Copper Increases the Cooperative Gating of Rat P2X2a Receptor Channels by Elias Leiva-Salcedo, Denise Riquelme, Juan Pablo Huidobro-Toro, Claudio Coddou

“…<b>Background/Objectives:</b> P2X receptor channels are widely expressed in the CNS, where they have multiple functions in health and disease. The rat P2X2a (rP2X2a) receptor channel is modulated by copper, an essential trace element that plays important roles in synaptic modulation and neurodegenerative disorders. …”
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Neural stem cells in adult neurogenesis and their therapeutic applications in neurodegenerative disorders: a concise review by Teketay Bayleyegn Derso, Bemrew Admassu Mengistu, Yitayew Demessie, Melkie Dagnaw Fenta, Kalkidan Getnet

“…While clinical trials have demonstrated some success in improving cognitive and motor functions in individuals with neurodegenerative impairments, challenges such as immunological rejection, the identification of compatible cell sources, ethical concerns, treatment efficacy, and potential side effects necessitate thorough investigation before widespread clinical implementation. …”
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Analysis of the molecular mechanism endogenous hormone regulating axillary bud development in Pinus yunnanensis by Haihao He, Junfei Xu, Nianhui Cai, Yulan Xu

“…Results We found that decapitation could effectively promote the releases of the axillary buds in P. yunnanensis. …”
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Results of surgical treatment of acute retinal necrosis by V. V. Neroev, P. A. Ilyukhin, R. A. Fedotov, V. E. Tankovsky

“…Purpose: to evaluate the effectiveness of surgical treatment of acute retinal necrosis. …”
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Performance Evaluation of Dough Mixing Machine by Kunle Oni, Omowanle Akinmolayan, Adeyemi Mathew Ige

“…This study was carried out to evaluate the performance of dough mixing machine designed, by assessing the functional properties of wheat flour for the pasting properties and farinograph characteristics of the flour suitable for use in the mixing machine. …”
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Internet of Things-Driven Precision in Fish Farming: A Deep Dive into Automated Temperature, Oxygen, and pH Regulation by Md. Naymul Islam Nayoun, Syed Akhter Hossain, Karim Mohammed Rezaul, Kazy Noor e Alam Siddiquee, Md. Shabiul Islam, Tajnuva Jannat

“…The research introduces a revolutionary Internet of Things (IoT)-based system for fish farming, designed to significantly enhance efficiency and cost-effectiveness. By integrating the NodeMcu12E ESP8266 microcontroller, this system automates the management of critical water quality parameters such as pH, temperature, and oxygen levels, essential for fostering optimal fish growth conditions and minimizing mortality rates. …”
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Salinity Gradients Override Hydraulic Connectivity in Shaping Bacterial Community Assembly and Network Stability at a Coastal Aquifer–Reservoir Interface by Cuixia Zhang, Haiming Li, Mengdi Li, Qian Zhang, Sihui Su, Xiaodong Zhang, Han Xiao

“…The coastal zone presents complex hydrodynamic interactions among inland groundwater, reservoir water, and intruding seawater, with important implications for ecosystem functioning and water quality. However, the relative roles of hydraulic connectivity and seawater-driven salinity gradients in shaping microbial communities at the aquifer–reservoir interface remain unclear. …”
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Community services for children and youth with behavioral problems and in conflict with the law: The idea and realization of a day care center by Gajić Miona, Hrnčić Jasna, Vučinić-Jovanović Marija

“…Based on the respondents' answers, we can conclude that the daycare service has multiple positive effects on both users and their families, as well as on the local community. …”
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Extracellular transfer of HuR promotes acquired cisplatin resistance in esophageal cancer cells by Yayun Cui, Xiaofeng Zhu, Liting Qian, Shu Zhang

“…CCK-8 and flow cytometry were employed to assess the functional role of exosomes in ESCA DDP-resistant cells and their parental cells. …”
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Two-Stage Optimal Dispatching Method for Highway Service-Area Microgrid Considering Emergency Power-Supply Vehicles by HU Junjie, QU Jiatong, LIU Xuetao, GUI Jiangyi

“…The lowest operating cost of the emergency power-supply vehicle and lowest load-shedding penalty are taken as objective functions to obtain the final intraday optimization scheduling. …”
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In Silico drug evaluation by molecular docking, ADME studies and DFT calculations of 2-(6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)-N, N-dipropylacetamide by Veysel Tahiroğlu, Kenan Gören, Mehmet Bağlan

“…Abstract In this study, the structural, electronic, pharmacokinetic, and biological properties of molecule 2-(6-kloro-2-(4-klorofenil)imidazo[1,2-a]piridin-3-il)-N, N-dipropilasetamid (Alpidem), an imidazopyridine derivative anxiolytic known for its high BZ₁ (benzodiazepine-1) receptor affinity and low adverse effect profile, were comprehensively investigated by density functional theory (DFT) and in-silico methods. …”
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Methods of Calculating the Indexes of Intellectual Capital of Organizations by V. A. Korzhak

“…Competitive functioning at the micro and macro levels of businesses in different industries creates the need to make changes in the assessment of the impact on the performance of companies of tangible and intangible assets, leading to an increase in the value of both products and companies. …”
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Prognostic value of acute National Institutes of Health Stroke Scale Items on disability: a registry study of first-ever stroke in the western part of Sweden by Katharina S Sunnerhagen, Hege Ihle Hansen, Tamar Abzhandadze, Haakon Ihle-Hansen, Guri Hagberg, Malin Reinholdsson

“…Objectives We aimed to study how the individual items of the National Institutes of Health Stroke Scale (NIHSS) at admission predict functional independence 3 months post-stroke in patients with first-ever stroke.Setting This registry-based study used data from two Swedish stroke registers (Riksstroke, the mandatory national quality register for stroke care in Sweden, and Väststroke, a local quality stroke register in Gothenburg).Participants This study included patients with first-ever acute stroke admitted from November 2014 to August 2018, with available NIHSS at admission and modified Rankin Scale (mRS) at 3-month follow-up.Primary outcome The primary outcome variable was mRS≤1 (defined as an excellent outcome) at 3-month follow-up.Results We included 1471 patients, mean age was 72 (± 14.5) years, 48% were female, and 66% had mild strokes (NIHSS≤3). …”
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The use of standardised tools to measure post-mastectomy quality of life among women in Africa: a scoping review by Alexis Harerimana, Gugu Mchunu

“…Mastectomy negatively affected overall QoL, body image, psychological wellbeing, sexual functioning, and social relationships. Educational and psychosocial interventions enhanced QoL, particularly those integrating self-compassion training, physical rehabilitation, and group counselling. …”
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A Patient-Oriented Implementation Strategy for a Perioperative mHealth Intervention: Feasibility Cohort Study by Daan Toben, Astrid de Wind, Eva van der Meij, Judith A F Huirne, Johannes R Anema

“…Patients recovering at home could benefit from tools tailored to their new care setting to effectively manage their convalescence. The mHealth application ikHerstel is one such tool, but although it administers its functions in the home, its implementation hinges on health care professionals within the hospital. …”
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Soil Conservation and Influencing Factors in Xiangyang City, Hanjiang River Basin by Xiaojing Liu, Xuanhui Li, Xiaohuang Liu, Wei Zhang, Songhang Liu, Jiaqi Xu, Guanzhong Zeng

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Retrofit design for automatic offtake system of natural gas pipeline station by Wenyi TANG, Baotang QU, Xianzhong ZHANG, Mingming ZHANG, Binbin LI, Yuqin WANG

“…Furthermore, several supplementary control functions are integrated, comprising undisturbed offtake branch switching, PID regulation, automatic offtake startup/shutdown, low-flow protection, low-pressure protection, and transmission shutdown for overpressure prevention. …”
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AGORA: Access to Global Online Research in Agriculture [Abstract only] by Mary Ochs

“…The AGORA portal ultimately will fulfill the multiple information transfer functions so necessary to information delivery in the developing countries. …”
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From darkness to twilight: Morphological divergence between cave and surface‐subterranean ecotone Niphargus species by Anna Biró, Gergely Balázs, Žiga Fišer, Cene Fišer, Gergely Horváth, Gábor Herczeg

“…To understand whether (i) habitat‐based phenotypic divergence is present between the cave and the ecotone species and (ii) similar phenotypes emerge independently in each ecotone, we studied morphological divergence between four cave and four ecotone Niphargus species based on 13 functional morphological traits. To account for different selection acting on the sexes, we included both males (N = 244) and females (N = 222). …”
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Interim Analysis of Treatment Outcomes of Young Children with 5q Spinal Muscular Atrophy on Gene Replacement Therapy with Onasemnogene Abeparvovec. Clinical Observations by Anna A. Kokorina, Sergei S. Nikitin

“…One injection to a patient with 5q spinal muscular atrophy (SMA) leads to replacement of the missing or defective SMN1 gene with its functional copy. It leads to normalization of survival motor neuron protein (SMN) production.Objective. …”
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