O-GlcNAcylation inhibition redirects the response of colon cancer cells to chemotherapy from senescence to apoptosis by Ingrid Loison, Adrien Pioger, Sonia Paget, Inès Metatla, OrgaRES Consortium, Audrey Vincent, Corinne Abbadie, Vanessa Dehennaut

“…Taken together, these results suggest that combing O-GlcNAcylation inhibitors to low doses of conventional chemotherapeutic drugs could potentially reduce treatment side effects while preserving efficacy. Furthermore, this approach may increase treatment specificity, as CRC cells exhibit higher O-GlcNAcylation levels compared to normal tissues.…”
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Case Report: Clinical impact of BRCA1 and BRIP1 vs. BRCA1 and BRCA2 germline double heterozygosity in ovarian cancer: a comparative case study by Limei Zheng, Qianyuan Zhu, Qianyuan Zhu, Fenglan Zhang, Hao Qiu, Lan Qin, Jianhua Yang, Ming Qi, Ming Qi, Ming Qi, Ming Qi

“…Future research should focus on expanding sample sizes and conducting in-depth functional analyses to further clarify the clinical implications of different GDH types, ultimately refining treatment approaches for GDH-associated OC.…”
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Care and decision-making at the end of life for migrants living in the Netherlands: An intersectional analysis by Marieke Torensma, Xanthe de Voogd, Roukayya Oueslati, Irene G.M. van Valkengoed, Dick L. Willems, Bregje D. Onwuteaka-Philipsen, Jeanine L. Suurmond

“…Preferences for discussion of medical aspects of care are subject to functional impairment and faith. Personal values and goals often remain unexpressed. …”
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Clinical Presentations and Treatment Approaches in a Retrospective Analysis of 128 Intracranial Arteriovenous Malformation Cases by Corneliu Toader, Mugurel Petrinel Radoi, Milena-Monica Ilie, Razvan-Adrian Covache-Busuioc, Vlad Buica, Luca-Andrei Glavan, Christian-Adelin Covlea, Antonio Daniel Corlatescu, Horia-Petre Costin, Carla Crivoi, Leon Danaila

“…Notably, open surgery was predominantly chosen for Grade II AVMs. The functional outcomes were favorable, with 69.5% achieving a good recovery score on the Glasgow Outcome Scale. …”
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Utilization of universal-targeting mSA2 CAR-T cells for the treatment of glioblastoma by Alexandros Kourtesakis, Eileen Bailey, Hiu Nam Hannah Chow, Hannah Rohdjeß, Normann Mussnig, Dennis Alexander Agardy, Dirk Carsten Frieder Hoffmann, Yu-Chan Chih, Rainer Will, Leon Kaulen, Melissa Hahn, Robin Wagener, Denise Reibold, Sonja Pusch, Felix Sahm, Tim Sauer, Michael Schmitt, Lukas Bunse, Michael Platten, Wolfgang Wick, Tobias Kessler

“…Finally, the mSA2 CAR-T cell-mediated anti-tumor functions were demonstrated in vivo. Immunocompromised mice orthotopically implanted with CD70+ or CD276+ GB cells and treated with mSA2 CAR-T cells pre-armed with antibodies against these two antigens exhibited control of tumor growth and induction of GB cell apoptosis after therapy. …”
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Biogenic and fossil main greenhouse gas emissions of dairy, beef, pig and poultry systems by M. Berton, E. Sturaro, S. Schiavon, G. Bittante, A. Cecchinato, G. Xiccato, L. Gallo

“…The production stages included animal and manure management, on– and off-farm feed production and the production and use of the farm materials. The functional unit was 1 kg of crude protein in animal food (CPAF). …”
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All-Trans Retinoic Acid Induces CD4+CD25+FOXP3+ Regulatory T Cells by Increasing FOXP3 Demethylation in Systemic Sclerosis CD4+ T Cells by Xiaohong Sun, Yangfan Xiao, Zhuotong Zeng, Yaqian Shi, Bingsi Tang, Hai Long, Takuro Kanekura, Jiucun Wang, Haijing Wu, Ming Zhao, Qianjin Lu, Rong Xiao

“…The quantitative and functional defects of Tregs may mediate the immune dysfunction in SSc. …”
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First principles investigation of bandgap modulation and light matter interaction in cubic X₂ScInI₆ halide double perovskites for emerging energy applications by Muhammad Yar Khan, Muhammad Awais Jehangir, It Ee Lee, Qamar Wali, Tariq Usman, Li Xiaojie, Abdullah Al Souwaileh

“…Additionally, we investigated the optical properties of these halides, focusing on their complex dielectric functions. Our results suggest that these X2ScInI6 (X = K, Rb) halides DPs can be effectively utilized in optoelectronic equipment due to their capacity to absorb light in the UV spectrum. …”
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Epstein-Barr virus hijacks histone demethylase machinery to drive epithelial malignancy progression through KDM5B upregulation by Ya-Qing Zhou, Jia-Xin Jiang, Shuai He, Yi-Qi Li, Xi-Xi Cheng, Shu-Qiang Liu, Pan-Pan Wei, Xin-Yuan Guan, Choon Kiat Ong, Vivien Ya-Fan Wang, Chun-Ling Luo, Jin-Xin Bei

“…Furthermore, treatment with the KDM5B inhibitor AS-8351 markedly attenuated this signaling activity and exhibited strong anti-tumor effect in both in vitro and in vivo patient-derived xenograft models from EBV-associated tumors. …”
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Adipose tissue from oesophageal adenocarcinoma patients is differentially affected by chemotherapy and chemoradiotherapy regimens altering immune cell phenotype and cancer cell met... by Fiona O'Connell, Eimear Mylod, Noel E. Donlon, Maria Davern, Christine Butler, Niamh O'Connor, Meghana S. Menon, Claire L. Donohoe, Narayanasamy Ravi, Derek G. Doherty, Margaret R. Dunne, John V. Reynolds, Helen M. Roche, Jacintha O'Sullivan

“…Adipose tissue is a regulatory organ with many unknown downstream functions, including its direct response to chemotherapy and radiotherapy. …”
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Androgen receptor inhibition sensitizes glioblastoma stem cells to temozolomide by the miR-1/miR-26a-1/miR-487b signature mediated WT1 and FOXA1 silencing by Ana Belén Díaz Méndez, Marta Di Giuliani, Andrea Sacconi, Elisa Tremante, Valentina Lulli, Marta Di Martile, Giulia Vari, Francesca De Bacco, Carla Boccaccio, Giulia Regazzo, Maria Giulia Rizzo

“…We recently identified the diagnostic/prognostic miR-1-3p, miR-26a-1-3p and miR-487b-3p signature that displays an oncosuppressive role on several glioma biological functions. In this study, we investigated the effects of the therapeutic potential of this three-miRNA signature as a regulator of response to TMZ. …”
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Targeted temperature management at 33 versus 36 degrees after out-of-hospital cardiac arrest: A follow-up study by Robert Doerning, Kyle R. Danielson, Jane Hall, Catherine R. Counts, Michael R. Sayre, Sarah Wahlster, James A. Town, Sue Scruggs, David J. Carlbom, Nicholas J. Johnson

“…Aim: Targeted temperature management (TTM) is commonly used in the setting of out-of-hospital cardiac arrest (OHCA) to improve survival and functional outcomes. However, real-world evidence of effects and optimal temperature are limited. …”
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Integrative spatial and single-cell transcriptomics elucidate programmed cell death-driven tumor microenvironment dynamics in hepatocellular carcinoma by Kai Lei, Kai Lei, Yutong Zhao, Shumin Li, Jiawei Liu, Wenhao Chen, Caihong Zhou, Yi Zhang, Jinmei Tan, Jian Wu, Qi Zhou, Qi Zhou, Jiehui Tan

“…Among the genes associated with the PCD prognostic model, UBE2E1 was identified as a key oncogenic marker in HCC.ConclusionsThe PCD prediction model effectively predicts prognosis in HCC patients and reveals critical insights into the tumor microenvironment and immune cell exhaustion. …”
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A Study of Mixed Non-Motorized Traffic Flow Characteristics and Capacity Based on Multi-Source Video Data by Guobin Gu, Xin Sun, Benxiao Lou, Xiang Wang, Bingheng Yang, Jianqiu Chen, Dan Zhou, Shiqian Huang, Qingwei Hu, Chun Bao

“…Then, the autocorrelation and partial autocorrelation functions of the signal are employed to distinguish among four classical stochastic signal parameter models. …”
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Inter- and intraspecific variation in flight muscle fibers is associated with migratory timing by Shangmingyu Zhang, Shane DuBay, Yuwen Cheng, Zhehan Dong, Zhengwei Liu, Yongjie Wu

“…Additionally, this study underscores the potential role of sexual selection in shaping functional phenotypic variation, further advancing our understanding of adaptive strategies in high-altitude migratory birds.…”
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Clarification of a unique mucosal vaccination route for improved systemic and mucosal immune response in broiler by Rupa Akter, Md Abdul Masum, Subrato Biswas, Md Zahir Uddin Rubel, Sujan Kumar Sarkar, Mohammad Saiful Islam, Hossain M. Golbar, Md Emtiaj Alam, Md Abdur Rakib, Md Zahirul Isalm Khan

“…The CALT contains antigen-presenting cells (dendritic cells, macrophages, B cells, MHC II molecules, and T cells) and is equipped with blood vessels and high endothelial venules, which indicate its functional status. More antibodies were produced in the treatment group compared to the vehicle control group after administration of the infectious bursal disease (IBD) and the Newcastle disease (ND) vaccine through cloaca. …”
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CLIC2 regulates immunosuppression and macrophage differentiation in genomically stable gastric cancer by Viviana Longo, Pellegrino Mazzone, Giovanni Calice, Pietro Zoppoli, Giuseppina Di Paola, Giuseppe Cesta, Margherita Luongo, Claudia Sabato, Sabino Russi, Simona Laurino, Tiziana Notarangelo, Giuseppe Patitucci, Chiara Balzamo, Valeria Lucci, Elena Amendola, Giuseppina Amodio, Paolo Remondelli, Valentina Pagliara, Maria Rita Milone, Roberta Guadagno, Cristofaro De Stefano, Ferdinando De Vita, Geppino Falco, Francesco Albano

“…Abstract Chloride intracellular channels (CLICs) are a family of six evolutionarily conserved proteins with diverse functions. Previously, we identified CLIC2, as the fifth-ranked master regulator associated with diffuse-type gastric cancer (dGC) showing increased expression in tumors. …”
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Application of Deep Learning to the Classification of Stokes Profiles: From the Quiet Sun to Sunspots by Ryan J. Campbell, M. Mathioudakis, Carlos Quintero Noda, P. H. Keys, D. Orozco Suárez

“…Asymmetrical (symmetrical) profiles are less (more) common in GREGOR than DKIST or Hinode data, consistent with narrower response functions in the 1564.85 nm line. Single-lobed profiles are extremely rare in GREGOR data. …”
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Dietary prebiotic-stevioside modulates the growth, antioxidant enzymes, and immune response in thinlip mullets (Liza ramada) subjected to chronic cold stress by Akram Ismael Shehata, Mohammed F. El Basuini, Ayaat M. Elmaghraby, Mayada Alhoshy, Ali A. Soliman, Asem A. Amer, Nermin A. Ibrahim, Yusuf Jibril Habib, Mahmoud S. Gewaily, Islam I. Teiba, Shimaa A. Shahin

“…This valuable information paves the way for sustainable aquaculture practices utilizing stevioside as a functional ingredient. This study provides key insights into the multi-level responses of juvenile mullets to dietary stevioside, with potential implications for aquatic animals exposed to similar circumstances. …”
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Root traits of different wheat cultivars influence soil structure: an X-ray computed tomography and root morphology study by Bartolo Giuseppe Dimattia, Angela Righi, Matteo Bettuzzi, John Koestel, Maria Pia Morigi, Rosa Brancaccio, Silvio Salvi, Maria C. Hernandez-Soriano, Marco Bittelli

“…Bare soil was analyzed as a control. Minkowski functionals and percolation theory parameters were computed to characterize soil pore network morphology. …”
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