Human Chondrocytes from Human Adipose Tissue-Derived Mesenchymal Stem Cells Seeded on a Dermal-Derived Collagen Matrix Sheet: Our Preliminary Results for a Ready to Go Biotechnolog... by Quan Tran Dang, Thao Duy Huynh, Francesco Inchingolo, Gianna Dipalma, Alessio Danilo Inchingolo, Stefania Cantore, Gregorio Paduanelli, Kieu Cao Diem Nguyen, Andrea Ballini, Ciro Gargiulo Isacco, Cong Toai Tran

“…Our findings have shown that the dermal collagen may exert important effects on the quality of in vitro expanded chondrocytes, leading in this way that the influence of collagen skin matrix helps to produce highly active and functional chondrocytes for long-term cartilage tissue regeneration. …”
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Early posttranscriptional response to tetracycline exposure in a gram-negative soil bacterium reveals unexpected attenuation mechanism of a DUF1127 gene by Jennifer A. F. Kothe, Till Sauerwein, Theresa Dietz, Robina Scheuer, Muhammad Elhossary, Susanne Barth-Weber, Jan Wähling, Konrad U. Förstner, Elena Evguenieva-Hackenberg

“…Besides ten upregulated ribosomal genes, there was no recognizable functional pattern in the observed changes. However, polar differential expression pattern was observed: Mostly, upregulated genes were first and downregulated genes downstream in operons. …”
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Case report: Novel homozygous ACVRL1 missense variant in a family with hereditary hemorrhagic telangiectasia and pulmonary arterial hypertension: findings suggest a hypomorphic all... by Akash Mathavan, Akshay Mathavan, Urszula Krekora, Adityanarayan Rao, Marc S. Zumberg, Jeb Justice, Pinar Bayrak-Toydemir, Jamie McDonald, Ali Ataya

“…Experimental studies, including functional and molecular assays, are therefore essential to confirm the pathogenic impacts of this variant, validate its classification as a hypomorphic allele, and elucidate its effects on BMP-TGF-β signaling.…”
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On the Use of Compressed Air and Synthetic Biodegradable Cutting Fluid to Enhance the Surface Quality of WAAM–CMT Manufactured Low-Alloy Steel Parts During Post-Processing Milling... by Déborah de Oliveira, Marcos Vinícius Gonçalves, Guilherme Menezes Ribeiro, André Luis Silva da Costa, Luis Regueiras, Tiago Silva, Abílio de Jesus, Lucival Malcher, Maksym Ziberov

“…However, parts produced by WAAM may need post-processing by machining to achieve functional surface requirements. Therefore, it is important that machining, even if minimized, does not lead to a significant environmental impact. …”
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Patellar motion and dysfunction of its stabilizers in a biomechanical model of the knee joint by A. S. Yurova, A. I. Tyagunova, F. B.  Loginov, Yu. V. Vassilevski, A. V. Lychagin, E. B. Kalinsky, E. V. Larina, N.  V. Gorohova, K. A. Devyatyarov, O. N. Bogdanov, I. B. Kovalenko, K. V. Chesnokova, M. A.  Dergachev, E. Yu. Mychka, O. N. Kosukhin

“…Disabling MPTL has minimal effects on patellar tilt and translation, which aligns with its small size. …”
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Bone metastasis and pain research through the dual lens of bibliometrics and bioinformatics: knowledge structure, frontiers, and core pathway analysis (2015–2024) by Linghan Meng, Linghan Meng, Jingna Tao, Jingna Tao, Guangda Zheng, Juanxia Ren, Lu Shang, Dongtao Li, Haixiao Liu, Yanju Bao, Baojin Hua

“…Additionally, we employed bioinformatic methods to screen core genes associated with both bone metastasis and cancer pain, and analysed their functions and signalling pathways.ResultsResearch output and academic influence demonstrated an upward trajectory, with the United States and China being the countries with the highest publication volumes. …”
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Oleic acid activates TGFβ-Smad3 signaling to promote ovarian cancer progression by Zhengyang Guo, Yinjia Li, Yunyun Guo, Aosong Zhang, Xiao Huo, Ying Song, Bing Li, Yuanjun Tang, Tianhui He, Tong Liu, Lixiang Xue, Yi Qu, Jiagui Song

“…Notably, oleic acid is abundant in ovarian cancer ascites, though its functional significance in TME modulation and tumor metastatic regulation remains poorly characterized. …”
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Relationship between Changes in Physicochemical Properties with Antioxidant and Antitumor Activity Changes in Vitro of Different Purified Fractions of Pu-erh Tea Polysaccharides by Yilong WU, Zaikun SHUI, Yan WANG, Zhenhao LIU, Xuanjun WANG, Chengting ZI

“…The results of this study may provide theoretical support for the application of PTPS in the field of bioactive polysaccharides and functional foods.…”
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Performance optimization of FASnI3 based perovskite solar cell through SCAPS-1D simulation by Ateeq ul Rehman, Shahbaz Afzal, Iqra Naeem, Dilawaiz Bibi, Sakhi Ghulam Sarwar, Faran Nabeel, Raphael M. Obodo

“…Additionally, this study also investigates the effect of various back contact work functions. Significant improvements in solar cell parameters, such as power conversion efficiency (PCE) from 22.06% to 24.87% and current density (Jsc) from 26.0274 to 30.675 mA/cm2, were observed by optimizing the device's parameters. …”
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The impact of blood MCP-1 levels on Alzheimer’s disease with genetic variation at the NAV3 and UNC5C loci by Jinghan Huang, Yixuan Wang, Thor D. Stein, Ting Fang Alvin Ang, Yibo Zhu, Qiushan Tao, Kathryn L. Lunetta, Jesse Mez, Rhoda Au, Lindsay A. Farrer, Wei Qiao Qiu, Xiaoling Zhang

“…Given that NAV3 and UNC5C are involved in regulating neurite outgrowth and guidance, increased MCP-1 levels may disturb the functions of vulnerable gene carriers to increase AD risk.…”
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Single-cell transcriptomics reveals cellular dynamics and chemokine CXCL2-mediated smooth muscle cell proliferation in arterial repair by Xingxiao Huang, Xingxiao Huang, Yan Ping, Yan Ping, Qiuli Sun, Qiuli Sun, Mingjun Yu, Mingjun Yu, Chao Yang, Xiao Liu, Long Wang, Jinyu Huang, Jinyu Huang

“…Animal models of FAI and cellular experiments were used to validate the effects of CXCL2 on smooth muscle cell proliferation.Results(1) Mesenchymal stem cells (MSCs), smooth muscle cells (SMCs), and macrophages play pivotal roles in arterial repair. …”
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Clinical Recommendations of the Northwest Society for Enteral and Parenteral Nutrition, Interregional Association for Emergency Surgery, Russian Gastroenterological Association, Un... by Yu. V. Averyanova, E. M. Batyrshin, A. E. Demko, G. E. Ivanova, V. T. Ivashkin, L. N. Kostyuchenko, A. V. Lapitsky, I. N. Leiderman, V. M. Luft, I. V. Maev, I. G. Nikitin, M. S. Novruzbekov, Е. A. Poluektova, A. L. Potapov, A. V. Sytov, A. S. Trukhmanov

“…To mitigate the dependence on intravenous fluid- and nutrient administration and attain enteral autonomy in SBS-IF patients, the use of recombinant glucagon-like peptide-2 (GLP-2) is justified as exerting a pronounced trophic effect on the epithelial regenerative potential as well as structural and functional adaptation of intestinal mucosa. …”
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Evaluating the safety and efficacy of Lacticaseibacillus paracasei TISTR 2593 as a therapeutic probiotic for obesity prevention by Jaruwan Sitdhipol, Kanidta Niwasabutra, Neungnut Chaiyawan, Kamonsri Nuankham, Thanaphol Thanagornyothin, Somboon Tanasupawat, Wasaporn Preteseille Chanput, Pongsathon Phapugrangkul, Chaivarakun Chaipanya, Sukanya Phuengjayaem, Saranporn Poothong, Engkarat Kingkaew

“…These findings suggest that L. paracasei TISTR 2593 possesses probiotic and functional properties, including antiadipogenic activity, supporting its potential as a therapeutic probiotic supplement for preventing obesity. …”
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Defense responses related to mycorrhizal-induced resistance in wheat against Zymoseptoria tritici by Thierry Allario, Yuko Krzyzaniak, Maryline Magnin-Robert, Benoît Tisserant, Joël Fontaine, Pierre-Emmanuel Courty, Alessandra Maia-Grondard, Ali Siah, Raymonde Baltenweck, Philippe Hugueney, Béatrice Randoux, Anissa Lounès-Hadj Sahraoui

“…Here, the protective systemic effect of the AMF species Funneliformis mosseae was evaluated in a susceptible wheat cultivar against Septoria tritici blotch (STB), caused by the hemibiotrophic ascomycete Zymoseptoria tritici. …”
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Smart biomimetic “nano-med-fireman” blocking inflammation and lactate metabolism crosstalk for normalized spatiotemporal photo-immunotherapy by Honglin Huang, Ningxi Li, Li Zeng, Qianyi Zeng, Ziman Yang, Jinyang Shen, Xiaodan Wei, Hong Yang, Dengfeng Wang, Yiyao Liu, Chunhui Wu

“…Ultimately, it aims to revitalize the immunosuppressive tumor microenvironment (TME) to spatiotemporally and effectively inhibit tumor metastasis and recurrence. …”
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Efficacy of a Soft Wearable Robot for Hip Assistance in Chronic Stroke Patients: A Randomized Crossover Trial by Seung-Hyeon Han, Sanguk Choi, Chanyoung Ko, Jong Weon Lee, Kyoungchul Kong, Dong-Wook Rha, Deog Young Kim

“…This research highlights the potential of SWR technology to enhance functional mobility and autonomy in stroke survivors. …”
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Landscapes of the main components, metabolic and microbial signatures, and their correlations during stack “sweating” of Eucommiae Cortex by Linfeng Wang, Linfeng Wang, Mengxian Wu, Mengxian Wu, Bingnan Gu, Bingnan Gu, Erfeng Wang, Erfeng Wang, Faliang Wu, Faliang Wu, Jiapeng Yang, Bing Guo, Xingke Li, Xingke Li, Pengpai Zhang, Pengpai Zhang

“…However, the mechanism of the effect of this traditional treatment of herbs on the quality of herbs is still unclear.MethodsIn this study, high performance liquid chromatography (HPLC), UPLC/MS-based untargeted metabolomics and high-throughput sequencing were applied to investigate the dynamic changes of the main active ingredients, differential metabolites and bacterial communities in the process of “sweating” in EC. …”
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Regulation of ofloxacin resistance in Escherichia coli strains causing calf diarrhea by quorum-sensing acyl-homoserine lactone signaling molecules by Zi Wang, Zi Wang, Zi Wang, Miao Sun, Yongqiang Wang, Yongqiang Wang, Jinchuan Shi, Wei Gao, Dongxu Han, Fanjun Zeng, Sanren, Liyin Du, Liyin Du, Hongxia Ma, Kai Liu, Kai Liu, Kai Liu

“…In this study, a type I quorum sensing AHL, N-Octanoyl-L-Homoserine lactone (C8), was added to E. coli growth medium to investigate its regulatory functions in drug resistance. After screening out the strains of E. coli that showed an obvious regulatory effect to the drug ofloxacin (OFX), transcriptomic sequencing was performed on the E. coli strains from the sub-inhibitory concentration group that concentration plus C8 group, and the control group. …”
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Rheological Behavior, Textural Properties, and Antioxidant Activity of <i>Porphyra yezoensis</i> Polysaccharide by Chenyang Ji, Xiaoshan Long, Jingjie Wang, Bo Qi, Yang Cao, Xiao Hu

“…Furthermore, PYPS possessed significant scavenging ability against DPPH, ABTS, and HO• radicals, demonstrating its potential application as a natural antioxidant in functional foods.…”
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Visible light photocatalytic degradation of tetracycline using copper ferrite nanoparticles synthesized via Glycine-Assisted combustion method by A. Dinesh, K. Radhakrishnan, V. Renuga, Rajendra P. Patil, Suriyaprakash Rajadesingu, S. Suthakaran, L. Guganathan, Manikandan Ayyar, Madhappan Santhamoorthy, Lalitha Gnanasekaran, Munawar Iqbal

“…X-ray diffraction (XRD) was used to check the phase’s structure and purity, FT-IR was used to find out what functional groups were present, UV–Vis diffuse reflectance spectroscopy (DRS) was used to look at the optical properties, and scanning electron microscopy (SEM) was used to see the structure’s shape. …”
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