Coronary-Heart-Disease-Associated Genetic Variant at the COL4A1/COL4A2 Locus Affects COL4A1/COL4A2 Expression, Vascular Cell Survival, Atherosclerotic Plaque Stability and Risk of... by Wei Yang, Fu Liang Ng, Kenneth Chan, Xiangyuan Pu, Robin N Poston, Meixia Ren, Weiwei An, Ruoxin Zhang, Jingchun Wu, Shunying Yan, Haiteng Situ, Xinjie He, Yequn Chen, Xuerui Tan, Qingzhong Xiao, Arthur T Tucker, Mark J Caulfield, Shu Ye

“…We investigated the functional effects of this genetic variant. Analyses of primary cultures of vascular smooth muscle cells (SMCs) and endothelial cells (ECs) from different individuals showed a difference between rs4773144 genotypes in COL4A2 and COL4A1 expression levels, being lowest in the G/G genotype, intermediate in A/G and highest in A/A. …”
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Radar-equivalent snowpack: reducing the number of snow layers while retaining their microwave properties and bulk snow mass by J. Meloche, N. R. Leroux, B. Montpetit, V. Vionnet, C. Derksen

“…A reduction in the mathematical complexity of SWE retrieval cost functions and a reduction in computation of up to 80 % can be gained by using fewer layers in the SWE retrieval.…”
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STUDY OF CHANGES IN TUMOR BLOOD FLOW FOR THE ASSESSMENT OF EARLY RESPONSE TO NEOADJUVANT CHEMOTHERAPY IN BREAST CANCER PATIENTS by M. V. Pavlov, P. I. Rykhtik, O. E. Ilyinskaya, P. V. Subochev, Yu. M. Kreinina, A. V. Maslennikova

“…To solve this problem, it is necessary to assess the functional and metabolic changes in tumor tissue during treatment. …”
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Abstract 212: Percutaneous Carotid access in Mechanical Thrombectomy ‐ a safe alternative to transfemoral approach by Sonia Bellara, James Hiana, Daniel Zumofen, Yohannes Mulatu

“…Methods 75‐year‐old left‐handed functional male (mRs:0) with past medical history of HTN, HLD presented to ED after being found on the floor by his family with slurred speech, new onset right sided weakness, with a last known well of 17 hours. …”
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Seashore paspalum in the Mediterranean transition zone: phenotypic traits of twelve accessions during and after establishment by Monica Gaetani, Marco Volterrani, Simone Magni, Lisa Caturegli, Alberto Minelli, Claudio Leto, Salvatore La Bella, Teresa Tuttolomondo, Giuseppe Virga, Nicola Grossi

“…Probably due to higher mean minimum temperatures a clear effect of location was recorded during the establishment year with fastest stolon growth rate and higher ground cover at 133 days after planting being registered in Palermo. …”
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From Generative Artificial Intelligence to Artificial General Intelligence: Enabling Innovation Models in Library Knowledge Services by Mo LI, Bin YANG

“…General AI has stronger generalization ability, which can achieve functions such as complex task understanding, multimodal data learning, zero-sample reasoning, and continuous dialogue, completing the transformation from data-driven AI to natural mechanism-driven AI. …”
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Allometric Growth of Annual <i>Pinus yunnanensis</i> After Decapitation Under Different Shading Levels by Pengrui Wang, Chiyu Zhou, Boning Yang, Jiangfei Li, Yulan Xu, Nianhui Cai

“…In addition, the synchronized allocation between main roots and lateral branches, as well as between main stems and lateral roots, suggested functional integration between corresponding belowground and aboveground structures to maintain balanced resource acquisition and architectural stability. …”
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Healthy Lifestyle and Cardiac Vagal Modulation Over 10 Years: Whitehall II Cohort Study by Vera K. Jandackova, Shaun Scholes, Annie Britton, Andrew Steptoe

“…Background Increased vagal modulation is a mechanism that may partially explain the protective effect of healthy lifestyles. However, it is unclear how healthy lifestyles relate to vagal regulation longitudinally. …”
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The mitochondrial E3 ligase MAPL SUMOylates Drp1 to facilitate mitochondrial fission in intervertebral disc degeneration by Zhidi Lin, Xiao Lu, Guangyu Xu, Jian Song, Hongli Wang, Xinlei Xia, Feizhou Lu, Jianyuan Jiang, Wei Zhu, Zuochong Yu, Xiaosheng Ma, Fei Zou

“…This study aimed to investigate the functions and mechanisms of mitochondria-anchored protein ligase (MAPL), a mitochondrial SUMO E3 ligase, during IVDD progression. …”
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Deciphering STAT3’s negative regulation of LHPP in ESCC progression through single-cell transcriptomics analysis by Yurao Chen, Zemao Zheng, Luoshai Wang, Ronghuai Chen, Ming He, Xiang Zhao, Liyan Jin, Juan Yao

“…Elevated levels of STAT3 and suppressed LHPP expression were validated in clinical samples. Functional assays confirmed that STAT3 directly represses LHPP at the promoter level, and disruption of this interaction by promoter mutations diminished STAT3's repressive effect. …”
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The Internationalization of Science and Education as a Global Process: a World-System Approach by A. A. Izgarskaya, S. I. Chernykh

“…The production of knowledge and national education systems are not autonomous from the general dynamics of the world system, they are integral parts of its functioning. The result of social relations "core-semi-periphery-periphery" is the unevenness in the accumulation of transnational academic capital. …”
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Sulforaphane induces cell morphology change and cell apoptosis by activating endoplasmic reticulum stress in glioblastoma by Nan Li, Yan Jiang, Ajun Wang, Tongchao Jiang, Huimin Dai, Chengyu Xia, Tongcui Jiang

“…Importantly, SFN had minimal cytotoxic effects on normal astrocytes, suggesting a favorable therapeutic window. …”
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Seasonal childhood anaemia in West Africa is associated with the haptoglobin 2-2 genotype. by Sarah H Atkinson, Kirk Rockett, Giorgio Sirugo, Philip A Bejon, Anthony Fulford, Maria A O'Connell, Robin Bailey, Dominic P Kwiatkowski, Andrew M Prentice

“…Haptoglobin polymorphisms result in proteins with altered haemoglobin-binding capacity and different antioxidant, iron-recycling, and immune functions. Previous studies examined the importance of haptoglobin polymorphism in malaria and iron homeostasis, but it is unknown whether haptoglobin genotype might be a risk factor for anaemia in children in a malaria-endemic area.…”
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Fetal-BET: Brain Extraction Tool for Fetal MRI by Razieh Faghihpirayesh, Davood Karimi, Deniz Erdogmus, Ali Gholipour

“…Development of a machine learning method to effectively address this task requires a large and rich labeled dataset that has not been previously available. …”
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Evaluation of the efficacy of complex analgesic therapy, including a combination of B vitamins, in patients with combination of osteoarthritis and chronic non-specific low back pai... by E. S. Filatova, A. E. Karateev, E. L. Shakhramanova, D. A. Ghukasyan, S. Yu. Shkireeva, A.  M. Lila

“…The vitamin B1, B6 and B12 complex (VBC) is frequently used to treat acute and chronic low back pain.Objective: to investigate the effect of a combination of a non-steroidal anti-inflammatory drug (NSAID) and a VBC on the main manifestations of nociceptive system dysfunction in patients with combination of osteoarthritis (OA) and chronic non-specific low back pain (NSLBP).Material and methods. …”
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New potential of Trimetazidine MB for coronary heart disease treatment in the real-world clinical practice: results of the Russian multi-centre randomised study PERSPECTIVE (Part I... by M. G. Bubnova, D. M. Aronov, R. G. Oganov, O. G. Rudomanov

“…The study included 981 patients with Functional Class (FC) II-III SA and various concomitant diseases and syndromes, such as chronic heart failure (CHF), Type 2 diabetes mellitus (DM-2), or chronic obstructive pulmonary disease (COPD) in smokers. …”
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Microbial diversity of soils under different land use and chemical conditions by Jung-Hwan Yoon, Mahesh Adhikari, Seok Soon Jeong, Sang Phil Lee, Hyuck Soo Kim, Geon Seung Lee, Duck Hwan Park, Heejung Kim, Jae E. Yang

“…Abstract Soil microbial communities are crucial to ecosystem functionality, influencing soil fertility and health. …”
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Combinatorial MD/QM studies to develop novel ionic liquid-based anticancer drug delivery systems with aminium derived from carbohydrates as cationic components by Sepideh Kalhor, Alireza Fattahi

“…The goal is to investigate the effects of these novel pharmaceutical active ionic liquids on the interactions between the drugs and cell membranes. …”
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Neutrophil extracellular traps-related genes contribute to sepsis-associated acute kidney injury by Tang Shaoqun, Yu Xi, Wang Wei, Luo Yaru, Lei Shaoqing, Qiu Zhen, Yang Yanlin, Sun Qian, Xia Zhongyuan

“…Additionally, the biological functions of the hub genes were analyzed with single sample gene set enrichment analysis. …”
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Comparative Study of PPARγ Targets in Human Extravillous and Villous Cytotrophoblasts by Fulin Liu, Christine Rouault, Mickael Guesnon, Wencan Zhu, Karine Clément, Séverine A. Degrelle, Thierry Fournier

“…Here, we aimed to explore the genome-wide effects of PPARγ on EVCTs and VCTs via treatment with the PPARγ-agonist rosiglitazone. …”
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