NRF2 maintains redox balance via ME1 and NRF2 inhibitor synergizes with venetoclax in NPM1-mutated acute myeloid leukemia by Jiayuan Hu, Zihao Yuan, Yan Shu, Jun Ren, Jing Yang, Lisha Tang, Xingyu Wei, Yongcan Liu, Fangfang Jin, Qiaoling Xiao, Xinyi Chen, Nan Wu, Wen Zhao, Ziwei Li, Ling Zhang

“…The high NRF2 expression levels were at least partially induced by fat mass and obesity-associated protein (FTO) via m6A modification. Functionally, NRF2 exerts its antioxidant effects by transcriptionally upregulating malic enzyme 1 (ME1) expression and enhancing its activity. …”
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Mechanistic insights into Jianpi Qinghua Sanyu Yin treatment of raised erosive gastritis: ceRNA-mediated PI3K/AKT signaling pathways by Liya Liu, Liya Liu, Liya Liu, Ying Cheng, Ying Cheng, Guosheng Lin, Guosheng Lin, Huifang Zheng, Huifang Zheng, Xinran Zhang, Xinran Zhang, Peilin Zhao, Peilin Zhao, Meixuan Guo, Meixuan Guo, Qihong Liu, Qihong Liu, Wenyi Fang, Wenyi Fang, Wenrong Wang, Wenrong Wang, Anjum Jafri, Aling Shen, Aling Shen, Xiao Ke, Xiao Ke, Youqin Chen

“…Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were used for functional exploration. Real-time quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was performed to validate RNA-seq analysis results. …”
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Selenium and its mechanisms mitigate cadmium toxicity in plants: Promising role and future potentials by Javed Hussian Sahito, Chenhui Ma, Jihong Zhang, Jianxin Li, Jiawen Zhao, Liqin Mu, Yuanyuan Zhang, Zeeshan Ghulam Nabi Gishkori, Dong Ding, Xuehai Zhang, Jihua Tang

“…Supplementation with Se minimize the detrimental effects of Cd by enhancing physiological, biochemical, and molecular functions, while also promoting Cd immobilization, co-precipitations, and compartmentalization. …”
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A new strategy of molecular breeding for optimal heading date and grain yield in rice by modulating elite allelic combinations of Ghd7, Hd3a, RFT1 and Gn1a by Qingmei Su, Rongsheng Wang, Xiaomin Feng, Mengyue Zhao, Guanlin Zhu, Qing Wang, Fang Zhang, Shaoyang Lin, Yuhang Zhang, Li Zhu, Qian Qian, Fan Chen

“…Under short-day (SD) conditions, the functions of Hd3a and RFT1 remain consistent with those under LD conditions, but Ghd7 does not inhibit their expression, resulting in a weaker phenotypic effect compared to Hd3a. …”
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The Structural Model of Happiness Based on Mindfulness with Mediator Role of Emotional Intelligence, Self-Compassion and Resilience by Mohammad Reza Tamannai far, Faezeh Taraffo

“…While the direct effect of mindfulness on emotional intelligence (β=0.899, p <0.001) and the direct effect of mindfulness on self-compassion (β=0/84, p <0/001) were significant. …”
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Pathogenetic Mechanisms of the Occurrence of Rheumatoid Arthritis and Ankylosing Spondylitis with the Activation-Enzymatic and Phenotypic Features of Lymphocytes by Lychkovska N., Chopyak V., Vorobets Z.

“…Studies of biochemistry and physiology in recent decades have shown that precision control (NO) and (Ca2+) and the functioning of cellular enzymatic systems are provided. …”
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Perovskite Solar Cells Modified with Conjugated Self-Assembled Monolayers at Buried Interfaces by Guorong Zhou, Faeze Hashemi, Changzeng Ding, Xin Luo, Lianping Zhang, Esmaeil Sheibani, Qun Luo, Askhat N. Jumabekov, Ronald Österbacka, Bo Xu, Changqi Ma

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Mir-218-5p from Extracellular Vesicles of Endometrium in Patients with Recurrent Implantation Failure Impairs Pre-Implantation Embryo Development by Cai L, Lv M, Wei J, Liu C, Li Y, Liao Z, Li T, Zhang H, Xi L, Sui C

“…Most significantly, our work introduces a novel therapeutic approach, employing engineered EVs encapsulating anti-miR-218-5p, which effectively mitigates the deleterious effects of miR-218-5p. …”
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Prediction of Soil Carbon Sequestration in Rangelands Regarding the Depth and Elevation of Sample Locations using Adaptive Neuro-Fuzzy Inference System (ANFIS) (Case Study: Lar Wat... by zeinab jafarian, zhila ghorbani

“…Results: The results of the analysis of variance (ANOVA) revealed that only soil sampling depth significantly affected the soil CS, but the effect of sampling location and the interaction effect of depth and height were not significant. …”
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Multimodal versus non-contrast computed tomography for assessment of acute ischaemic stroke: the PRACTISE RCT by Keith W Muir, Salwa El Tawil, Alex McConnachie, Alicia Murray, Ian Ford, Grant Mair, Joanna Wardlaw

“…Treatment decision and delivery times, early neurological recovery and day 90 functional outcomes did not differ significantly between groups. …”
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A high-definition spatiotemporal transcriptomic atlas of mammalian kidney development by Shan Jiang, Hao Yu, Ting Zhao, Yao Lu, Xuesong Li, Lei Gao, Jie Mi, Wenzhe Xia, Lanjun Geng, Panpan Li, Mingyue Chen, Mengyao Kang, Jiang Liu, Yuwen Ke

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Aducanumab binds high molecular weight soluble Aβ oligomers and restores intracellular calcium levels by Lu Yu, Xueying Wang, Tri H. Doan, Yutian Fan, Thierry Bussiere, Brian J. Bacskai, Ksenia V. Kastanenka

“…However, its specificity toward different AβO species and its functional impact on calcium homeostasis remain unclear. …”
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Maternal and paternal infant directed speech is modulated by the child’s age in two and three person interactions by Manuela Filippa, Hervé Tissot, Tiffany Mancinelli, Nicolas Favez, Didier Grandjean

“…Abstract Prosody in infant-directed speech (IDS) serves important functions for the infant’s attention, regulation, and emotional expression. …”
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Transcutaneous permeation enhancer complex for polymer-based transdermal patches by E. G. Kuznetsova, L. A. Salomatina, O. M. Kuryleva, Yu. B. Basok, V. I. Sevastianov

“…The PEC contained apricot kernel oil, dioctyl sodium sulfosuccinate, dihydroquercetin and alpha-tocopherol acetate – substances that have a good impact on the functional properties of polymer-based TPs. Low-molecular alcohol-soluble drugs (chlorpropamide, caffeine and sodium benzoate and lidocaine hydrochloride) used to treat diseases of various etiologies were used as active ingredients. …”
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Access to rehabilitation services for families of children with disabilities in Ghana by Hasehni Vampere, Ebenezer Dassah, Rebecca Tawiah, Melody A. Quarm

“…Background: Early rehabilitation interventions can significantly mitigate the effects of disabilities in children as they grow older. …”
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Construction of a novel copper-induced-cell-death-related gene signature for prognosis in colon cancer, with focus on KIF7 by Hua Li, Jingying Chen, Zhengxian Liu, Lujuan Pan, Xiaoling Lan, Lihe Jiang, Fuda Huang

“…Conclusion The CRG prognostic signature can effectively predict overall survival, immune microenvironment and chemotherapy response in CC. …”
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NUMERICAL SIMULATION OF CAVITY FLOW AND FLOW OVER AIRCRAFT COMPARTMENT USING SEMI-EMPIRICAL TURBULENCE MODELS by E. V. Larina, I. A. Kryukov, I. E. Ivanov

“…The changes in height of protruding part of the geometry to the external flow have led to changes in pressure pulsation amplitude without changing the frequency. The spectral functions obtained while using the two considered models of turbulence have been compared for this case. …”
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Aquatic habitat response to small dam removal demonstrates recovery in three years by Jeremy Dietrich, Alison Rickard, Suresh A. Sethi, Scott Cuppett, Patrick Sullivan

“…To help address this gap, we implemented a suite of geomorphic, biological, and water quality monitoring efforts to assess the effect of a small dam (3.7 m) removal project in the Hudson River Estuary watershed, New York State (USA). …”
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Humic acids as drivers of plant growth: regulating root development and photobiology through redox modulation by Daniel Basílio Zandonadi, Hiarhi Monda, Jason Gralian, Aletia James, Richard T. Lamar, Mirella Pupo Santos

“…Conclusions These findings suggest that HA promote plant development in roots by modulating oxidative stress through the RBOH/ROS/auxin/H+-ATPase pathways while potentially influencing photobiological processes via their electron-donating and accepting properties. These effects may be attributed to the interplay between the pro-oxidant (e.g., quinones and semiquinone radicals) and the antioxidant functionalities (e.g., polyphenols) inherent in HA, both contributing to the observed eustress response. …”
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Cytosolic delivery of monobodies using the bacterial type III secretion system inhibits oncogenic BCR: ABL1 signaling by Chiara Lebon, Sebastian Grossmann, Greg Mann, Florian Lindner, Akiko Koide, Shohei Koide, Andreas Diepold, Oliver Hantschel

“…Phospho flow cytometry and apoptosis assays were performed to assess the functional effects of monobody translocation into BCR:ABL1-expressing leukemia cells. …”
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