Massive dissemination of a SARS-CoV-2 Spike Y839 variant in Portugal by Vítor Borges, Joana Isidro, Helena Cortes-Martins, Sílvia Duarte, Luís Vieira, Ricardo Leite, Isabel Gordo, Constantino P. Caetano, Baltazar Nunes, Regina Sá, Ana Oliveira, Raquel Guiomar, João Paulo Gomes

“…Our data supports population/epidemiological (founder) effects contributing to the Y839 variant superspread. …”
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Deciphering the role of SEMA4A/MAPK signaling in sepsis: insights from Mendelian randomization, transcriptomic, single-cell sequencing analyses, and vitro experiments by Meng-Qin Pei, Yan-Ling Lin, Li-Ming Xu, Yu-Shen Yang, Zhen-Dong Sun, Ya-Fen Zeng, Gui-Dan Wang, He-Fan He, Li-Ying Yu, Li-Ying Yu

“…Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were conducted to elucidate the functional pathways of core genes. Single-cell RNA sequencing (scRNA-seq) analysis was employed to evaluate gene expression profiles across various cell types in sepsis. …”
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Dietary Chinese herbal formula supplementation improves yolk fatty acid profile in aged laying hens by Zhihua Li, Chengwen Meng, Md. Abul Kalam Azad, Wencao Lin, Jue Gui, Yadong Cui, Wei Lan, Qinghua He, Xiangfeng Kong

“…Chinese herbal formula (CHF) has the potential to improve the performance of aged laying hens through integrated regulation of various physiological functions. The present study aimed to investigate the effects of dietary CHF supplementation on the yolk fatty acid profile in aged laying hens. …”
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Personalized brain models link cognitive decline progression to underlying synaptic and connectivity degeneration by Lorenzo Gaetano Amato, Alberto Arturo Vergani, Michael Lassi, Jacopo Carpaneto, Salvatore Mazzeo, Valentina Moschini, Rachele Burali, Giovanni Salvestrini, Carlo Fabbiani, Giulia Giacomucci, Giulia Galdo, Carmen Morinelli, Filippo Emiliani, Maenia Scarpino, Sonia Padiglioni, Benedetta Nacmias, Sandro Sorbi, Antonello Grippo, Valentina Bessi, Alberto Mazzoni

“…Here, we introduce a Brain Network Model (BNM) simulating the effects of neurodegeneration on neural activity during cognitive processing. …”
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Evaluating PFAS-Induced modulation of peripheral blood mononuclear cells (PBMCs) immune response to SARS-CoV-2 spike in COVID-19 Vaccinees by Humblenoble Stembridge Ayuk, Arkadiusz Pierzchalski, Tamara Tal, Oddvar Myhre, Birgitte Lindeman, Nicola Margareta Smith, Violeta Stojanovska, Ana Claudia Zenclussen

“…The persistent nature of the environmental contaminants per- and polyfluoroalkyl substances (PFAS) has recently received considerable attention, particularly because of their adverse effects on immune system functionality in the context of vaccine responses to infectious diseases. …”
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Insights into the human cDNA: A descriptive study using library screening in yeast by Zina Alaswad, Nayera E. Attallah, Basma Aboalazm, Eman S. Elmeslhy, Asmaa S. Mekawy, Fatma A. Afify, Hesham K. Mahrous, Ashrakat Abdalla, Mai A. Rahmoon, Ahmed A. Mohamed, Ahmed H. Shata, Rana H. Mansour, Fareed Aboul-ela, Mohamed Elhadidy, Biola M. Javierre, Sherif F. El-Khamisy, Menattallah Elserafy

“…The utilization of human cDNA libraries in yeast genetic screens is an approach that has been used to identify novel gene functions and/or genetic and physical interaction partners through forward genetics using yeast two-hybrid (Y2H) and classical cDNA library screens. …”
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Wearable Arduino-Based Electronic Interactive Tattoo: A New Type of High-Tech Humanized Emotional Expression for Electronic Skin by Chuanwen Luo, Yan Zhang, Juan Zhang, Linyuan Hui, Ruisi Qi, Yuxiang Han, Xiang Sun, Yifan Li, Yufei Wei, Yiwen Zhang, Haoying Sun, Ning Li, Bo Zhang

“…Skin is the largest organ of the human body and holds the functions of sensing, protecting, and regulating. Since ancient times, people have decorated their skin by painting themselves, cutting, and using accessories to express their personality and aesthetic consciousness as a kind of artistic expression, one that shows the development and change of aesthetic consciousness. …”
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Engineering the T6SS of Pseudomonas for targeted delivery of antibacterial and antifungal effectors by Alicia Isabel Pérez-Lorente, Mario Araujo-Garrido, Antonio de Vicente, Diego Romero, Carlos Molina-Santiago

“…Similarly, the engineered strain effectively inhibited Aeromonas hydrophila growth using the phospholipase toxin TplE from Pseudomonas aeruginosa. …”
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CD38 Deficiency Promotes Inflammatory Response through Activating Sirt1/NF-κB-Mediated Inhibition of TLR2 Expression in Macrophages by Yisong Qian, Chuqiao Chen, Leliang Ma, Ziwei Wang, Ling-Fang Wang, Li Zuo, Yaqin Yang, Xiang Huang, Meixiu Jiang, Xiaolei Wang, Huidong Shi, Mingui Fu, Ke-Yu Deng, Hong-Bo Xin

“…CD38 was first identified as a lymphocyte-specific antigen and then has been found to be widely expressed in a variety of cell types. The functions of CD38 are involved in numerous biological processes including immune responses. …”
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Contribution of IL-17C-mediated macrophage polarization to Type 17 inflammation in neutrophilic asthma by Yuhuan Wen, Qile Chen, Hao Wang, Shiyun Xie, Honglv Chen, Wenruo Yao, Le Zhang, Weimin Sun, Junjie Wen, Xiaojing Yang, Kian Fan Chung, Qingling Zhang, Ailin Tao, Jie Yan

“…In vitro, IL-17C in synergy with IFN-γ induced STAT1 activation in Il-17re overexpressed Raw264.7 to upregulate M1-related genes expression, and promoted pro-inflammatory M1 polymerization, whereas IL-17C in contrast to the effect of IL-4 inhibited STAT6 activation, to reduce Raw264.7 differentiation to M2 macrophage and functional M2-related genes expression. …”
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Investigating the temperature-dependent selectivity of CO2 reduction on Ru-cluster catalysts supported by MXene by Yueying Liu, Xiang Li, Yi Li, Rong Wei, Hongwei Tan, Xichen Li, Guangju Chen

“…The catalytic conversion of carbon dioxide (CO2) into valuable products represents a promising strategy for mitigating the greenhouse effect. However, developing catalysts that exhibit both high activity and selectivity remains a considerable challenge. …”
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Targeted protein editing technique in living mammalian cells by peptide-fused PNGase by Min Wu, Guijie Bai, Ziyi Zhang, Haixia Xiao, Wenliang Sun, Chaoguang Tian

“…This tool enables editing protein sequences post-de-N-glycosylation in living human cells, shedding light on protein N-glycosylation functions, and Asn to Asp editing in organisms. It also offers the potential for developing protein degradation technologies.…”
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Trade-Offs of Plant Biomass by Precipitation Regulation Across the Sanjiangyuan Region of Qinghai–Tibet Plateau by Mingxue Xiang, Gang Fu, Junxi Wu, Yunqiao Ma, Tao Ma, Kai Zheng, Zhaoqi Wang, Xinquan Zhao

“…Climate change alters plant biomass allocation and aboveground–belowground trade-offs in grassland ecosystems, potentially affecting critical functions such as carbon sequestration. However, uncertainties persist regarding how precipitation gradients regulate (1) responses of aboveground biomass (AGB), belowground biomass (BGB), and total biomass in alpine grasslands, and (2) precipitation-mediated AGB-BGB allocation strategies. …”
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Treating postextubation dysphagia after stroke with pharyngeal electrical stimulation –insights from a randomized controlled pilot trial by Sonja Suntrup-Krueger, Bendix Labeit, Jonas von Itter, Anne Jung, Inga Claus, Sigrid Ahring, Tobias Warnecke, Rainer Dziewas, Paul Muhle

“…FEDSS at days 5–7 and 8–10 showed a sustained treatment effect over time (2.4 vs. 3.7 ​pts. and 2.2 vs. 3.4 ​pts), resulting in better FOIS at discharge (4.7 vs. 3.5 pts.). …”
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Optical Imaging Demonstrates Tissue-Specific Metabolic Perturbations in Mblac1 Knockout Mice by Busenur Ceyhan, Parisa Nategh, Mehrnoosh Neghabi, Jacob A. LaMar, Shalaka Konjalwar, Peter Rodriguez, Maureen K. Hahn, Matthew Gross, Gregory Grumbar, Kenneth J. Salleng, Randy D. Blakely, Mahsa Ranji

“…Interestingly, the AD risk associated with MBLAC1 arises in subjects with cardiovascular morbidity, suggesting a broader functional insult arising from reduced MBLAC1 protein expression and one possibly linked to metabolic alterations. …”
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Integrating multi-omics techniques and in vitro experiments reveals that GLRX3 regulates the immune microenvironment and promotes hepatocellular carcinoma cell proliferation and in... by Yang Li, Yuan Chen, Yuan Chen, Yang Zhang, Yunsheng Fang, Yunsheng Fang, Ling Wu, Ying Zhao, Danqiong Wang, Xiaoyuan Qiao

“…By cell communication analysis as well as GO and KEGG enrichment analysis, we determined the functional role of iron metabolism in different cell types. …”
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PRDM16 suppresses ferroptosis to protect against sepsis-associated acute kidney injury by targeting the NRF2/GPX4 axis by Qiang Zheng, Jihong Xing, Xiaozhou Li, Xianming Tang, Dongshan Zhang

“…This study reveals that lipopolysaccharide (LPS) and cecum ligation and puncture (CLP) instigated PRDM16 expression in Boston University mouse proximal tubule (BUMPT) cells and mouse kidneys, respectively. Functionally, PRDM16 curtailed LPS-induced ferroptosis. …”
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Feedback of patient-reported outcomes to healthcare professionals for comparing health service performance: a scoping review by Dominique A Cadilhac, Shaun L Hancock, Olivia F Ryan, Violet Marion, Sharon Kramer, Paulette Kelly, Sibilah Breen

“…Objective Patient-reported outcomes (PROs) provide self-reported patient assessments of their quality of life, daily functioning, and symptom severity after experiencing an illness and having contact with the health system. …”
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Leucine-rich repeat-containing 56 promotes breast cancer progression via modulation of the RhoA/ROCKs signaling axis by Xiqian Zhou, Jiaxin Wang, Meiling Lu, Lin Fang, Junyong Zhao, Dengfeng Li

“…Further, via in-vivo assessments, we demonstrated that downregulation of LRRC56 effectively inhibits the growth of breast cancer xenograft tumors and their metastasis to the lungs. …”
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Vaspin alleviates pathological cardiac hypertrophy by regulating autophagy-dependent myocardial senescence by Haiying Rui, Huaxiang Yu, Dan Zou, Kai Chi, Ping Xu, Xiaoshuai Song, Lulu Liu, Xuting Wu, Jinxin Wang, Li Xue

“…However, it remains unclear whether vaspin exerts specific effects on pathological cardiac hypertrophy. Methods. …”
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