Impact of aging on alanine aminotransferase levels and frailty in chronic kidney disease patients: laboratory-based cross-sectional study in Northwest Ethiopia by Melaku Mekonnen Agidew, Anemut Tilahun Mulu, Awgichew Behaile Teklemariam, Misganaw Asmamaw Mengstie, Addisu Melake, Edgeit Abebe Zewde, Zelalem Tilahun Muche, Samuel Berihun Dagnew, Nega Dagnew Baye, Bezawit Adane, Muluken Walle, Girma Derso

“…BackgroundChronic kidney disease (CKD) is a non-communicable progressive condition that leads to a gradual decline in kidney functions, resulting in different complications. Serum alanine aminotransferase (ALT) is an important biomarker for diagnosing liver comorbidities. …”
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Silicon-enriched meat consumption mitigates brain cortex damage associated with diabetic dyslipidemia in a late-stage type 2 diabetes mellitus rat model by Rocío Redondo-Castillejo, Luis Apaza Ticona, Adrián Macho-González, Aránzazu Bocanegra, Alba Garcimartín, Marina Hernández-Martín, Anastasia Parfenova, Sara Bastida, Luis García-García, M. Elvira López-Oliva, Francisco J. Sánchez-Muniz, Juana Benedí

“…This study aimed to evaluate the effects of silicon-enriched meat (Si-RM) on the brain cortex of T2DM rats. …”
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Prevalence and Factors Associated with Self-Reported Vision Disability among the Elderly in Malaysia: Findings from National Health and Morbidity Survey (NHMS) 2018 by Muhammad Solihin Rezali, Nor’ Ain Ab Wahab, Norhafizah Sahril, Muhd Hafizuddin Taufik Ramli, Nik Adilah Shahein, Ying Ying Chan, Nur Liana Ab Majid, Mohd Hasnan Ahmad, Mohd Shaiful Azlan Kassim

“…The Washington Group Extended Question Set on Functioning (WG ES-F) was used to determine the vision disability. …”
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Atypical cancer risk profile in carriers of Italian founder BRCA1 variant p.His1673del: Implications for classification and clinical management by Giovanni Innella, Cristina Fortuno, Laura Caleca, Bing‐Jian Feng, Courtney Carroll, Michael T. Parsons, Sara Miccoli, Marco Montagna, Daniele Calistri, Laura Cortesi, Barbara Pasini, Siranoush Manoukian, Daniela Giachino, Laura Matricardi, Maria Cristina Foti, Valentina Zampiga, Claudia Piombino, Elena Barbieri, Francesca Vignolo Lutati, Jacopo Azzolini, Rita Danesi, Valentina Arcangeli, Sandrine M. Caputo, Nadia Boutry‐Kryza, Vincent Goussot, Susan Hiraki, Marcy Richardson, Hereditary Breast/Ovarian Cancer IOV network (HBOC IOVnet), Simona Ferrari, Paolo Radice, Amanda B. Spurdle, Daniela Turchetti

“…Methods Maximum likelihood penetrance of breast/ovarian and other cancer types was estimated using full pedigree data from 53 informative Italian families. The effect of the variant on BRCA1‐ABRAXAS1 interaction was assessed using a GFP‐fragment reassembly‐based PPI assay. …”
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A Fusion Strategy for High-Accuracy Multilayer Soil Moisture Downscaling and Mapping by Xu Zhang, Xin Liu, Xiang Zhang, Aminjon Gulakhmadov, Jiefeng Wu, Xihui Gu, Won-Ho Nam, Panda Rabindra Kumar, Veber Afonso Figueiredo Costa, Mahlatse Kganyago, Berhanu Keno Terfa, Wenying Du, Chao Wang, Peng Wang, Jing Yuan, Nengcheng Chen

“…Soil moisture (SM) is a critical factor influencing plant growth, agricultural yield, ecosystem functions, and water resource management. Existing SM products, such as SMAP, ERA5, and ESA-CCI, provide daily SM data. …”
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The relationship between childhood trauma, rs1360780 genotypes, FKBP5 intron 7 methylation and posttraumatic stress disorder in women who have experienced rape by Jani Nöthling, Jacqueline Samantha Womersley, Shibe Mhlongo, Carl Lombard, Naeemah Abrahams, Soraya Seedat, Sian Megan Joanne Hemmings

“…FK506 binding protein (FKBP5) is a co-chaperone and functional regulator of the glucocorticoid receptor and the HPA-axis.Objective: This study investigated main and interaction effects of childhood trauma and the FKBP5 rs1360780 genotype on longitudinal FKBP5 intron 7 methylation, and whether change in FKBP5 methylation over time was associated with PTSD symptom severity over time.Method: Women who experienced rape (n = 96) were recruited from post-rape care services in KwaZulu Natal, South Africa. …”
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Evaluation of antimicrobial, anticancer, and neuroprotective activities of silver nanoparticles (AgNPs) green-synthesized using a red pigment produced by Streptomyces sp. A23 strai... by Mokhnache Mohamed, Hani Belhadj, Koca Fatih Dogan, Unal Gokhan, Rahman Nasrat Abdul, Basma Aysegul, Bozkurt Nuh Mehmet, Bachir Ahmed Alien Mohamed, Daoud Harzallah

“…Furthermore, FT-IR analysis revealed the specific functional groups at 3471 to 478 cm-1. In addition, FE-SEM showed that the mean size of the spherical AgNPs was 54.5 nm in diameter. …”
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Robust, fully-automated assessment of cerebral perivascular spaces and white matter lesions: a multicentre MRI longitudinal study of their evolution and association with risk of de... by Giuseppe Barisano, Michael Iv, Jeiran Choupan, Melanie Hayden-Gephart, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Enchi Liu, Tom Montine, Ronald G. Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Danielle Harvey, Michael Donohue, Matthew Bernstein, Nick Fox, Paul Thompson, Norbert Schuff, Charles DeCarli, Bret Borowski, Jeff Gunter, Matt Senjem, Prashanthi Vemuri, David Jones, Kejal Kantarci, Chad Ward, Robert A. Koeppe, Norm Foster, Eric M. Reiman, Kewei Chen, Chet Mathis, Susan Landau, Nigel J. Cairns, Erin Householder, Lisa Taylor Reinwald, Virginia Lee, Magdalena Korecka, Michal Figurski, Karen Crawford, Scott Neu, Tatiana M. Foroud, Steven Potkin, Li Shen, Faber Kelley, Sungeun Kim, Kwangsik Nho, Zaven Kachaturian, Richard Frank, Peter J. Snyder, Susan Molchan, Jeffrey Kaye, Joseph Quinn, Betty Lind, Raina Carter, Sara Dolen, Lon S. Schneider, Sonia Pawluczyk, Mauricio Beccera, Liberty Teodoro, Bryan M. Spann, James Brewer, Helen Vanderswag, Adam Fleisher, Judith L. Heidebrink, Joanne L. Lord, Ronald Petersen, Sara S. Mason, Colleen S. Albers, David Knopman, Kris Johnson, Rachelle S. Doody, Javier Villanueva Meyer, Munir Chowdhury, Susan Rountree, Mimi Dang, Yaakov Stern, Lawrence S. Honig, Karen L. Bell, Beau Ances, John C. Morris, Maria Carroll, Sue Leon, Erin Householder, Mark A. Mintun, Stacy Schneider, Angela Oliver, Daniel Marson, Randall Griffith, David Clark, David Geld-macher, John Brockington, Erik Roberson, Hillel Grossman, Effie Mitsis, Leyla deToledo-Morrell, Raj C. Shah, Ranjan Duara, Daniel Varon, Maria T. Greig, Peggy Roberts, Marilyn Albert, Chiadi Onyike, Daniel D’Agostino, Stephanie Kielb, James E. Galvin, Dana M. Pogorelec, Brittany Cerbone, Christina A. Michel, Henry Rusinek, Mony J. de Leon, Lidia Glodzik, Susan De Santi, P. Murali Doraiswamy, Jeffrey R. Petrella, Terence Z. Wong, Steven E. Arnold, Jason H. Karlawish, David Wolk, Charles D. Smith, Greg Jicha, Peter Hardy, Partha Sinha, Elizabeth Oates, Gary Conrad, Oscar L. Lopez, MaryAnn Oakley, Donna M. Simpson, Anton P. Porsteinsson, Bonnie S. Goldstein, Kim Martin, Kelly M. Makino, M. Saleem Ismail, Connie Brand, Ruth A. Mulnard, Gaby Thai, Catherine Mc Adams Ortiz, Kyle Womack, Dana Mathews, Mary Quiceno, Ramon Diaz Arrastia, Richard King, Myron Weiner, Kristen Martin Cook, Michael DeVous, Allan I. Levey, James J. Lah, Janet S. Cellar, Jeffrey M. Burns, Heather S. Anderson, Russell H. Swerdlow, Liana Apostolova, Kathleen Tingus, Ellen Woo, Daniel H.S. Silverman, Po H. Lu, George Bartzokis, Neill R. Graff Radford, Francine Parfitt, Tracy Kendall, Heather Johnson, Martin R. Farlow, AnnMarie Hake, Brandy R. Matthews, Scott Herring, Cynthia Hunt, Christopher H. van Dyck, Richard E. Carson, Martha G. MacAvoy, Howard Chertkow, Howard Bergman, Chris Hosein, Sandra Black, Bojana Stefanovic, Curtis Caldwell, Ging-Yuek Robin Hsiung, Howard Feldman, Benita Mudge, Michele Assaly, Andrew Kertesz, John Rogers, Dick Trost, Charles Bernick, Donna Munic, Diana Kerwin, Marek Marsel Mesulam, Kristine Lipowski, Chuang Kuo Wu, Nancy Johnson, Carl Sadowsky, Walter Martinez, Teresa Villena, Raymond Scott Turner, Kathleen Johnson, Brigid Reynolds, Reisa A. Sperling, Keith A. Johnson, Gad Marshall, Meghan Frey, Jerome Yesavage, Joy L. Taylor, Barton Lane, Allyson Rosen, Jared Tinklenberg, Marwan N. Sabbagh, Christine M. Belden, Sandra A. Jacobson, Sherye A. Sirrel, Neil Kowall, Ronald Killiany, Andrew E. Budson, Alexander Norbash, Patricia Lynn Johnson, Thomas O. Obisesan, Saba Wolday, Joanne Allard, Alan Lerner, Paula Ogrocki, Leon Hudson, Evan Fletcher, Owen Carmichael, John Olichney, Charles DeCarli, Smita Kittur, Michael Borrie, T.Y. Lee, Rob Bartha, Sterling Johnson, Sanjay Asthana, Cynthia M. Carlsson, Steven G. Potkin, Adrian Preda, Dana Nguyen, Pierre Tariot, Adam Fleisher, Stephanie Reeder, Vernice Bates, Horacio Capote, Michelle Rainka, Douglas W. Scharre, Maria Kataki, Anahita Adeli, Earl A. Zimmerman, Dzintra Celmins, Alice D. Brown, Godfrey D. Pearlson, Karen Blank, Karen Anderson, Robert B. Santulli, Tamar J. Kitzmiller, Eben S. Schwartz, Kaycee M. Sink, Jeff D. Williamson, Pradeep Garg, Franklin Watkins, Brian R. Ott, Henry Querfurth, Geoffrey Tremont, Stephen Salloway, Paul Malloy, Stephen Correia, Howard J. Rosen, Bruce L. Miller, Jacobo Mintzer, Kenneth Spicer, David Bachman, Elizabeth Finger, Stephen Pasternak, Irina Rachinsky, John Rogers, Andrew Kertesz, Dick Drost, Nunzio Pomara, Raymundo Hernando, Antero Sarrael, Susan K. Schultz, Laura L. Boles Ponto, Hyungsub Shim, Karen Elizabeth Smith, Norman Relkin, Gloria Chaing, Lisa Raudin, Amanda Smith, Kristin Fargher, Balebail Ashok Raj

“…We analysed 46,478 clinical measurements of cognitive functioning and 20,845 brain MRI scans from 10,004 participants (71.1 ± 9.7 years-old, 56.6% women) from three publicly available observational studies on ageing and dementia (the Alzheimer’s Disease Neuroimaging Initiative, the National Alzheimer’s Coordinating Centre database, and the Open Access Series of Imaging Studies). …”
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In vitro efficacy of cetyltrimethylammonium bromide (CETAB)-modified nano-montmorillonite against aflatoxin B1 associated toxicity and methanogenesis by Yosra A. Soltan, Amr S. Morsy, Nesrein M. Hashem, Mahmoud A. I. Elazab, Mohamed A. Sultan, Amr El-Nile, Gomaa Abo El Lail, Nagwa El-Desoky, Nourhan S. Hosny, Ahmed M. Mahdy, Elsayed E. Hafez, Sobhy M. A. Sallam

“…Results The MNMCETAB showed better physicochemical traits than NM clay, including narrower particle size range, higher cation exchange capacity (CEC), greater specific surface area (SSA), and more functional groups. A significant linear decreasing effect (P < 0.05) of MNMCETAB addition on methane (CH) production was observed by the increasing level of the MNMCETAB clay. …”
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Gut-Microbiome Signatures Predicting Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer: A Systematic Review by Ielmina Domilescu, Bogdan Miutescu, Florin George Horhat, Alina Popescu, Camelia Nica, Ana Maria Ghiuchici, Eyad Gadour, Ioan Sîrbu, Delia Hutanu

“…Narrative synthesis and random-effects proportion meta-analysis were performed where data were homogeneous. …”
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Perioperative Oral decontamination and ImmunoNuTrition (POINT) to prevent postoperative pulmonary complications in elderly patients scheduled for elective non-cardiac surgeries: pr... by Jing Zhang, Yuguang Huang, Wen Wang, Yuelun Zhang, Xiaochun Zheng, Lu Che, Junping Chen, Lan Yao, Jiawen Yu, Lining Huang, Qianmei Zhu, Lichi Xu, Ji Fu, Meizheng You, Chaolei Liu, Guoping Fan

“…The secondary outcomes are the incidence of postoperative pneumonia, infectious complications, Comprehensive Complication Index, postoperative functional recovery, length of hospital stay and hospital expenses. …”
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Genome‐wide association study and BSR‐seq identify nitrate reductase–related genes in rice landraces (Oryza sativa L.) by Shuangshuang Luo, Zuyu Liao, Shilv Huang, Xiuzhong Xia, Zongqiong Zhang, Baoxuan Nong, Tongping Luo, Chenli Zhu, Can Chen, Hui Guo, Rui Feng, Yinghua Pan, Shuhui Liang, Yongcheng Li, Jianhui Liu, Yongfu Qiu, Danting Li, Xinghai Yang

“…Moreover, 98 significant SNPs were associated (logarithm of odds ≥ 3) with three traits through 3 V multi‐locus random‐SNP‐effect mixed linear model. Interestingly, we found that Chr1_15896481 was significantly associated in the GLM, MLM, LM, and LMM models. …”
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Formulation Optimization and Quality Analysis of Dendrobium officinale Chewable Tablets by Wenyu ZHANG, Xianshu FU, Xue BAI, Shiwen WU, Jiabin LI, Xiaoping YU, Mingzhou ZHANG, Zihong YE

“…To explore whether Dendrobium officinale, Polygonatum sibiricum, and Ziziphus jujuba can be used as active pharmaceutical ingredient (APIs), a functional snack that is easy to carry and eat was developed. …”
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Quantifying the Impact of Comorbidities on Outcomes Following Surgery for Osteoporotic Vertebral Compression Fractures by Anmol Gupta, Thomas Cha, Joseph Schwab, Harold Fogel, Daniel Tobert, Afshin E. Razi, Carl Paulino, Christopher M. Bono, Stuart Hershman

“…Results A history of cerebrovascular accident (CVA), coagulopathy, diminished preoperative functional status, and/or an American Society of Anesthesiologists (ASA) class > 2 were statistical predictors of postoperative complications. …”
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Alpine peatland degradation enhances soil nitrogen losses and alters plant nitrogen uptake strategies: evidence from nitrogen isotopes by Xiaodong Zhang, Lijuan Cui, Xin Jia, Liang Yan, Yong Li, Zhongqing Yan, Kerou Zhang, Ao Yang, Yuechuan Niu, Enze Kang, Xiaoming Kang

“…Abstract Background Nitrogen plays a critical role in sustaining ecosystem functions in peatlands; however, the degradation of approximately 12% of global peatlands substantially alters nitrogen cycling. …”
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Expert review in diagnostic, therapeutic and follow-up of Fabry disease in Latin America based on patient care standards by Roberto Giugliani, Juan Politei, Ana Martins, Nelson Murillo, Paula Rozenfeld, Mauricio Lopera, Sergio Salgado, Gustavo Quirós, Charles Marques Lourenço, Osvaldo Vieira, Hernán Amartino, Fernando Perretta, Sandra Marques e Silva, Joseph Brooks, Laura Titievsky, Jacobo Villalobos, Cassiano Braga, Harris A. Peñaranda

“…As it has been described, there are currently three therapeutic options, for which the appropriate profile must be defined to achieve the best clinical outcomes, considering that it is a permanent treatment; experts consider that Fabry patients need comprehensive and interdisciplinary management to stop the progression and functional deterioration of the affected organs by its multiple systemic manifestations. …”
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Lnc-MEG8 regulates yak myoblast differentiation via the miR-22-3p/RTL1 axis by Xiaoming Ma, Yongfu La, Tong Wang, Chun Huang, Fen Feng, Xian Guo, Pengjia Bao, Xiaoyun Wu, Min Chu, Chunnian Liang, Ping Yan

“…Our results indicated that Lnc-MEG8's subcellular localization varies during muscle cell growth: it is found in both the nucleus and cytoplasm during proliferation but shifts mainly to the cytoplasm during differentiation. Functional experiments showed that Lnc-MEG8 promotes cell proliferation and inhibits differentiation, while its silencing had the opposite effect. …”
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Virtual human retina: Simulating neural signalling, degeneration, and responses to electrical stimulation by Keith Ly, Michael L. Italiano, Mohit N. Shivdasani, David Tsai, Jia-Yi Zhang, Chunhui Jiang, Nigel H. Lovell, Socrates Dokos, Tianruo Guo

“…Introduction: Current brain-based visual prostheses pose significant challenges impeding adoption such as the necessarily complex surgeries and occurrence of more substantial side effects due to the sensitivity of the brain. This has led to much effort toward vision restoration being focused on the more approachable part of the brain - the retina. …”
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Pecan-medicinal crops intercropping improved soil fertility and promoted interactions between soil microorganisms and metabolites by Ruyuan Wang, Chenyang Liu, Xuesong Bie, Yan Dai, Xu Feng, Ren Wang, Ming Wang, Shu Xu, Yu Chen

“…A combined analysis of soil microbiomes and metabolomes was performed to discover the effects of intercropping on bulk and rhizosphere soils. …”
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First-in-human Results of the Novel Transcatheter Mitral Valve Repair System for Severe Mitral Regurgitation by Zhi-Nan Lu, Yutong Ke, Yingnan Bian, Jing He, Wenhui Wu, Xinmin Liu, Yang Li, Ran Liu, Taiyang Luo, Xunan Guo, Guangyuan Song

“…To evaluate the feasibility, safety, and effectiveness of a novel edge-to-edge mitral valve repair system (the NovoClasp system) in patients with severe mitral regurgitation. …”
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