and antidiabetic properties. …”
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Pulmonary complications in children and adolescents after allogeneic hematopoietic stem cell transplantation by A. S. Frolova, A. G. Volkova, O. V. Paina, P. V. Kozhokar, K. A. Ekushov, Zh. Z. Rakhmanova, L. A. Cvetkova, E. D. Dobrovolskaya, B. I. Smirnov, E. A. Kulagin, T. A. Bykova, E. V. Semenova, L. S. Zubarovskaya

“…However to date, the effect of HSCT on functional and morphological pulmonary changes in recipients remains insufficiently studied.The objective of current study was to evaluate risk factors affecting long-term survival in children and adolescents after allo-HSCT.Methods and materials. …”
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MLinvitroTox reloaded for high-throughput hazard-based prioritization of high-resolution mass spectrometry data by Katarzyna Arturi, Eliza J. Harris, Lilian Gasser, Beate I. Escher, Georg Braun, Robin Bosshard, Juliane Hollender

“…While the original proof of concept study was accompanied by the release of a MLinvitroTox v1 KNIME workflow, in this study, we release a Python MLinvitroTox v2 package, which, in addition to automation, expands functionality to include predicting toxicity from structures, cleaning up and generating chemical fingerprints, customizing models, and retraining on custom data. …”
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Adsorption, Modeling, Thermodynamic, and Kinetic Studies of Methyl Red Removal from Textile-Polluted Water Using Natural and Purified Organic Matter Rich Clays as Low-Cost Adsorben... by Dalila Fkih Romdhane, Yosra Satlaoui, Rawya Nasraoui, Abdelkrim Charef, Rim Azouzi

“…X-Ray diffraction, Fourier transform infrared (FTIR) spectroscopy, and scanning electron microscopy (SEM) analysis confirmed that functional groups of clay adsorbed the dye. Langmuir maximum adsorption capacities of ANb and ANp were found to be 397 mgg−1 and 132.3 mgg−1 at pH 7 and 5, respectively. …”
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2bRAD-M reveals differences in microbial communities between Modic changes and disc herniation by Fang Yang, Jingtao Zhang, Junpu Zha, Guolei Zhang, Jia Li, Wei Du, Lin Liu, Jun Di

“…Additionally, 19 discriminatory taxa were determined by linear discriminant analysis effect size (LEfSe). In a random forest model for partitioning the two groups, the species with the highest variable importance were Afipia_broomeae, Phyllobacterium_calauticae, and Escherichia_coli. …”
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A splice‐switching antisense oligonucleotide targeting APP reduces accumulation of α‐synuclein in a mouse model of Parkinson's disease by Rijwan U. Ahammad, Brian Spencer, Bao Quach, Sahar Salehi, Robert A. Rissman

“…In this study, we evaluated the effects of reducing amyloid precursor protein (APP) processing on α‐syn pathology using a splice‐switching oligonucleotide (SSO) targeting APP exon 15 in Thy1‐α‐syn transgenic (α‐syn‐tg) mice. …”
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Physical performance on the early 6-minute walk test in coronary artery bypass grafting patients during inpatient cardiac rehabilitation by Yao Wu, Bao Ren, Jing Li, Liqun Chi, Ping Li, Jiahui Wu

“…BackgroundThe 6 min walk test (6MWT) is widely used to evaluate functional exercise capacity, therapeutic effects, and prognosis in patients with cardiopulmonary diseases. …”
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Maternal loss of mouse Nlrp2 alters the transcriptome and DNA methylome in GV oocytes and impairs zygotic genome activation in embryos by Zahra Anvar, Michael D. Jochum, Imen Chakchouk, Momal Sharif, Hannah Demond, Alvin K. To, Daniel C. Kraushaar, Ying-Wooi Wan, Michael C. Mari, Simon Andrews, Gavin Kelsey, Ignatia B. Van den Veyver

“…SCMC proteins are encoded by maternal effect genes and play a pivotal role in the maternal-to-zygotic transition (MZT), early embryogenesis, and epigenetic (re)programming. …”
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Engineered nanofiber scaffolds prime chromatin reorganization to sensitize cells for long-term and low-dose chemical hazard detection by Yupeng Zhang, Hang Zhao, Li Jiang, Qi Zhang, Tingbao Cao, Zesheng Wang, Yang Song, Kunpeng Qu

“…To evaluate functional consequences, fibroblasts were challenged with 0.1% paraformaldehyde (PFA), a commonly encountered chemical with known long-term health risks. …”
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Predictive potential of cardiovascular risk factors and their associations with arterial stiffness in people of European and Korean ethnic groups by T. A. Brodskaya, V. A. Nevzorova, K. I. Shakhgeldyan, B. I. Geltser, D. A. Vrazhnov, Yu. V. Kistenev

“…Aim. To compare the effect of cardiovascular risk factors on aortic stiffness in people of European and East Asian ethnic groups.Material and methods. …”
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Integrated Multi-Level Investigation of Friend Leukemia Integration 1 Transcription Factor as a Novel Immune-Inflammatory Biomarker in Rheumatoid Arthritis: Bridging Bioinformatics... by Zhang M, Wan L, Fang H, Zhang X, Wang S, Li F, Yan D

“…Receiver operating characteristic analysis and gene-set enrichment analysis-KEGG were conducted to elucidate the biological functions of these target genes. Finally, cellular experiments were performed to validate FLI1’s regulatory effects on its target genes and its impact on synovial cell viability and apoptosis in RA.Results: FLI1 was upregulated in RA. …”
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AQP5 trafficking is regulated by its C-terminal tail and interaction with prolactin-inducible protein by Claudia D’Agostino, Egor Zindy, Louise Conrard, Amel Takkal, Françoise Gregoire, Nargis Bolaky, Susanna Törnroth-Horsefield, Jason Perret, Christine Delporte

“…This study investigates the multifaceted regulatory mechanisms of AQP5 trafficking, with specific emphasis on the role of the carboxyl-terminal (C-terminal) tail and the functional involvement of prolactin-inducible protein (PIP) as an interacting protein partner. …”
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Engineering of covalent organic framework (COF) via mono-doping and co-doping for the detection of CO2 gas pollutant by John A. Agwupuye, Ekere Nwachukwu Romanus, Janefrances Ngozi Ihedioha, Ismail O. Amodu, Bassey O. Ekpong, Destiny E. Charlie, Fehintola E. Umo, Modestar Chinecherem Agwupuye, Muhammad Zeeshan

“…In this work, the detection of CO2 gas on newly modified covalent organic framework (COF) surface was investigated using density functional theory (DFT). All computational calculations were performed using the DFT/ωB97XD/6–311 + +g(d,p)/def2svp/LANL2DZ computational method. …”
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Health promotion and cardiovascular risk reduction in people with spinal cord injury: physical activity, healthy diet and maintenance after discharge— protocol for a prospective na... by Nicolaj Jersild Holm, Tom Møller, Lis Adamsen, Line Trine Dalsgaard, Fin Biering-Sorensen, Lone Helle Schou

“…A primary study designed as a controlled, pragmatic, preintervention- postintervention study with 6-month follow-up evaluates the effect of the clinical intervention; a prospective national cohort study on body mass index (BMI) serves as a historical control. …”
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C→U transition biases in SARS-CoV-2: still rampant 4 years from the start of the COVID-19 pandemic by Peter Simmonds

“…The genome of SARS-CoV-2 is also increasingly scarred by the effects of multiple C→U mutations from host genome editing as a cellular defense mechanism akin to restriction factors for retroviruses. …”
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Kinetics and dynamics of dissolved organic nitrogen, and nitrogen cycling genes in the soil profile of an irrigated vineyard with surface-applied organic amendments by Mehdi Sharifi, Lori Phillips, Seanna Zintel, Brent Seuradge

“…Microbial N cycling functional potential was determined, and initial DON concentrations, and potentially releasable DON (N0-DON), and the DON release rate constant (k-DON) were assessed via 100-day aerobic incubation. …”
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The amino acid composition of Polygonum hydropiper L. and Polygonum persicaria L. herbs of Ukrainian flora by I. A. Lukina, O. V. Mazulin, H. P. Smoilovska, H. V. Mazulin, I. N. Shevchenko

“…Plant amino acids play an important role in the functioning of various systems and organs of the human body and are characterized by distinct pharmacological properties, as well as contribute to more rapid absorption and potentiate the effect of other biologically active compounds present in plants. …”
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