Carbon and nitrogen cycling in an urban constructed technosol: The artist-led carbon sponge pilot study by Sara Perl Egendorf, Maha Deeb, Brooke Singer, Nkwi Flores, Marisa Prefer, Zhongqi Cheng, Peter Groffman

“…However, CTs must be better understood, particularly in terms of their nutrient dynamics, to optimize their ecological functions. In the Carbon Sponge pilot study, located at the New York Hall of Science in Queens, NY, USA, our objective, through an artist-led collaboration, was to evaluate the effects of different plant communities on CT formation and carbon (C) and nitrogen (N) cycling. …”
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Combined targeting of TCF7L1/2, PTEN, CDK6, and BCCIP by microRNA miR‐29c‐3p is associated with reduced invasion and proliferation of endometriotic cells by Teresa Helene Wentges, Heba M. El‐Shorafa, Janine Beckmann, Michael Gabriel, Matti Poutanen, Burkhard Greve, Ludwig Kiesel, Sebastian D. Schäfer, Martin Götte

“…We aimed to identify novel molecular targets of miR‐29c‐3p functionally linked to proliferation and invasive growth in endometriosis. …”
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The responses of vegetation water use efficiency to biomass density and CO2 balance in dryland of Central Asia during 21st century by Alphonse Kayiranga, Xi Chen, Xuexi Ma, Dative Ingabire, Tie Liu, Yaoming Li, Emeka Edwin Igboeli, Eldiiar Duulatov, Hubert Hirwa, Clement Nzabanita, Ping Hu

“…Water-use efficiency (WUE) is a critical component that links plant carbon (CO2) and water cycles through various aspects of plant ecosystem functioning. However, the variations of plant CO2 in response to water use efficiency (WUE) across temperate dryland ecosystems remains inadequately understood. …”
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VGluT3 BNST neurons transmit GABA and restrict sucrose consumption by Annie Ly, Rachel Karnosky, Emily D. Prévost, Hayden Hotchkiss, Julianne M. Pelletier, Robert L. Spencer, Christopher P. Ford, David H. Root

“…BNST VGluT3 neurons functionally transmit GABA to both ARC and PVN, with rare glutamate co-transmission to ARC. …”
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Pregnancy exacerbates neutrophil responses in murine lungs and alters gut microbiota composition after cigarette smoke exposure by Ali Dehghani, Ali Dehghani, Lei Wang, Lei Wang, Johan Garssen, Johan Garssen, Eirini Styla, Thea Leusink-Muis, Ingrid van Ark, Gert Folkerts, Jeroen van Bergenhenegouwen, Jeroen van Bergenhenegouwen, Saskia Braber, Saskia Braber

“…DiscussionIn conclusion, pregnancy as well as CS exposure induce differences in lung transcriptomic responses which might drive exacerbated lung inflammatory responses measured as neutrophil influx and activity. Microbiota functional and compositional states are also affected by both pregnancy and CS exposure, possibly indicating a gut-lung bidirectional effect.…”
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PXMP2 inhibits tumor stemness and immune infiltration in hepatocellular carcinoma based on stemness risk by Dingde Ye, Jiaqing Chen, Jian Wang, Qing Ge, Xianzhong He, Jiamu Qu, Ting Fang, Runze Wang, Shuai Mao, Qiang Wang, Qingxiang Xu, Beicheng Sun

“…The hub genes identified in the model underwent significant preliminary in vitro and in vivo phenotypic validation, which included evaluating their effects on tumor stemness and their functional roles and interactions in TME. …”
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H3K14 lactylation exacerbates neuronal ferroptosis by inhibiting calcium efflux following intracerebral hemorrhagic stroke by Tingting Sun, Jian-Nan Zhang, Ting Lan, Lei Shi, Liye Hu, Liyan Yan, Chao Wei, Lisha Hei, Weihua Wu, Zhaoli Luo, Meng Liu, Xingmei Ren, Yamei Wang, Yabin Lu, Peipei Wang, Chenguang Zhang, Liheng Bian, Xingquan Zhao, Fei Yang, Qian Li

“…In line with our in vitro findings, inhibiting H3K14la/PMCA2 reduced neuronal degeneration and improved functional outcomes in an ICH mouse model induced by intracranial injection of collagenase into the striatum. …”
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Enhancing Medium-Chain Fatty Acid Delivery Through Bigel Technology by Manuela Machado, Eduardo M. Costa, Sara Silva, Sérgio C. Sousa, Ana Maria Gomes, Manuela Pintado

“…The bigels exhibited high oil binding capacity, ranging from 87% to 98%, effectively retaining MCFAs within the matrix, with lauric acid (C12) being the main component detected within the bigels at 178.32 ± 0.10 mg/g. …”
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KRT6A Restricts Influenza A Virus Replication by Inhibiting the Nuclear Import and Assembly of Viral Ribonucleoprotein Complex by Yu Chang, Zhibo Shan, Wenjun Shi, Qibing Li, Yihan Wang, Bo Wang, Guangwen Wang, Hualan Chen, Li Jiang, Chengjun Li

“…Together, our data uncover a novel role of KRT6A in counteracting the nuclear import and functions of the vRNP complex, thereby restricting the replication of IAV.…”
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Sponge-like Modified White-Rot Fungi Adsorbent for Rapid Removal of Pb(II) and Cd(II) from Solution: Selective Performance and Mechanistic Insights by Chunxiao Wang, Zhirong Chen, Nana Wang, Jianqiao Wang, Runshen He, Yu Chen, Haerfosai Nuhu, Hang Chen, Zhixuan Lin, Minqi Fan, Mingdong Chang

“…Characterization showed that XBS has a sponge-like structure with abundant functional groups, significantly enhancing its adsorption capacity and kinetics. …”
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Droplets Cas13a‐RPA measurement delineates potential role for plasma circWDR37 in colorectal cancer by Jingsong Xu, Li Cao, Shuang Yang, Ying Jian, Yu Liu, Zhen Shen, Qian Liu, Xiang Chen, Min Li, Shun Li, Xiaolei Zuo, Min Li, Hua Wang

“…The arraystar circRNA microarray assays, functional experiments in vitro and in vivo, and qPCR were performed to discover and validate that circWDR37 is a biomarker for early screening and prognosis evaluation of CRC. …”
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Single‐cell RNA sequencing of peripheral blood mononuclear cells from bronchopulmonary dysplasia by Yufeng Liu, Chun Yan, Yushan Li, Ruoxing Zhou, Xiaoyu Lin, Qiong Meng, Sitao Li, Limei Zhong, Yanfang Tan, Wangkai Liu

“…T and B cell subsets exhibited phenotypic and functional changes, with B cells serving as crucial interaction hubs in cell communication networks. …”
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Investigating the genomic background of calving-related traits in Canadian Jersey cattle by Pedro F.C. Aponte, Paulo L.S. Carneiro, Andre C. Araujo, Victor B. Pedrosa, Patrick R. Fotso-Kenmogne, Delvan Alves Silva, Filippo Miglior, Flavio S. Schenkel, Luiz F. Brito

“…Therefore, the primary objectives of this study were to estimate genetic parameters and perform GWAS and functional enrichment analyses for stillbirth, gestation length, calf size, and calving ease traits in North American Jersey cattle. …”
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International Consensus on Evidence Gaps and Research Opportunities in Extracorporeal Cardiopulmonary Resuscitation for Refractory Out‐of‐Hospital Cardiac Arrest: A Report From the... by Laurie J. Morrison, Elizabeth A. Hunt, Brian Grunau, Thomas P. Aufderheide, Clifton Callaway, Joseph E. Tonna, Comilla Sasson, Audrey Blewer, Bryan F. McNally, Demetris Yannopoulos, Jan Belohlavek, Jason Bartos, Alain Combes, Ahamed Idris, Raina M. Merchant, Leith States, Emily Tinsley, Renee Wong, Scott T. Youngquist, George Sopko, Karl B. Kern

“…In addition, well‐designed efficacy trials, recruiting across different regions of care evaluating long‐term follow‐up, including patient reported outcomes, cost effectiveness, and equity measures, would contribute significantly to the body of science. …”
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The Role of Fat Mass and Obesity-Associated (FTO) Gene in Non-Small Cell Lung Cancer Tumorigenicity and EGFR Tyrosine Kinase Inhibitor Resistance by Aayush Rastogi, Rong Qiu, Rachel Campoli, Usama Altayeh, Sarai Arriaga, Muhammad J. Khan, Subaranjana Saravanaguru Vasanthi, Robert Hillwig, Neelu Puri

“…FTO inhibition also slowed down the migration of ER cells, and the effect was even more pronounced when combined with erlotinib. …”
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Loss of endothelial ZEB2 in mice attenuates steatosis early during metabolic dysfunction-associated steatotic liver disease by Wouter Dheedene, Stefaan Verhulst, Louise Demuynck, Bram Callewaert, Willeke de Haan, Stefan Vinckier, Jore Van Wauwe, Petra Vandervoort, Marleen Lox, Mathias Stroobants, Renaud Lavend’homme, Wilfred F. J. van IJcken, Elizabeth A. V. Jones, An Zwijsen, Marc Jacquemin, Leo A. van Grunsven, Kimberly Martinod, Danny Huylebroeck, Eskeatnaf Mulugeta, Aernout Luttun

“…The disease-promoting role of endothelial ZEB2 in early MASLD as opposed to its protective role in fibrosis underscores a context-dependent effect in liver disease.…”
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An Nrf2-NF-κB Crosstalk Controls Hepatocyte Proliferation in the Normal and Injured LiverSummary by Andrii Kuklin, Coenraad Frederik Slabber, Luigi Tortola, Chan Lap Kwan, Gerhard Liebisch, Vangelis Kondylis, Florian Mair, Manfred Kopf, Achim Weber, Sabine Werner

“…Although their individual functions in hepatocytes are well characterized, knowledge about their crosstalk in the adult liver is limited. …”
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Sprayable hydrogel sponge for neurovascular microenvironment reconstruction and inflammation modulation in diabetic wound healing by Xiaozhen Zhou, Pengchao Ma, Yihao Liu, Zhaojian Wang, Shida Chen, Zekun Cheng, Songlu Tseng, Hui Wu, Mengdi Zhang, Fengzhou Du, Nanze Yu, Xiao Long, Jiuzuo Huang, Xiumei Wang

“…Here, we developed a sprayable hydrogel sponge based on gelatin methacryloyl and methacrylamide-modified ε-poly-L-lysine (S-GPL), co-functionalized with VEGF-mimetic peptide (KLT) and BDNF-mimetic peptide (RGI). …”
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Unsealed 188Rhenium Resin Brachytherapy in Non-Surgical Candidates With Refractory Basal Cell Carcinoma: Clinical Outcomes by Marco Adriano Chessa, Carlotta Baraldi, Francesco Savoia, Lorenzo Maltoni, Giacomo Clarizio, Federica Filippi, Bianca Maria Piraccini, Emi Dika, Annalisa Pitino, Giovanni Tripepi, Federico Zagni, Lidia Strigari, Luigia Vetrone, Stefano Fanti, Paolo Castellucci

“…Inclusion criteria: histologically proven cutaneous BCC; thickness invasion not deeper than 3 mm; lesion located in the scalp, face, ears, or fingers or other areas in which surgery would have been difficult to perform or to destroy with scarce cosmetic-functional result; and contraindication or refusal of surgery. …”
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Lavender Exosome-Like nanoparticles attenuate UVB-Induced Photoaging via miR166-Mediated inflammation and collagen regulation by Sixu Li, Fei Liu, Song Zhang, Xin Sun, Xiaojing Li, Qiulin Yue, Le Su, Suzhen Yang, Lin Zhao

“…Through high-throughput small RNA sequencing and transfection of miRNA mimics analysis, we identified key miRNAs in LELNs, particularly cpa-miR166e and zma-miR166h-3p, both of which belonged to the miR166 family and played a critical role in regulating inflammation and collagen metabolism. Functional enrichment analysis indicated that these miRNAs in LELNs were involved in DNA repair, oxidative stress response, and collagen synthesis pathways. …”
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