Astrocytes Differentiated from LRRK2-I1371V Parkinson’s-Disease-Induced Pluripotent Stem Cells Exhibit Similar Yield but Cell-Intrinsic Dysfunction in Glutamate Uptake and Metaboli... by Roon Banerjee, Aishwarya Raj, Chandrakanta Potdar, Pramod Kumar Pal, Ravi Yadav, Nitish Kamble, Vikram Holla, Indrani Datta

“…Owing to the presence of multiple enzymatic domains, LRRK2 has been associated with a diverse set of cellular functions and signaling pathways. It also has several pathological mutant-variants, and their incidences show ethnicity biases and drug-response differences with expression in dopaminergic-neurons and astrocytes. …”
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Chloroquine induces eryptosis in P. falciparum-infected red blood cells and the release of extracellular vesicles with a unique protein profile by Claudia Carrera-Bravo, Claudia Carrera-Bravo, Tianchi Zhou, Tianchi Zhou, Trang Chu, Jing Wen Hang, Harshvardhan Modh, Chenyuan Huang, Chenyuan Huang, Sitong Zhang, Sitong Zhang, Haining Hao, Haining Hao, Haining Hao, María José Cabada-García, Benoit Malleret, Benoit Malleret, Matthias G. Wacker, Jiong-Wei Wang, Jiong-Wei Wang, Jiong-Wei Wang, Jiong-Wei Wang, Laurent Rénia, Kevin S. W. Tan

“…Notably, the outward budding and blebbing of the iRBC plasma membrane led to the formation of EVs, which are complex structures with unique functional properties. Proteomic characterization of EVs from CQ-treated iRBCs revealed a high enrichment of proteasome and ribosome protein clusters. …”
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A genome-wide association study identifies new loci associated with response to SARS-CoV-2 mRNA-1273 vaccine in a cohort of healthy healthcare workers by Antonio José Cabrera-Serrano, Antonio José Cabrera-Serrano, Lucía Ruiz-Durán, Lucía Ruiz-Durán, Juan Francisco Gutiérrez-Bautista, Juan Francisco Gutiérrez-Bautista, Juan Francisco Gutiérrez-Bautista, Juan Francisco Gutiérrez-Bautista, María Carretero-Fernández, María Carretero-Fernández, Rob ter Horst, Rob ter Horst, Rob ter Horst, Yang Li, Yang Li, Fernando Jesús Reyes-Zurita, Francisco José García-Verdejo, Francisco José García-Verdejo, Mihai G. Netea, Mihai G. Netea, Pedro Sánchez-Rovira, Pedro Sánchez-Rovira, Miguel Ángel López-Nevot, Miguel Ángel López-Nevot, Miguel Ángel López-Nevot, Antonio Sampedro, Antonio Sampedro, Juan Sainz, Juan Sainz, Juan Sainz, Juan Sainz

“…Functional results showed that some of the novel risk alleles influence the absolute counts of specific B cell subsets (p=2.57×10-5-8.82×10-3), which are involved in immune signaling pathways and metabolic processes. …”
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SARS-CoV-2 immune responses in patients with multiple myeloma and lenalidomide maintenance therapy by Ioana Martac, Sina A. Beer, Aileen Schenk, Osama Ahmad, Claus-Philipp Maier, Claus-Philipp Maier, Gülay Demirel, Beate Preuß, Reinhild Klein, Anna M. P. Stanger, Britta Besemer, Luca Hensen, Claudia Lengerke

“…Here, immunomodulatory drugs (IMiDs) like Lenalidomide (Lena) become interesting, as they may have stimulatory effects on T-cell functioning.MethodsIn this study we investigated immune responses elicited by COVID-19 vaccine or infection comparing 43 healthy volunteers (avg. 35y, 72.1% female, 81.4% previously COVID-19 infected), with 41 MM patients under Lena maintenance therapy (avg. 63.8y, 51.2% female, 61% previously COVID-19 infected). …”
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Genetic and epigenetic regulation of Treg cell fitness by autism-related chromatin remodeler CHD8 by Jun-Qi Yang, Chen Wang, Ramesh C. Nayak, Manohar Kolla, Mingjun Cai, Mario Pujato, Yi Zheng, Q. Richard Lu, Fukun Guo

“…CHD8 deletion did not alter Treg homeostasis but increased their functional plasticity with elevated expression of effector T cell cytokines. …”
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Recent trends in rubberized and non-rubberized ultra-high performance geopolymer concrete for sustainable construction: A review by Alshaeer Honin, Amran Mugahed, Rezzoug Aïssa, Murali Gunasekaran, Makul Natt, Al-Yaari Mohammed, Avudaiappan Siva, Maureira-Carsalade Nelson, Alluqmani Ayed Eid

“…However, the inclusion of rubber compromises compressive strength because of inadequate interfacial adhesion, enhancements in surface treatment and the optimization of composite formulations can effectively overcome these challenges, and merging customized rubber proportions with advanced polymeric or fiber reinforcements maintains mechanical integrity while capitalizing on rubber’s elasticity, suggesting the necessity for ongoing investigation into microstructural optimization and long-term performance to thoroughly harness the sustainability and functionality of UHPRGC.…”
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Identification of A1/A2 β-Casein Genotypes and Comparison of Their Digestive Properties by Shihang LI, Hongtao XU, Xiao LI, Meiling SUN, Xinyan YANG, Pengyu XIANG, Zhihao YANG, Chaoxin MAN, Yujun JIANG

“…To more comprehensively explore the possible biological activity effects on the human body, by analyzing and monitoring the changes of this protein during the digestion process, the exploration of the biological functions of A1/A2 β-casein is further achieved. …”
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Parvoviruses NS1 oncolytic attributes: mechanistic insights and synergistic anti-tumor therapeutic strategies by Abdul Haseeb, Wafa Yousaf, Zhigang Cao, Kuohai Fan, Kuohai Fan, Na Sun, Panpan Sun, Yaogui Sun, Huizhen Yang, Wei Yin, Hua Zhang, Zhenbiao Zhang, Jia Zhong, Jianzhong Wang, Hongquan Li

“…It is comprised of three fundamental domains: the N-terminal origin binding, helicase domain, and C-terminal domain, all crucial for significant functions. In several parvovirus species, such as CPV, MVM, BPV, and HPV-B19, NS1 halts the cell cycle at distinct stages, including G1, G2, and S phases of the life cycle, and induces cell death. …”
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Sialylated IgG-activated integrin β4-Src-Erk axis stabilizes c-Myc in a p300 lysine acetyltransferase-dependent manner to promote colorectal cancer liver metastasis by Jing Chen, Shenghua Zhang, Xinmei Huang, Qianqian Wang, Weiyan Xu, Jing Huang, Yuming Su, Qinkun Sun, Xiaojuan Du, Baocai Xing, Xiaoyan Qiu

“…Notably, anti-sialylated IgG antibody effectively blocks colorectal cancer liver metastasis in mouse models. …”
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Liprotide-encapsulated vitamin D3 modulates circulated PTH levels and improved bone microstructure by Claradhita Ayu Shauma, Faizah Fulyani, Adriyan Pramono, Endang Mahati, Sylvia Rahmi Putri, Reza Achmad Maulana, Gemala Anjani

“…Little attention has been paid to utilizing liprotide as a delivery system for vitamin D and evaluating its functional activity. Objective: to investigate the effect of liprotide-encapsulated vitamin D3 on PTH levels and bone microstructure in vitamin D and calcium (VD-Ca) deficient rats. …”
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Carbon dioxide flush as a soil health indicator in contrasting edaphoclimatic conditions by Lucila Bassi, Cecilia Crespo, Gisela Vanesa García, Walter Daniel Carciochi, Nahuel Ignacio Reussi Calvo, Pablo Barbieri, Hernán René Sainz Rozas, Nicolás Wyngaard

“…All differences and correlations were considered statistically significant at a p-value below 0.05. The FCO2 effectively differentiated soybean monoculture from more diverse cropping systems, particularly in the 0–5  cm soil layer. …”
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Ginsenoside Rh4 inhibits colorectal cancer via the modulation of gut microbiota-mediated bile acid metabolism by Xue Bai, Zhiguang Duan, Jianjun Deng, Zhuo Zhang, Rongzhan Fu, Chenhui Zhu, Daidi Fan

“…Finally, we elucidated the pivotal role of key functional bacteria and metabolites regulated by Rh4 in CRC. …”
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InsNet-CRAFTY v1.0: integrating institutional network dynamics powered by large language models with land use change simulation by Y. Zeng, C. Brown, C. Brown, M. Byari, J. Raymond, T. Schmitt, M. Rounsevell, M. Rounsevell, M. Rounsevell

“…We present InsNet-CRAFTY (Institutional Network – Competition for Resources between Agent Functional Types) v1.0, a multi-LLM-agent model with a polycentric institutional framework coupled with an agent-based land system model. …”
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MtDNA copy number enrichment is associated with poor prognosis and eosinophilic morphology in clear cell renal cell carcinoma by Sarah Bellal, Sarah Bellal, Cyrielle Rolley, Jeremy Richard, Nolwenn Bounaix, Vincent Le Corre, Marie-Christine Copin, Odile Blanchet, Pierre Bigot, Pierre Bigot, Vincent Procaccio, Vincent Procaccio, Céline Bris, Céline Bris

“…The main goal of our study was to assess the effect of mtDNA genetics on the prognosis of ccRCC patients and to explore morphologic correlation. …”
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Evaluating the anticancer efficacy of Chara vulgaris ethanolic extract and selenium nanoformulation in Ehrlich carcinoma mice: role of autophagy and apoptosis by Maha Alsunbul, Thanaa A. El-Masry, Maisra M. El-Bouseary, Enas I. El Zahaby, Mostafa M. El-Sheekh, Mohamed M. S. Gaballa, Eman Wahsh, Heba Kamel Badawy, Jawaher Abdullah Alamoudi, Reem ALQahtani, Naifa Alenazi, Maysa M. F. El-Nagar

“…Abstract Background Bioactive compounds with a wide range of chemical compositions and biological functions are found in the Chlorophyceae family. The present work investigated the anticancer effect of ethanolic extract from Chara vulgaris (C. vulgaris) and its selenium nanoformulation (CvSeNPs) against solid Ehrlich carcinoma (SEC). …”
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Remediation of Hg-Contaminated Groundwater via Adsorption on Supramolecular Polymers in Batch Process and Column Test by Zongwu Wang, Wei Liu, Xiaoyan Sun, Qing Zhang, Jiapu Ji, Yimeng Yan, Jianhui Sun

“…A low influent mercury concentration, low pore velocity, and high SP dosage can effectively extend the breakthrough time in column tests. …”
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Impact of a Formulation Containing Chaga Extract, Coenzyme Q10, and Alpha-Lipoic Acid on Mitochondrial Dysfunction and Oxidative Stress: NMR Metabolomic Insights into Cellular Ener... by Maria D’Elia, Carmen Marino, Rita Celano, Enza Napolitano, Chiara Colarusso, Rosalinda Sorrentino, Anna Maria D’Ursi, Luca Rastrelli

“…This effect was mainly due to the combination of Chaga, CoQ10, and ALA, main components of the RP25 formulation. …”
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Identification and predictive machine learning models construction of gut microbiota associated with lymph node metastasis in colorectal cancer by Yongzhi Wu, Chengen Deng, Zigui Huang, Yongqi Huang, Chuanbin Chen, Mingjian Qin, Zhen Wang, Fuhai He, Shenghai Liu, Rumao Zhong, Jun Liu, Chenyan Long, Jungang Liu, Weizhong Tang, Xiaoliang Huang

“…By conducting 16S rRNA sequencing on fecal samples from 147 CRC patients and combining it with the linear discriminant analysis effect size algorithm, we successfully identified significant differences in the gut microbiota between patients with LNM and those with no lymph node metastasis (NLNM). …”
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Improved longevity and in vivo performance of neurotransmitter detection using 30 µm cone-shaped carbon fiber microelectrode by Haeun Kwon, Hyun-U Cho, Jeongeun Sim, Kyung-Jun Boo, Kyung-Jun Boo, Yumin Kang, Sangmun Hwang, Youngjong Kwak, Jaehyun Jang, Kyung Min Kim, Se Jin Jeon, Chan Young Shin, Kevin E. Bennet, Kevin E. Bennet, Yoonbae Oh, Yoonbae Oh, Hojin Shin, Hojin Shin, Kendall H. Lee, Kendall H. Lee, Dong Pyo Jang, Dong Pyo Jang

“…To improve mechanical robustness and long-term functionality, we fabricated 30 µm diameter CFMEs and modified their geometry via electrochemical etching to form cone-shaped tips. …”
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Diabetes is causally associated with increased breast cancer mortality by inducing FIBCD1 to activate MCM5-mediated cell cycle arrest via modulating H3K27ac by Binbin Tan, Yang Liu, Qianqian Chen, Weijie Yang, Wenhan Yang, Kaiping Gao, Li Fu, Tiantian Zhang, Penglong Chen, Yongyi Huang, Yuting Wang, Guoqiang Zhang, Juan Xiong, Rihong Zhai

“…Our findings provide new evidence that co-existing DM has a causal effect on overall mortality in BC-DM patients. Targeting FIBCD1 may be a promising therapy for BC-DM.…”
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