Human PCSK9D374Y exacerbates methionine choline deficiency diet-induced nonalcoholic steatohepatitis in mice by Abidan·ABUDURUSULI, CHEN Xiaocui, CUI Yuanfeng, Tuoluonayi·MIJITI, DENG Lihui, CHEN Bangdang

“…Objective To investigate the effect of mutation human proprotein convertase subtilism/kexin type 9(hPCSK9D374Y) in PCSK9 gene on methionine choline deficiency diet (MCD)-induced nonalcoholic steato-hepatitis (NASH) in mice. …”
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Progress in application of rhamnolipids in oil and gas development by YU Fengmei, WANG Xiao, LIU Jiayin, MA Guiyang, LIU Yifei, GONG Zheng

“…The paper focused on summarizing the five main application directions of rhamnolipids in oil and gas development： in terms of reducing viscosity of heavy oil， rhamnolipids can effectively reduce the viscosity of heavy oil and enhance oil recovery； in terms of treating oil-contaminated soil and water， rhamnolipids show excellent emulsification performance and can separate oil from soil and form easy-to-treat emulsion； in terms of promoting hydrate generation， rhamnolipids can reduce the induction time of hydrates and improve the generation rate and stability of hydrates； in terms of oil and gas pipeline transportation， the anti-aggregation characteristics of rhamnolipids can help solve the problem of pipeline blockage； the authors finally proposed the following research suggestions for the future： in terms of production method， it is necessary to increase the research and application of local extraction strains； in terms of characteristic research， it is necessary to explore the other functional characteristics of rhamnolipids besides the existing ones and expand its application scopes in oil and gas development； in terms of application， it is important to study the recyclable use of rhamnolipids and the synergistic application of multiple technologies to solve problems such as high development costs in super-heavy oil production. …”
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ELECTROKINETIC PROPERTIES, IN VITRO DISSOLUTION, AND PROSPECTIVE HEMOAND BIOCOMPATIBILITY OF TITANIUM OXIDE AND OXYNITRIDE FILMS FOR CARDIOVASCULAR STENTS by I. A. Khlusov, V. F. Pichugin, A. A. Pustovalova, M. E. Konischev, A. N. Dzyuman, M. Epple, M. Ulbricht, E. Cicinskas, V. S. Gulaya, V. V. Vikhareva

“…It is supposed decreasing hazard of fast thrombosis and loss of materials functional properties. According to in vitro experiment conducted, prospective biocompatibility of materials tested before and after their contact with SBF lines up following manner: Ti–O–N (1/3) > Ti–O–N (1/1), TiO2 > Steel. …”
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Application of the Double Approximation Method for Constructing Stiffness Matrices of Volumetric Finite Elements by P. P. Gaidzhurov, N. A. Saveleva

“…The mathematical apparatus of the double approximation method based on the principle of a separate representation of the distribution functions of displacements and deformations inside the element, was used to construct the stiffness matrices of volumetric FE. …”
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A detailed transcriptome study uncovers the epigenetic characteristics associated with Aromatase inhibitor-induced masculinization in Takifugu rubripes larvae gonads by Xufang Shen, Hongwei Yan, Mingtao Hu, Huiting Zhou, Qi Zhang, Rui Gao, Qi Liu, Qunwen Sun

“…Conclusions This research comprehensively reveals the potential regulatory effects of ncRNAs on cellular motility, fate regulation, and hormonal regulation during gonadal masculinization in T. rubripes. …”
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Genome-wide survey and expression analysis of the OMT gene family in Stephania japonica by Zenghao Bi, Tianxing He, Yuting Liang, Changqing Zhou, Yuetong Yu, Liang Leng

“…These findings provide insight into understanding the functions and characterization of OMTs from S. japonica and lay a foundation for further revealing the role of the OMT genes in the biosynthesis of cepharanthine.…”
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Time-Series Modeling of Ozone Concentrations Constrained by Residual Variance in China from 2005 to 2020 by Shoutao Zhu, Bin Zou, Xinyu Huang, Ning Liu, Shenxin Li

“…However, due to the unstable functional relationships between variables across spatiotemporal scales, the outlier predictions will reduce the accuracy of the prediction model. …”
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Application of Machine Learning Models for the Early Detection of Metritis in Dairy Cows Based on Physiological, Behavioural and Milk Quality Indicators by Karina Džermeikaitė, Justina Krištolaitytė, Ramūnas Antanaitis

“…This study provides novel evidence that ML methods can effectively detect metritis using routinely collected, non-invasive on-farm data. …”
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Low-frequency oscillations in human tibial somatosensory evoked potentials Oscilações de baixa freqüência no potencial evocado somato-sensitivo do nervo tibial humano by Carlos Julio Tierra-Criollo, Antonio Fernando Catelli Infantosi

“…Oscillatory cerebral electric activity has been related to sensorial and perceptual-cognitive functions. The aim of this work is to investigate low frequency oscillations (<300 Hz), particularly within the gamma band (30-110 Hz), during tibial stimulation. …”
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Projecting Water Yield Amidst Rapid Urbanization: A Case Study of the Taihu Lake Basin by Rui Zhou, Yanan Zhou, Weiwei Zhu, Li Feng, Lumeng Liu

“…Changes in land cover and land use (LULC) can impact water availability by altering the structure and functioning of land ecosystems. Accurately projecting the impacts of LULC on water yield (WY) is of utmost importance for regional landscape management. …”
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Evaluating the Potential of Roof Water Harvesting System for Drinking Water Supplies During Emergencies Under the Impacts of Climate Change: ‘A Case Study of Swat District, Pakista... by Shamaima Wafa Qammar, Fayaz Ahmad Khan, Rashid Rehan

“…While the roof water harvesting system (RWHS) is well established and functional in many developed regions, its potential remains underexplored in Pakistan. …”
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Network toxicology combined with molecular docking technology to explore the molecular mechanism of amatoxin causing liver injury by Chenglin Wang, Xin Wang, Yaxing Deng, Yingchun Hu, Li Hu

“…PPI network topology revealed critical nodal connections, while functional enrichment analyses delineated key biological processes and signaling pathways associated with these targets. …”
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Features of the influence of the antioxidant ethylmethylhydroxypyridine malate and the drug ubidecarenone on plasma concentrations of ubiquinone, ubiquinol and the redox state of c... by V. I. Zozina, S. N. Kondratenko, E. V. Shikh, L. M. Krasnykh, E. S. Melnikov, V. G. Kukes

“…The study included 58 patients with functional class (FC) of CHF 0−III (according to NYHA), who were divided into 2 groups for subsequent assessment of the effect of ethylmethylhydroxypyridine malate and ubidecarenone on endogenous plasma concentrations of total CoQ10, ubiquinol and ubiquinone. …”
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Chitosan-TPP Nanogels for Ocular Delivery of Folic Acid: Release Profile, Corneal Permeation, and Mucoadhesion Assessment by Sebastián G. Bruno, Sofía M. Martínez, Camila Costa Gobbato, Daniela A. Quinteros, Agustina Alaimo, Oscar E. Pérez

“…<b>Background</b>: Folic acid (FA) is essential for cellular functions but has limited ocular bioavailability, restricting its therapeutic effectiveness. …”
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Low-Cost Monitoring of Airborne Heavy Metals Using Lichen Bioindicators: Insights from Opole, Southern Poland by Liubomyr Bahinskyi, Paweł Świsłowski, Oznur Isinkaralar, Kaan Isinkaralar, Małgorzata Rajfur

“…., a species whose vital functions or morphological structure can reveal the qualitative state of the environment. …”
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Association studies of ERCC1 polymorphisms with lung cancer susceptibility: a systematic review and meta-analysis. by Jinhong Zhu, Rui-Xi Hua, Jing Jiang, Li-Qin Zhao, Xiuwei Sun, Jinwei Luan, Yaoguo Lang, Yanqi Sun, Kun Shang, Shiyun Peng, Jianqun Ma

“…<h4>Background</h4>Excision repair cross-complimentary group 1 (ERCC1) is an essential component of the nucleotide excision repair system that is responsible for repairing damaged DNA. Functional genetic variations in the ERCC1 gene may alter DNA repair capacity and modulate cancer risk. …”
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Uncovering soil compaction: performance of electrical and electromagnetic geophysical methods by A. Carrera, A. Carrera, L. Peruzzo, M. Longo, G. Cassiani, F. Morari

“…In this context, soil compaction resulting from inappropriate agricultural practices not only affects soil ecological functions, but also decreases the water-use efficiency of plants by reducing porosity and increasing water loss through superficial runoff and enhanced evaporation.…”
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Unveiling Usage Patterns and Explaining Usage of Symptom Checker Apps: Explorative Longitudinal Mixed Methods Study by Anna-Jasmin Wetzel, Christine Preiser, Regina Müller, Stefanie Joos, Roland Koch, Tanja Henking, Hannah Haumann

“…The varied applications of SCA fit into the concept of health literacy as bricolage, where SCA is leveraged as flexible tools by patients based on individual and situational requirements, functioning alongside other health care resources.…”
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Feasibility and acceptability of switching from a previous-generation to a new-generation mask for positive airway pressure therapy of sleep apnea using remote care by Xueling Zhu, Adam Benjafield, Ross Deas, Leslee Willes, Jeff Armitstead

“…Rates of PAP-related side effects were generally acceptable. Conclusion: Remote management of mask change was associated with good outcomes in terms of objective device data and patient acceptability. …”
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Targeting microRNA methylation: Innovative approaches to diagnosing and treating hepatocellular carcinoma by Albert Sufianov, Murad Agaverdiev, Andrey Mashkin, Tatiana Ilyasova

“…These factors contribute to the limited effectiveness of current treatment modalities and result in poor patient prognosis. …”
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