Combined tumor-associated microbiome and immune gene expression profiling predict response to neoadjuvant chemo-radiotherapy in locally advanced rectal cancer by Raffaello Roesel, Francesco Strati, Camilla Basso, Samantha Epistolio, Paolo Spina, Julija Djordjevic, Elisa Sorrenti, Martina Villa, Agnese Cianfarani, Francesco Mongelli, Jacopo Galafassi, Sotirios G. Popeskou, Federica Facciotti, Cecilia Caprera, Federica Melle, Pietro Edoardo Majno-Hurst, Alessandra Franzetti-Pellanda, Sara De Dosso, Ferdinando Bonfiglio, Milo Frattini, Dimitrios Christoforidis, Giandomenica Iezzi

“…A minority of patients show complete response (CR) to nCRT and may avoid surgery and its functional consequences. Instead, most patients show non-complete response (non-CR) and may benefit from additional treatments to increase CR rates. …”
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Rapeseed Green Manure Coupled with Biochar and Vermicompost Enhances Soil Aggregates and Fungal Communities in Gleyed Paddy Fields by Zhenhao Zhu, Shihong Gao, Yuhao Zhang, Guohan Si, Xiangyu Xu, Chenglin Peng, Shujun Zhao, Wei Liu, Qiang Zhu, Mingjian Geng

“…The GMB strategy mitigates reductive stress, enhances nutrient availability, and activates microbial functionality. These findings offer insights and frameworks for sustainable soil management in subtropical rice agroecosystems.…”
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Schizophrenia genetic risk and labour market outcomes in the Finnish general population: Are schizophrenia-related traits penalised or rewarded? by Aaro Hazak, Johanna Liuhanen, Katri Kantojärvi, Sonja Sulkava, Tuija Jääskeläinen, Veikko Salomaa, Seppo Koskinen, Markus Perola, Tiina Paunio

“…Background: Schizophrenia polygenic risk scores (SCZPRS) have been linked to cognitive functioning, creativity, behavioural traits, and psychiatric conditions beyond schizophrenia. …”
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Exploring Soil Hydro-Physical Improvements Under No-Tillage: A Sustainable Approach for Soil Health by Gabriel-Dumitru Mihu, Tudor George Aostăcioaei, Cosmin Ghelbere, Anca-Elena Calistru, Denis Constantin Țopa, Gerard Jităreanu

“…However, its long-term effects on soil pore networks and hydro-physical functions remain underexplored. …”
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ESTIMATING THE LEVEL OF TROPOSPHERIC ABSORPTION AT MICROWAVE FREQUENCIES AND OPERATIONAL PARAMETERS OF PERTINENT AERONOMIC AND RADIO ASTRONOMICAL INSTRUMENTS IN THE "MAXIMUM CONFID... by V. V. Myshenko, O. M. Korolev, Yu. V. Karelin, A. V. Antyufeyev, D. L. Chechotkin, D. V. Shulga, O. G. Turutanov, A. A. Poladich

“…The same way the experimental data obtained in the 3-mm range of wavelengths, with diff erent receivers and meteorological circumstances were processed. The effectiveness of the "maximum confidence" method proposed by the authors has been proven. …”
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Gait-Based AI Models for Detecting Sarcopenia and Cognitive Decline Using Sensor Fusion by Rocío Aznar-Gimeno, Jose Luis Perez-Lasierra, Pablo Pérez-Lázaro, Irene Bosque-López, Marina Azpíroz-Puente, Pilar Salvo-Ibáñez, Martin Morita-Hernandez, Ana Caren Hernández-Ruiz, Antonio Gómez-Bernal, María de la Vega Rodrigalvarez-Chamarro, José-Víctor Alfaro-Santafé, Rafael del Hoyo-Alonso, Javier Alfaro-Santafé

“…<b>Background/Objectives</b>: Sarcopenia and cognitive decline (CD) are prevalent in aging populations, impacting functionality and quality of life. The early detection of these diseases is challenging, often relying on in-person screening, which is difficult to implement regularly. …”
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MicroRNA-150 Modulates Adipogenic Differentiation of Adipose-Derived Stem Cells by Targeting Notch3 by Xiang Li, Yu Zhao, Xiuquan Li, Qiao Wang, Qiang Ao, Xiaohong Wang, Xiaohong Tian, Hao Tong, Deyu Kong, Shijie Chang, Shuling Bai, Jun Fan

“…MicroRNAs (miRNAs) influence stem cell functions, including mobilization, proliferation, and differentiation. miR-150 is abundantly expressed in monocytes. …”
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The extensive cultivation of Pyropia haitanensis along the coastal areas influences the ecological dynamics of nearby intertidal mudflat pond water by Peihao Liu, Qijun Luo, Shanshan Zhu, Juanjuan Chen, Rui Yang, Tingting Niu, Tiegan Wang, Peng Zhang, Haimin Chen

“…These changes in the seawater subsequently affected the dynamics in the corresponding aquaculture ponds, where the water quality was improved, the microbial diversity was enhanced, and the abundance of functional bacteria such as Microbacteriaceae was increased. …”
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Dual CD47 and PD‐L1 blockade elicits anti‐tumor immunity by intratumoral CD8+ T cells by Susan N Christo, Keely M McDonald, Thomas N Burn, Nadia Kurd, Jessica Stanfield, Megan M Kaneda, Ruth Seelige, Christopher P Dillon, Timothy S Fisher, Bas Baaten, Laura K Mackay

“…While dual blockade negates anti‐CD47‐mediated toxicity, the effect of combined innate and adaptive immune activation on protective tumor‐resident CD8+ T cells has yet to be fully elucidated. …”
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Demethylzeylasteral inhibits proliferation and metastasis of osteosarcoma cells by modulating the PI3K/AKT/Autophagy pathways by Xuhui Yuan, Jiayu Li, Bo Yu, Feng Cai, Binqi Chen, Jun Liu, Yuanxiang Peng, Duo Zeng, Qi Liao, Lang Liu

“…Methods: OS cell lines (MG63 and 143B) were exposed to varying concentrations of DEM, followed by assessment of diverse cell functions. RNA sequencing was implemented to identify the molecular pathways affected by DEM exposure. …”
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Immunological role of chlorogenic acid in broiler intestinal health under chronic heat stress by Aftab Shaukat, Sana Hanif, Rizwan Shukat, Muhammad Tahir Aleem, Irfan Shaukat, Mikhlid H. Almutairi, Bader O. Almutairi, Mubashar Hassan, Shahid Ali Rajput, Shu-cheng Huang, Kasim Sakran Abass, Ren-Wei Su

“…These findings highlight the potential of CA as a functional additive to mitigate the adverse effects of heat stress in poultry production.…”
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A comparison between extracorporeal shockwave therapy and dextrose prolotherapy on quadriceps muscle performance in knee osteoarthritis by Lydia Arfianti, I Putu Alit Pawana, Nurul Kusuma Wardani, Abdul Jabbar Al Hayyan, Fahmi Aulia Rizqi, I Made Yoga Prabawa, Andre Bayu Nugroho, Luh Putu Surya Handarini

“…Emerging therapies such as hypertonic Dextrose Prolotherapy (DP) and Extracorporeal Shockwave Therapy (ESWT) offer promising intervention for knee OA, focusing on pain relief and functional improvement. This study aims to evaluate and compare the effects between ESWT and DP on pain, quadriceps femoris muscle thickness and the Vastus Medial Oblique (VMO) electromyography (EMG) activity in knee OA patients. …”
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Predicting hepatocellular carcinoma outcomes and immune therapy response with ATP-dependent chromatin remodeling-related genes, highlighting MORF4L1 as a promising target by Chao Xu, Litao Liang, Guoqing Liu, Yanzhi Feng, Bin Xu, Deming Zhu, Wenbo Jia, Jinyi Wang, Wenhu Zhao, Xiangyu Ling, Yongping Zhou, Wenzhou Ding, Lianbao Kong

“…Experimental validation was conducted using quantitative real-time Polymerase Chain Reaction (qRT-PCR), Western blotting, and functional assays in HCC cell lines and xenograft models. …”
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A Two-Decade Overview of the Environmental Carrying Capacity in Bahía Santa Maria–La Reforma Coastal Lagoon System by Omar Calvario-Martínez, Julio Medina-Galvan, Virginia P. Domínguez-Jiménez, Rosalba Alonso-Rodríguez, Miguel A. Sánchez-Rodríguez, Paulina M. Reyes-Velarde, Miguel Betancourt-Lozano, David Serrano-Hernández

“…We found that during each season of the year and its transitions, the system functions as a nitrogen and phosphorus sink, which is associated with autotrophic net ecosystem metabolism and nitrogen fixation processes. …”
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Shading Impairs Mycorrhizal Benefits on Plant Growth, Leaf Gas Exchange, and Active Ingredients in <i>Polygonum cuspidatum</i> by Ci Deng, Ze-Zhi Zhang, Fábio Sérgio Barbosa da Silva, Abeer Hashem, Elsayed Fathi Abd_Allah, Ying-Ning Zou, Qiang-Sheng Wu

“…<i>Polygonum cuspidatum</i>, an important medicinal plant, often experiences shading from surrounding vegetation during its growth phase, raising questions about the impact of such conditions on the functionality of arbuscular mycorrhizal fungi. This study investigated the effects of an arbuscular mycorrhizal fungus (<i>Funneliformis mosseae</i>) on the growth, leaf gas exchange, and concentrations of active ingredient concentrations in leaves and roots of <i>P. cuspidatum</i> under shading (with a 72% shading rate) conditions. …”
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FimC binds to the promoter region of agn43 to modulate autoaggregation by Zhihao Wang, Xiangpeng Niu, Ningyuan Zhong, Lanfang Kong, Saqib Nawaz, Haiyang Zhang, Wei Jiang, Yuanyuan Liu, Jian Tu, Xiangan Han

“…It also highlights the importance of fimC in the biofilm formation and adhesion ability of APEC, which provides new insights into the functions of the fimbrial chaperone protein FimC.…”
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Multimodality Imaging in Aldosterone-Induced Cardiomyopathy: Early Detection and Prognostic Implications by Francesca Zoccatelli, Gabriele Costa, Matteo Merlo, Francesca Pizzolo, Simonetta Friso, Luigi Marzano

“…Multimodality cardiac imaging, led primarily by conventional and speckle-tracking echocardiography, and complemented by exploratory cardiac magnetic resonance (CMR) techniques such as T1 mapping and late gadolinium enhancement, enables non-invasive assessment of structural, functional, and tissue-level changes in aldosterone-mediated myocardial damage. …”
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Phyllotaxy and environmental factors influences on leaf trait dimensions in Fraxinus mandshurica: a multidimensional approach within temperate forests by Mingyue Jin, Mingyue Jin, Mingyue Jin, Yunfei Diao, Yunfei Diao, Yunlong Wang, Mingke Zhang, Tianyi Wang, Yajun Ren, Yajun Ren, Yajun Ren, Ming Zhong, Ming Zhong, Ming Zhong, Wanting Cheng, Wanting Cheng, Wanting Cheng, Chengdong Wang, Chengdong Wang, Chengdong Wang, Honghui Teng, Honghui Teng, Honghui Teng

“…., stomatal density, size) in leaflets at different phyllotactic positions of the compound-leaved species Fraxinus mandshurica in temperate forests of Northeast China, while assessing the effects of phyllotaxy and environmental factors (light, soil nutrients) on these traits.ResultsWe found that (1) specific leaf area and leaf nitrogen concentration significantly increase along the phyllotaxy gradient (from phyllotaxy 1 to 6), while leaf dry matter content, leaf thickness, and stomatal density significantly decrease. …”
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IDO‐1 Promotes Pulmonary Vascular Remodeling Via Kynurenine Pathway in Pulmonary Arterial Hypertension by Zongye Cai, Ly Tu, Siyu Tian, Lin Deng, Yahong Fu, Carole Phan, Thierry P. P. van den Bosch, Karin Tran‐Lundmark, Bence M. Nagy, Horst Olschewski, Xiaoxuan Li, Sihao Wang, Danan Wang, Yi Yan, Lijun Fu, Karin A. Boomars, Christophe Guignabert, Daphne Merkus

“…We investigated the functional role and molecular mechanisms of KP activation in PAH. …”
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An international Phase IV field study - psychometric properties of the updated module on assessing quality of life of patients with breast cancer EORTC QLQ-BR42 by Vesna Bjelic-Radisic, Fatima Cardoso, Joachim Weis, Katarzyna Pogoda, Juan Ignacio Arraras, Elfriede Greimel, Andrew Bottomley, David Cameron, Etienne Brain, Sue Hartup, René Aloisio da Costa Vieira, Nicolette Hoefnagels, Chi-Cheng Huang, Omar Shamieh, Monica Pinto, Yared Belete Belay, Samantha Serpentini, Eveline Bleiker, Manjunath Nookala Krishnamurthy, Akihiko Shimomura, Elisabeth C. Sturm-Inwald, Mikiyas Amare Getu, Brigitte Bliem, Guro Astrup, Ofir Morag, Yuichiro Kikawa, Karin Kuljanic, Nora Nevries, Mirjam Sprangers, Neil K. Aaronson, Parisa Sinai, Krzysztof Tomaszewski, Razvan Galalae, Thierry Conroy, Francois Duhoux, Wei-chu Chie, Galina Velikova

“…The psychometric analyses resulted in a final questionnaire containing 42 items divided into 10 scales: Breast Symptoms, Body Image, Sexual Functioning, Arm Symptoms, Systemic Chemotherapy Side Effects, Hand/Feet Symptoms/Neuropathy, Skeletal Symptoms, Endocrine Symptoms, Breast Satisfaction, Vaginal Symptoms, and 3 single items: Weight Gain, Sexual Enjoyment and Future Perspective. …”
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