Geriatric hip fracture with proximal upper extremity fracture increases morbidity and mortality by Zachary Jodoin, MD, Travis Kotzur, BS, Aaron Singh, BA, Kyle Paul, MD, Case Martin, MD, Ravi Karia, MD, Thomas Hand, MD

“…Subgroup analysis demonstrated that these effects were most pronounced in proximal—versus more distal—upper extremity fractures. …”
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Sustainable dyeing of cotton, silk and leather using natural dye from Bixa orellana seeds: extraction, optimization and assessment of antibacterial activity by Moorthy Muruganandham, Yuvaraj Tamilselvi, Kanagasabapathy Sivasubramanian, Palanivel Velmurugan, Fatimah Oleyan Al-Otibi, Subpiramaniyam Sivakumar

“…The color strength of the extracted dye was investigated using a UV-Visible spectrophotometer to measure the absorbance wavelength. The functional groups identified in the extracted natural dye were described using an FTIR spectrophotometer.Results and discussionUsing methanol as the solvent and 5 g of seed at 60°C for 60 min, the highest color yield was observed in USB. …”
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Dietary inclusion of Hermetia illucens larvae meal modifies caecal microbiota diversity and composition in barbary partridges (Alectoris barbara) by Elie Atallah, Tiziana Maria Mahayri, Jakub Mrázek, Fulvia Bovera, Giovanni Piccolo, Kateřina Olša Fliegerová, Giuseppe Moniello

“…Several of these taxa are associated with gut health, fiber fermentation, and metabolic functions, indicating a biological importance of the observed microbial shifts. …”
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Green solvents assisted de-novo synthesis and defect-engineered UiO-66 for improved CO2 adsorption and kinetics- experimental and DFT approach by Saleem Nawaz Khan, Ming Zhao

“…Furthermore, through periodic Density Functional Theory (DFT) calculations, a variety of linker defects are engineered onto the UiO-66 structure to preserve more open metal sites. …”
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The Role of Plant Evolutionary History in Shaping the Variation in Specific Leaf Area Across China by Minyue Si, Caiyi Zhang, Chunzhu Xiang, Mingxia Jiang, Linwei Guo, Junjiong Shao

“…ABSTRACT Specific leaf area (SLA, leaf area per unit leaf dry mass) occupies a central position in both community assembly and ecosystem functioning. Although SLA has significant phylogenetic signals, how and to what extent the evolutionary history influences the variation in SLA remain poorly understood. …”
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Unlocking The Potential of Hybrid Models for Prognostic Biomarker Discovery in Oral Cancer Survival Analysis: A Retrospective Cohort Study by Leila Nezamabadi Farahani, Anoshirvan Kazemnejad, Mahlagha Afrasiabi, Leili Tapak

“…Eleven key genes with the highest degree, including RBM25, SMC3, PRPF40A, POLE, SRRT, BCLAF1, PDS5B, HNRNPR, JAK1, MED23, and SULT1A1 were identified as significant biomarkers associated with OC survival.Conclusion: The PSO-based hybrid model effectively improved SVR performance in survival prediction for OC patients and identified key prognostic biomarkers. …”
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Sensitivity analysis on protein-protein interaction networks through deep graph networks by Alessandro Dipalma, Michele Fontanesi, Alessio Micheli, Paolo Milazzo, Marco Podda

“…In recent years, the size and information content of PPINs have grown thanks to techniques that allow for the functional association of proteins. However, PPINs are static objects that cannot fully describe the dynamics of the protein interactions; these dynamics are usually studied from external sources and can only be added to the PPIN as annotations. …”
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Linking protective GAB2 variants, increased cortical GAB2 expression and decreased Alzheimer's disease pathology. by Fanggeng Zou, Olivia Belbin, Olivia Belbin, Minerva M Carrasquillo, Oliver J Culley, Talisha A Hunter, Li Ma, Gina D Bisceglio, Mariet Allen, Dennis W Dickson, Neill R Graff-Radford, Ronald C Petersen, Genetic and Environmental Risk for Alzheimer’s disease (GERAD1) Consortium, Kevin Morgan, Steven G Younkin

“…Four variants were hetergeneous across the populations (all p<0.02) due to a potentially inflated effect size (OR = 0.61-0.66) only observed in the smallest series (702 LOAD, 209 controls). …”
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Factors Influencing the Intentions of Patients With Inflammatory Rheumatic Diseases to Use a Digital Human for Medication Information: Qualitative Study by Lex L Haegens, Victor J B Huiskes, Bart J F van den Bemt, Charlotte L Bekker

“…These identified themes should be considered during the further development of the digital human and during implementation to increase intention to use and future adoption. Thereafter, the effect of applying a digital human as an instrument to improve patients’ self-management regarding DRPs could be researched.…”
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Design of a Non-Destructive Seed Counting Instrument for Rapeseed Pods Based on Transmission Imaging by Shengyong Xu, Rongsheng Xu, Pan Ma, Zhenhao Huang, Shaodong Wang, Zhe Yang, Qingxi Liao

“…Human–machine interaction software based on PyQt5 was developed, integrating functions such as communication between upper and lower machines, image acquisition, storage, and processing. …”
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Multomic analysis reveals the potential of LAG3 as a prognostic and immune biomarker and its validation in osteosarcoma by Qianqian Cao, Yuzhe Zhang, Cheng Cheng, Xiaoyang Wang, Panlong Fan, Jincheng Huang, Zhipeng Dai

“…Meanwhile, LAG3 expression not only has an impact on patient immunotherapy prognosis and immunotherapy response, but also has a significant effect on drug sensitivity. In vitro experiments have shown that LAG3 promotes the proliferation, migration and invasion of osteosarcoma cells. …”
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Narciclasine enhances cisplatin-induced apoptotic cell death by inducing unfolded protein response-mediated regulation of NOXA and MCL1 by Ji Hae Lee, Seung Hee Seo, Jaegal Shim, Yong-Nyun Kim, Kyungsil Yoon

“…After conducting bioinformatic analysis using RNA sequencing data and functional validation experiments, we identified NOXA as a key gene responsible for the enhanced apoptosis observed with the combination of cisplatin and narciclasine. …”
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Biomarker Investigation Using Multiple Brain Measures from MRI Through Explainable Artificial Intelligence in Alzheimer’s Disease Classification by Davide Coluzzi, Valentina Bordin, Massimo W. Rivolta, Igor Fortel, Liang Zhan, Alex Leow, Giuseppe Baselli

“…Its aim is quantitatively measuring how effectively these models fare against established AD biomarkers in their decision-making. …”
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Engineering Phosphatidylserine Containing Asymmetric Giant Unilamellar Vesicles by Jake McDonough, Trevor A. Paratore, Hannah M. Ketelhohn, Bella C. DeCilio, Alonzo H. Ross, Arne Gericke

“…Among these, phosphatidylserine (PS) plays a crucial role in various important physiological functions. Over the last decade several methods have been developed that allow for the fabrication of large or giant unilamellar vesicles (GUVs) with an asymmetric lipid composition. …”
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Cross-cohort multi-omics analysis identifies novel clusters driven by EMT signatures in colorectal cancer by Wu Ning, Wenqing Jia, Jingyuan Ning, Lei Zhou, Zongze Li, Lin Zhang, Xin Song

“…Furthermore, molecular docking revealed that the targeted agent abemaciclib effectively binds HOXC6, with both cellular and animal experiments confirming its ability to inhibit CRC cell functions and significantly reduce tumor burden in nude mice.DiscussionThis study establishes the first single-cell-resolution molecular classification system for CRC, delineates the mechanistic link between EMT subtypes and metastatic progression, and identifies HOXC6 as a novel therapeutic vulnerability. …”
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Second Trimester Umbilical Cord Coiling Index and Perinatal Outcomes by Yusuf Aytaç Tohma, Mehmet Metin Altay, Derya Turgut, Selcan Coşkun, Eylem Ünlübilgin, Sertaç Esin, Orhan Gelişen, Okyar Erol

“… OBJECTIVE: Umbilical cord usually seems simple functionally and structurally but it's the life link between fetus and mother that was critically important for growing fetus. …”
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Reactive Oxygen Species: A Double-Edged Sword in the Modulation of Cancer Signaling Pathway Dynamics by Manisha Nigam, Bajrang Punia, Deen Bandhu Dimri, Abhay Prakash Mishra, Andrei-Flavius Radu, Gabriela Bungau

“…By systematically integrating data on ROS source-specific functions and redox-sensitive signaling pathways, the complex interplay between ROS concentration, localization, and persistence is elucidated, revealing how these factors dictate the paradoxical support of tumor progression or induction of cancer cell death. …”
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Evaluating Magnetic Stimulation as an Innovative Approach for Treating Dry Eye Disease: An Initial Safety and Efficacy Study by Hadas Ben-Eli, Shimon Perelman, Denise Wajnsztajn, Abraham Solomon

“…<b>Results:</b> No statistically significant changes were found in visual acuity, IOP, or Schirmer’s test results between the RMS-treated and control groups (<i>p</i> < 0.05), indicating that RMS does not negatively impact these ocular functions. However, RMS treatment was associated with improved tear film stability (<i>p</i> = 0.19 vs. …”
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Reduced Quality of Life in Elderly Patients with Glaucoma by N. M. Agarkov, A. M. Chukhraev, O. L. Fabrikantov, N. V. Yablokova

“…The survey was conducted on a special questionnaire-National Eye Institute Visual Functioning Questionnaire among patients of the above group by direct interviewing. …”
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Machine learning reveals the dynamic importance of accessory sequences for Salmonella outbreak clustering by Chao Chun Liu, William W. L. Hsiao

“…Annotating the genomic features important for cluster classification revealed functional enrichment of molecular fingerprints in genes involved in membrane transportation, trafficking, and carbohydrate metabolism. …”
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