Suppressing mitochondrial inner membrane protein (IMMT) inhibits the proliferation of breast cancer cells through mitochondrial remodeling and metabolic regulation by Li Liu, Qingqing Zhao, Daigang Xiong, Dan Li, Jie Du, Yunfei Huang, Yan Yang, Rui Chen

“…Mitochondria, as pivotal organelles, play a crucial role in the metabolic regulation of tumor cells, and their morphological and functional alterations are intricately linked to the biological characteristics of tumors. …”
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Designing and Construction of a Traditional Hand Bellow Device. by Olwal, Dunoish

“…The main advantage of a traditional hand bellows is its cost-effectiveness in producing a strong airflow for fire management. …”
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An anti-androgen resistance-related gene signature acts as a prognostic marker and increases enzalutamide efficacy via PLK1 inhibition in prostate cancer by Ruilin Zhuang, Ruihui Xie, Shirong Peng, Qianghua Zhou, Weilong Lin, Yuan Ou, Bingliang Chen, Tong Su, Zean Li, Hai Huang, Kaiwen Li, Yu Duan

“…This gene signature effectively stratified PCa patients into high- and low-risk groups, with the high-risk group exhibiting shorter recurrence-free survival and distinct immune characteristics. …”
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Short light/dark cycles favour photosynthetic efficiency and growth in grapevines by Mariana Gómez Tournier, Laurent Torregrosa, Jana Kändler, Angélique Christophe, Romain Boulord, Anna Medici, Anne Pellegrino

“…Light and temperature in greenhouses or growth chambers are major regulatory factors in plant functioning, which can be easily modulated. Shortening the photo-/nycti-periods, compared to the standard cycle (12 h light/12 h dark), has been shown to enhance the photosynthetic activity and growth in annual crops, but its effect on perennial crops such as grapevines remains unexplored. …”
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Norcantharidin inhibits TOP2A expression via H3K27me3 mediated epigenetic regulation to alleviate the progression of hepatocellular carcinoma by Ruibing Wu, Hengye Yuan, Yuehua Wang, Xianggang Gou, Wanhua Hou, Zhongzheng Zhou, Xinran Wang, Xiuling Deng, Changshan Wang, Haisheng Wang, Jia Yan, Jia Yan

“…Molecular docking simulations were employed to examine structural interactions between NCTD and EZH2 (enhancer of zeste homolog 2), while co-immunoprecipitation assays were further conducted to validate protein-protein interactions between EZH2 and protein phosphatase 1 (PP1).ResultsWe identified topoisomerase IIα (TOP2A) as a critical molecular target mediating NCTD’s anti-HCC effects. Functional characterization revealed that NCTD significantly attenuated HCC cell proliferation and induced G2/M phase cell cycle arrest through disruption of the TOP2A-p53 signaling axis. …”
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Preparation Optimization and Antioxidant Properties of the <i>β</i>-Glucan and Ferulic Acid/Quercetin Complex from Highland Barley (<i>Hordeum vulgare</i> var. <i>nudum</i>) by Yuanhang Ren, Yanting Yang, Mi Jiang, Wentao Gu, Yanan Cao, Liang Zou, Lianxin Peng

“…The interactions between these compounds can influence multiple characteristics of food products, including their physicochemical properties and functional performance, such as bioavailability, stability, and digestibility, which may support promising application of the phenol and polysaccharide complex in health food industry. …”
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Assessing the prognostic and therapeutic value of cuproptosis-related genes in colon adenocarcinoma patients by Zhanhui Ye, Yixian Song, Mengqing Zhu, Fuying Zheng, Wenjie Qin, Wenjie Qin, Xue Li, Pei Wang, Zihua Li, Kequan Chen, Aimin Li

“…Using the Weighted Gene Co-expression Network Analysis (WGCNA) method, we identified the gene module most strongly linked to cuproptosis and conducted functional enrichment analysis to explore the roles of genes within this module in COAD tumorigenesis. …”
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Filtered and unfiltered lipoaspirates reveal novel molecular insights and therapeutic potential for osteoarthritis treatment: a preclinical in vitro study by Alissa Behn, Saskia Brendle, Saskia Brendle, Marianne Ehrnsperger, Marianne Ehrnsperger, Magdalena Zborilova, Thomas M. Grupp, Thomas M. Grupp, Joachim Grifka, Joachim Grifka, Nicole Schäfer, Susanne Grässel, Susanne Grässel

“…However, further research is needed to determine its effects on cartilage regeneration.…”
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Systematizing peer recovery support services for substance use disorder: a taxonomy for measuring recovery milestones by Kimberly Horn, Ryan E. Flinn, Angela Marie Hagaman, Kristyn Zajac, Lauren A. Hoffman, Melissa N. Poulsen, Camille C. Cioffi, Ducel Jean-Berluche, Ethan Spana, Patrick F. Hibbard, Tess K. Drazdowski, Aaron Hogue

“…However, variability in PRSS roles, training, and settings creates challenges for consistent evaluation and measurement of effectiveness.ObjectiveIntroduce a systematic taxonomy to clarify the roles, functions, and activities within PRSS, providing a structured framework for evaluating their impact on key SUD recovery milestones.MethodsThe taxonomy was developed through a rapid narrative literature review, expert consultation, and an iterative consensus process informed by a Delphi-like approach. …”
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Targeting PCNA/PARP1 axis inhibits the malignant progression of hepatocellular carcinoma by Jipin Li, Jipin Li, Tao Yong, Tao Yong, Yali Chen, Tingyu Zeng, Kaifeng Zhang, Shuping Wang, Youcheng Zhang

“…Protein-protein interactions between PCNA and PARP1 were validated through co-immunoprecipitation and functional assays. The sensitivity of HCC cells to the PARP1 inhibitor Olaparib was evaluated under PCNA inhibition. …”
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hucMSC-derived exosomes targeting macrophage polarization attenuate systemic inflammation in T1DM via INS/SOD1 delivery by Xin Chen, Hong An, Yongbiao Du, Hao Zhong, Fangfang Zhang, Xiaomei Zeng, Fen Lv, Zhihua Tian, Zaixue Jiang, Qi Peng, Zengbao Li, Siping Li, Baimao Zhong, Xiaomei Lu, Yinghua Zhu

“…Proteomic profiling, pharmacological inhibition, and functional assays were employed to identify critical exosomal components. …”
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Positive impact of early-probiotic administration on performance parameters, intestinal health and microbiota populations in broiler chickens by M. Hussain, O. Aizpurua, A. Pérez de Rozas, N. París, M. Guivernau, A. Jofré, N. Tous, Z.W. Ng'ang'a, A. Alberdi, E. Rodríguez-Gallego, M.H. Kogut, J. Tarradas

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Psychometric properties and meaningful change thresholds for the QOL-E instrument in patients with myelodysplastic neoplasms by Esther Natalie Oliva, Shien Guo, Jennifer Lord-Bessen, Aylin Yucel, Roberto Latagliata, Massimo Breccia, Giuseppe A. Palumbo, Grazia Sanpaolo, Marta Riva, Valeria Santini, Uwe Platzbecker, Guillermo Garcia-Manero, Pierre Fenaux, Christopher G. Pelligra

“…MWPC thresholds were proposed for all other domains and summary scores.ConclusionThe study results demonstrate that the QOL-E is generally fit for purpose to assess treatment effects in populations with LR-MDS and the proposed MWPC thresholds can be used to assess within-patient treatment effect on PROs, as assessed by the QOL-E, in future studies.…”
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Unlocking amyotrophic lateral sclerosis: the role of adiponectin in inflammation and disease progression by Mei Tian, Mei Tian, Mei Tian, Cheng Xin, Cheng Xin, Cheng Xin, Jia Huo, Jia Huo, Jia Huo, Qi Liu, Qi Liu, Qi Liu, Hui Dong, Hui Dong, Hui Dong, Lin Bai, Lin Bai, Lin Bai, Yafei Wang, Yafei Wang, Yafei Wang, Rui Li, Rui Li, Rui Li, Yaling Liu, Yaling Liu, Yaling Liu

“…Adiponectin produces anti-inflammatory effects via its adiponectin receptor 1 (AdipoR1) and adiponectin receptor 2 (AdipoR2). …”
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Application of <i>Lactobacillus plantarum</i> and <i>Pediococcus lactis</i> on Lipid Metabolism, Anti-Inflammatory, and Fecal Microbiota in Cats by Shukun Liang, Xinshu Gu, Jintao Sun, Xiumin Wang, Hui Tao, Zhenlong Wang, Yougang Zhong, Jinquan Wang, Bing Han

“…Probiotics have been used in functional foods and dietary supplements, and in recent years, they have become more widely used in pets. …”
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Multiomics integration analysis identifies tumor cell-derived MIF as a therapeutic target and potentiates anti-PD-1 therapy in osteosarcoma by Yan Liao, Hao Yao, Weidong Chen, Yutong Zou, Ji Fang, Jiongfeng Zhang, Zehao Guo, Jian Tu, Junkai Chen, Zijun Huo, Lili Wen, Xianbiao Xie

“…In vitro coculture functional assays were performed to validate the role of macrophage migration inhibitory factor (MIF) in macrophage polarization and chemotaxis. …”
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ZEB1 stratifies the response to Sorafenib and Mdivi-1 combination therapy in hepatocellular carcinoma by H. Freudenstein, M. Strecker, S. Gylstorff, W. Shi, M. Boettcher, S. Medunjanin, C. Catapano, C. Siba, C. Wex, T. Wartmann, A. Y. Sanin, M. Franz, J. Arend, D. Mougiakakos, M. Pech, R. S. Croner, U. D. Kahlert, F. Stelter

“…Mdivi-1 treatment in human-physiological achievable concentration effectively induced apoptosis in all tested cell models. …”
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Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids by Amy R. Bentley, Michael R. Brown, Solomon K. Musani, Karen L. Schwander, Thomas W. Winkler, Mario Sims, Tuomas O. Kilpeläinen, Hugues Aschard, Traci M. Bartz, Lawrence F. Bielak, Jin-Fang Chai, Kumaraswamy Naidu Chitrala, Nora Franceschini, Mariaelisa Graff, Xiuqing Guo, Fernando P. Hartwig, Andrea R.V.R. Horimoto, Elise Lim, Yongmei Liu, Alisa K. Manning, Ilja M. Nolte, Raymond Noordam, Melissa A. Richard, Albert V. Smith, Yun Ju Sung, Dina Vojinovic, Rujia Wang, Yujie Wang, Mary F. Feitosa, Sarah E. Harris, Leo-Pekka Lyytikäinen, Giorgio Pistis, Rainer Rauramaa, Peter J. van der Most, Erin Ware, Stefan Weiss, Wanqing Wen, Lisa R. Yanek, Dan E. Arking, Donna K. Arnett, Christie Ballantyne, Eric Boerwinkle, Yii-Der Ida Chen, Martha L. Daviglus, Lisa de las Fuentes, Paul S. de Vries, Joseph A. C. Delaney, Amanda M. Fretts, Lynette Ekunwe, Jessica D. Faul, Linda C. Gallo, Sami Heikkinen, Georg Homuth, M. Arfan Ikram, Carmen R. Isasi, Jost Bruno Jonas, Liisa Keltikangas-Järvinen, Pirjo Komulainen, Aldi T. Kraja, Jose E. Krieger, Lenore Launer, Lifelines Cohort Study, Jianjun Liu, Kurt Lohman, Annemarie I. Luik, Ani W. Manichaikul, Pedro Marques-Vidal, Yuri Milaneschi, Stanford E. Mwasongwe, Jeffrey R. O’Connell, Kenneth Rice, Stephen S. Rich, Pamela J. Schreiner, Lars Schwettmann, James M. Shikany, Xiao-ou Shu, Jennifer A. Smith, Harold Snieder, Nona Sotoodehnia, E. Shyong Tai, Kent D. Taylor, Lesley Tinker, Michael Y. Tsai, André G. Uitterlinden, Cornelia M. van Duijn, Diana van Heemst, Melanie Waldenberger, Robert B. Wallace, Hwee-Lin Wee, David R. Weir, Wen-Bin Wei, Ko Willems van Dijk, Gregory Wilson, Jie Yao, Kristin L. Young, Xiaoyu Zhang, Wei Zhao, Xiaofeng Zhu, Alan B. Zonderman, Ian J. Deary, Christian Gieger, Hans Jörgen Grabe, Timo A. Lakka, Terho Lehtimäki, Albertine J. Oldehinkel, Martin Preisig, Ya-Xing Wang, Wei Zheng, Michele K. Evans, Michael Province, James Gauderman, Vilmundur Gudnason, Catharina A. Hartman, Bernardo L. Horta, Sharon L. R. Kardia, Charles Kooperberg, Ching-Ti Liu, Dennis O. Mook-Kanamori, Brenda WJH Penninx, Alexandre C. Pereira, Patricia A. Peyser, Bruce M. Psaty, Jerome I. Rotter, Xueling Sim, Kari E. North, Dabeeru C. Rao, Laura Bierut, Clint L. Miller, Alanna C. Morrison, Charles N. Rotimi, Myriam Fornage, Ervin R. Fox

“…The genetic diversity of included samples was key in identifying these novel loci: four of the lead variants displayed very low frequency in European ancestry populations. Functional annotation highlighted promising loci for further experimental follow-up, particularly rs73597733 (MACROD2), rs59808825 (GRAMD1B), and rs11702544 (RRP1B). …”
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Investigating the relationship between the monetary policy shock through the exchange rate channel on the management quality index in the banking system: by examining the productiv... by Farhad Sharifi Bagha, Jafar Haqiqat, Zahra Karimi Takanloo

“…In the present study, we show that replacing ECB balance sheet size with random numbers leads to statistically indistinguishable shock response functions and time series of abnormal monetary policy shocks. …”
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Epicardial Adipose Tissue: A Multimodal Imaging Diagnostic Perspective by Giancarlo Trimarchi, Maria Ludovica Carerj, Concetta Zito, Gianluca Di Bella, Giovanni Taverna, Maurizio Cusmà Piccione, Pasquale Crea, Stefania Lo Giudice, Angela Buonpane, Michela Bonanni, Davide Restelli, Umberto Paradossi, Angelo Monteleone, Antonio Micari, Scipione Carerj

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