Identification of long InDels through whole genome resequencing to fine map qIF05-1 for seed isoflavone content in soybean (Glycine max L. Merr.) by Jia Jia, Huan Wang, Ximeng Yang, Bo Chen, Ruqian Wei, Qibin Ma, Yanbo Cheng, Hai Nian

“…A total of 10,002 long InDels (15.85% of total) were located in genic regions, including 1,139 large-effect long InDels which resulted in truncated or elongated protein sequences. …”
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Assessment of pH-Induced Conformational Changes in Whey Protein Isolate–Dextran Conjugate Using Spectral Technology by Qingyuan Dai, Huiqin Wang, Xiuling Zhu, Polyanna Silveira Hornung, Yuru Zhang, Wenxuan Hu, Anqi Lin, Anyi Yao, Trust Beta

“…The functional properties of proteins are closely related to their structure and conformation. …”
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European survey on CAR T-Cell analytical methods from apheresis to post-infusion immunomonitoring by Biagio De Angelis, Maria Luisa D’Amore, Pacôme Lecot, Kerstin Neininger, Margot Lorrain, Laetitia Gambotti, Caroline Dreuillet, Elise Courcault, Sampurna Chatterjee, Sampurna Chatterjee, Julio Delgado, Anne Galy, Paul Franz, Juan Roberto Rodriguez-Madoz, Yolanda Cabrerizo, Anne Richter, Charis Girvalaki, Maddalena Noviello, Elena Tassi, Carmen Sanges, Maik Luu, Michael Hudecek, Andreas Kremer, Franco Locatelli, Franco Locatelli, Helene Negre, Concetta Quintarelli, Concetta Quintarelli

“…These efforts are anticipated to significantly enhance cancer patients' access to engineered T cell therapy safely and effectively throughout Europe.…”
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Identification and characterization of the anti-viral interferon lambda 3 as direct target of the Epstein-Barr virus microRNA-BART7-3p by Juliane Blümke, Marcus Bauer, Christoforos Vaxevanis, Andreas Wilfer, Ofer Mandelboim, Claudia Wickenhauser, Barbara Seliger, Simon Jasinski-Bergner

“…., the disruption of human leukocyte antigen (HLA) class Ia and NKG2D functions. To determine novel targets of EBV-miRs involved in immune surveillance, ebv-miR-BART7-3p, an EBV-encoded miR with high expression levels during the different lytic and latent EBV life cycle phases, was overexpressed in human HEK293T cells. …”
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Multifunctional physical simulation test system for deep coal rockburst development and its application by Shoujian PENG, Qingfeng XU, Jiang XU, Liang CHENG, Bin ZHOU, Yan YANG, Feng JIAO

“…In order to conduct an in-depth research on the disaster causing laws of coal-rock burst and rock burst in deep strata, a multi-functional physical simulation test system for rock burst in deep strata has been independently developed. …”
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miR-32-5p suppresses the progression of hepatocellular carcinoma by regulating the GSK3β/NF-κB signaling by Wang Guangzhi, Yang Qianqian, Han Yaqi, Zhang Yunlong, Pan Wei, Ma Zhongliang, Tian Hui, Qu Xudong

“…In this study, qRT-PCR is utilized to precisely determine the downregulated expression levels of miR-32-5p in HCC. Subsequently, functional analysis reveals the suppressive role of miR-32-5p in modulating the proliferative and migratory capabilities of HCC cells. …”
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Evaluation of the efficacy and safety of a precise thymalfasin-regulated PRaG regimen for advanced refractory solid tumours: protocol for the open-label, prospective, multicentre s... by Yong Peng, Hong Zhang, Junjun Zhang, Liyuan Zhang, Pengfei Xing, Yuehong Kong, Rongzheng Chen, Meiling Xu, Guangqiang Chen, Zhihui Hong, Xiaoxiao Dai, Yifu Ma, Xiangrong Zhao, Chenyang Zhang

“…Coupling the PRaG regimen with immunomodulatory agents that augment the number and functionality of lymphocytes may yield further survival benefits in this cohort of patients.Objective The aim of this study is to investigate the effectiveness and safety of a meticulously thymalfasin-controlled PRaG regimen in patients with advanced and chemotherapy-resistant solid tumours.Methods and analysis The study has a prospective, single-arm, open-label, multicentre design and aims to recruit up to 60 patients with histologically confirmed advanced solid tumours that have relapsed or metastasised. …”
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Vertical distribution patterns and potential activities of methanogenic and methanotrophic communities in permafrost peatlands of Greater Khingan Mountains by Anwen Liu, Weiping Yin, Dalong Ma, Xu Wang, Shuping Kan

“…These results provide unique insights into forecasting the response of microbial functional groups driving CH4 cycling in peatlands to climate change in high-latitude permafrost regions.…”
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Rapid diagnosis of rheumatoid arthritis and ankylosing spondylitis based on Fourier transform infrared spectroscopy and deep learning by Wei Shuai, Xue Wu, Chen Chen, Enguang Zuo, Xiaomei Chen, Zhengfang Li, Xiaoyi Lv, Lijun Wu, Cheng Chen

“…Objective: Rheumatoid arthritis and Ankylosing spondylitis are two common autoimmune inflammatory rheumatic diseases that negatively affect activities of daily living and can lead to structural and functional disability, reduced quality of life. Here, this study utilized Fourier transform infrared (FTIR) spectroscopy on dried serum samples and achieved early diagnosis of rheumatoid arthritis and ankylosing spondylitis based on deep learning models. …”
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Loss of PTPN21 disrupted mitochondrial metabolic homeostasis and aggravated experimental pulmonary fibrosis by Hui Lian, Kai Xu, Airu Chang, Yaxuan Wang, Shuaichen Ma, Lianhui Cheng, Wenyu Zhao, Cong Xia, Lan Wang, Guoying Yu

“…Non-receptor protein tyrosine phosphatase 21 (PTPN21) performs various functions in cancer; however, its role in IPF has not been studied. …”
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Identification of the putative regulatory regions and candidate genes associated with backfat thickness and intramuscular fat content traits in Xiang pigs by Xia Chen, Yundi Zheng, Fengbin Hu, Xiaoli Liu, Wei Wang, Fenfang Qi, Xi Niu, Shihui Huang, Jiafu Wang, Xueqin Ran

“…These findings enhance our understanding of the genetic mechanisms underlying fat deposition in Xiang pigs and provide a theoretical framework for future functional studies and genomic selection.…”
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Domestication of different varieties in the cheese-making fungus Geotrichum candidum by Bennetot, Bastien, Vernadet, Jean-Philippe, Perkins, Vincent, Hautefeuille, Sophie, Rodríguez de la Vega, Ricardo C., O’Donnell, Samuel, Snirc, Alodie, Grondin, Cécile, Lessard, Marie-Hélène, Peron, Anne-Claire, Labrie, Steve, Landaud, Sophie, Giraud, Tatiana, Ropars, Jeanne

“…Domestication is an excellent model for studying adaptation processes, involving recent adaptation and diversification, convergence following adaptation to similar conditions, as well as degeneration of unused functions. Geotrichum candidum is a fungus used for cheese making and is also found in other environments such as soil and plants. …”
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A brief exploration of the physical properties of single living cells under dynamic loading conditions by Dasen Xu, Chongyu Zhang, Ruining Peng, Ruining Peng, Ru Zhang, Haoyu Chen, Yulong Li, Yulong Li, Hui Yang, Hui Yang

“…Introduction:Single living cells exhibit both active biological functions and material-like mechanical behaviors. While extensive research has focused on static or quasi-static loading, the purely mechanical properties under high-rate impact remain underexplored. …”
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Maintaining operability at a high personal cost – a mixed method study on maternal healthcare workers’ experiences during the COVID-19 pandemic by Magnus Akerstrom, Anna Wessberg, Emina Hadžibajramović, Sofie Graner, Ylva Carlsson, Ola Andersson, Maria Jonsson, Elin Naurin, Malin Veje, Verena Sengpiel, Karolina Linden

“…Abstract Introduction The COVID-19 pandemic forced leaders and employees in health care services to take difficult decisions to manage risks associated with employee health and the organizations’ functioning. This study aims to identify the changes in employee working routines, job demands, and job resources within Swedish maternal healthcare during the COVID-19 pandemic, and how these changes affected workload and health. …”
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Social context affects tissue-specific copper distribution and behaviour of threespine stickleback (Gasterosteus aculeatus) by Sienna L. Overduin, Shaun S. Killen, Alex M. Zimmer, Jenelle D. McCuaig, Lucy Cotgrove, Isabel Aragao, Kelly J. Rozanitis, Kurt O. Konhauser, Daniel S. Alessi, Tamzin A. Blewett

“…The objective of this study was to investigate whether inducing social stress in marine threespine stickleback (Gasterosteus aculeatus) through social isolation during a sublethal water-borne copper (Cu) exposure would affect Cu uptake and whether that would translate to differences in behaviour and biochemical functioning. We hypothesized that isolating threespine stickleback during a Cu exposure would increase Cu uptake and sublethal toxicity compared to a grouped exposure. …”
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Sheep grazing in vineyards benefits wild bees in vineyard embankments and sheep dung attracts dung beetles to vineyards by Felix Fornoff, Johanna Mattenklodt, Frauke Thul, Jörn Buse, Alexandra-Maria Klein, Jakob Hörl, Nicolas Schoof

“…Therefore, sheep grazing in vineyards offers opportunities for biodiversity conservation and maintaining ecosystem functions, though is not an all-in-one solution.…”
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Psychological wellbeing of student-athletes: a comparative study between European and American athletes by Hugo Keriven, Hugo Keriven, Alberto Sánchez-Sierra, Alberto Sánchez-Sierra, Alberto Sánchez-Sierra, Marta de-la-plaza-San-Frutos, Marta de-la-plaza-San-Frutos, Guillermo García-Pérez-de-Sevilla, Vicente Clemente-Suarez, Eduardo Garcia-Laredo, Marisa Saenz-Bravo, Oluwatoyosi B. A. Owoeye, Diego Miñambres-Martín, Diego Miñambres-Martín, Diego Domínguez-Balmaseda, Diego Domínguez-Balmaseda, Diego Domínguez-Balmaseda

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Molecular classification of head and neck squamous cell carcinoma based on hypoxia-related genes and clinical significance of STC2 by ZHU Jianing, WANG Tiantian, ZHANG Rui, SONG Hongquan

“…Objective To construct a molecular classification system for head and neck squamous cell carcinoma (HNSCC) utilizing hypoxia-related gene (HAG) expression profiles, and to comprehensively examine the clinicopathological significance and biological functions of the hypoxia gene stanniocalcin 2 (STC2) in HNSCC. …”
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Realidad virtual inmersiva y su influencia en parámetros fisiológicos de personas sanas (Immersive virtual reality and its influence on physiological parameters in healthy people)... by Gustavo Rodriguez-Fuentes, Pablo Campo-Prieto, Xose Carlos Souto, Jose Maria Cancela Carral

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Dynamic Adaptation of Hematological Parameters, Albumin, and Non-Esterified Fatty Acids in Saddlebred and Standardbred Horses During Exercise by Giuseppe Piccione, Francesca Arfuso, Elisabetta Giudice, Francesca Aragona, Pietro Pugliatti, Maria Francesca Panzera, Alessandro Zumbo, Vincenzo Monteverde, Vincenzo Bartolo, Adalberto Barbera, Claudia Giannetto

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