Study protocol for a randomised, double-blind, placebo-controlled study evaluating the Efficacy of cannabis-based Medicine Extract in slowing the disease pRogression of Amyotrophic... by Simon Broadley, Berzenn Urbi, Richard Bedlack, Ethan Russo, Arman Sabet

“…The primary objective of the study is to evaluate the efficacy of CBME compared with placebo in slowing the disease progression measured by differences in mean ALS Functional Rating Scale-Revised and FVC score between the groups at the end of treatment. …”
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Biofortified Calcium Phosphate Nanoparticles Elicit Secondary Metabolite Production in Carob Callus via Biosynthetic Pathway Activation by Doaa E. Elsherif, Fatmah A. Safhi, Mai A. El-Esawy, Alaa T. Mohammed, Osama A. Alaziz, Prasanta K. Subudhi, Abdelghany S. Shaban

“…To address this, we use biofortified calcium phosphate nanoparticles, which refer to CaP-NPs that have been enriched with bioactive compounds via green synthesis using Jania rubens extract, thereby enhancing their functional properties as elicitors in carob callus. …”
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FSI modeling and simulation of blood viscosity impacts on cavitation in mechanical heart valves by Joseph Amponsah, Archibong Archibong-Eso, Aliyu M. Aliyu, Tabbi Wilberforce Awotwe

“…However, mechanical issues like cavitation can undermine the valve's functionality, posing risks to both its longevity and the overall efficacy of cardiovascular treatments. …”
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A Rapid Evaluation Method of Permafrost Bearing Capacity in the Tibetan Plateau Region Based on the Correlation Between CPT-CBR by Haowu Wang, Bo Tian, Lei Quan, Panpan Zhang, Lihui Li, Yitong Hou, Sen Hu

“…To address this, this study investigates the correlation between CPT parameters and laboratory mechanical indices under the combined effects of multiple factors in frozen sandy soils. …”
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TriM-Net: Trinityformer-Mamba fusion for road extraction in remote sensing by Zhenzhong Huang, Hongjuan Shao, Chao Ren, Hongman Li, Haoming Bai, Zhou Lei, Gu Yao, Qinyi Chen

“…By leveraging their internal CausalConv1D and SSM modules, this block enhances modeling and local perception while effectively merging Transformer and CNN information for improved image reconstruction. …”
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Geospatial Robust Wheat Yield Prediction Using Machine Learning and Integrated Crop Growth Model and Time-Series Satellite Data by Rana Ahmad Faraz Ishaq, Guanhua Zhou, Guifei Jing, Syed Roshaan Ali Shah, Aamir Ali, Muhammad Imran, Hongzhi Jiang, Obaid-ur-Rehman

“…Crop traits, which historically capture the cumulative effect of these factors, exhibit functional relationships critical for optimizing productivity. …”
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The influence of halogen-containing modifier on the thermo-oxidative stability of styrene–butadiene–styrene triblock copolymers by I. S. Almatova, K. V. Sukhareva, L. R. Lyusova, S. G. Karpova, T. V. Monakhova, N. O. Belyaeva

“…However, the creation of new functional materials based on modified styrene–butadiene block copolymers will enable the development of materials with enhanced resistance to thermal-oxidative degradation. …”
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Mobilome of Environmental Isolates of <i>Clostridioides difficile</i> by Khald Blau, Claudia Gallert

“…Conclusions: The results of the current study suggest that the identified plasmids are abundant and may encode functions that are relevant to <i>C. difficile</i> physiology. …”
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Lutein-Containing Antioxidants in Patients with Primary Open-Angle Glaucoma and Dry Type of Age-Related Macular Degeneration by D. A. Dorofeev

“…To assess the dynamics of structural-functional markers in patients with combined pathology: primary open-angle glaucoma (POAG) and age-related macular degeneration (AMD) with the background of lutein-containing drugs at long-term follow-up. …”
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Preliminary Investigation of GC–MS Profiling and Antibacterial Activities of Different Solvent Extracts From Litchi chinensis Sonn. Seed by Samia Sharmin, Ali Ahsan Muzahid, Md. Mohibul Islam, Mst. Sarmina Yeasmin, Amit Kumar Dey, Md. Jasim Uddin, G. M. Masud Rana, Jaytirmoy Barmon, Safaet Alam, Md. Nurul Huda Bhuiyan, Nazim Uddin Ahmed

“…Eventually, comprehending the potential biological functions of the detected compounds is explored. GC–MS analysis revealed a diverse array of chemical compounds, with 34, 35, and 25 compounds identified in the n-hexane, n-hexane–chloroform (2:1), and methanol extracts, respectively. …”
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Dynamics of social and labor status in patients undergoing pulmonary thromboendarterectomy by A. S. Klinkova, O. V. Kamenskaya, I. Y. Loginova, S. S. Porotnikova, A. G. Edemskiy, V. N. Lomivorotov, A. M. Chernyavskiy

“…We analyzed clinical and functional data, as well as social and labor status before and 6 months after PEA. …”
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Prevalence of insomnia among university students in Saudi Arabia: a systematic review and meta‑analysis by Mohamed Baklola, Mohamed Terra, Mohamed Al-barqi, Yaqeen Hasan AbdulHusain, Sohaila Ahmed Asiri, Norah Saad Jadaan, Ali Haroona, Sayed Almosawi, Sarah Saud Al Ahmari

“…Abstract Background Insomnia is a prevalent sleep disorder affecting cognitive functions critical to academic performance. University students, particularly in high-stress academic settings, are highly vulnerable. …”
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Quantifying degradation in animal acoustic signals with the R package baRulho by Marcelo Araya‐Salas, Erin E. Grabarczyk, Marcos Quiroz‐Oliva, Adrián García‐Rodríguez, Alejandro Rico‐Guevara

“…We highlight the package features with a case study testing the effects of habitat and acoustic structure on signal propagation, two common factors evaluated in such experiments. …”
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Assessment of adherence to drug and non-drug treatments and its changes under the influence of an education program in patients with rheumatoid arthritis by E V Orlova, L N Denisov, A O Arsenyev, D E Karateev

“…The number of patients who were compliant to the procedures for shaping a correct functional stereotype increased by 14 and 10 times following 3 and 6 months (60.9% and 43.5%, respectively; p &lt; 0.01). …”
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The CONSTANCES cohort, an epidemiological research infrastructure. Methods and results of the pilot phase by Marie Zins, Lisa F Berkman, Marcel Goldberg

“…<p><strong>Background:</strong> prospective cohorts represent an essential design for epidemiological studies and allow for the study of the combined effects of lifestyle, environment, genetic predisposition, and other risk factors on a large variety of disease endpoints. …”
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KAT5 knockdown alleviates microglial inflammatory injury following acute cerebral ischemia through enhanced STAT6 activity by Yixin Li, Li Peng, Yang Zhou, Yan You, Jin Jiang, Yong Luo

“…In ischemic stroke (IS), microglia exhibit dynamic functional shifts, contributing to tissue damage during the acute phase and promoting repair in the chronic phase. …”
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Importance of ice algae versus phytoplankton in the diet of megabenthic organisms under contrasting sea ice conditions (Canadian Arctic): a dual biochemical approach (SIA and HBIs) by Thibaud Combaz, Thibaud Combaz, Ursula Witte, Thomas A. Brown, Philippe Archambault

“…The effects of global warming are most pronounced at high latitudes and are a threat to primary productivity patterns and, in particular, to sea ice algae. …”
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Abstract 219: Determining the Proportion of Patients with Poor Premorbid mRS presenting with Large Volume Stroke by Madheea Siddiqi

“…Introduction Several lines of evidence demonstrate the effectiveness of endovascular treatment (EVT) for large volume stroke (LVS) as defined by Alberta Stroke Program Early CT Score (ASPECTS) of <6 in decreasing severe disability and death. …”
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Usutu virus NS4A induces autophagy and is targeted by the selective autophagy receptor p62/SQSTM1 for degradation by Tessa Nelemans, Ali Tas, Nina L. de Beijer, George M. C. Janssen, Peter A. van Veelen, Martijn J. van Hemert, Marjolein Kikkert

“…P62 thus plays an antiviral role during USUV infection, although this antiviral effect might also be related to its functions outside the autophagy pathway, such as modulation of the immune response. …”
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Crocin nano-chitosan-coated compound mitigates hippocampal blood-brain barrier disruption, anxiety, and cognitive deficits in chronic immobilization stress-induced rats by Mohsen Khodadadi, Gila Pirzad Jahromi, Gholam Hossein Meftahi, Hossein Khodadadi, Mohammadmehdi Hadipour, Masoud Ezami

“…Stressful conditions can disrupt the central nervous system's normal homeostasis and physiological functions, resulting in blood-brain barrier malfunction, memory and learning impairment, anxiety, etc. …”
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