Periodontitis promotes tumor growth and immune evasion via PD-1/PD-L1 by Suli Wang, Fujiao Nie, Qiuyue Yin, Haoyang Tian, Pizhang Gong, Jinhong Ju, Jiayi Liu, Pishan Yang, Chengzhe Yang

“…Conclusion Periodontitis may facilitate tumor growth and immune escape evidenced by the increased immune-suppressive cells and the decreased functional T cells, via enhancing PD-1/PD-L1 expression in the tumor microenvironment.…”
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Linguistic accuracy and authenticity of the content of the Russian version of the module of gastrointestinal symptoms of the PedsQL^™ questionnaire for pediatric patient... by Anna L. Arakelyan, Andrey N. Surkov, Aleksander A. Baranov, Leyla S. Namazova-Baranova, Valeri V. Gorev, Elena B. Moskvina, Tamara A. Skvorcova, Artem V. Nikitin, Vladislav V. Chernikov

“…Health Related Quality of Life (HRQL) is a person’s perception of the effect of a disease on physical, social and psychological functioning and wealth. …”
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A novel self-assembled nanocarrier-mediated dsRNA fungicide for broad-spectrum management of Rhizoctonia solani by Xiaojie Ding, Xinchun Li, Yan Li, Huiyan Guo, Kexin Cao, Mengnan An, Chong Zhang, Yuanhua Wu, He Liu, Rujun Zhou

“…In this study, R. solani glycosyl hydrolase family 1 (RsGH1), which functions as a cell wall degrading enzyme (CWDE), and was screened as a prospective RNAi target gene for managing R. solani AG3 TB. …”
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EGFRvIII-driven microenvironmental fibroblast activation and transformation accelerate oral cancer progression via lipocalin-2/STAT3 axis by Hsuan-Yu Peng, Kwang-Yu Chang, Wei-Min Chang, Chia-Yu Wu, Hsin-Lun Lee, Yung-Chieh Chang, Ko-Jiunn Liu, Shine-Gwo Shiah, Ching-Chuan Kuo, Jang-Yang Chang

“…Among EGFR mutation, EGFRvIII, an extracellular domain truncated form without exons 2–7, exhibits ligand-independent and constitutive EGFR activation. Although EGFRvIII functions as an oncogene in glioblastoma, its role in OSCC remains unclear. …”
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Health-Related Quality of Life and Fatigue in Children with Pompe Disease by Linda E. Scheffers, Karolijn Dulfer, PhD, Charlotte Lanser, Maarten Mackenbach, MD, Ans T. van der Ploeg, MD, PhD, Johanna M.P. van den Hout, MD, PhD, Linda E. van den Berg, MD, PhD

“…As expected in relation to disease severity, unfavorable effects on HR-QOL and fatigue were more pronounced in patients with classic infantile Pompe disease.…”
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Class B Scavenger Receptor CD36 as a Potential Therapeutic Target in Inflammation Induced by Danger-Associated Molecular Patterns by Irina N. Baranova, Alexander V. Bocharov, Tatyana G. Vishnyakova, Zhigang Chen, Yunbo Ke, Anna A. Birukova, Peter S. T. Yuen, Takayuki Tsuji, Robert A. Star, Konstantin G. Birukov, Amy P. Patterson, Thomas L. Eggerman

“…The class B scavenger receptor CD36 is known to bind and mediate the transport of lipid-related ligands and it functions as a pattern recognition receptor (PRR) for a variety of pathogens, including bacteria and viruses. …”
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Outdoor Air Pollution Is Related to Amygdala Subregion Volume and Apportionment in Early Adolescence by Jessica Morrel, L. Nate Overholtzer, Kirthana Sukumaran, Devyn L. Cotter, Carlos Cardenas-Iniguez, J. Michael Tyszka, Joel Schwartz, Daniel A. Hackman, Jiu-Chiuan Chen, Megan M. Herting

“…Background: Outdoor air pollution exposure is associated with structural and functional brain differences and an increased risk for psychopathology. …”
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Observational longitudinal multicentre investigation of acute pancreatitis (GOULASH PLUS): follow-up of the GOULASH study, protocol by Péter Hegyi, Andrea Szentesi, Eszter Hegyi, Miklós Sahin-Tóth, Patrícia Sarlós, Bálint Erőss, Katalin Márta, Áron Vincze, László Czakó, Mária Papp, Ferenc Izbéki, Markus M Lerch, Ole H Petersen, Dezső Kelemen, Dániel Pécsi, László Gajdán, Alexandra Mikó, Péter Hegyi Jr, Beáta Bódis, Orsolya Nemes, Nándor Faluhelyi, Orsolya Farkas, Róbert Papp, János Novák

“…The exocrine and endocrine pancreatic, liver and kidney functions will be determined by laboratory tests, stool sample analyses and imaging. …”
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Available Nitrogen as the Determinant of Variability in Soil Microbial Communities Throughout <i>Lycium chinense</i> Growth Zones in the Qaidam Basin, Qinghai, China by Qianqian Su, Jie Li, Jingui Wang, Gang Li, Yang Sun, Xiaoqin Liu, Lan Luo, Xinrui Wang, Guilong Zhang

“…Understanding the compositional and functional dynamics of soil microbial communities is crucial for optimizing soil fertility and promoting agricultural sustainability. …”
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Extraction of fermentable sugars and phenolic compounds from Colombian cashew (Anacardium occidentale) nut shells using subcritical water technology: Response surface methodology a... by Luis J. Cruz-Reina, Jader Rodríguez-Cortina, Fabrice Vaillant, Israel Herrera-Orozco, Chiara Carazzone, Rocío Sierra

“…The resulting hydrochar comprised lignin (58.82 ± 3.44 %) and structural carbohydrates (approximately 40 %), showing thermal stability up to 200 °C, OH functional groups on its surface, and a textured morphology under microscopy. …”
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Microbiota-derived IPA alleviates intestinal mucosal inflammation through upregulating Th1/Th17 cell apoptosis in inflammatory bowel disease by Han Gao, Mingming Sun, Ai Li, Qiaoyan Gu, Dengfeng Kang, Zhongsheng Feng, Xiaoyu Li, Xuehong Wang, Liang Chen, Hong Yang, Yingzi Cong, Zhanju Liu

“…The gut microbiota-derived metabolite indole-3-propionic acid (IPA) plays an important role in maintaining intestinal mucosal homeostasis, while the molecular mechanisms underlying IPA regulation on mucosal CD4+ T cell functions in inflammatory bowel disease (IBD) remain elusive. …”
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Features of the formation of specific immunity after vaccination against viral hepatitis B in children and young people by E. O. Kochetova, O. V. Shamsheva, I. V. Polesko, A. V. Semenenko, O. A. Maiorova, V. V. Belyakova, V. V. Gorev

“…Thus, due to the weak response to the recombinant hepatitis B vaccine and the high medical and social significance of hepatitis B infection, various approaches are currently being developed to enhance the effectiveness of vaccination: changes in the vaccination regimen; correction of immune system functions to restore an adequate response to vaccine preparations, the use of various adjuvants, including recombinant interferons.…”
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Cannabinoid type-1 receptors in CaMKII neurons drive impulsivity in pathological eating behavior by Elena Martin-Garcia, Laura Domingo-Rodriguez, Beat Lutz, Rafael Maldonado, Inigo Ruiz de Azua

“…Methods: We applied a genetic strategy to reconstitute cannabinoid type-1 receptor (CB1) expression at functional levels specifically in CaMKII+ neurons (CaMKII-CB1-RS) and adipocytes (Ati-CB1-RS), respectively, in a CB1 deficient background. …”
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Community, facility and individual level impact of integrating mental health screening and treatment into the primary healthcare system in Sehore district, Madhya Pradesh, India by Crick Lund, Vikram Patel, Rahul Shidhaye, Emily Baron, Vaibhav Murhar, Sujit Rathod, Azaz Khan, Abhishek Singh, Sanjay Shrivastava, Shital Muke, Ritu Shrivastava

“…Patients with depression who received care as part of the MHCP had higher rates of response (52.2% in the treatment group vs 26.9% in the comparison/usual care group), early remission (70.2% in the treatment group vs 44.8% in the comparison/usual care group) and recovery (56.1% in the treatment group vs 28.5% in the comparison/usual care group), but there was no impact of treatment on their functioning.Conclusions While dedicated human resources (eg, Case Managers) and dedicated space for mental health clinics (eg, Mann-Kaksha) strengthen the ‘formal’ healthcare platform, without substantial additional investments in staff, such as Community Health Workers/Accredited Social Health Activists to improve community level processes and provision of community-based continuing care to patients, we are unlikely to see major changes in coverage or clinical outcomes.…”
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Relaxin mimetic in pulmonary hypertension associated with left heart disease: Design and rationale of Re‐PHIRE by Marcin Ufnal, Kathleen Connolly, Marcus Millegard, Elena Surkova, Marco Guazzi, Diana Bonderman, Justin Ezekowitz, Finn Gustafsson, Michał Ciurzyński, Raquel López Vilella, Tariq Ahmad, Roy Gardner, Pavel Jansa, Sandra vanWijk, Koichiro Kinugawa, Erik Björklund, Zhi‐Cheng Jing, Stephan Rosenkranz

“…Abstract Aims Despite receiving guideline‐directed medical heart failure (HF) therapy, patients with pulmonary hypertension associated with left heart disease (PH‐LHD) experience higher mortality and hospitalization rates than the general HF population. AZD3427 is a functionally selective, long‐acting mimetic of relaxin, a hormone that has the potential to induce vasodilation and prevent fibrosis. …”
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NAD+ metabolism enzyme NNMT in cancer-associated fibroblasts drives tumor progression and resistance to immunotherapy by modulating macrophages in urothelial bladder cancer by Jian Huang, Bo Wang, Dong Yan, Tianxin Lin, Lu Pei, Hao Yu, Wang He, Kaiwen Li, Meihua Yang, Weibin Hou, Honghui Zeng, Xin-Ke Zhang, Long Huang, Haide Qin

“…Targeting NNMT using the inhibitor 5-Amino-1-methylquinolinium iodide significantly reduced tumor growth and enhanced the apoptotic effects of the anti-PD-L1 antibody in UBC mouse models. …”
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N-terminus GTPase domain of the cytoskeleton protein FtsZ plays a critical role in its adaptation to high hydrostatic pressure by Xue-Hua Cui, Xue-Hua Cui, Yu-Chen Wei, Xue-Gong Li, Xue-Gong Li, Xiao-Qing Qi, Xiao-Qing Qi, Long-Fei Wu, Long-Fei Wu, Long-Fei Wu, Wei-Jia Zhang, Wei-Jia Zhang

“…The specific characteristics of FtsZ that allow for functional cell division in the deep-sea environments, especially in obligate piezophiles that grow exclusively under HHP condition, remain enigmatic. …”
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SENP1-SIRT3 axis mediates glycolytic reprogramming to suppress inflammation during Listeria monocytogenes infection by Yan Xiong, Yongliang Du, Feng Lin, Beibei Fu, Dong Guo, Zhou Sha, Rong Tian, Rui Yao, Lulu Wang, Zixuan Cong, Bohao Li, Xiaoyuan Lin, Haibo Wu

“…We have demonstrated that sentrin-specific protease 1 (SENP1) functions as a protective gene in the host, suppressing the inflammatory response triggered by Listeria monocytogenes. …”
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A review of anticorrosive, superhydrophobic and self-healing properties of coating-composites as corrosion barriers on magnesium alloys: Recent advances, challenges and future dire... by Babalola Aisosa Oni, Olusegun Stanley Tomomewo, Solomon Evro, Andrew N. Misiani, Samuel Eshorame Sanni

“…The most recent research efforts have been directed towards the preparation of multifunctional composites, with an emphasis on nanomaterials, functional polymers, and state-of-the-art fabrication techniques in order to take advantage of their synergistic effects. …”
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Massage positively influences daytime brain activity and reduces arousal state in poor sleepers: a randomized controlled trial by Ilias Ntoumas, Christina Karatzaferi, Fotini Boubougiatzi, Nefeli Manakou, Artemis Aslanidi, Christoforos D. Giannaki, Fotini Papanikolaou, Efthimios Dardiotis, Eleftherios Lavdas, Giorgos K. Sakkas

“…The purpose of the present study was to investigate the effect of two different types of manual massage sessions on day-time napping in poor sleepers. …”
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