Evolution history dominantly regulates fine root lifespan in tree species across the world by Xingzhao Huang, Zhouying Lu, Fangbing Li, Yang Deng, Fangfang Wan, Quancheng Wang, Fousseni Folega, Jinsong Wang, Zijian Guo

“…We compiled a dataset of 421 fine root lifespan observations from 76 tree species globally to assess phylogenetic signals among species, explored relationships between fine root lifespan and biotic and abiotic factors, and quantified the relative importance of phylogeny, root system structure and functions, climatic and edaphic factors in driving global fine root lifespan variations. …”
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DNA Imprinting and Differentially Expressed Genes in <i>Longissimus thoracis</i> Muscle of <i>Bos indicus</i> Submitted to Early Weaning Management by Gustavo Tinoco, Gustavo Russo, Rogério Curi, Marcelo Vicari, Paloma Melo, Isabella Souza, Juliana Torrecilhas, Philipe Moriel, Welder Baldassini, Luis Chardulo, Otávio Neto, Guilherme Pereira

“…<b>Results:</b> A total of 481 differentially methylated regions were identified, with 52% (250) being hypermethylated and 48% (231) hypomethylated. Functional enrichment analysis of 53 differentially methylated and differentially expressed genes was performed. …”
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GLUT3 enhances chemosensitivity in glioblastoma by transporting temozolomide and capecitabine by Honglin Diao, Yuxin Sun, Xiaojia Zhou, Qikai Wang, Mingyue Wang, Keyu Chen, Zhihua Huang, Jianlei Wei, Zeping Li, Yaxin Lou, Zebin Mao, Wenhua Yu

“…GLUT3, which is highly expressed in GBM and primarily functions as a glucose transporter, has emerged as a promising therapeutic target. …”
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Optimized non-toxic double absorber perovskite solar cell with efficiency beyond 33% by Sheikh Hasib Cheragee, Jannatul Afroj Akhi, Mishion Dev, Md. Mahfuzul Haque, Md. Alomgir Kabir, Tamim Hossain, Mohammad Tahsin Alam, Mohammad Jahangir Alam

“…After achieving the optimal configuration, the defect concentration was varied to assess its impact on cell functionality. Device modeling indicates that the proposed design performs effectively at a temperature of 300 K, with the optimal thickness for the La2NiMnO6 absorber estimated to approximately 0.8 µm under AM 1.5G 1 sun illumination. …”
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Sulforaphane attenuates CD36-mediated platelet hyperreactivity through modulating cAMP/PKA/NOX2 signaling in hyperlipidemic conditions by Weiqi Li, Chunting Wu, Xinyu Zhou, Xinhui Huang, Chunmei Zhang, Yongjie Ma, Jinqiu Hu, Xiaoyan Bi, Junyu Ma, Mengyao Li, Dong Lu, Liang Hu, Jiahua Fan, Fuli Ya

“…Using a series of platelet functional assays in human platelets in vitro, we demonstrated that SFN attenuated ox-LDL-increased platelet aggregation and activation (surface CD62P expression). …”
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The pivotal regulatory role of the FEV-SLC7A11 axis in ferroptosis elucidates the anti-aging mechanism of β-sitosterol in a cross-species study by Zhihan Fang, Zhihan Fang, Liyao Xie, Jing Wang, Junyi Li, Yirui Pan, Lei Chen, Shuyi Cao, Qi Zhou, Shaobin Li, Chao Zhang, Li Li

“…Furthermore, RNA interference targeting fev, the human homolog of ets-5, reduced oxidative stress, and subsequent BS treatment further enhanced this protective effect. Dual luciferase assays indicated that FEV functions as a transcriptional repressor of SLC7A11; BS treatment altered FEV expression, thereby promoting SLC7A11 expression and facilitating the nuclear import of reduced glutathione. …”
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The nematicidal potential of Moringa oleifera extracts and rhizobacteria against Meloidogyne incognita in tomato by Wajahat Azeem, Wajahat Azeem, Tariq Mukhtar, Muhammad Inam-ul-Haq, Muhammad Azam Khan, Muhammad Suhail Ibrahim, Ahmad Hassan, Homan Regmi, Larry W. Duncan

“…FTIR analysis of M. oleifera extract indicated the presence of functional groups such as hydroxyl, C=C, S=O, and C–O, suggesting bioactive potential. …”
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Fusion of SARS-CoV-2 neutralizing LCB1 peptide with Bacillus amyloliquefaciens RNase improves antiviral efficacy by Nikita N. Kostin, Tatyana V. Bobik, Elena V. Konovalova, Milita V. Kocharovskaya, Maria A. Simonova, Natalia Yu Rushkevich, Yuliana A. Mokrushina, George A. Skryabin, Roman S. Kalinin, Sergey I. Kovalchuk, Rustam H. Ziganshin, Leonid A. Kaluzhskiy, Oksana V. Gnedenko, Evgeniy O. Yablokov, Alexis S. Ivanov, Aleksandr S. Chernov, Vitaly A. Kazakov, Oksana N. Khokhlova, Arkady N. Murashev, Senlian Hong, Elena I. Shramova, Alexey A. Schulga, Ekaterina N. Lyukmanova, Mikhail P. Kirpichnikov, Ivan V. Smirnov, Alexey A. Belogurov, Yuri P. Rubtsov, Alexey V. Stepanov, Hongkai Zhang, Alexander G. Gabibov, Sergey M. Deyev

“…Abstract Virus-neutralizing peptides (VNPs) emerged as promising antiviral drug candidates with unprecedented specificity and cost-effectiveness during the recent COVID-19 pandemic. However, limited avidity, lack of effector functions, short circulatory half-life, and restricted administration routes make them inferior compared to neutralizing antibodies. …”
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Bibliometric analysis of global research on PD-L1/PD-1 pathway and neurodegenerative diseases over the last two decades (2004–2023) by Jialin Wu, Jialin Wu, Chaojin Zhang, Chaojin Zhang, Qiang Cao, Wei Xuan, Xiaorong Huai, Jie Zhou, Jie Tian, Jie Tian

“…BackgroundProgrammed death receptor 1 (PD-1), encoded by the PDCD1 gene, functions as a pivotal immunosuppressive molecule. …”
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Cirrhosis of the liver and hepatocellular carcinoma in the outcome of chronic hepatitis C: a case report by V. V. Makashova, Kh. G. Omarova, Zh. B. Ponezheva, O. S. Astrina, V. V. Breder, I. V. Pogrebnyakov, I. A. Dzhanyan, S. A. Magomedova

“…Given the continuing effect, the second course of transarterial chemoembolization is not shown. …”
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Transcriptomic and Metabolomic Analysis Reveals Multifaceted Impact of Gcn5 Knockdown in <i>Drosophila</i> Development by Youfeng Li, Yue Xu, Ruike Li, Sirui Huang, Qiong Wu, Jing Yan, Zhigang Jiang, Xiushan Wu, Fang Li, Yuequn Wang, Yongqing Li, Xiongwei Fan, Wuzhou Yuan

“…In <i>Drosophila</i>, Gcn5 is crucial for embryonic development, with maternal Gcn5 supporting early development. However, the functional mechanisms of Gcn5 after the depletion of maternal deposits remain unclear. …”
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AP1-mediated reprogramming of EGFR expression triggers resistance to BLU-667 and LOXO-292 in RET-rearranged tumors by Daniela Esposito, Claudia Maria Ascione, Stefania Belli, Fabiana Napolitano, Alberto Servetto, Felice Pepe, Umberto Malapelle, Antonino Iaccarino, Giancarlo Troncone, Diletta Barone, Emilio Bria, Roberto Ferrara, Daniele Lorenzini, Giuseppe Lo Russo, Maria Rosa Ghigna, Arianna Marinello, Mihaela Aldea, Benjamin Besse, Luigi Formisano, Roberto Bianco

“…RNA-Sequencing analysis identified differentially expressed genes in resistant versus sensitive cells, followed by in vitro and in vivo functional assays to explore novel therapeutic strategies. …”
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Comprehensive analysis of phosducin-like 3 as a diagnostic, prognostic and immunological marker in pan-cancer by Zihao Li, Jiayi Li, Jiayi Li, Fengchang Li, Honghua Liang, Zuotao Wu, Yongjie Zhu, Jusen Nong, Ting Zhuo, Peng Luo, Lingyun He, Weijia Huang, Jianbin Cao

“…However, there is no pan-cancer analysis, and few studies have explored the effect of PDCL3 on tumor immune infiltration.MethodPublic datasets were used to explore the diagnostic and prognostic value of PDCL3. …”
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A new therapeutic pathway in autoimmune diseases: chimeric antigen receptor T cells (CAR-T) targeting specific cell subtypes or antigen-specific B lymphocytes—a brief review by María Fernanda Segovia, Diana Landoni, Yohana Defranchi, Rodrigo Calderón Jofré, Carlos A. Flores Olivares, Gerson D. Keppeke

“…CAAR-T allows the elimination of autoreactive B lymphocytes without compromising the general functionality of the immune system, minimizing common side effects in general immunosuppressive therapies, including immunobiologicals and CAR-T. …”
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Prevalence and Clinical Characteristics of NEUROD1‐MODY in Chinese Early‐Onset Type 2 Diabetes Mellitus and a Literature Review by Tianhao Ba, Qian Ren, Siqian Gong, Meng Li, Hong Lian, Xiaoling Cai, Wei Liu, Yingying Luo, Simin Zhang, Rui Zhang, Lingli Zhou, Yu Zhu, Xiuying Zhang, Jing Chen, Jing Wu, Xianghai Zhou, Yufeng Li, Xirui Wang, Fang Wang, Liyong Zhong, Xueyao Han, Linong Ji

“…Results Four rare variants were identified in 679 patients with EOD, but only P197H decreased the transcriptional activity in in vitro functional assays to an extent comparable to the well‐known mutation causing NEUROD1‐MODY. …”
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Intelligent biosensors for human movement rehabilitation and intention recognition by Mehrab Rafiq, Nouf Abdullah Almujally, Asaad Algarni, Mohammed Alshehri, Yahya AlQahtani, Ahmad Jalal, Ahmad Jalal, Hui Liu, Hui Liu, Hui Liu

“…These sensors, initially intended to enhance device functionality, are now pivotal in applications such as Human Locomotion Recognition (HLR), with relevance in sports, healthcare, rehabilitation, and context-aware systems. …”
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External particle mixing influences hygroscopicity in a sub-urban area by S. Deshmukh, L. Poulain, B. Wehner, S. Henning, J.-E. Petit, P. Fombelle, P. Fombelle, O. Favez, H. Herrmann, M. Pöhlker, M. Pöhlker

“…These emphasise the large effect of external particle mixing and its influence on predicting hygroscopicity. …”
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Linking dietary fiber to human malady through cumulative profiling of microbiota disturbance by Xin Zhang, Huan Liu, Yu Li, Yanlong Wen, Tianxin Xu, Chen Chen, Shuxia Hao, Jielun Hu, Shaoping Nie, Fei Gao, Gengjie Jia

“…By leveraging microbiota disturbance similarities, we (1) classified 32 types of dietary fibers into six functional subgroups, revealing correlations with fiber solubility; (2) established associations among 161 diseases, uncovering shared microbiota disturbance patterns that explain disease co‐occurrence (e.g., type II diabetes and kidney diseases) and distinct microbiota patterns that discern symptomatically similar diseases (e.g., inflammatory bowel disease and irritable bowel syndrome); (3) designed a body‐site‐specific microbiota disturbance scoring scheme, computing a disturbance score (DS) for each disease and highlighting the pronounced capacity of Crohn's disease to disturb gut microbiota (DS = 14.01) in contrast with food allergy's minimal capacity (DS = 0.74); (4) identified 1659 fiber‐disease associations, predicting the potential of dietary fiber to modulate specific microbiota changes associated with diseases of interest; (5) established murine models of inflammatory bowel disease to validate the preventive and therapeutic effects of arabinoxylan that notably perturbed the Bacteroidetes and Firmicutes phyla, as well as the Bacteroidetes and Lactobacillus genera, aligning with our model predictions. …”
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Roles of Response Regulators in the Two-Component System in the Formation of Stress Tolerance, Motility and Biofilm in <i>Salmonella</i> Enteritidis by Mengjun Hu, Zhuoan Zhou, Chenqi Liu, Zeqiang Zhan, Yan Cui, Shoukui He, Xianming Shi

“…Here, we characterized the functions of RRs in TCS in the formation of stress tolerance, motility and biofilm using twenty-six <i>S</i>. …”
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LncRNA CTD-2555A7.2 promotes bone formation with LncRNA-specific cascade amplification strategy by Fanjin Meng, Kaiyuan Zheng, Meng Deng, Yuwen Ma, Yang Yu, Junxiong Li, Hong Chen, Shan Meng, Bin Guo, Xiaolan Guo, Li Jiao, Beilei Zeng, Chun Yang, Bing Yang, Chong Yin

“…To investigate this hypothesis, we conducted systematic functional analyses of CTD-2555A7.2 in osteogenesis and explored its mechanisms and potential therapeutic applications. …”
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