Results of long-term riociguat therapy, including a switching strategy from sildenafil, in patients with pulmonary hypertension of various genesis by S. A. Musashaykhova, Z. S. Valieva, T. V. Martynyuk

“…The most common AEs were nasopharyngitis, nasal congestion, and dyspnea.Conclusions: Riociguat therapy for 36 months demonstrated a persistent positive effect on the functional and hemodynamic status, remodeling of the right heart both in previously untreated patients with IPH and inoperable CTEPH, and in patients from the switching groups who did not achieve treatment goals with sildenafil therapy.…”
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Content of Some Pro- and Anti-inflammatory Factors, Insulin Resistance Parameters in Patients with Type 2 Diabetes Mellitus and Cardiovascular Autonomic Neuropathy, Influence of Om... by Serhiyenko V., Serhiyenko О.

“…However, the data about the ω-3 PUFAs effectiveness are incomplete, the future investigation are needed. …”
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Circ‐myh8/KAT7 Affects PANoptosis in Pulmonary Arterial Smooth Muscle Cells: Involvement of Super‐Enhancers in FOSL2 Expression by Jingya Zhang, Xinru Wang, Xu Wang, Songyue Li, Jianli Hou, Yibin Zhang, Xinyue Song, Shukun Cao, Ya Xu, Jing Qi, Baoshan Zhao, Xiaodong Zheng, Yan Xing

“…Conclusions Circ‐myh8 RNA, which functions jointly with KAT7, enhances H3K27ac enrichment, thereby promoting SE activity for FOSL2 transcription. …”
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Acmeological technology of forecasting individual professional-oriented trajectories of students’ personality development by E. F. Zeer, L. N. Stepanova

“…The method of structural and functional modelling of acmeological technology was applied. …”
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Uncovering genetic mechanisms associated with harmful use of alcohol in admixed Latin Americans by Edson H. B. Amaral, Gabriela de S. G. Britto, Raquel B. de São Pedro, Alberto O. Moreira, Marília O. Scliar, Ricardo Lyra, Natália P. Lima, Caroline A. Feitosa, Camila A. V. Figueiredo, Helena M. Pitangueira, Thiago Magalhães da Silva, Luydson R. S. Vasconcelos, Rodrigo F. Carmo, Maurício L. Barreto, Eduardo Tarazona-Santos, Bernardo L. Horta, Ana L. Brunialti-Godard, Pablo R. S. Oliveira

“…Association analysis was performed using multivariate logistic regression, and the functional impacts of variants were investigated through in silico analysis. …”
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Enhancing the recovery yield and quality of oil from coconut residue by ultrasound pretreatment-assisted ethanol extraction by Wanhusnee Che-U-Bong, Parichat Hongsprabhas, Attasak Jaree, Utai Klinkesorn

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Norbornenic anhydride as versatile additive optimizing interphases to enable high-performance LiNi0.8Co0.1Mn0.1O2/Li batteries by Fujie Yang, Zihao Yang, Qiujie Huang, Pipi Wang, Chong Mao, Zhanqiang Li, Huiyang Li, Xudong Chen

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High-performance ZrNiSn-based half-Heusler thermoelectrics with hierarchical architectures enabled by reactive sintering by Xin Ai, Yu Wu, Haiyan Lyu, Lars Giebeler, Wenhua Xue, Andrei Sotnikov, Yumei Wang, Qihao Zhang, Denys Makarov, Yuan Yu, G. Jeffrey Snyder, Kornelius Nielsch, Ran He

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Enhancing the Photocatalytic Efficacy of g-C₃N₄ Through Irradiation Modification and Composite Construction with Ti₃C₂ for Photodynamic... by Bin Huang, Yilun Wang, Xuguang Chen, Yue Wu, Kaidi Xu, Simeng Xie, Ziyang Qin, Xiang Liu, Huangqin Chen, Yuesheng Li

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Targeted destruction of follicle stimulating hormone receptor-positive cancer cells in vitro and in vivo by a lytic peptide Phor21-FSHβ conjugate by Nafis A. Rahman, Marcin Chrusciel, Donata Ponikwicka-Tyszko, Kamila Pulawska-Moon, Milena Doroszko, Joanna Stelmaszewska, Oliver J. Keuzer, Adolfo Rivero-Muller, Piotr Bernaczyk, Grzegorz Zalewski, Peilan Guo, Jorma Toppari, Xiangdong Li, Adam J. Ziecik, Slawomir Wolczynski, Ilpo Huhtaniemi

“…CTX alone exerted pro-apoptotic effects. CTX significantly inhibited the growth of prostate cancer LNCaP cell xenografts. …”
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RBM15 recruits myeloid-derived suppressor cells via the m6A-IGF2BP3/CBR3-AS1/miR-409-3p/CXCL1 axis, facilitating radioresistance in non-small-cell lung cancer by Songliu Hu, Ning Zhan, Jian Li, Liqun Wang, Yiyan Liu, Ke Jin, Yixuan Wang, Juxuan Zhang, Yiyang Chen, Yang Bai, Yichong Wang, Lishuang Qi, Shilong Liu

“…In vitro, RBM15 silencing enhanced the effects of radiation on the growth and invasion inhibition, and apoptosis induction of NSCLC cells; RBM15 overexpression had the opposite effects. …”
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Development and validation of a 14-CpG DNA methylation signature and drug targets for prognostic prediction in breast cancer by Bao-xing Tian, Zhi-xi Yu, Xia Qiu, Li-ping Chen, Yu-lian Zhuang, Qian Chen, Yan-hua Gu, Meng-jie Hou, Yi-fan Gu

“…Gene Ontology (GO) functional enrichment and KEGG pathway analyses indicated that the top 3,000 differentially expressed genes (DEGs) were enriched in pathways related to DNA replication and repair and cell cycle regulation. …”
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NPT100-18A rescues mitochondrial oxidative stress and neuronal degeneration in human iPSC-based Parkinson’s model by Julian E. Alecu, Veronika Sigutova, Razvan-Marius Brazdis, Sandra Lörentz, Marios Evangelos Bogiongko, Anara Nursaitova, Martin Regensburger, Laurent Roybon, Kerstin M. Galler, Wolfgang Wrasidlo, Beate Winner, Iryna Prots

“…In addition, we provide first mechanistic insights into how a compartment-specific antioxidant effect in mitochondria might contribute to the neuroprotective effects of NPT100-18A.…”
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Efficacy and tolerability of pharmacological interventions for schizophrenia non-responsive to prior treatment: a systematic review and network meta-analysisResearch in context by Myrto Samara, Andreas S. Lappas, Elisavet Pinioti, Eleni Glarou, Iwo Fober, Christos Christogiannis, Spyridon Siafis, Nikos Christodoulou, Bartosz Helfer, Dimitris Mavridis, Stefan Leucht

“…Secondary outcomes included treatment response, individual symptom domains, discontinuation, adverse events, quality of life, and functioning. Effect sizes were reported as standardized mean differences (SMDs) for continuous outcomes and odds ratios (ORs) for dichotomous outcomes, with 95% confidence intervals (CIs). …”
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Comparative efficacy and safety of Faricimab with other intravitreal anti-vascular endothelial growth factor in the treatment of Neovascular age related macular degeneration- A Sys... by Renuga Devi Kaliaperumal, Nandhini P, Reena Mohan, Nallamuthu P, Jenifer Florence Mary J

“…The fixed-effect model was used to assess and compare the effectiveness of Faricimab with other intravitreal anti-VEGF therapy. …”
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Mycorrhizal and nutrient controls of carbon sequestration in tropical rainforest soil by Jie Chen, Xin Tang, Han Xu, Yanpeng Li, Adriana Corrales, Yide Li, Yakov Kuzyakov, Zhanfeng Liu, Shirong Liu

“…The AM tree community patterns had inconsistent regulations on SOC, with basal area showing a positive while species richness exerting a negative effect on SOC content. Such counteracting effects from AM trees might attenuate SOC accumulation along the P gradient, resulting in a positive trend in SOC with soil total N:P ratios. …”
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Characterization of two novel chia (Salvia hispanica L.) white and black genotypes via DNA barcoding, physiological, and agronomic traits by Clara R. Azzam, Mokhtar Said Rizk, Soha Sayed Mohammad Mostafa, Ramadan A. Arafa, Mohamed Samy Al-Nabawi, Nahid Abdelaty Ali Morsi, Marwa Mahmoud Nasr El-Din, Enass Hassan Taher, Khaled Adly Khaled

“…Functional analyses highlighted the conserved roles of key genes, including rbcL (carbon fixation), rpoC1 (chloroplast transcription), and matK (RNA splicing). …”
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Dietary Dunaliella salina microalgae enriches eggs with carotenoids and long-chain omega-3 fatty acids, enhancing the antioxidant and immune responses in heat-stressed laying hens by Mahmoud Madkour, Sami I. Ali, Mahmoud Alagawany, Mohamed S. El-Kholy, Farouk K. El-Baz, Abdulmohsen H. Alqhtani, Abdulrahman S. Alharthi, Anthony Pokoo-Aikins, Ahmed A. Elolimy

“…Feeding heat-stressed laying hens DS improved their productivity and antioxidant status, resulting in functional eggs enriched with bioactive carotenoids (astaxanthin, zeaxanthin, and lutein) and beneficial omega-3 fatty acids.…”
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Synthetic CB1 Cannabinoids Promote Tunneling Nanotube Communication, Cellular Migration, and Epithelial–Mesenchymal Transition in Pancreatic PANC-1 and Colorectal SW-620 Cancer Cel... by David A. Bunsick, Leili Baghaie, Yunfan Li, Abdulrahman M. Yaish, Emilyn B. Aucoin, Elizabeth Skapinker, Rashelle Aldbai, Myron R. Szewczuk

“…During this reprogramming process, cancer cells’ metabolism and other cellular activities are integrated and mutually regulated by tunneling nanotube communications to alter their specific metabolic functional drivers of tumor growth and progression. …”
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A one-base therapeutic insertion in the HBG2 distal promoter reactivates γ-globin expression by Xiuqin Bao, Yuanyi Gao, Xiaoyi Chen, Zhongju Wang, Xiaoqin Feng, Liren Wang, Jing Du, Yuhua Ye, Feijing Chen, Li Du, Aihua Yin, Xiangmin Xu

“…Importantly, neither did insA have any off-target effects nor did it affect the maturation of erythroid cells. …”
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