The P2X7 receptor in depression: Novel insights and therapeutic implications by Yue-ting Zhong, Chao Pi, Ying Zuo, Yan Wei, Wen Li, Yong-qiang Jiang, Lei Tao, Wen-wu Zheng, Jun Jiang, Yan Yang, Shi-feng Chu, Bin-yan Liu, Ke-zhi Liu, Yu-meng Wei, Ling Zhao

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Identification and prognostic analysis of propionate metabolism-related genes in head and neck squamous cell carcinoma by Shitong Zhou, Shitong Zhou, Yu Jiang, Panhui Xiong, Zhongwan Li, Lifeng Jia, Wei Yuan, Xiufu Liao, Xiang An, Jie Hu, Rui Luo, Hailan Mo, Hongyan Fang, Yucheng Yang

“…Recent studies have suggested that propionate metabolism-related genes (PMRGs) may play key roles in tumor progression and immune regulation, yet their functions in HNSCC remain unclear.MethodsTranscriptomic data from 502 HNSCC tumor samples and 44 normal tissue samples were obtained from the UCSC Xena database as the training set. …”
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Antibiofilm properties of 4-hydroxy-3-methyl-2-alkenylquinoline, a novel Burkholderia-derived alkaloid by McKinley D. Williams, Taylor R. Sweeney, Sabrina Trieu, Ravi Orugunty, Abdelahhad Barbour, Fereshteh Younesi, Michael Glogauer, Nopakorn Hansanant, Ronald Shin, Shi-En Lu, Kevin Cao, Abraham Tenorio, Sigmund J. Haidacher, Anthony M. Haag, Thomas D. Horvath, Leif Smith

“…HMAQ-7 also demonstrated an ability to modulate additional cellular behaviors in Bacillus subtilis, including motility and sporulation, suggesting that this molecule is important to the interspecies dynamics present across many diverse microenvironments.IMPORTANCEThe present study furthers our understanding of the structural complexity and the biological functions of the 2-alkyl-4(1H)-quinolone metabolites produced by Burkholderia spp. …”
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Using Artificial Intelligence-informed Experience-Based Co-Design (AI-EBCD) to create a virtual reality-based mindfulness application to reduce diabetes distress: protocol for a mi... by Angeliki Bogosian, Glenn Robert, Siobhan O'Connor, Jackie Sturt, Emma Stanmore, David Woodcock, Nicola Milne, Womba Mubita, Shraboni Ghosal, Mengying Zhang

“…Mobile apps for mindfulness may overcome these issues but evidence of their effectiveness is limited, and some have poor interface design with basic visualisations and feedback.Methods and analysis Our study will explore using virtual reality (VR) as an immersive and interactive technology that could support mindfulness practice to help reduce diabetes distress. …”
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SH3GL1‐activated FTH1 inhibits ferroptosis and confers doxorubicin resistance in diffuse large B‐cell lymphoma by Zi‐Wen Duan, Wei‐Ting Wang, Yan Wang, Rong Wang, Wei Hua, Chun‐Yu Shang, Rui Gao, Hao‐Rui Shen, Yue Li, Jia‐Zhu Wu, Hua Yin, Li Wang, Jian‐Yong Li, Wei Xu, Jin‐Hua Liang

“…This approach combined high‐throughput sequencing technologies, such as Deep‐DIA and LC‐MS, with functional validation techniques, including CRISPR/Cas9 gene editing, xenograft models, and molecular pathway analyses. …”
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Development and validation of a novel prediction model for osteoporosis: from serotonin to fat-soluble vitamins by Jinpeng Wang, Lianfeng Shan, Jing Hang, Hongyang Li, Yan Meng, Wenhai Cao, Chunjian Gu, Jinna Dai, Lin Tao

“…The prediction model was developed based on Bayes and Fisher’s discriminant functions, and validated via leave-one-out cross-validation. …”
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Critical care services in Bagmati province of Nepal: A cross sectional survey [version 4; peer review: 4 approved, 2 approved with reservations] by Subekshya Luitel, Sushila Paudel, Diptesh Aryal, Janaki Pandey, Hem Raj Paneru, Roshni Shakya, Prashant Acharya, Isha Amatya, Rashan Haniffa, Suman Pant, Abi Beane, Pradip Gyanwali

“…Although there were disparities, numerous ICUs were effectively carrying out multiple critical care procedures. …”
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Screening and evaluation of specific blood MiRNAs as potential biomarkers in diagnostics of gastric Cancer by Xize Li, Qingyu Wang, Zhouhan Xu, Xuesi Yang, Ruiqi Zhao, Haocheng Wang, Xueling Li, Jiping Zeng

“…The miRNA-target genes prediction, conduct Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) functional enrichment analyses were performed with the Database for Annotation, Visualization and Integrated Discovery (DAVID) 6.8. …”
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Conversion of ATP to adenosine by CD39 and CD73 in multiple myeloma can be successfully targeted together with adenosine receptor A2A blockade by Torstein Baade Rø, Rui Yang, Zachary Cooper, Richard Woessner, Samah Elsaadi, Kristine Misund, Pegah Abdollahi, Esten Nymoen Vandsemb, Siv Helen Moen, Anna Kusnierczyk, Geir Slupphaug, Therese Standal, Anders Waage, Tobias S Slørdahl, Even Rustad, Anders Sundan, Carl Hay, Alwin G Schuller, Alexandra Borodovsky, Eline Menu, Magne Børset, Anne Marit Sponaas

“…Transplantable 5T33MM myeloma cells were used to determine the effect of inhibiting CD39, CD73 and A2AR in mice in vivo.Results Elevated level of adenosine was found in BM plasma of MM patients. …”
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Initial experience of laparoendoscopic single-site radical prostatectomy with a novel purpose-built robotic system by Zheng Wang, Chao Zhang, Chengwu Xiao, Yang Wang, Yu Fang, Baohua Zhu, Shouyan Tang, Xiaofeng Wu, Hong Xu, Yi Zhou, Lingfen Wu, Zhenjie Wu, Bo Yang, Yi He, Yi Liu, Linhui Wang

“…The demographic and baseline data, surgical, oncological, and functional outcomes as well as follow-up data were recorded. …”
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Genetic variants of m1A modification genes and the risk of neuroblastoma: novel insights from a Chinese case-control study by Jiaming Chang, Lei Lin, Wenli Zhang, Jiliang Yang, Mengzhen Zhang, Huimin Yin, Xinxin Zhang, Chunlei Zhou, Yan Zou, Jing He

“…Abstract Background The N1-adenosine methylation (m1A) modification plays a significant role in various cancers. However, the functions of m1A modification genes and their variants in neuroblastoma remain to be elucidated. …”
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Intention to leave and missed nursing care: A scoping review by Gianluca Azzellino, Angelo Dante, Cristina Petrucci, Valeria Caponnetto, Ernesto Aitella, Loreto Lancia, Lia Ginaldi, Massimo De Martinis

“…Introduction: The nursing profession is fundamental to the functioning of healthcare systems but is often characterised by high turnover rates, considerable job dissatisfaction, and a significant intention to leave. …”
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General anesthesia is an independent predictor for worse maternal outcome in pregnant pulmonary arterial hypertension patients without cardiac shunt but not for those with shunt by Weida Lu, Min Li, Fuqing Ji, Hua Feng, Liangyi Qie, Guo Li, Qiushang Ji, Mingying Ling, Fan Jiang, Xiaopei Cui

“…Both World Health Organization functional class (WHO-FC) III/IV and general anesthesia were predictors for gravidae without shunt, whereas only WHO-FC III/IV was a predictor for gravidae with shunt. …”
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miR-4537 curtails ferroptosis by targeting MIOX in renal cell carcinoma by Hui Li, Mengyu Fu, Lingli Wang, Yanpeng Dai, Zongxing Lv, Shilin Geng

“…Further investigations into MIOX regulation identified four miRNAs via TargetScan predictions, with miR-4537 significantly upregulated in ccRCC cell lines. Functional assays involving miR-4537 mimics and inhibitors, combined with ferroptosis inducers and inhibitors, elucidated its impact on ccRCC cell growth and ferroptosis modulation. …”
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Smartwatch ECG and artificial intelligence in detecting acute coronary syndrome compared to traditional 12-lead ECG by Jina Choi, Joonghee Kim, Carmen Spaccarotella, Giovanni Esposito, Il-Young Oh, Youngjin Cho, Ciro Indolfi

“…Meanwhile, smartwatches offering ECG functionality have become widespread. This study evaluates the feasibility of an image-based ECG analysis artificial intelligence (AI) system with smartwatch-based multichannel, asynchronous ECG for diagnosing ACS. …”
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New mutation of the TP53 gene associated with the hereditary breast cancer in a young Tuvinian woman by P. A. Gervas, A. Yu. Molokov, A. A. Zarubin, A. A. Ponomareva, N. N. Babyshkina, V. A. Belyavskaya, L. F. Pisareva, E. L. Choynzonov, N. V. Cherdyntseva

“…In accordance with proteinpaint tool, the lrg_321t1: c.80c>t mutation is located in functionally specialized transactivation domains and codon of the tp53 gene, where the pathogenic mutation associated with li-Fraumeni syndrome has been earlier described. …”
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Interleukin-21 engineering enhances CD19-specific CAR-NK cell activity against B-cell lymphoma via enriched metabolic pathways by Bailin He, Hong Chen, Jiaxu Wu, Shiqiu Qiu, Qiusui Mai, Qing Zeng, Cong Wang, Shikai Deng, Zihong Cai, Xiaoli Liu, Li Xuan, Chengyao Li, Hongsheng Zhou, Qifa Liu, Na Xu

“…The phenotypic profile, transcriptomic characteristics, functionality and anti-tumor activity of CAR-21 NK cells and CAR-15 NK cells were compared. …”
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Gender differences in the associations of recreational walking with indoor and outdoor falls among older adults-the Healthy Aging and Neighborhood Study (HANS) by Lingming Chen, Elizabeth Procter-Gray, Qun Le, Danielle LoPilato, Marianella Ferretto, Kevin Kane, Marian T. Hannan, Sarah Berry, Wenjun Li

“…Models were adjusted for sociodemographic variables, physical health, functional status, lifestyle behaviors, mental health, and fear of falling.ResultsThere were 394 (55%) female and 322 (45%) male participants enrolled in the study, and the mean (SD) age was 74.08 (6.29). …”
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Targeting HK3 in tumor-associated macrophages enhances antitumor immunity through augmenting antigen cross-presentation in cervical cancer by Hui Wang, Ying Chen, Min Wu, Jian Liu, Jingyu Wang, Yifan Yang, Chaoyang Sun, Shan He, Shen Qu, Xun Tian, Jinglan Chen, Han Jiang, Liting Liu, Yafei Huang

“…In vivo tumor models were established to assess the functional impact of HK3-expressing cells on the TME, with interventions including Hk3 knockout and CD8+ T-cell depletion. …”
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Co-inoculation maintains yields and lowers N2O emission by affecting rhizosphere bacterial diversity in common bean grown on a C-rich clayey Ferralsol by Pablo Schulman, Marcia Thais de Melo Carvalho, Raquel Neves de Mello, Beata Emoke Madari, Pedro Luiz Oliveira de Almeida Machado, Enderson Petronio de Brito Ferreira, Tatiana Maris Ferraresi, Tereza Cristina de Oliveira Borba, Rodrigo Mendes, Edson Hirose, Wilker Alves de Araujo, Matheus Mentone de Britto Siqueira, Ryan Rodrigues da Silva, Pedro Augusto de Oliveira Morais

“…Microbial diversity was generally lower under N fertilization, with shifts in the abundance of nitrogen-related functional groups, particularly in the second year. …”
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