The role of scavenger receptor B1 in infection with Mycobacterium tuberculosis in a murine model. by Georgia Schäfer, Reto Guler, Graeme Murray, Frank Brombacher, Gordon D Brown

“…Like many other receptors for these pathogens, the loss of SR-B1 can be functionally compensated for under normal conditions.…”
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Predictive value of the combined triglyceride-glucose and frailty index for cardiovascular disease and stroke in two prospective cohorts by Yi-Chang Zhao, Shi-Qi Wu, Jia-Kai Li, Zhi-Hua Sun, Bi-Kui Zhang, Rao Fu, Miao Yan

“…By integrating metabolic and functional risk dimensions, TyGFI provides a more comprehensive risk stratification tool, with significant implications for early identification and prevention of cardiovascular events in aging populations.…”
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Features of tactics of inspection of accident sites in the investigation of illegal interference in the activities of energy facilities using unmanned vehicles by S. L. Kislenko, A. B. Smushkin

“…At the same time, the importance of urgently studying the volatile memory of a working device is stated.Conclusions about the achievement of the research goal: the paper proposes adaptive algorithms for the investigator's actions in various investigative situations: when the functioning of the device was suppressed by electronic warfare; when the UAV was physically damaged or destroyed; when an attacker with a UAV control device (remote control, smartphone, laptop, special glasses, etc.) was detained at the scene; when the control device is detected, but the attacker himself has disappeared; when the attacker has destroyed the control device; when information from the UAV (video and sensor readings) was transmitted not only to the operator's device, but also to another addressee; when the operator was detained on the territory of the fuel and energy complex. …”
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Modular and signal-responsive transcriptional regulation using CRISPRi-aided genetic switches in Escherichia coli by Seong Keun Kim, Seung-Gyun Woo, Jun-Hong Park, Seung-Goo Lee, Dae-Hee Lee

“…This study aimed to develop a CRISPRi-aided genetic switch platform that overcomes these limitations and expands the functionality of transcriptional regulation tools in synthetic biology. …”
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Ultrasound-triggered drug release and cytotoxicity of microbubbles with diverse drug attributes by Chi-Fen Chuang, Chia-Wei Lin, Chih-Kuang Yeh

“…DOX-lipid aggregates delayed initial uptake, leading to less pronounced short-term (2 h) effects compared to the rapid release of free CPT from CPT-MBs. …”
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RECONSTRUCTION OF THE ALVEOLAR RIDGE IN PERIODONTAL TISSUE PATHOLOGY UNDER COMPLEX ANATOMICAL CONDITIONS (CLINICAL CASE). by Yu.O. Kіnash, L.V. Kіnash

“… The optimal placement of dental implants in the jawbone tissue in cases of periodontal disease ensures conditions for the long-term success of osteointegration and the functioning of the prosthetic construction. However, the anatomical features of the mandible and maxilla often prevent dental implant surgeons from achieving the desired results after the placement of dental implants in cases of horizontal atrophy of the alveolar bone tissue [3,5-7]. …”
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Advanced smart assistance with enhancing social interaction and daily activities for visually impaired individuals using deep learning with modified seagull optimization by Sana Alazwari, Hussah Nasser AlEisa, Mohammed Rizwanullah, Radwa Marzouk

“…The ADD-MSGOEL method is designed to enhance the social life and daily functioning of visually impaired people by accurately detecting damage and potential hazards in their surroundings. …”
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Prediction of teaching quality in the context of smart education: application of multimodal data fusion and complex network topology structure by Chunzhong Li, Chenglan Liu, Wenliang Ju, Yuanquan Zhong, Yonghui Li

“…Through testing the collected multimodal data such as grades, classroom behavior, and psychological characteristics, it was found that this article’s method could optimize teaching strategies and improve teaching effectiveness. The prediction model based on attention mechanism optimized deep neural network achieved an average accuracy of 94.16% in the first test; the average F1 score was 90.60%; the AUC (Area Under the Curve) value was 0.975; the average mean square error was 0.271. …”
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A network Meta-analysis of tripterygium wilfordii polyglycosides tablet,ambrette capsule and RAS blocker in the treatment of IgA nephropathy by FANG Xin-ying, WANG Xiao-qin, JIN Shan-shan, LIN La-mei

“….;(2)Compared to RAS blockers alone,TW+RAS blockers was superior to RAS blockers for reducing serum creatinine(P<0.05),with a SMD(95% CI)of-6.32(-11.06,-1.69);(3)In the risk of adverse events,ambrette capsule+RAS blockers was superior to TW+RAS blockers,with a SMD(95% CI)of 0.19(0.04,0.73).Conclusions Ambrette capsule combined with RAS blockers can effectively reduce urine protein level in IgAN patients with proteinuria,and has a minimal risk of adverse events.TW combined with RAS blockers can reduce serum creatinine to protect patients’ renal functions,with an increased risk of adverse events.…”
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Mechanical Structure Design and Motion Simulation Analysis of a Lower Limb Exoskeleton Rehabilitation Robot Based on Human–Machine Integration by Chenglong Zhao, Zhen Liu, Yuefa Ou, Liucun Zhu

“…The lower limb exoskeleton rehabilitation robot has great potential in areas such as enhancing human physical functions, rehabilitation training, and assisting the elderly and disabled. …”
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Konjac glucomannan as an emerging nutritional strategy for obesity control via gut microbiota and metabolic regulation by Anindita Ghosh, Priyanka Mohol, Sumana Ghosh

“…Conclusion KGM emerges as a promising functional dietary component in regulating obesity and metabolic syndrome, with its effects attributed to both its physicochemical properties and its influences on gut-microbial dynamics. …”
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Clinical application of hemoperfusion therapy combined with continuous venovenous hemofiltration in patients with sepsis by LUO Jian-yu, WANG Xiao-yuan, LV Guang-yu, CAI Tian-bin

“…Objective To observe the clinical efficacy and safety of hemoperfusion(HP) therapy combined with continuous venovenous hemofiltration(CVVH) for patients with sepsis.Methods A total of 70 ICU patients meeting the sepsis criteria was selected to divide into two groups(group A and B,35 patients for each group) based on the random number table method.The patients in group A were treated in combination with CVVH on the basis of the medical treatment,and the ones in group B received combination of HP with CVVH on the basis of the medical treatment.Results In group A,the hypersensitivity C-reactive protein(hs-CRP),tumor necrosis factor a(TNF-a),interleukin 6(IL-6) and calcitonin protoxin(PCT) and lipopolysaccharide(LPS) decreased in at 120 h of treatment(P<0.05).In group B,the above indexes decreased at 72 h and 12 h of treatment,and the decrease for group A was more significant than that for group A(P<0.05).The mean arterial pressure(MAP) was improved in the two groups(P<0.05) at 120 h of treatment,but there was no significant difference between the two groups(P>0.05).In group B,at 120 h of treatment,heart rate(HR),vasoactive-inotropic score(VIS),oxygenation index(OI),acute physiology and chronic health evaluation(APACHE II) score and sequential organ failure assessment score(SOFA) were all decreased(P<0.05),and the decrease for group B was more significant than for group A(P<0.05).After treatment,the levels of blood serum creatinine(Scr) and total bilirubin(TBIL) decreased in both groups(P< 0.05),but there was no significant difference between the two groups at the same time point.There was no significant difference in blood purification time,incidence of serious bleeding events and 28-day mortality rate between the two groups(P>0.05);and,ICU hospitalization time and mechanical ventilation time in group B were shorter than those in group A(P<0.05),and ICU mortality rate in group B was smaller than that in group A(P<0.05).Conclusions Compared to alone CVVH,HP therapy combined with CVVH for patients with sepsis can remove inflammatory mediators more effectively and improve organ functions and prognosis,with no significant increase in incidence of the complication of bleeding.…”
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SPP1 as a Prognostic and Immunotherapeutic Biomarker in Gliomas and Other Cancer Types: A Pan-Cancer Study by Wang K, Wan J, Zheng R, Xiao Y, Lv F, Ge H, Yang G, Cheng Y

“…The correlation of SPP1 expression with overall survival (OS), progression-free survival (PFS), immune cell infiltration, and immune checkpoint markers was analyzed. Functional validation was performed via SPP1 knockdown in glioma cell lines to evaluate effects on proliferation, invasion, and immune interactions.Results: SPP1 was found to be overexpressed in 27 tumor types, with high expression correlating with poor OS, PFS, and increased immune cell infiltration, particularly with CD8+ T cells and macrophages. …”
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Changes in the physicochemical and microbiological properties of probiotic-fermented low-fat yoghurt enriched with barley β-glucan during cold storage by Rafaat Mohamed Elsanhoty, Mohamed Fawzy Ramadan

“…It could be concluded that substitution of fat with BβG is a sufficient delivery truck of probiotic culture and BβG could be used safely in functional dairy products.…”
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Personalized approaches to the prescription of protein-based oral nutritional supplements in older adults: A scoping review by Catherine M. Fallon, Clare A. Corish, Katy Horner, Caitriona Cunningham

“…Summary: Background and aims: Oral nutritional supplements (ONS) are prescribed for older adults with malnutrition and sarcopenia to prevent nutritional and functional deterioration. Studies investigating ONS effectiveness commonly provide the same ONS prescription for participants. …”
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Study protocol for the Outcomes Post-Treatment: Impact on Motor Impairment of Sleep Efficiency in Spinal Cord Injury (OPTIMISE SCI) – a randomised controlled trial by Julio C Furlan, Sandra Walsh, Mark Boulos, Christie Yao, Martha McKay

“…Primary outcome measures include neurological and functional recovery after SCI.Ethics and dissemination The protocol for this randomised clinical trial (RCT) raised an interesting discussion with our research ethics board about delaying CPAP therapy by 3 months when a participant is diagnosed with moderate-to-severe SRBD. …”
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Impact of epiretinal membrane peeling on steroid dependency in uveitic eyes: a retrospective analysis by Verena Schöneberger, Julia Schirrwagen, Claudia Brockmann, Thomas A. Fuchsluger, Friederike Schaub

“…While surgical removal can improve anatomical and visual outcomes, its effect on intraocular inflammation and steroid requirement remains unclear. …”
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Signs of Nervous System Sensitization in Female Runners with Chronic Patellofemoral Pain by Brian J. Eckenrode, David M. Kietrys, Allison Brown, J. Scott Parrott, Brian Noehren

“…Data was analyzed utilizing independent t-tests for comparison of between-group data, effect sizes for QST measures (Pearson's r), and Pearson's correlation coefficient between pressure pain threshold values at the knee and functional testing…”
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Expression profiles and potential roles of microRNAs in erythrocytes during the aging process by Liping Sun, Xiaofei Li, Xiaoxing Liang, Cuimi Duan, Fengxian Li, Yang Yu, Deqing Wang

“…A bioinformatics analysis identified the potential targets and biological functions of these miRNAs. The experiment of miR-22-3p in the human erythroblast cell line K562 confirmed its negative effects on PK levels. …”
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Analysis of medication rule of Traditional Chinese Medicine in treating depression based on data mining by Jin Yang, Shuai Wang, Zhen Zhang, Junjie Huang, Weihai Chen, Zhan Xu

“…As a highly prevalent disorder, it seriously endangers the psychosocial functioning of patients. Many scholars have conducted clinical studies on the treatment of depression using different herbal remedies, but there are no studies that integrate these remedies to explore the general medication rule. …”
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