Lactic Acid Bacteria as Probiotics Improve Bioactive Compounds in Radix <i>Angelica gigas</i> (Danggui) via Solid-State Fermentation by Jeong Heo, Youn-Kyung Ham, Ah Yeong Choi, Hyouk Yoon, Ha Gyun Sung

“…Solid-state fermentation (SSF) is increasingly applied to enhance the functional properties of traditional herbal medicines. …”
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Developing an Evidence- and Theory-Informed Mother-Daughter mHealth Intervention Prototype Targeting Physical Activity in Preteen Girls of Low Socioeconomic Position: Multiphase Co... by Carol Brennan, Grainne ODonoghue, Alison Keogh, Ryan E Rhodes, James Matthews

“…These were to be targeted by 6 intervention functions (eg, education, persuasion, and modeling) and 27 behavior change techniques (eg, goal setting and self-monitoring). …”
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The Safety of Using Body-Transmit MRI in Patients with Implanted Deep Brain Stimulation Devices. by Joshua Kahan, Anastasia Papadaki, Mark White, Laura Mancini, Tarek Yousry, Ludvic Zrinzo, Patricia Limousin, Marwan Hariz, Tom Foltynie, John Thornton

“…Finally, we investigated the effect of transmit-coil choice on DBS stimulus delivery during MRI.…”
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Appropriateness of NHS 111 Wales outcomes—using the Call Prioritisation Streaming System: a RAND/UCLA modified Delphi method by Craig Brown, Conrad Fivaz, Rebecca Malin, Mike Brady, Rhiannon Elizabeth Roynon, Peter Noblett

“…Because of this significant change, it was essential to ensure that the system was functioning correctly and safely after it was implemented. …”
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Institutional animal care and use committees and the challenges of evaluating animal research proposals by John J. Pippin, Jarrod Bailey, Mark Kennedy, Deborah Dubow Press, Janine McCarthy, Ron Baron, Stephen Farghali, Elizabeth Baker, Neal D. Barnard

“…Objective To understand factors that may limit the effectiveness of Institutional Animal Care and Use Committees and identify possible solutions. …”
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CRISPR/Cas9 technology in tumor research and drug development application progress and future prospects by Han Han, Xiaoyan Sun, Xiaoyun Guo, Jiaxin Wen, Xiaoming Zhao, Weiqiang Zhou

“…Additionally, the article discusses key applications of CRISPR/Cas9 in anticancer drug discovery, including drug target identification, drug target screening and validation, combinatorial genetic screening, screening of small molecules to overcome resistance to CAR-T therapies, and multimodal functional genomics integration strategies. Finally, although CRISPR/Cas9 has demonstrated great potential for efficient gene editing, precise target discovery, and promotion of personalized therapy and drug screening in oncology research, its application still faces technical bottlenecks such as off-target effects, genomic instability, and low editing efficiency in solid tumors, as well as ethical controversies in gene editing, safety assessment of delivery systems and immune responses in clinical translation, and other ethical and translational challenges.…”
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SLCO3A1, A novel crohn's disease-associated gene, regulates nf-κB activity and associates with intestinal perforation. by Shu-Chen Wei, Yan-Yin Tan, Meng-Tzu Weng, Liang-Chuan Lai, Jen-Hao Hsiao, Eric Y Chuang, Chia-Tung Shun, Deng-Cheng Wu, Ai-Wen Kao, Chiao-Shung Chuang, Yen-Hsuan Ni, Ming-Jium Shieh, Chien-Chih Tung, Yun Chen, Cheng-Yi Wang, Ramnik J Xavier, Daniel K Podolsky, Jau-Min Wong

“…Finally, the candidate gene was cloned and its effect on NF-κB activity assessed using a reporter luciferase assay.…”
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Iol optic power calculation in patients with eye axial length 24‑28 mm without preceding refractive surgery by K. B. Pershin, N. F. Pashinova, A. Iu. Tsygankov, S. L. Legkih

“…Aim. Analysis of effectiveness of IOL calculating formulas and frequency of intra- and postoperative complications of phacoemulsification in patients with eye axial length 24.0‑28.0 mm.Patients and methods. …”
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Histomorphometric changes in pituitary gonadotropic endocrinocytes when exposed to dark deprivation by L. I. Kondakova, S. A. Kalashnikova

“…Aim. To assess the effect of 30-day dark deprivation on functional and histomorphometric changes in adenohypophysis gonadotropic endocrinocytes and their reversibility in mature male rats.Materials and methods. …”
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Proteomic Profiling of COVID-19 Patients Sera: Differential Expression with Varying Disease Stage and Potential Biomarkers by Iman Dandachi, Ayodele Alaiya, Zakia Shinwari, Basma Abbas, Alaa Karkashan, Ahod Al-Amari, Waleed Aljabr

“…Protein–protein interactions and functional annotations of identified proteins were performed using the STRING. …”
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Reactive oxygen species responsive double-locked liposome collaborative photodynamic therapy for reducing electrical conduction recurrence after radiofrequency catheter ablation by Ying Zhuge, Gonghao Li, Mingyue Sun, Jiajia Zhang, Jiafeng Zou, Feng Gao, Fang Wang

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Anti-virulence strategy of diaryl chalcogenide compounds against Candida albicans infection by Shihao Song, Shuo Zhao, Xiuyun Sun, Lili Meng, Zijie Wang, Huihui Tan, Jingyun Liu, Min Zhang, Yinyue Deng

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Polydatin combined with hawthorn flavonoids alleviate high fat diet induced atherosclerosis by remodeling the gut microbiota and glycolipid metabolism by Dan Li, Dan Li, Yujuan Li, Shengjie Yang, Xiaonan Zhang, Yu Cao, Ran Zhao, Ran Zhao, Yixi Zhao, Yixi Zhao, Xiao Jin, Jing Lu, Jing Lu, Xinyue Wang, Qiutao Wang, Longtao Liu, Min Wu

“…According to the metagenetic results, functional annotations also suggested that the biological processes of each group mainly focused on metabolism-related processes. …”
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Temporal optimization of CD25-biased IL-2 agonists and immune checkpoint blockade leads to synergistic anticancer activity despite robust regulatory T cell expansion by Blanka Rihova, Kathy Liu, Katerina Behalova, Vladyslav Mazhara, Milada Sirova, Marek Kovar, Irfan Baki Kilic, Petra Weberova, Derek VanDyke, Katerina Kubesova, Charina S Fabilane, Bohumil Ptacek, Jamie B Spangler

“…Importantly, we found that timing is crucial, as administration of IL-2cx after (but not before) ICIs led to profound antitumor effects. Mechanistically, CD25-biased IL-2cx selectively stimulated expansion and effector functions of tumor-specific CD8+ T cells in a CD25-dependent manner, overcoming Treg cell-mediated suppression. …”
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THE ROLE OF MAGNETIC RESONANCE RESEARCH IN THE TREATMENT OF DYSFUNCTION OF THE TEMPOROMANDIBULAR JOINT by V.M. Novikov, M.A. Korostashova, V.I. Dodatko, O.S. Svyryda, Ya.O. Yushchenko

“…Therefore, the next stage of treatment depended on the anatomical and functional changes of TMJ and consolidation of therapeutic effect was been necessary. …”
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KiKli Fit: Investigating the Implementation of a Physical Activity Program in Pediatric Cancer by Lars Rehbein, Ann Christin Schneider, Christina Hillebrech, Christina Schindera, Amika Singh, Katharina Eva, Valentin Benzing

“…The mediational role of executive functions for the relationship between motor ability and academic performance in pediatric cancer survivors. …”
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Long-Term Outcomes Associated with Traumatic Brain Injury in Childhood and Adolescence: A Nationwide Swedish Cohort Study of a Wide Range of Medical and Social Outcomes. by Amir Sariaslan, David J Sharp, Brian M D'Onofrio, Henrik Larsson, Seena Fazel

“…These risks were only marginally attenuated when the comparisons were made with their unaffected siblings, which implies that the effects of TBI were consistent with a causal inference. …”
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Zagociguat prevented stressor-induced neuromuscular dysfunction, improved mitochondrial physiology, and increased exercise capacity in diverse mitochondrial respiratory chain disea... by Leonard Burg, Heeyong Yoon, Min Peng, Peter Germano, Emily Reesey Gretzmacher, Rui Xiao, Vernon E. Anderson, Eiko Nakamaru-Ogiso, Eiko Nakamaru-Ogiso, Marni J. Falk, Marni J. Falk

“…No morphological or functional toxic effects of zag were observed on larvae viability. …”
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Human adenovirus type 7 (HAdV-7) infection induces pulmonary vascular endothelial injury through the activation of endothelial autophagy by Zhihe Chen, Zhongying Yang, Lifen Rao, Changgen Li, Na Zang, Enmei Liu

“…Results GSEA analysis showed significant enrichment of gene sets related to endothelial functions (barrier, defense, and regeneration) and ALI in the HAdV-7-infected group. …”
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Melatonin Alleviates Photosynthetic Injury in Tomato Seedlings Subjected to Salt Stress via OJIP Chlorophyll Fluorescence Kinetics by Xianjun Chen, Xiaofeng Liu, Yundan Cong, Yao Jiang, Jianwei Zhang, Qin Yang, Huiying Liu

“…Conversely, the injection of exogenous p-CPA exacerbated salt stress-related damage to the photosystem of tomato seedlings and diminished the beneficial effects of MT. The findings suggest that exogenous MT mitigates salt stress-induced photoinhibition by (1) modulating endogenous MT concentrations, (2) augmenting PSII reaction center functionality, (3) safeguarding the oxygen-evolving complex (OEC), (4) reinstating PSI redox potential, (5) facilitating photosynthetic electron transport, and (6) optimizing energy absorption and dissipation. …”
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