c-Myc promotes metabolic reprogramming in pulmonary hypertension via the stimulation of glutaminolysis and the reductive tricarboxylic acid cycle by Manivannan Yegambaram, Xutong Sun, Qing Lu, Alejandro Garcia Flores, Marina Zemskova, Jamie Soto, Adam Rauckhorst, Emin Maltepe, Ting Wang, Jeffrey R. Fineman, Stephen M. Black

“…Therefore, we assessed the effect of increased c-Myc expression on metabolic reprogramming, glutaminolysis, and proliferation in control PAECs. …”
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Inertial-Based Dual-Task Gait Normalcy Index at Turns: A Potential Novel Gait Biomarker for Early-Stage Parkinson’s Disease by Lin Meng, Xiaofei Zhang, Yu Shi, Xinge Li, Jun Pang, Lei Chen, Xiaodong Zhu, Rui Xu, Dong Ming

“…We also observed that the turning-based GNI has larger effect size compared to clinical scales, demonstrating that GNI during turning can reflect the changes of functional mobility in rehabilitation for the early PD. …”
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Development of CSOARG: a single-cell and multi-omics-based machine learning model for ovarian cancer prognosis and drug response prediction by Junyu Chen, Junyu Chen, Bin Guan, Bin Guan, Jihong Zhang, Xin Li, Xin Li, Jingyi Fang, Jingyi Fang, Wencai Guan, Qi Lu, Qi Lu, Qi Lu, Guoxiong Xu, Guoxiong Xu

“…Immunology analysis, functional enrichment, single-cell analysis, and therapeutic responses of ovarian cancer were conducted using the data from public databases. …”
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Antioxidant Substance Basis and Mechanism of Flavonoids from Apios americana Medic. by Memitimin METSAWUR, Tong LI, Yadi NI, Tianjie YUAN, Daijie WANG, Jin'ao DUAN, Ping XIAO

“…These findings provide a theoretical basis for developing and utilizing Apios americana as a functional food ingredient.…”
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DPV pUL15 possesses a potential NLS, which is important for the location of the terminase complex and for viral proliferation and genome cleavage by Qiao Yang, Yaya Feng, Lizhen Liu, Linlin Yang, Mingshu Wang, Ying Wu, Bin Tian, Xumin Ou, Renyong Jia, Dekang Zhu, Shun Chen, Mafeng Liu, Xinxin Zhao, Shaqiu Zhang, Juan Huang, Di Sun, Yu He, Zhen Wu, Ling Zhang, Yanling Yu, Anchun Cheng

“…These findings indicate that the NLS is important for the functions of DPV pUL15. Overall, a potential NLS and the key amino acids in DPV pUL15 were identified. …”
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Handgrip strength predicts leg power but not cardiorespiratory fitness in children by Salem Alotaibi, Rizwan Qaisar, Rizwan Qaisar, Rizwan Qaisar, M. Azhar Hussain, M. Azhar Hussain, Osama Aljuhani, Maha H. Alhussain, Diogo Luís Marques, Diogo Luís Marques, Daniel Almeida Marinho, Daniel Almeida Marinho, Shaea A. Alkahtani

“…In the regression models, HGS had a significant positive effect on predicting SLJ distance (β = 2.64, p < 0.001). …”
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Obesity-Derived Biomolecules Promote the Differentiation of THP1 Monocytes to Macrophages In Vitro by Luis I. Terrazas, Valeria Gutiérrez-Almaraz, Valentina García-Garay, Victoria Hernández-Gómez, Nohemí Salinas-Jazmín, Mónica Graciela Mendoza-Rodríguez, Jonadab Efraín Olguín

“…Background: It is well known that the microenvironment in which an immune response develops, generally pro-inflammatory or immunosuppressive, along with other overproduced biomolecules recognized by pattern recognition receptors, may promote the stimulation and differentiation of monocytes into macrophages with effector functions. Low-density lipoprotein (LDL) plays a fundamental role in cholesterol transport. …”
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Is maternal SARS-CoV-2 infection in the first trimester associated with congenital heart defects? by Athina Samara, Athina Samara, Athina Samara, Conrado Milani Coutinho, Paul T. Heath, Asma Khalil, Asma Khalil, Asma Khalil

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A novel thiazole-sulfonamide hybrid molecule as a promising dual tubulin/carbonic anhydrase IX inhibitor with anticancer activity by Hussam Elddin Nabeih Khasawneh, Elryah I. Ali, Ranya Mohammed Elmagzoub, Raed Fanoukh Aboqader Al-Aouadi, Wesam Taher Almagharbeh, Ghallab Alotaibi, Stefan Bräse, Abdullah Alkhammash

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Associations Between Perinatal Dioxin Exposure and Circadian Clock Gene mRNA Expression in Children in Dioxin-Contaminated Areas of Vietnam by Thao Ngoc Pham, Hoa Thi Vu, Takafumi Tasaki, Tai Pham-The, Nghi Ngoc Tran, Muneko Nishijo, Tien Viet Tran, Hai Anh Tran, Tomoya Takiguchi, Yoshikazu Nishino

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1α,25(OH)2D3 reverses exhaustion and enhances antitumor immunity of human cytotoxic T cells by Peng Li, Hua Zhang, Xiao Wang, Biyun Chen, Ke Li, Zhinan Yin, Xinhai Zhu, Guangchao Cao, Ruan Wu, Wenhui Yuan, Guodong Sun, Xichun Xia, Ligong Lu, Yunfei Gao

“…We performed phenotypical and functional analysis of T-cell through flow cytometry. …”
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Synergistic induction of PGE2 by oral pathogens and TNF promotes gingival fibroblast-driven stromal-immune cross-talk in periodontitis by Elwira Nieboga, Aureliusz Schuster, Dominika M. Drapala, Mariia Melnykova, Aleksander Gut, Weronika Lipska, Mateusz Kwitniewski, Marcin Migaczewski, Marta Czesnikiewicz-Guzik, Tomasz Kaczmarzyk, Jan Potempa, Aleksander M. Grabiec

“…This study aimed to investigate the functional consequences of the interplay between oral pathogens and a pro-inflammatory environment in the activation of the PGE2 pathway in primary human gingival fibroblasts (GFs). …”
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A personal sensing technology enabled service versus a digital psychoeducation control for primary care patients with depression and anxiety: a pilot randomized controlled trial by Colleen Stiles-Shields, Karen M. Reyes, Tanvi Lakhtakia, Shannon R. Smith, Olga E. Barnas, Elizabeth L. Gray, Charles J. Krause, Kaylee P. Kruzan, Mary J. Kwasny, Zara Mir, Sameer Panjwani, Steven K. Rothschild, Lisa Sánchez-Johnsen, Nathan W. Winquist, Emily G. Lattie, Nicholas B. Allen, Madhu Reddy, David C. Mohr

“…There was no interactive effect of intervention and time for the PHQ-9 (p = .90) nor the GAD-7 (p = .49). …”
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Gut microbiota, immune cell, colorectal cancer association mediators: a Mendelian randomization study by Yuegang Li, Meng Zhuang, Shiwen Mei, Gang Hu, Jinzhu Zhang, Wenlong Qiu, Xishan Wang, Jianqiang Tang

“…Methods The analysis used genome-wide association study (GWAS) data encompassing 207 microbial taxa and 205 functional pathways and data on 731 immune cell phenotypes. …”
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Cognitive impact and brain structural changes in long COVID patients: a cross-sectional MRI study two years post infection in a cohort from Argentina by Sol A. Cataldo, Andrea Micciulli, Laura Margulis, Melina Cibeyra, Sabrina Defeo, Silvina G. Horovitz, Analía Martino, Raul Melano, Milagros Mena, Francisco Parisi, Diego Santoro, Florencia Sarmiento, Martin A. Belzunce

“…Neuroimaging studies have identified structural alterations in brain regions linked to cognitive functions. However, most of these studies have focused on patients within months of their initial infection. …”
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Vermicompost application improves leaf physiological activity, 2-acetyl-1-pyrroline, and grain yield of fragrant rice through efficient nitrogen assimilation under Cd stress by Anas Iqbal, Xiaoyuan Chen, Rayyan Khan, Maid Zaman, Aamir Hamid Khan, Marcin Kiedrzyński, Mohamed Ebaid, Abdulwahed Fahad Alrefaei, Sobhi F. Lamlom, Xiangru Tang, Muhammad Zeeshan, Muhammad Zeeshan

“…This study investigated the effects of VC on the soil chemical properties and the physio-biochemical functions of fragrant rice, as well as nitrogen (N) metabolism and assimilatory enzyme activities, 2-acetyl-1-pyrroline (2AP) content in rice grains, and the grain yields of fragrant rice cultivars, i.e., Xiangyaxiangzhan (XGZ) and.Meixiangzhan-2 (MXZ-2) under Cd stress condition. …”
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Genetic dissection of plant height-related traits by combined methods in wheat (Triticum aestivum L.) by Haiyan Zhang, Yue Li, Naicui Wei, Yuqiong Hao, Xiaohua Li, Bangbang Wu, Xingwei Zheng, Jiajia Zhao, Jun Zheng

“…Association mapping detected 22 SNP loci and 19 SCV loci, and these loci exhibited additive effects. This study identifies novel loci for the genetic basis of plant height-related traits.…”
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Development of ZHPV16E7- granzyme B immunoaffitoxin: dual mechanisms targeting hpv16-positive cervical cancer through epithelial-mesenchymal transition inhibition and cell death by Xiaochun Tan, Xiaochun Tan, Jiani Yang, Jiani Yang, Yanheng Li, Kairong Wan, Sicong Feng, Xishang Jing, Zhenyun Xie, Lifang Zhang, Wenshu Li

“…Crucially, ZHPV16E7-GrB demonstrated selective toxicity, effectively killing HPV16-positive cells while sparing non-HPV16-positive cells, minimizing off-target effects.DiscussionThis study highlights the dual mechanism of ZHPV16E7-GrB, inhibiting EMT and inducing cell death (apoptosis and pyroptosis). …”
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Deciphering the tumor ecosystem dynamics undergoing immunochemotherapy therapy across multiple cancer types unveils the immunosuppressive role of S100A4 in fibroblasts by promoting... by Bo Yang, Bo Yang, Ruiji Chen, Ruiji Chen, Mali Zu, Jie Yao, Hong Ren, Hong Ren, Yingxue Lin, Yingxue Lin, Bo Zhang, Tianjiao Ji, Yang Liu

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Targeting p62 by sulforaphane promotes autolysosomal degradation of SLC7A11, inducing ferroptosis for osteosarcoma treatment by Qiuming Zou, Xiaofeng Zhou, Jianqin Lai, Haixia Zhou, Jinxuan Su, Zhijing Zhang, Xiaosong Zhuang, Lili Liu, Ruijie Yuan, Sijia Li, Siyu Yang, Xinyi Qu, Jiezhu Feng, Yongqi Liu, Zisheng Li, Shiting Huang, Zhi Shi, Yu Yan, Zhiming Zheng, Wencai Ye, Qi Qi

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