Incorporating the Acclimation of Photosynthesis and Leaf Respiration in the Noah‐MP Land Surface Model: Model Development and Evaluation by Yanghang Ren, Han Wang, Sandy P. Harrison, I. Colin Prentice, Giulia Mengoli, Long Zhao, Peter B. Reich, Kun Yang

“…While some land surface models (LSMs) now account for thermal acclimation, they do so by assigning empirical parameterizations for individual plant functional types (PFTs). Here, we have implemented an Eco‐Evolutionary Optimality (EEO)‐based scheme to represent the universal acclimation of photosynthesis and leaf respiration to multiple environmental effects, and that therefore requires no PFT‐specific parameterizations, in a standard version of the widely used LSM, Noah MP. …”
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Customization of Ethylene Glycol (EG)‐Induced BmoR‐Based Biosensor for the Directed Evolution of PET Degrading Enzymes by Min Li, Zhenya Chen, Wuyuan Zhang, Tong Wu, Qingsheng Qi, Yi‐Xin Huo

“…The ingeniously designed SUMO‐MHETase‐FastPETase (SMF) chimera successfully addresses the functional soluble expression of MHETase in Escherichia coli and mitigates the inhibitory effect of mono‐(2‐hydroxyethyl) terephthalic acid (MHET) intermediate commonly observed with PETase alone. …”
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Real-world evaluation of ImmuCare-PRO patient-reported outcomes in melanoma patients treated with immune checkpoint inhibitors by S. Belkaïd, S. Milley, R. Saux, M. Bonjour, A. Augros, P.-J. Souquet, D. Maillet, D. Maucort-Boulch, C. Dolla, L. Thomas, S. Dalle

“…False alerts often resulted from functional or non-specific symptoms (32.3%), such as fatigue or general pain. …”
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Integrating geographic information systems into veterinary education within the one health framework: an interdisciplinary approach by Antonio Contreras, Víctor Cuevas, Jorge Rivera-Gomis, Jorge Rivera-Gomis, Antonio Sánchez, Pelayo Acevedo, Joaquin Vicente

“…This gap limits the ability of veterinary students to effectively utilize spatial data in their future professional practice.MethodsTo address this educational shortfall, we implemented a teaching innovation project at the University of Murcia, aimed at incorporating GIS training into veterinary education. …”
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Antioxidant activity and metabolic profile changes in Poria cocos fermented by breast-milk-derived Limosilactobacillus reuteri HM-R28 by Xiaojing Li, Xianping Li, Xianping Li, Lu Liu, Lu Liu, Junying Zhao, Junying Zhao, Yue Zhang, Lijun Chen, Lijun Chen

“…IntroductionThe fermentation of lactic acid bacteria can alter the nutraceutical and functional efficacy of food and medicinal products, particularly when involving bioactive compounds similar to those in Poria cocos (P. cocos), which include polysaccharides and triterpenoids. …”
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Photocatalytic degradation of phenol using cadmium-TiO2/chitosan hybrid catalysts by D Ángeles-Beltrán, G Chavez-Esquivel, J A Tavizón-Pozos, V A Suárez-Toriello, C E Santolalla-Vargas, O Aguilar-Martínez

“…Incorporating the Cd and Q into TiO _2 system modified the surface properties of the Cd-TiO _2 /Q catalyst, reducing the surface area by up to 7-fold compared to TiO _2 . The synergistic effect of the Cd ^2+ and Q functional groups is responsible for the improved performance of Cd-TiO _2 /Q, despite its lower specific surface area. …”
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The African swine fever virus MGF300-4L protein is associated with viral pathogenicity by promoting the autophagic degradation of IKKβ and increasing the stability of IκBα by Tao Wang, Rui Luo, Jing Zhang, Jing Lan, Zhanhao Lu, Huanjie Zhai, Lian-Feng Li, Yuan Sun, Hua-Ji Qiu

“…In this study, we found that MGF300-4L could effectively inhibit the production of proinflammatory cytokines IL-1β and TNF-α, which are regulated by the NF-κB signaling pathway. …”
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Exploring the Potential of a New Nickel(II):Phenanthroline Complex with L-isoleucine as an Antitumor Agent: Design, Crystal Structure, Spectroscopic Characterization, and Theoretic... by Jayson C. dos Santos, João G. de Oliveira Neto, Ana B. N. Moreira, Luzeli M. da Silva, Alejandro P. Ayala, Mateus R. Lage, Rossano Lang, Francisco F. de Sousa, Fernando Mendes, Adenilson O. dos Santos

“…A Hirshfeld surface analysis highlighted intermolecular interactions stabilizing the crystal lattice, with hydrogen bonds (H···H and O···H/H···O) dominating (99.1% of contacts). Density functional theory (DFT) calculations, including solvation effects (in water and methanol), demonstrated strong agreement with the experimental geometric parameters and revealed higher affinity to the water solvent. …”
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Targeting the mTOR Signaling Pathway Through miR‐100 and miR‐101 in De Novo Acute Myeloid Leukemia: Implications for Therapeutic Intervention by Maryam Kargar, Mehdi Allahbakhshian Farsani, Javad Garavand, Mahnaz Gorji, Mohammad Rafiee, Seyed Sobhan Bahreiny, Mohammad Hossein Mohammadi

“…ABSTRACT Background Microribonucleic acid (MicroRNAs/miRNAs) play a significant role in cancer progression by changing cellular functions through the modulation of protein expressions. …”
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Identification of dimethyl 2,2’-((methylenebis(2-(2H-benzo[d][1,2,3]triazol-2-yl)-4-(2,4,4-trimethylpentan-2-yl)-6,1phenylene))bis(oxy))diacetate (TAJ4) as antagonist of NEK-Family... by Mubashir Aziz, Syeda Abida Ejaz, Pervaiz Ali Channar, Ali G. Alkhathami, Tahir Qadri, Zahid Hussain, Mumtaz Hussaain, Rabail Ujan

“…Furthermore, in-silico investigations, including density functional theory (DFT) calculations and molecular docking studies, revealed a substantial reactivity profile of TAJ4, with promising molecular interactions against NEK7, NEK9, TP53, NF-KAPPA-B, and caspase-3 proteins. …”
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A Quantitative Risk Assessment Model for <i>Listeria monocytogenes</i> in Non-Ready-to-Eat Frozen Vegetables by Ursula Gonzales-Barron, Régis Pouillot, Juliana De Oliveira Mota, Akio Hasegawa, Ana Allende, Qingli Dong, Matthew J. Stasiewicz, Jovana Kovacevic, Vasco Cadavez, Laurent Guillier, Moez Sanaa

“…Based on available published data, the model was coded in nine sequential R functions designed to assess the effectiveness of blanching, the improvement in processing environment hygiene, the implementation of sampling schemes at the end of processing, and improved consumer instructions on the product’s package. …”
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Abundant Cu3P/Co2P/CoP@NC Heterostructures Boost Charge Transfer Toward Fast and Durable Sodium Storage by Yuzhang Zhou, Yunxiu Wang, Yifan Zhang, Zhongchao Bai, Ming Yue Wang, Yanjun Zhai, Wei Du, Zhenhua Yan, Shi Xue Dou, Nana Wang, Fuyi Jiang, Caifu Dong

“…Kinetic analyses (cyclic voltammetry, electrochemical impedance spectroscopy, and galvanostatic intermittent titration technique) and density functional theory calculations show that the three‐phase heterostructure and carbon layer effectively improve Na adsorption and migration as well as the electrochemical reactivity of the electrode. …”
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Complete remission of advanced hepatocellular carcinoma following transient chemoembolization and portal vein ligation by Yuki Koga, Toru Beppu, Katsunori Imai, Kunitaka Kuramoto, Tatsunori Miyata, Yuki Kitano, Shigeki Nakagawa, Hirohisa Okabe, Kazutoshi Okabe, Yo-ichi Yamashita, Akira Chikamoto, Hideo Baba

“…Sorafenib is recommended in such patients, but it has limited therapeutic effectiveness. Case presentation A 54-year-old man was diagnosed with a liver abscess that was treated by puncture and drainage at a regional hospital. …”
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GERD-associated laryngeal granuloma: a series of clinical observations. Case report by Svetlana V. Starostina, Olga V. Tashchyan, Marina G. Mnatsakanyan, Konstantin A. Nazarov, Liana S. Karapetyan, Polina A. Loskutova, Irina V. Kuprina

“…Diagnosis of laryngopharyngeal reflux includes analysis of the patient's life history, registration of complaints using questionnaires, assessment of the clinical and functional state of the larynx using visual analog scales of reflux signs, the use of instrumental methods and laboratory tests. …”
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Molecular mechanism and biological pathway of high-expressed RAD51 in regulating cell adhesion and potentially affecting oral squamous cell carcinoma by Yu-Xing Tang, Yu-Yan Pang, Yan Cui, Guo-Jiao Wu, Lin-Qing Huang, Chang-Zhan Zhou, Bin Li, Qi Li, Bang-Teng Chi, Rong-Quan He, Di-Yuan Qin, Jian-Di Li, Gang Chen, Dong-Ming Li, Yi-Wu Dang

“…However, its multi-platform expression patterns and functional role in cell adhesion within the context of OSCC have not yet been comprehensively validated. …”
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Molecular Screening of SCN1A‐Related Seizures in Children With Febrile Seizures: Diagnostic Yield and Variant Distribution by Jia Wang, Yang‐Yang Wang, Lin‐Yan Hu, Xiu‐Yu Shi, Wen He, Dan Sun, Baoguang Li, Xiaoming Liu, Sanqing Xu, Lijun Du, Chunhui Tang, Li‐Ping Zou

“…Missense variants accounted for 76.5% of all pathogenic SCN1A variants, and among previously reported missense variants, those in critical functional domains were frequently associated with severe phenotypes (p = 0.042). …”
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A novel variant c.7104 + 6T > A of ABCA12 linked to autosomal recessive congenital ichthyosis verified by minigene splicing assay by Linyan Zhu, Rui Zhou, Lianxiao Zhang, Mei Chen, Shengmin Zhang, Xiaxi Huang, Yubo Shi, Huiqing Ding

“…Milder forms like LI and CIE usually involve at least one non-truncating ABCA12 variant.MethodsWhole-exome sequencing (WES) was performed on fetal and parental DNA, and ABCA12 gene variants were validated by Sanger sequencing. The functional effect of the novel variant c.7104 + 6T &gt; A was evaluated using an in vitro minigene system, with splicing analysis conducted via PCR and Sanger sequencing.ResultsA compound heterozygous variation in the ABCA12 gene, comprising c.5784G &gt; A (p.W1928*) and c.7104 + 6T &gt; A, was identified in the fetus, inherited from the father and mother, respectively. …”
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Targeting the major pro-inflammatory interleukin-6-type cytokine receptor gp130 by antagonistic single domain antibodies by Silke Pudewell, Julia Heuser, Inna Dorogobed, Britta Lipinski, Thi Hong Hue Tran, Pia Metzenmacher, Richard Kunze, Felix Geyer, Stefan Zielonka, Doreen M. Floss, Harald Kolmar, Jens M. Moll, Jürgen Scheller

“…However, this view is being reconsidered in light of the clinical success of Janus kinase (JAK) inhibitors, which broadly disrupt cytokine signaling, including pathways mediated by gp130.MethodsHere we developed four single domain antibodies (sdAb), consisting out of a camelid-derived nanobody and a human Fc-fragment, and characterized them by direct protein interaction analysis, epitope binding, epitope binning, as well as inhibition of cytokine-induced stimulation and proliferation of appropriate Ba/F3 cell lines and trans-migration in HT-29 cells.ResultsThe four sdAb-Fc constructs GP01-, GP11- GP13- and GP20-Fc bind directly to gp130 in the cytokine binding module (CBM) and largely inhibit IL-6-type cytokine signaling by interfering with the high-affinity binding site of IL-6, IL-11, CLCF1, CT1, CNTF, OSM and LIF. Furthermore, we functionally demonstrate the inhibitory effect of the selected nanobodies in cell-based transmigration assays of the human colorectal cancer cell line HT-29.DiscussionIn summary, our study has identified and characterized four novel inhibitory high-affinity gp130 nanobodies with potential for use in cytokine-dependent autoimmunity or cancer therapy.…”
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Green Synthesis of Zinc Oxide Nanoparticles with <i>Psidium cattleianum</i> Leaves Extracts as Reducing Agent: Influence of Extraction Method on Physicochemical and Biological Acti... by Christian Israel Padilla-Hernández, Jorge Manuel Silva-Jara, Martha Reyes-Becerril, Abril Fonseca-García, Luis Miguel Anaya-Esparza, Paulo Roberto Orozco-Sánchez, Juan José Rivera-Valdés, Mireille López-Orozco, Carlos Arnulfo Velázquez-Carriles, María Esther Macías-Rodríguez

“…Additionally, the reducing effect of the antioxidant extracts obtained through traditional techniques, such as infusion and maceration, was studied and compared against an emerging unconventional technology like ultrasound assisted extraction. …”
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Machine learning-based prediction model for lung ischemia-reperfusion injury: insights from disulfidptosis-related genes by Yanpeng Zhang, Yanpeng Zhang, Yanpeng Zhang, Jingyang Sun, Jingyang Sun, Jingyang Sun, Yihan Lin, Yihan Lin, Yihan Lin, Rongxuan Jiang, Rongxuan Jiang, Rongxuan Jiang, Niuniu Dong, Niuniu Dong, Niuniu Dong, Huanhuan Dong, Huanhuan Dong, Huanhuan Dong, Peng Li, Peng Li, Peng Li, Jinteng Feng, Jinteng Feng, Jinteng Feng, Zijiang Zhu, Guangjian Zhang, Guangjian Zhang, Guangjian Zhang

“…Differential expressed analysis and functional enrichment analysis were conducted to identify key genes associated with lung transplant IRI. …”
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