UV-Vis-NIR Broadband Dual-Mode Photodetector Based on Graphene/InP Van Der Waals Heterostructure by Mingyang Shen, Hao Liu, Qi Wang, Han Ye, Xueguang Yuan, Yangan Zhang, Bo Wei, Xue He, Kai Liu, Shiwei Cai, Yongqing Huang, Xiaomin Ren

“…Dual-mode photodetectors (DmPDs) have attracted considerable interest due to their ability to integrate multiple functionalities into a single device. However, 2D material/InP heterostructures, which exhibit built-in electric fields and rapid response characteristics, have not yet been utilized in DmPDs. …”
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Integrating voltammetry and substrate-enhanced luminescence for noninvasive glucose sensing by Gabriel López-Peña, Ana Pallarés Vilar, Aida Jaafar, Silvia Simón-Fuente, Antonio Arranz, Maria Ribagorda, Miguel Manso-Silván, Emma Martín Rodríguez

“…The sensor incorporates NaGdF4:20% Yb3+, 2% Er3+ nanoparticles (YbEr-NPs) immobilized on a PSi substrate functionalized with a phenylboronic ester molecule. The YbEr-NPs enable luminescence-based sensing, exploiting the sensitivity of Er3+ ions to the OH vibrational groups present in D-glucose. …”
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Wogonin inhibits the proliferation of prolactinoma through the PI3K/AKT signaling pathway by Zhiyong Du, Zhiyong Du, Zhiyong Du, Zhiyong Du, Cuiping Sun, Cuiping Sun, Cuiping Sun, Cuiping Sun, Jiawei Wu, Jiawei Wu, Hongwei Gao, Hongwei Gao, Hongwei Gao, Hongwei Gao, Jialong Wu, Jialong Wu, Jialong Wu, Jialong Wu, You Zhou, You Zhou, You Zhou, You Zhou, Xuechao Wu, Xuechao Wu, Liping Shen, Liping Shen, Qing Wang, Qing Wang, Qing Wang, Qing Wang

“…ObjectivesThis investigation sought to explore the inhibitory impact of wogonin on prolactinoma and elucidate its underlying mechanisms through network pharmacology, molecular docking (MD), and molecular biology experiments.MethodsTarget identification for wogonin and prolactinoma was conducted using relevant databases, followed by protein-protein interaction (PPI) analysis of intersecting targets via the STRING database. Functional and pathway enrichment analyses were executed utilizing Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) methodologies. …”
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Sugarcane Responses to Water Deficit Are Modulated by Environmental CO₂ Concentration in a Genotype and Scale Dependent-Manner by Zulma Catherine Cardenal-Rubio, Elberth Hernando Pinzón-Sandoval, Paulo Cássio Alves Linhares, Antonia Almeida da Silva, Claudia Rita de Souza, Mewael Kiros Assefa, João Paulo Rodrigues Alves Delfino Barbosa, Paulo Eduardo Ribeiro Marchiori

“…In general, variety RB855536 showed greater physiological responses: a better water use efficiency and alteration in the carboxylation rate of Rubisco enzyme, while variety RB867515 showed a greater morphological response determined by changes in biomass allocation and anatomical alterations of stomatal densities and functionality. The sugarcane varieties exposed to water deficit and high CO₂ concentration developed different strategies based on morphological, physiological, and/or anatomical changes that are useful for facing climate change scenarios, and the effects of drought can be mitigated by the high (CO₂) in the air.…”
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The impact of mobilization protocols on the length of postoperative hospitalization among cardiac surgery patients by V. V. Vitomskyi, O. B. Lazarieva, E. Yu. Doroshenko, M. V. Vitomskа, T. М. Kovalenko, A. М. Hertsyk, S. V. Gavreliuk

“…To determine the impact of implementing the extra early mobilization protocol (EEM) on the length of intensive care unit (LICU) stay and postoperative unit (LPOU) stay and to assess the role of age, heart contractility, functional class and surgical outcomes. Materials and methods. …”
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The KNAT3a1-WND2A/3A module positively regulates fiber secondary cell wall biosynthesis in Populus tomentosa by Kuan Sun, Di Fan, Yingying Peng, Chang Liu, Lingfei Kong, Ting Lan, Xianqiang Wang, Dan Li, Chaofeng Li, Keming Luo

“…PtoKNAT3a1 overexpression caused fiber SCW thickening and increased all measured SCW compositions by upregulating the expression of SCW -biosynthetic genes and -associated TFs, but had no effect on the vessels of SCW. The opposite phenotype was observed in the PtoKNAT3a1-knockout lines. …”
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Land use change has profoundly altered the process of bacterial community assembly in the northeastern black soil zone by Ning Sun, Xu Zhao, Xu Zhao, Fangyuan Liu, Fangyuan Liu, Ge Song, Mengmeng Zhang, Fuqiang Song

“…IntroductionSoil microorganisms play a critical role in maintaining ecological functions; however, their responses to grassland reclamation and tillage remain poorly understood. …”
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Moderating role of positive aspects of caregiving in the relationship between caring burden and suicidal ideation in family caregivers of community-dwelling older adults with neuro... by Zhaohua Huo, Benjamin Hon-Kei Yip, Allen Ting-Chun Lee, Sheung-Tak Cheng, Wai Chi Chan, Ada Wai-Tung Fung, Suk Ling Ma, Calvin Pak-Wing Cheng, Frank Ho-Yin Lai, Samuel Yeung-Shan Wong, Linda Chiu-Wa Lam

“…A conceptual model was developed to test the mediation and moderation effects among caregiving burden, psychological distress, suicidal ideation, and PAC. …”
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Examining the relationship between emotion regulation, sleep quality, and anxiety disorder diagnosis by Bryana L. Schantz, Emma R. Toner, Mackenzie L. Brown, Nikki Kaiser, Alan Chen, Samrachana Adhikari, Susanne S. Hoeppner, Eric Bui, Naomi M. Simon, Kristin L. Szuhany

“…For those with better emotion regulation, poor sleep quality and worse daytime functioning due to sleep were important predictors of anxiety diagnosis. …”
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Selective arm-usage of pre-miR-1307 dysregulates angiogenesis and affects breast cancer aggressiveness by Oyku Ece Sumer, Korbinian Schelzig, Janine Jung, Xiaoya Li, Janina Moros, Luisa Schwarzmüller, Ezgi Sen, Sabine Karolus, Angelika Wörner, Verônica Rodrigues de Melo Costa, Nishanth Belugali Nataraj, Efstathios-Iason Vlachavas, Clarissa Gerhäuser, Karin Müller-Decker, Dominic Helm, Yosef Yarden, Birgitta Elisabeth Michels, Cindy Körner

“…A pre-miRNA, such as pre-miR-1307, gives rise to several mature miRNA molecules with distinct functions. However, the impact of global deregulation of pre-miR-1307 and its individual mature miRNAs in breast cancer has not been investigated in breast cancer, yet. …”
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TRIM25‐Mediated INSIG1 Ubiquitination Promotes MASH Progression Through Reprogramming Lipid Metabolism by Hao Zhang, Xiangxu Kong, Wei Wang, Huaxin Zhou, Haoran Qu, Zhengyao Guan, Honglei Wu, Xiangyu Zhai, Bin Jin

“…It identifies C27H26N2O4S as a specific inhibitor of TRIM25. C27H26N2O4S effectively decreased INSIG1 ubiquitination and attenuated lipid accumulation in the hepatocytes. …”
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Association of pregnancy complications/risk factors with the development of future long-term health conditions in women: overarching protocol for umbrella reviews by Richard Riley, Shakila Thangaratinam, Kelvin Okoth, Holly Hope, Francesca Crowe, Siang Ing Lee, Jemma Healey, Mairead Black, Ngawai Moss, Katherine Phillips, Kelly-Ann Eastwood, Kathryn Mary Abel, Steven Wambua, Megha Singh, Neil Cockburn, Zoe Vowles

“…Where a meta-analysis has been carried out, we will report the combined effect size from individual studies. For binary data, pooled ORs with 95% CIs will be presented. …”
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Pilot study to evaluate the use of remote patient monitoring to guide the timing of valve intervention in patients with severe asymptomatic aortic stenosis (APRAISE-AS): study prot... by James M Cotton, Derek Kyte, Nazish Khan, Winnie Chua, Larissa Fabritz, Richard P Steeds, Yongzhong Sun, Samir Mehta, Katie Kirkham, Philip Collis, Clive Stubbs, Mary Nulty

“…Proactive surveillance of symptoms, quality of life and functional capacity should enable timely identification of people who will benefit from aortic valve replacement. …”
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Single-cell analyses of intestinal epithelium reveal the dysregulation of gut immune microenvironment in systemic lupus erythematosus by Qiaolin Wang, Yutong Wu, Lianlian Ouyang, Xiaoli Min, Meiling Zheng, Lingyu Gao, Xiaoyun Chen, Zhi Hu, Shuang Yang, Wenjuan Jiang, Sujie Jia, Qianjin Lu, Ming Zhao

“…Additionally, subsets of CD8 + IELs exhibiting significantly enhanced effector functions were found to be markedly enriched in Lpr mice. …”
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A recurrent ABCC2 c.2439 + 5G > A variant disturbs mRNA splicing and causes Dubin-Johnson syndrome by Rongyue Sun, Ting Zhu, Tingmin Zhou, Yanzhao Luo, Tiantian Jiang, Chuangjie Gu, Ruiting Wu, Yue Wang, Fengzhen Xu, Shikang Fan, Dan wang, Yiming Chen

“…Minigene assays were performed to investigate the effects of the identified variant on mRNA splicing. …”
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Spatial transcriptomics reveals Inhba/Smad2/E2f4 axis in Lrp2high thecal cell proliferation in androgen-induced PCOS mice by Man Luo, Man Luo, Xiaona Tian, Li Li, Guomei Zhang, Wenzhi Liu, Linlin Mei, Haoran Li, Xiaoyan You, Dongmei Zhang, Mengsi Zhou, Mengsi Zhou, Cheng Xiao, Cheng Xiao, Jianping Ye, Jianping Ye, Xiaofeng Yang, Xiaofeng Yang

“…Differential expression analysis, pathway enrichment, and spatial co-localization were performed to identify regulatory networks. Functional assays were conducted in cultured TCs using siRNA-mediated knockdown of target genes, and cell proliferation and cell cycle progression were evaluated using EdU incorporation and flow cytometry.ResultsSpatial transcriptomic profiling revealed widespread transcriptional changes in the ovaries of PCOS mice, including a marked expansion of a TCs subpopulation with high Lrp2 expression. …”
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Research Progress on Extraction, Isolation, Purification, Structure Characterization, and Bioactivities of Polysaccharides from Sugarcane Leaves and Bagasse by Jinhua LU, Qingxia YUAN, Zhenzhen YANG, Chunxiu HUANG, Ling Tang Pei, Zheng LI, Yaowen LIAO, Jian ZHANG, Longyan ZHAO, Xiaotao HOU, Jiagang DENG

“…These materials are abundant in resources and rich in bioactive compounds, and their significant potential for the development of functional foods and health products is acknowledged. …”
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Dap10 co-stimulation enhances the anti-HCC efficacy of NKp30 chimeric antigen receptor T cells by JieYu Li, LiMei Chen, MingShui Chen, Miao Lin, Zineng Xie, HuiLing Wu, ZhiFeng Zhou, WanSong Lin

“…In the killing assay, chNKp30-Dap10 T cells demonstrated stronger anti-tumor effects. Similarly, better tumor regression was observed in the hepatocellular carcinoma transplantation tumor model. …”
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HIV-1 Vpu interacts with RBM10 to promote HIV-1 infection by Boye Li, Yanzhe Hao, Xianbin Meng, Xiaoming Wang, Qingyan Li, Runqing Jia, Yishu Yang, Jinning Yang, Boyang Yu, Tian Chen, Wenmei Zhang, Xiaoguang Zhang, Xiayan Wang, Qin Hu

“…ABSTRACT Viral protein U (Vpu), an accessory protein of HIV-1, functions by antagonizing or hijacking various host factors to allow the virus to evade host immune surveillance and facilitate viral release. …”
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GPX4 is a key ferroptosis regulator orchestrating T cells and CAR-T-cells sensitivity to ferroptosis by Marta Kłopotowska, Iwona Baranowska, Szymon Hajduk, Anna Jurga, Natalia Leśniowska, Michał Łaźniewski, Monika Granica, Marta Krawczyk, Milena Dziewicka, Agnieszka Graczyk, Jan Słupski, Radosław Zagożdżon, Dariusz Plewczynski, Magdalena Winiarska, Malgorzata Bajor

“…Subsequently, we identified GPX4 as a master regulator orchestrating T/CAR-T-cells’ sensitivity to ferroptosis and observed that GPX4 inhibitors impair CAR-T cells’ antitumor functions. Our study demonstrated differential GPX4 expression and diverse susceptibility to ferroptosis between CD4⁺ and CD8⁺ T cells. …”
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