The Severity of CVB3-Induced Myocarditis Can Be Improved by Blocking the Orchestration of NLRP3 and Th17 in Balb/c Mice by Jifei Chen, Fan Yang, Song Shi, Xuexiang Liu, Fengxian Qin, Xiaomou Wei, Yujie Huang, Wenwu Liang, Lin Miao

“…Background. The functional characteristics of NLRP3 in the pathogenesis of coxsackievirus B3- (CVB3-) induced viral myocarditis (VMC) have not been fully elucidated, and the targeted therapeutic effect of NLRP3 or its related pathway in VMC has not been reported. …”
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RETRACTED ARTICLE: Melatonin attenuates the TLR4-mediated inflammatory response through MyD88- and TRIF-dependent signaling pathways in an in vivo model of ovarian cancer by Luiz Gustavo A Chuffa, Beatriz A Fioruci-Fontanelli, Leonardo O Mendes, Fábio R Ferreira Seiva, Marcelo Martinez, Wagner J Fávaro, Raquel F Domeniconi, Patrícia FF Pinheiro, Lucilene Delazari dos Santos, Francisco Eduardo Martinez

“…Abstract Background Toll-like receptors (TLRs) are effector molecules expressed on the surface of ovarian cancer (OC) cells, but the functions of the TLR2/TLR4 signaling pathways in these cells remain unclear. …”
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ITGA4 as a potential prognostic and immunotherapeutic biomarker in human cancer and its clinical significance in gastric cancer: an integrated analysis and validation by Jiaxing Zhang, Jiaxing Zhang, Gang Wang, Jie Liu, Futian Tang, Song Wang, Yumin Li, Yumin Li

“…It demonstrated diagnostic value in 20 cancer types and effectively predicted 1-, 3-, and 5-year survival rates as part of a prognostic model. …”
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Inhibition of -type amino acid transporter 1 activity as a new therapeutic target for cholangiocarcinoma treatment by Supak Yothaisong, Hasaya Dokduang, Naohiko Anzai, Keitaro Hayashi, Nisana Namwat, Puangrat Yongvanit, Sakkarn Sangkhamanon, Promsuk Jutabha, Hitoshi Endou, Watcharin Loilome

“…Our previous study reported that l -type amino acid transporter-1 and its co-functional protein CD98 were highly expressed and implicated in cholangiocarcinoma progression and carcinogenesis. …”
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Novel HSA-PMEMA Nanomicelles Prepared via Site-Specific In Situ Polymerization-Induced Self-Assembly for Improved Intracellular Delivery of Paclitaxel by Yang Chen, Shuang Liang, Binglin Chen, Fei Jiao, Xuliang Deng, Xinyu Liu

“…<b>Conclusions</b>: In comparison with HSA, HSA-PMEMA nanomicelles exhibit improved cellular uptake and higher loading efficiency for PTX, effectively promoting the intracellular delivery of PTX. …”
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Pan-cancer analysis identified CD248 as a potential target for multiple tumor types by Li Guo, Yan Liao, Xuyang Zhang, Rongjuan Guo, Zheng Wang, Deqin Yang, Deqin Yang, Deqin Yang

“…CD248 plays a crucial role in tumor cells’ functions, including invasion, migration, and proliferation. …”
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Genetic regulation of sperm DNA methylation in cattle through meQTL mapping by Corentin Fouéré, Valentin Costes, Chris Hozé, Amrita Raja Ravi Shankar, Florian Besnard, Gabriel Costa Monteiro Moreira, Valentin Sorin, Chrystelle Le Danvic, Aurélie Chaulot-Talmon, Francesca Ali, Marie Christine Deloche, Aurélie Bonnet, Eliaou Sellem, Hélène Jammes, Sébastien Fritz, Mekki Boussaha, Didier Boichard, Hélène Kiefer, Marie-Pierre Sanchez

“…Abstract Background DNA methylation (DNAm) plays an important functional role and is influenced by genetic variants known as methylation QTLs (meQTLs). …”
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Placental Mesenchymal Stromal Cells (PMSCs) and PMSC-Derived Extracellular Vesicles (PMSC-EVs) Attenuated Renal Fibrosis in Rats with Unilateral Ureteral Obstruction (UUO) by Regul... by Zhu Zhu, Chaonan Han, Shuli Xian, Feng Zhuang, Feng Ding, Wei Zhang, Yingli Liu

“…Our research investigated the effects of intravenously administered placenta mesenchymal stromal cells (PMSCs) or treatment with extracellular EVs (EVs) derived from PMSCs (PMSC-EVs) on the polarization of CD4+ T cells in rats with unilateral ureteral obstruction (UUO). …”
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Spatial complex correlation characteristics of carbon emissions and carbon transboundary transfer: Assessment of the carbon footprint in four mega-urban agglomerations in China by Chengxue Yu, Haimeng Lei, Hongbo Zheng, Tong Xu, Zhanfeng Dong

“…The spatial correlation networks of regional carbon footprints within the four mega-urban agglomerations were categorized into four functional blocks. These blocks underwent varying degrees of reorganization throughout the study period. 4. …”
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Intratracheal Administration of Itraconazole-Loaded Hyaluronated Glycerosomes as a Promising Nanoplatform for the Treatment of Lung Cancer: Formulation, Physiochemical, and In Vivo... by Sultan Aati, Hanan O. Farouk, Marwa H. Elkarmalawy, Hanan Y. Aati, Nahla Sameh Tolba, Hossam M. Hassan, Mostafa E. Rateb, Doaa S. Hamad

“…Methods: The glycerosomes were functionalized with hyaluronic acid (HA-GLY) to potentiate the anticancer efficacy of ITZ and extend its local bio-fate. …”
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Quantitative Characterization and Prediction of the Binding Determinants and Immune Escape Hotspots for Groups of Broadly Neutralizing Antibodies Against Omicron Variants: Atomisti... by Mohammed Alshahrani, Vedant Parikh, Brandon Foley, Nishank Raisinghani, Gennady Verkhivker

“…According to our results, the E1 and F3 groups of Abs effectively exploit binding hotspot clusters of hydrophobic sites that are critical for spike functions along with the selective complementary targeting of positively charged sites that are important for ACE2 binding. …”
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Construction of a Wilms tumor risk model based on machine learning and identification of cuproptosis-related clusters by Jingru Huang, Yong Li, Xiaotan Pan, Jixiu Wei, Qiongqian Xu, Yin Zheng, Peng Chen, Jiabo Chen

“…This involved analyzing associated immune cell infiltration and conducting functional enrichment analysis. Disease-characteristic genes were pinpointed using weighted gene co-expression network analysis. …”
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Prognostic Value of Epicardial Adipose Tissue in Heart Failure With Mid‐Range and Preserved Ejection Fraction: A Multicenter Study by Wenxian Wang, Yan Gao, Jian Wang, Congshan Ji, Hui Gu, Xianshun Yuan, Shifeng Yang, Ximing Wang

“…We constructed a baseline multivariable model including comorbidities, New York Heart Association functional class, extracellular volume, age, body mass index, left ventricular ejection fraction, and N‐terminal pro‐brain natriuretic peptide. …”
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Surveying the Distribution and Diversity of Predominant Mycobiota in Cultivated and Uncultivated Soils of Zaria, Northwestern Nigeria by Nafisat Aliyu, Maryam L Faragai, Adamu Ibrahim, Karimat Aliyu, M D Ibrahim, Saratu Hussaini Mahmud

“…Understanding soil biodiversity and its biological functioning will help not only in crop yields but also in a healthier society as it directly or indirectly enters the food chain. …”
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Developmental trajectories and heterogeneity of social engagement among Chinese older adults: a growth mixture model by Han Zhou, Cheng Zhang, Shengnan Wang, Chao Yu, Lei Wu

“…In contrast, the time-varying analysis showed that a decline in functional ability, insufficient exercise (means no exercise at present), deteriorating self-reported health and quality of life, negative mood, monotonous diet, and reduced community services were closely related to the reduction in social engagement levels (P < 0.05). …”
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Challenges and inequalities in the management of financing the tasks of local government units: a critical analysis by Arkadiusz Ciach

“…Research objectives and hypothesis/research questions The aim is to critically analyze the challenges and inequalities in the management of the financing of the tasks of local government units (LGUs) in Poland, with particular emphasis on the impact of legislative, political, and financial factors on the effectiveness of their tasks. Research questions: 1. …”
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The reliability of witness memories: a review of the factors influencing accuracy in the forensic context by João Miguel Alves Ferreira, Sergii Tukaiev

“…Another factor explored is the effect of stress and trauma at the time of the event and during the recall process. …”
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Analytical model of Iran-Saudi Arabia relations from 1979 to 2024 by Sajad Mohseni

“…Over the years, both Iran and Saudi Arabia have adapted to a political existence that functions independently of the other, shaped by longstanding distrust and tension. …”
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4D Marine Cadastre Data Models – Turkey &amp; Malaysia by H. Gürsoy Sürmeneli, A. Abdul Rahman, M. Alkan, A. Zamzuri, M. I. Hassan

“…It also primarily defines marine parcels. The functions of the marine cadastre and the definition of marine parcels should be developed following the cadastral systems of individual countries and relevant international standards (Zamzuri et al., 2022). …”
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Особенности сакральной архитектуры протестантов Украины как визуальное выражение духовности верующих... by Иван ГУЦУЛ

“…Garbuz and other scientists who claiming the new approach to the concept of what should be a Protestant temple (house of prayer) and its functional purpose. Consider the extent of Christian symbols in the context of the use of her Protestant denominations. …”
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