Analyzing the Nature of Apparent Authority in Islamic Jurisprudence and Iranian Law by Hamid Reza Habibi, Behzad Pourseyyed

“…Irreversibility: The effects of apparent authority are legally non-negotiable.     …”
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Modulating contact properties by molecular layers in organic thin‐film transistors by Li Sun, Yating Li, Jiacheng Xie, Liqi Zhou, Peng Wang, Jian‐Bin Xu, Yi Shi, Xinran Wang, Daowei He

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Aripiprazole Lauroxil: Development and Evidence-Based Review of a Long-Acting Injectable Atypical Antipsychotic for the Treatment of Schizophrenia by Citrome L, Correll CU, Cutler AJ, Dunbar M, Hoberg AR, Hopkinson C, Mattingly GW, McGrory JA, Rege B, Weiden PJ, McDonnell D

“…In longer-term studies, side effects were similar to those expected when using oral aripiprazole, and symptoms improved over extended durations of treatment lasting up to 3.5 years. …”
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Research on All-Age Friendliness Evaluation of Urban Comprehensive Parks by Xiaofang LIU, Yiran WANG, Chenchen XIAO, Sisheng YANG

“…It is suggested to optimize the planning of urban comprehensive parks in terms of functional layout, access system, spatial site, diverse land sense and evaluation mechanism in the future, apply the evaluation indicator system for all-age friendliness to implement the evaluation of planning and design schemes, built environment, etc., and coordinate innovative implementation mechanisms for urban renewal, quality improvement actions and other projects to effectively promote the construction of all-age-friendly parks and achieve high-quality urban development.…”
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Comparison of ultra-ultrabrief and ultrabrief pulse widths in right unilateral electroconvulsive therapy: A randomized trial by Jana Žaludová Heidingerová, Jakub Albrecht, Martin Anders, Daniel Divácký, Gabriela Jirečková, Thai Le Hong, Tadeáš Mareš, Václav Čapek, Harold A. Sackeim, Jozef Buday

“…Background: Ultrabrief stimulation in electroconvulsive therapy (ECT) using a 0.25 or 0.30 ms pulse width markedly reduces the charge required to reach the seizure threshold (ST) and cognitive side effects. It is not known whether further reduction of pulse width to 0.15 ms is advantageous. …”
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Tumor-associated bacteria activate PRDX1-driven glycolysis to promote immune evasion and PD-1 antibody resistance in hepatocellular carcinoma by Heng Zhang, Xi Lan, Liquan Cai, Xunfeng Gao, Feng Gao, Dan Yu, Jinlong Zhang, Jinhui Zhang, Qinwen Tai

“…In vivo, bacterial infection decreased the antitumor efficacy of PD-1 blockade by 43% (tumor volume vs. control; p = 0.008), an effect that was reversed upon PRDX1 inhibition.ConclusionOur findings identify PRDX1 as a central node in bacteria-driven metabolic reprogramming that facilitates immune evasion and resistance to PD-1 therapy in HCC. …”
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Overexpressing natural killer group 2 member A drives natural killer cell exhaustion in relapsed acute myeloid leukemia by Juan Xie, Xue-Fei Liu, Tong Zhou, Long Liu, Rui-Qin Hou, Xing-Xing Yu, Ze-Ying Fan, Qian-Nan Shang, Ying-Jun Chang, Xiao-Su Zhao, Yu Wang, Lan-Ping Xu, Xiao-Hui Zhang, Xiao-Jun Huang, Xiang-Yu Zhao

“…Blockade or genetic knockout of NKG2A effectively reversed NK cell exhaustion both in vitro and in an AML mouse model. …”
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Identification of signaling networks associated with lactate modulation of macrophages and dendritic cells by Rapeepat Sangsuwan, Bhasirie Thuamsang, Noah Pacifici, Phum Tachachartvanich, Devan Murphy, Abhineet Ram, John Albeck, Jamal S. Lewis

“…Recent studies have shown that lactate significantly modulates immune functions, especially in innate immune cells. Dendritic cells (DCs) and macrophages (MΦs) are specialized antigen-presenting cells serving as key players in innate immunity and anticancer-associated immune responses. …”
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Reprogramming Lung Redox Homeostasis by NIR Driven Ultra‐Small Pd Loaded Covalent Organic Framework Inhibits NF‐κB Pathway for Acute Lung Injury Immunotherapy by Doudou Lei, Lin Liao, Tao Qin, Xiaoxuan Guan, Kunpeng Duan, Zhiwei Gao, Weiqian Jin, Mingjing Yin, Ke Zhang, Yan Liu, Yin Chen, Huyang Gao, Jiaxiao Li, Feifei Huang, Wenjing Liu, Chengde Xia, Bailei Wang, Hualin Huang, Shengqiu Lv, Qiang Zhi, Jiahao Huang, Ming Gao, Junyu Lu

“…Notably, the TP@Pd+NIR strategy demonstrated the excellent synergistic effects in alleviating lung inflammation storms, reducing diffuse alveolar damage, and accelerating lung tissue repair. …”
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IFN-γ downregulates miR-4319 to enhance NLRC5 and MHC-I expression in MHC-I-deficient breast cancer cells by Ming-Zhen Zhao, Hua-Chuan Zheng, Yu Sun, Xiao-Feng Jiang, Li Liu, Chun-Yan Dang, Jun-Ying Li, Li-Xin Sun

“…IFN-γ inhibits miR-4319 and upregulates NLRC5, thereby enhancing expression of MHC-I in SKBR3 breast cancer cells, while limitations include the absence of functional rescue experiments and in vivo validation. …”
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Critical risks of haemoadsorption for COVID-19 patients and directions for future evaluations: a nationwide propensity score matched cohort study by Jan Andreas Kloka, Thomas Jasny, Oliver Old, Elina Nürenberg-Goloub, Christina Scharf, Patrick Meybohm, Alexander Supady, Kai Zacharowski, Benjamin Friedrichson

“…Two-sided probability values for group comparisons and regression models with spline functions controlling for non-linear relationships and medically relevant interaction variables were calculated. …”
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Ring finger protein 5 mediates STING degradation through ubiquitinating K135 and K155 in a teleost fish by Xiaowei Qin, Chuanrui Li, Mincong Liang, Zhen Qian, Yanlin You, Shaoping Weng, Jianguo He, Jianguo He, Changjun Guo, Changjun Guo

“…In mammals, ring finger protein 5 (RNF5) functions as an E3 ubiquitin ligase, mediating STING regulation through K150 ubiquitylation to prevent excessive IFN production. …”
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Identification and attribution analysis of integrated ecological zones based on the XGBoost-SHAP model: A case study of Chengdu, China by Xiaobin Huang, Xiaosheng Liu, Yuanhang Jin, Xue Gao, Youliang Chen

“…The framework integrates Ecosystem Service Value (ESV) and Landscape Ecological Risk (LER) as core indicators, applies Z-score standardization and quadrant classification to delineate four ecological zone types with distinct ecological functions, and further employs the XGBoost-SHAP model to identify key natural and anthropogenic drivers and explain their roles in spatial environmental evolution. …”
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Smoking promotes the progression of bladder cancer through FOXM1/CKAP2L axis by Feixiang Wu, Shasha Wu, Yu Huang, Xiao Xiao, Haitao Yu, Xuesong Bai, Chunlin Zhang, Zhenwei Feng, Li Li, Yuhua Mei, Xinyuan Li, Xin Gou

“…Results Both cross-sectional and MR analyses confirmed the positive relationship between smoking and bladder cancer. Functional experiments revealed that CSE treatment promoted the proliferation and metastasis of bladder cancer cells. …”
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Integration of nontarget screening and QSAR modeling to identify novel butachlor transformation products of high priority in soil and water environment by Feng Chen, Chi Wu, Lan Zhang, Liangang Mao, Lizhen Zhu, Xingang Liu

“…A probable transformation mechanism was suggested based on the identified TPs and Density Functional Theory (DFT) based calculations. Mechanistically, BTR degradation in soil primarily involves N-demethylation, N-debutoxylation and hydrolysis, whereas in water it proceeds through a more diverse array of pathways – including dechlorination, hydroxylation, dehydrogenation, N-debutoxylation, cyclization, hydrolysis, dehydration, and oxidation. …”
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Efficacy and safety of Shenxiong-Xinmaikang Decoction in patients with stable angina pectoris: a real-world prospective observational study by Yanchen Dong, Yanchen Dong, Yanchen Dong, Kaojuan Zeng, Yongzhen Liang, Yongzhen Liang, Guoping Xie, Donghui Liang, Donghui Liang

“…This study aimed to evaluate the real-world effectiveness and safety of SXXMKD as an adjunct to standard therapy for SAP.MethodsThis was a prospective, single-center, real-world observational study conducted between 2019 and 2023, enrolling 219 SAP patients (Registry: ChiCTR2100052872). …”
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Immunogenic Activity of Secreted Protein-Based Compounds Staphylococcus aureus № 6 by I. M. Gruber, E. A. Astashkina, O. V. Lebedinskaya, N. B. Egorova, M. V. Kiselevsky, F. V. Donenko, N. E. Yastrebova, O. M. Ignatova, E. A. Kurbatova, L. S. Cherkasova

“…Difficulties in the therapy of infection, caused by S. aureus, depends on the resistance of staphylococci to antibiotics, proceeding to chronicity of the diseases and the development on that background the depression of innate immunity functions and decreasing of the host resistance to the infection. …”
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Integrator complex subunit 12 knockout overcomes a transcriptional block to HIV latency reversal by Carley N Gray, Manickam Ashokkumar, Derek H Janssens, Jennifer L Kirchherr, Brigitte Allard, Emily Hsieh, Terry L Hafer, Nancie M Archin, Edward P Browne, Michael Emerman

“…We performed a CRISPR screen in conjunction with AZD5582 & I-BET151 and identified a member of the Integrator complex as a target to improve this LRA combination, specifically Integrator complex subunit 12 (INTS12). Integrator functions as a genome-wide attenuator of transcription that acts on elongation through its RNA cleavage and phosphatase modules. …”
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Adsorption of thiotepa on B12N12, Mg12O12, and Si12C12 fullerene-like cages: A DFT study by Mahboubeh Pishnamazi, Majed Ahmed Algarni, Abdullah Ali Alshehri, Humood Al Shmrany, Sameer Alshehri

“…We examined the adsorption of thiotepa (TTP) on the outer surface of B12N12, Mg12O12, and Si12C12 fullerene-like cages using density functional theory (DFT) calculations. The computations were carried out at the Perdew-Burke-Ernzerhof level with the D3 dispersion correction (PBE-D3) in a water solvent. …”
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Cellular immune signatures and differences of four porcine circovirus type 2 vaccines to heterologous PCV2d infection by Shuai Li, Jiawei Liu, Lingbo Meng, Susu Yin, Hua Wu, Jianwen Zou, Dongbo Yuan, Hairong He, Guanghao Yin, Xianfeng Jia, Xiaoli Hao, Shaobin Shang

“…Abstract Multiple PCV2 vaccines originating from different antigens and formula are commercially available and have shown great effectiveness in protecting pigs from clinical disease. …”
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