Artificial intelligence-based spatial analysis of tertiary lymphoid structures and clinical significance for endometrial cancer by Haruka Suzuki, Kohei Hamada, Junzo Hamanishi, Akihiko Ueda, Ryusuke Murakami, Mana Taki, Rin Mizuno, Koichi Watanabe, Hanako Sato, Yuko Hosoe, Hiroaki Ito, Koji Yamanoi, Hiroyuki Yoshitomi, Nobuyuki Kakiuchi, Ken Yamaguchi, Noriomi Matsumura, Seishi Ogawa, Hideki Ueno, Masaki Mandai

“…Our findings indicate that the functions and prognostic implications of TLSs may vary with their locations, and dTLSs may serve as prognostic factors and predictors of treatment efficacy. …”
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Isolation and Characterization of L-Asparaginase-Producing Bacteria from the Arabian–Persian Gulf Region: First Report on <i>Bacillus xiamenensis</i> ASP-J1-4 as a Producer and Its... by Ghofran M. Al-Harbi, Essam Kotb, Abeer A. Almiman, Mahmoud M. Berekaa, Salwa Alhamad, Nada F. Alahmady, Meneerah A. Aljafary, Nadiyah M. Alqazlan, Reem I. Alyami, Joud M. Alqarni, Ebtesam Abdullah Al-Suhaimi

“…L-asparaginase (L-ASNase) functions as a chemotherapeutic enzyme with antitumor properties. …”
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Phosphorus enrichment mediates the responses of plant lignin and microbial necromass accumulation to nitrogen addition in subalpine forest soil by Ruyi Luo, Yakov Kuzyakov, Ji Chen, Wei Qiang, Yan Zhang, Xueyong Pang

“…We used amino sugars and lignin phenols as biomarkers for quantifying microbial necromass and plant lignin components, respectively, and separated SOC into distinct functional C pools, such as particulate organic C (POC) and mineral-associated organic C (MAOC). …”
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Isobavachalcone ameliorates Alzheimer disease pathology by autophagy-mediated clearance of amyloid beta and inhibition of NLRP3 inflammasome in primary astrocytes and 5x-FAD mice by Dilpreet Kour, Dilpreet Kour, Parul Khajuria, Parul Khajuria, Kuhu Sharma, Kuhu Sharma, Alpa Sharma, Alpa Sharma, Ankita Sharma, Ankita Sharma, Syed Mudassir Ali, Priya Wazir, P. Ramajayan, P. Ramajayan, Sanghapal D. Sawant, Sanghapal D. Sawant, Sanghapal D. Sawant, Utpal Nandi, Utpal Nandi, Zabeer Ahmed, Zabeer Ahmed, Ajay Kumar, Ajay Kumar

“…Two months of treatment of 5x-FAD mice with IBC at 25 and 50 mg/kg significantly improved cognitive functions, as evidenced by enhanced memory and motor performance in behavioral tests. …”
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ErbB4 precludes the occurrence of PTSD-like fear responses by supporting the bimodal activity of the central amygdala by Kibong Sung, Min-Jae Jeong, Taesik Yoo, Jung Hoon Jung, Sumin Kang, Jong-Yeon Yoo, Hyun Jin Kim, Kyunghyun Park, Jung Hyun Pyo, Hyun-Yong Lee, Noah Koo, Soo-Hee Choi, Joung-Hun Kim

“…Taken together, our data substantiate the correlation between PTSD-like fear responses and ErbB4 expression in CeLSST neurons and further underscore the functional effects of ErbB4 in CeLSST neurons, supporting the bimodal responses of CeL neurons.…”
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Adipocyte-Mediated Electrophysiological Remodeling of PKP-2 Mutant Human Pluripotent Stem Cell-Derived Cardiomyocytes by Justin Morrissette-McAlmon, Christianne J. Chua, Alexander Arking, Stanley Chun Ming Wu, Roald Teuben, Elaine Zhelan Chen, Leslie Tung, Kenneth R. Boheler

“…Conclusions: Our study shows that hiPSC-CMs from normal and mPKP2 ACM lines exhibit distinct molecular and functional responses to paracrine factors, with differences in RNA expression and electrophysiology. …”
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Dissolved organic matter fosters core mercury-methylating microbiomes for methylmercury production in paddy soils by Q. Pu, B. Meng, J.-H. Huang, K. Zhang, K. Zhang, J. Liu, Y. Liu, M. A. Abdelhafiz, M. A. Abdelhafiz, M. A. Abdelhafiz, X. Feng, X. Feng

“…Overall, DOM simultaneously changes core Hg-methylating microbiome composition and functional activity and thus enhances MeHg production in paddy soils.…”
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Two-year follow-up of patients with myocardial injury during acute COVID-19: insights from the CARDIO COVID 20–21 registry by Juan Pablo Arango-Ibanez, Juan Pablo Arango-Ibanez, Brayan Daniel Cordoba-Melo, Brayan Daniel Cordoba-Melo, Mario Miguel Barbosa Rengifo, Mario Miguel Barbosa Rengifo, Jesika Daniela Tobar-Arteaga, Maria Lucia Castro-Trujillo, Cesar José Herrera, Miguel Ángel Quintana Da Silva, Andrés Felipe Buitrago Sandoval, María Lorena Coronel Gilio, Freddy Pow Chon Long, Liliana Cárdenas Aldaz, Andrea Valencia, Carlos Enrique Vesga-Reyes, Carlos Enrique Vesga-Reyes, Carlos Enrique Vesga-Reyes, Juan Esteban Gómez-Mesa, Juan Esteban Gómez-Mesa, Juan Esteban Gómez-Mesa

“…Patients with MI had greater odds of cardiopulmonary hospitalizations during follow-up (aOR 3.67, 95% CI 1.07–13.07, p = 0.037) after adjusting for age and sex.ConclusionPatients with prior MI during COVID-19 had a higher prevalence of comorbidities, poorer functional status, and increased odds of cardiopulmonary hospitalizations over a two-year follow-up evaluation compared to those without MI. …”
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Microsurgical and endovascular treatment of large and giant aneurysms of the anterior circulation: A systematic review by Alejandra Mosteiro, Leire Pedrosa, Marta Codes, Luís Reyes, Mariano Werner, Sergio Amaro, Joaquim Enseñat, Ana Rodríguez-Hernández, Marlien Aalbers, Jeroen Boogaarts, Ramon Torné

“…Discussion and conclusions: According to contemporary data about occlusion rates, functional outcomes, and complications, primary or secondary treatment of LGIAs of the anterior circulation seems justified. …”
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Comparison of Dietary Inorganic and Small-Peptide Chelating Trace Minerals on Growth Performance, Immunity, Meat Quality, and Environmental Release in <i>Litopenaeus vannamei</i> by Jingshen Chen, Nan Liu, Shumeng Wang, Hailong Wang, Kun Ouyang, Yuxuan Wang, Junyi Luo, Jiajie Sun, Qianyun Xi, Yuping Sun, Yongguo Si, Yongliang Zhang, Ting Chen

“…Therefore, replacing 40–50% ITMs with SPMs can maintain growth performance while enhancing physiological functions. In conclusion, the results of this study demonstrate that the incorporation of 30–50% SPMs into one’s diet constitutes a viable alternative to 100% ITMs.…”
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Utility of [18F]FDG PET/CT in sarcoidosis management: A retrospective case series by Mourad Zekri, Majdouline Bel Lakhdar, Dounia Alami, Soumia Kriouile, Leila Achachi, Abdellah Achir, Hicham Harmouche, Ayat Mouaden, Hasnae Guerrouj, Imad Ghfir

“…It is crucial to assess the disease’s extent, activity, and severity to effectively manage and monitor patients with sarcoidosis. …”
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The NFATC2/Nrf2 cascade regulates spinal cord ischemia-reperfusion injury by controlling inflammation, apoptosis and oxidative stress by Kunbin Li, Liming Lu, Xianli Yao, Zhiyuan Wu, Pingge Sun, Xiaopeng Wen, Xiaoxing Li, Kai Wang, Xiran Yin

“…The upregulation of Nrf2, a primary orchestrator of the oxidative stress response, has beneficial effects in SCII. Here, we aimed to uncover a SCII-related transcription factor that is able to elevate Nrf2 expression. …”
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Drone mapping links reindeer browsing during an herbivory pulse to divergent vegetation community responses by Marcus P Spiegel, Jeffrey T Kerby, Dorothée Ehrich, Alexander Volkovitskiy, Alexandra Terekhina, Violetta Filippova, Kirill Shklyar, Natalia Sokolova, Aleksandr A Sokolov, Marc Macias-Fauria

“…Large herbivores regulate ecosystem structure and functioning across Earth’s biomes, but vegetation community responses to herbivory depend on complex interactions involving the timing and intensity of herbivory pressure and other, often abiotic, controls on vegetation. …”
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Hamilton Rating Scale for Anxiety: exploring validity with robust measures of classical theory parameters and a rating scale model in university students by Md Dilshad Manzar, Faizan Z. Kashoo, Mohammed Salahuddin, Dejene Nureye, Habtamu Acho Addo, Seithikurippu R. Pandi-Perumal, Amir H. Pakpour, Ahmed S. Bahammam

“…Four threshold estimates (τi1, τi2, τi3 and τi4) for each item were ordered as expected. Differential item functions showed item-level measurement invariance for all the 14 HRSA items across gender for both uniform and non-uniform estimates. …”
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Proteomic profiling improves prognostic risk stratification of the Sarculator nomogram in soft tissue sarcomas of the extremities and trunk wall by Madhumeeta Chadha, Sara Iadecola, Andrew Jenks, Valeriya Pankova, Yuen Bun Tam, Jessica Burns, Amani Arthur, Christopher P. Wilding, Liang Chen, Priya Chudasama, Dario Callegaro, Dirk C. Strauss, Khin Thway, Alessandro Gronchi, Robin L. Jones, Rosalba Miceli, Sandro Pasquali, Paul H. Huang

“…Results DNA replication and cell cycle proteins were upregulated in high‐risk versus very low‐risk patients. Evaluation of the functional effects of CRISPR‐Cas9 gene knockdown of proteins enriched in high‐risk patients using the cancer cell line encyclopaedia database identified candidate drug targets. …”
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Changes in the structure and properties of graphene oxide surfaces during reduction and modification by M. T. Kartel, K. V. Voitko, Y. Grebelna, S. V. Zhuravskyi, K. Ivanenko, T. V. Kulyk, S. M. Makhno, Yu. I. Sementsov

“…According to the results of IR spectroscopy, also confirmed by TPD-MS, GO has a large number of functional surface groups: (OH), (C=O), (C=C), (C-O-C), (CO-O-CO), (CH). …”
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Risk for ocular hypertension progression to early glaucoma: A predictive model and key predictors by Shaofen Huang, Man Luo, Guitong Ye, Zhenlan Yang, Lingling Liao, Nina Wu, Yingting Zhu, Xing Liu, Yehong Zhuo, Hui Xiao

“…Methods: Patients with OHT with at least two follow-up visits within 3 years were categorized into non-progressive and progressive groups based on optic nerve morphology and/or functional changes during follow-up. Data were split into training and testing sets (8:2 ratio). …”
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Interleukin‐11 promotes lung adenocarcinoma tumourigenesis and immune evasion by Cristina Cirauqui, Laura Ojeda, Itziar Otano, Irene Pazos, Alba Santos, Eva M. Garrido‐Martín, Patricia Yagüe, Javier Ramos‐Paradas, Sonia Molina‐Pinelo, Giovanna Roncador, José Luis Solórzano, M. Teresa Muñoz, Patricia Cozar, Patricia Plaza, Rocío Suárez, Marta Jiménez, Roberto Moreno, Arantxa Rosado, Pablo Gámez, Ricardo García‐Luján, Jon Zugazagoitia, E. Alejandro Sweet‐Cordero, Mariano Barbacid, Amancio Carnero, Irene Ferrer, Luis Paz‐Ares

“…Conclusion The IL‐11/IL‐11RA axis emerges as a critical driver of LUAD tumourigenesis, exerting its effects through enhanced tumour cell proliferation and remodelling of the tumour microenvironment. …”
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Linoleic acid metabolite 13-Hydroxyoctadecadienoic acid as a biphasic ferroptosis modulator in granulosa cells: multi-omics analysis of ovine atretic follicles by Yukun Song, Erhan Hai, Lixia He, Ning Zhang, Nan Zhang, Junlan Wang, Yupeng Sun, Dengke Zeng, Jiaxin Zhang, Jiaxin Zhang

“…Cell viability, lipid peroxidation levels, ferroptosis-related markers, and ferroptosis-related genes were measured.ResultsThe metabolomic analysis identified 87 and 48 differentially expressed metabolites in healthy and atretic follicles, respectively. Functional enrichment of atretic follicle fluid highlighted pathways related to linoleic acid and purine metabolism. …”
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Valorization of resistant starch from acorns as a new ingredient for chocolate milk puddings by Luís M.G. Castro, Sérgio C. Sousa, Manuela Machado, Elisabete M.C. Alexandre, Jorge A. Saraiva, Manuela Pintado

“…Milk puddings are widely consumed all over the world and are usually produced using representative amounts of starch, making them an enticing food matrix for incorporating acorn starches. Hence, the effects of replacing commercial corn starch with acorn starch extracted by high hydrostatic pressure and pulsed electric field on the nutritional composition, functional and sensorial properties, and shelf-life of puddings were studied. …”
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