Anthocyanin Degradation Drives Heat-Induced Petal Fading in <i>Chrysanthemum morifolium</i> at Full Bloom: A Multi-Omics Analysis by Ge Zhao, Yanan Li, Jialin Peng, Xiuge Li, Wenhao Xia, Yuhe Tian, Yukun Li, Lijie Zhou

“…In this study, ‘Nannong Fencui’ chrysanthemums at full bloom—when anthocyanin accumulation peaks—were exposed to 35 °C, while a control group was maintained at 22 °C, to assess heat stress effects on anthocyanin metabolism, including both biosynthesis and degradation. …”
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Critical care services in Bagmati province of Nepal: A cross sectional survey [version 3; peer review: 3 approved, 1 approved with reservations] by Subekshya Luitel, Sushila Paudel, Diptesh Aryal, Janaki Pandey, Hem Raj Paneru, Roshni Shakya, Prashant Acharya, Isha Amatya, Rashan Haniffa, Suman Pant, Abi Beane, Pradip Gyanwali

“…Although there were disparities, numerous ICUs were effectively carrying out multiple critical care procedures. …”
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2-Hydroxyisobutyric acid targeted binding to MT-ND3 boosts mitochondrial respiratory chain homeostasis in hippocampus to rescue diabetic cognitive impairment by Minzhen Xie, Siqi Gu, Yan Liu, Haolin Yang, Yuqi Wang, Wei Yin, Yang Hong, Wanying Lu, Chengbing He, Lin Li, Limin Zhao, Jianjia Zhang, Heng Liu, Tian Lan, Shuijie Li, Qi Wang

“…Conclusion: MT-ND3 is a crucial target for improving diabetic cognitive dysfunction, and 2-HIBA can directly bind to the MT-ND3 protein to alleviate the functional impairment of the mitochondrial respiratory chain in mice to treat DCI.…”
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Genomic Characterization and Safety Evaluation of <i>Enterococcus lactis</i> RB10 Isolated from Goat Feces by Nattarika Chaichana, Sirikan Suwannasin, Jirasa Boonsan, Thunchanok Yaikhan, Chollachai Klaysubun, Kamonnut Singkhamanan, Monwadee Wonglapsuwan, Rattanaruji Pomwised, Siriwimon Konglue, Rusneeta Chema, Manaschanan Saivaew, Komwit Surachat

“…<b>Methods:</b> In this study, <i>Enterococcus lactis</i> RB10, isolated from goat feces, was subjected to comprehensive genomic and functional analysis to assess its safety and potential as a probiotic strain. …”
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Arbuscular Mycorrhizal Fungi Increase Blast Resistance and Grain Yield in Japonica Rice Cultivars in Flooded Fields by Héctor Martín-Cardoso, Laia Castillo, Iratxe Busturia, Gerrit Bücker, Luís Marqués, Eva Pla, Mar Català-Forner, Concha Domingo, Blanca San Segundo

“…However, once fungal penetration into the rice root has occurred, the functional capacities of the AM fungus are not affected by flooding. …”
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Impact of extraction methods on the properties of Carica papaya pseudostem fibers from Cameroon used as reinforcement in biocomposites by Jean Aimé Mono, Sandrine Emvoutou Ndongo, Odette Thérèse Adegono Assiene, Armel Mewoli, Rachelle Appolince Nguefack Assona, Richard Hervé Bitete, Giresse Ulrich Defo Tatchum, Claude Takoumbe

“…These agricultural wastes can be effectively used as natural fibers in the manufacture of biocomposites. …”
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Targeting CTP synthetase 1 to restore interferon induction and impede nucleotide synthesis in SARS-CoV-2 infection by Youliang Rao, Chao Qin, Bianca Espinosa, Ting-Yu Wang, Shu Feng, Ali Can Savas, Jill Henley, Lucio Comai, Chao Zhang, Pinghui Feng

“…Screening a SARS-CoV-2 expression library, we identified several viral proteins that interact with CTPS1. Functional analyses demonstrate that ORF8 and Nsp8 activate CTPS1 to deamidate IRF3 and negate IFN induction, whereas ORF7b and ORF8 activate CTPS1 to promote CTP synthesis. …”
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Using the PET/CT radiotracer [68Ga]Ga-DOTA-mDesmo to target V1b receptors and localize corticotropinoma in Cushing’s disease by Somit Pandey, Rama Walia, Gurvinder Kaur, Kumud Pandav, Imran Rather, Nivedita Rana, Sushant Sahoo, Bhagwant Rai Mittal, Jaya Shukla

“…This study aims to develop and evaluate a corticotropinoma specific radiopharmaceutical, [68Ga]Ga-DOTA-mDesmo, that targets the V1b receptor for both anatomical and functional identification of corticotropinomas. Methods Molecular docking was used to validate the binding affinity of [68Ga]Ga-DOTA-mDesmo to the V1b receptor. …”
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In silico evaluation of N-aryl-1,10-phenanthroline-2-amines as potential inhibitors of T. cruzi GP63 zinc-metalloprotease by docking and molecular dynamics simulations by Priscila Goes Camargo, Ramon Borges da Silva, Aline Araujo Zuma, Simon J. Garden, Magaly Girão Albuquerque, Carlos Rangel Rodrigues, Camilo Henrique da Silva Lima

“…RMSD and RMSF analyses confirmed the stability of these interactions, particularly for compounds with electron-withdrawing groups by inductive effect as R-substituents, such as p-OCH3 (Phen7) and p-CN (Phen10). …”
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Probiotic <i>Lactobacillus johnsonii</i> Reduces Intestinal Inflammation and Rebalances Splenic Treg/Th17 Responses in Dextran Sulfate Sodium-Induced Colitis by Hao-Yu Liu, Shicheng Li, Kennedy Jerry Ogamune, Peng Yuan, Xinyu Shi, Wael Ennab, Abdelkareem A. Ahmed, In Ho Kim, Ping Hu, Demin Cai

“…Inflammatory bowel disease (IBD), a chronic inflammatory disorder of the gastrointestinal tract, is frequently complicated by extraintestinal manifestations such as functional hyposplenism. Increasing evidence highlights its pathogenesis as a multifactorial interplay of gut dysbiosis, intestinal barrier dysfunction, and dysregulated immune responses. …”
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TSPAN4+ fibroblasts coordinate metastatic niche assembly through migrasome-driven metabolic reprogramming and stromal-immune crosstalk in pancreatic adenocarcinoma by Qingwen Hu, Qingwen Hu, Jiali Chen, Yang Liu, Yang Liu, Haiqing Chen, Haotian Lai, Lai Jiang, Xuancheng Zhou, Shengke Zhang, Jinbang Huang, Hao Chi, Bo Li, Xiaolin Zhong

“…Targeting these fibroblasts represents a promising therapeutic strategy to improve clinical outcomes and enhance the effectiveness of immunotherapies in pancreatic cancer.…”
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The Cecal Distribution of Microalgal Pigments in Rats: Do Carotenoids and Chlorophylls Play a Pharmacobiotic Role? by Tatiele Casagrande do Nascimento, Patrícia Acosta Caetano, Marcylene Vieira da Silveira, Luiz Eduardo Lobo, Uashington Da Silva Riste, Mariany Costa Deprá, Maria Rosa Chitolina Schetinger, Cristiano Ragagnin de Menezes, Roger Wagner, Eduardo Jacob-Lopes, Leila Queiroz Zepka

“…This study investigated the cecal distribution of lipophilic pigments (carotenoids and chlorophylls) from <i>Scenedesmus obliquus</i> and their effects on the activity of the intestinal microbiota in rats. …”
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Predictive Role of Complete Blood Count-Derived Inflammation Indices and Optical Coherence Tomography Biomarkers for Early Response to Intravitreal Anti-VEGF in Diabetic Macular Ed... by Ece Ergin, Ana Maria Dascalu, Daniela Stana, Laura Carina Tribus, Andreea Letitia Arsene, Marina Ionela Nedea, Dragos Serban, Claudiu Eduard Nistor, Corneliu Tudor, Dan Dumitrescu, Paul Lorin Stoica, Bogdan Mihai Cristea

“…<b>Conclusions:</b> CBC-derived inflammation indices and OCT biomarkers have prognostic value in predicting early response to anti-VEGF therapy in DME in terms of functional and anatomical outcomes. These findings could help identify poor responders and guide personalized treatment strategies.…”
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CO₂ Capture: A Comprehensive Review and Bibliometric Analysis of Scalable Materials and Sustainable Solutions by Domingo Cesar Carrascal-Hernández, Carlos David Grande-Tovar, Maximiliano Mendez-Lopez, Daniel Insuasty, Samira García-Freites, Marco Sanjuan, Edgar Márquez

“…Notable methods include chemical absorption using solvents, and the development of functionalized porous materials, such as MCM-41, impregnated with amines like polyethyleneimine. …”
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A Dual-Recognition Electrochemical Sensor Using Bacteria-Imprinted Polymer and Concanavalin A for Sensitive and Selective Detection of <i>Escherichia coli</i> O157:H7 by Xuejie Niu, Yuanbing Ma, Hui Li, Shuang Sun, Luoyuan Shi, Juan Yan, Donglei Luan, Yong Zhao, Xiaojun Bian

“…The BIP is formed in situ on the electrode surface as the capture probe, while gold nanoparticles co-functionalized with ConA and the electroactive molecule 6-(ferrocenyl)hexanethiol (Au@Fc-ConA) serve as the signaling probe. …”
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Robot-assisted radical cystectomy with intracorporeal urinary diversion versus open radical cystectomy (iROC): protocol for a randomised controlled trial with internal feasibility... by Gareth Ambler, Simon Dixon, Chris Brew-Graves, Norman R Williams, James W F Catto, John D Kelly, John McGrath, Melanie Tan, Muhammad Shamim Khan, Edward Rowe, Anthony Koupparis, Pramit Khetrapal, Rachael Sarpong, Andrew Feber, Louise Goodwin

“…Secondary outcomes will measure functional recovery (activity trackers, chair-to-stand tests and health related quality of life (HRQOL) questionnaires), morbidity (complications and readmissions), cost-effectiveness (using EuroQol-5 Domain-5 levels (EQ-5D-5L) and unit costs) and surgeon fatigue. …”
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Exogenous Trehalose Assists <i>Zygosaccharomyces rouxii</i> in Resisting High-Temperature Stress Mainly by Activating Genes Rather than Entering Metabolism by Xiong Xiao, Quan Liu, Qian Zhang, Zhenzhen Yan, Dongbo Cai, Xin Li

“…Trehalose is generally considered to be a protective agent that helps stable yeast cells resist heat shock stress, but its functional mechanism for yeast cells in the adaptation period under heat stress is unclear. …”
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Identification of core outcomes for quality in routine care provided to people living with dementia in Australia: a multilevel modified Delphi consensus study by Jane Thompson, Susanna Dodd, Paula Williamson, Leon Flicker, Judy Lowthian, Len Gray, Tracy Comans, John Quinn, Julie Smith, Kim-Huong Nguyen, Dominic Trépel, Tom Morris, Fleur O’Keefe, Alyssa Welch, Anna Kearney, Carly Meyer, Osvaldo Almeida, Colm Cunningham, Jack Nunn, Danelle Kenny, Glenys Petrie, Tiet-Hanh Dao-Tran, Karen Gainey, Karyn Lendich, Debbie Brittain, Bronte Parkin, Ruth Semler, Benedict Davies, Sue Kurrle, Safa Alrababah, Sanjib Hasa, Zoe Selby, Sonia Markoff, Subin Acharaya, Anthony Arrigo, Deborah Remfry, Joy & Bruce How, Margaret & Myles Hampton-Chubb, Michelle Finnegan, Mithrani Mahadeva, Sandra Lewis, Virginia Aquilizan, Wernher Dela Cruz

“…Round 1 included 10 panellists; subsequent rounds extended the number of participants to 24.Results Seven outcome domains (Death, Physiological and clinical, Functional, Life impact, Resources, Adverse events and Education), encompassing 105 individual outcomes were considered by the panel over four rounds.The 105 outcomes were distilled to 16 outcomes identified as important in home care and 15 in residential aged care. …”
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YWHAG promotes bladder cancer metastasis by regulating TMOD3 to activate ERK1/2 and JNK phosphorylation in the MAPK pathway by Tai Tian, Shiming He, Han Hao, Bao Guan, Yanqing Gong, Jian Fan, Zhenpeng Zhu, Wenzhi Gao, Yucai Wu, Ninghan Feng, Aixiang Wang, Yuexian Guo, Xuesong Li

“…Finally, TMOD3 knockdown experiments were conducted to verify whether the pro-metastatic effects of YWHAG in bladder cancer are mediated through TMOD3. …”
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BRD4 silencing attenuates hemin-induced neuronal ferroptosis and inflammation via the H3K27ac–ATF3 axis in an in vitro model of cerebral hemorrhage by Jing Yi, Hua Tang, Siwei Que, Tao Zheng, Hu Zeng, Xiaoming Xie, Hua Chen

“…Mechanistic studies revealed that BRD4 cooperated with H3K27ac to bind the ATF3 promoter, thereby promoting ATF3 transcription. Functional rescue experiments further demonstrated that ATF3 overexpression counteracted the inhibitory effects of BRD4 knockdown on hemin-induced inflammation and ferroptosis. …”
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