Montbretia flowers as a source of bioactive crocins: Biotechnology tools and delivery systems by Lucía Morote, Cristian Martínez Martínez Fajardo, María Mondéjar López, Elena Moreno-Gimenez, Ángela Rubio-Moraga, Olivia Costantina Demurtas, Gianfranco Diretto, Enrique Niza, Verónica Aragonés, Alberto López Jiménez, José-Antonio Daròs, Oussama Ahrazem, Lourdes Gómez-Gómez

“…Furthermore, we investigated the bioactivity of crocins and discovered that their anti-inflammatory effects depend on their vehiculation within exosomes or liposomes. …”
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Exploratory actor mapping of social interactions within tick risk surveillance networks in France by Iyonna Zortman, Laurence Vial, Thomas Pollet, Aurélie Binot

“…Tick presence and TBD incidence are increasing, questioning the effectiveness of existing surveillance systems. At the European level TBD burden is likely underestimated as surveillance differs amongst and within countries. …”
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Soluble β-Amyloid Oligomers Selectively Upregulate TRPC3 in Excitatory Neurons via Calcineurin-Coupled NFAT by Zhengjun Wang, Dongyi Ding, Jiaxing Wang, Ling Chen, Qingming Dong, Moumita Khamrai, Yuyang Zhou, Akihiro Ishii, Kazuko Sakata, Wei Li, Jianyang Du, Thirumalini Vaithianathan, Fu-Ming Zhou, Francesca-Fang Liao

“…The selective downregulation of the <i>Trpc6</i> gene induced synaptotoxicity, while no significant effect was observed from the Trpc3-targeting siRNA, suggesting potentially differential roles of TRPC3 and 6 in modulating the synaptic morphology and functions. …”
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METTL3-dependent DLG2 inhibits the malignant progression of cervical cancer by inactivating the Hippo/YAP signaling by Mei Pu, Xia Xiao, Shasha Lv, Daqing Ran, Qian Huang, Mingming Zhou, Qirong Lei, Lingshuang Kong, Qing Zhang

“…Moreover, lowering DLG2 expression mitigated the effects of METTL3 silencing on cervical cancer cell malignancy. …”
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β-Arrestin 2 as a Prognostic Indicator and Immunomodulatory Factor in Multiple Myeloma by Parker Mathews, Xiaobei Wang, Jian Wu, Shaima Jabbar, Kimberly Burcher, Lindsay Rein, Yubin Kang

“…In light of recent trends towards the use of immune checkpoint inhibitors across malignancies, the effect of ARRB2 in the regulation of the PD-1/PD-L1 axis was also investigated. …”
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Expanded and activated marrow-infiltrating lymphocytes exhibit potent antimyeloma activity against autologous multiple myeloma cells by Seo-Yeon Ahn, Manh-Cuong Vo, Van-Tan Nguyen, Van-Dinh-Huan Tran, Tien Nguyen Duc, Mihee Kim, Ga-Young Song, Jae-Sook Ahn, Deok-Hwan Yang, Hyeoung-Joon Kim, Sung-Hoon Jung, Je-Jung Lee

“…The expansion rate, proportions of effector cells (including CD4+ T cells, CD8+ T cells, natural killer cells, and memory T cells), and the functional capacity of eMILs were assessed over 2 weeks of culture. …”
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Ultrasound-guided cross-pin technique for paediatric supracondylar humerus fractures: minimizing iatrogenic ulnar nerve injury by Xing Wu, Xiaoliang Chen, Xiongtao Li, Teng Wang, Jun Li, Xiantao Shen

“…At the latest follow-up, all patients demonstrated excellent and good functional outcomes according to the Flynn criteria. …”
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Combining iRGD with HuFOLactis enhances antitumor potency by facilitating immune cell infiltration and activation by Jie Shao, Kai Xin, Zhaoye Qian, Fangcen Liu, Lin Li, Junmeng Zhu, Qin Liu, Manman Tian, Baorui Liu

“…Following brief stimulation with HuFOLactis, immune cell phenotypes and functions were assessed using flow cytometry. Confocal microscopy was employed to demonstrate the infiltrative and cytotoxic capabilities of iRGD-modified HuFOLactis-activated immune cells within tumor spheroids. …”
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Polyunsaturated Fatty Acids and Human Health: A Key to Modern Nutritional Balance in Association with Polyphenolic Compounds from Food Sources by Magdalena Mititelu, Dumitru Lupuliasa, Sorinel Marius Neacșu, Gabriel Olteanu, Ștefan Sebastian Busnatu, Andreea Mihai, Violeta Popovici, Nicoleta Măru, Steluța Constanța Boroghină, Sebastian Mihai, Corina-Bianca Ioniță-Mîndrican, Alexandru Scafa-Udriște

“…Beyond the fact that they provide a substantial supply of energy to the body (a role that saturated fats can also perform), these unsaturated fatty acids and, especially, the essential ones are involved in cell membrane structure, blood pressure regulation, and coagulation; participate in the proper functioning of the immune system and assimilation of fat-soluble vitamins; influence the synthesis of pro- and anti-inflammatory substances; and protect the cardiovascular system. …”
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CircRALGPS2 modulates chicken follicle development through promotion of granulosa cell apoptosis and autophagy via the miR-200a-3p/TGFβ2/SMAD pathway by Haorong He, Xinghong Yu, Can Cui, Yao Zhang, Zhuanjian Li, Shunshun Han, Huadong Yin

“…Moreover, we demonstrated that circRALGPS2 functions as a molecular sponge for miR-200a-3p, revealing that miR-200a-3p and circRALGPS2 exert antagonistic effects on GC autophagy and apoptosis. …”
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Identification of genetic locus with resistance to take-all in the wheat-Psathyrostachys huashanica Keng introgression line H148 by Sheng-sheng BAI, Han-bing ZHANG, Jing HAN, Jian-hui WU, Jia-chuang LI, Xing-xia GENG, Bo-ya LÜ, Song-feng XIE, De-jun HAN, Ji-xin ZHAO, Qun-hui YANG, Jun WU, Xin-hong CHEN

“…Sixty-two genes were found in the target interval of the Chinese Spring reference genome sequence. According to the functional annotation of genes, two protein genes that can improve the systematic resistance of plant roots were predicted as candidate genes. …”
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Galectin-3 in tumor-stromal cells enhances gemcitabine resistance in pancreatic adenocarcinoma by suppressing oxidative phosphorylation by Yaheng Wu, Guo An, Jia Tong, Wenlong Zhang, Zhihua Tian, Bin Dong, Xijuan Liu, Lin Zhao, Chunxiang Ye, Jingtao Liu, Wei Zhao, Huachong Ma

“…Particularly, mitochondrial oxidative phosphorylation was functionally arrested in Gal-3-high tumor cells, as demonstrated by a lower oxygen consumption rate and mitochondrial ATP production through abnormal mitochondrial morphology. …”
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Adapting an agroecosystem model to account for cover crop management in the Midwest USA by Anna Orfanou, Gregg R. Sanford, Randall D. Jackson, Matthew D. Ruark, Claudio Gratton, Dimitrios Pavlou, Spyridon Mourtzinis, Shawn P. Conley, Christopher J. Kucharik

“…To achieve this, the winter wheat plant functional type (PFT) in Agro-IBIS was adapted to represent winter cereal rye as a cool-season winter annual grass cover crop. …”
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The intersection of ferroptosis and non-coding RNAs: a novel approach to ovarian cancer by Youyi Jiang, Tamara Nazar Saeed, Karar H. Alfarttoosi, Ashok Kumar Bishoyi, M. M. Rekha, Mayank Kundlas, Bhavik Jain, Jasur Rizaev, Waam Mohammed Taher, Mariem Alwan, Mahmood Jasem Jawad, Ali M. Ali Al-Nuaimi

“…Current research has shed light on the critical functions of non-coding RNAs, such as circRNAs, lncRNAs, and miRNAs, in regulating ferroptosis in ovarian cancer. …”
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Real-world of Limosilactobacillus reuteri in mitigation of acute experimental colitis by Ningning Yue, Hailan Zhao, Peng Hu, Yuan Zhang, Chengmei Tian, Chen Kong, Zhiliang Mai, Longbin Huang, Qianjun Luo, Daoru Wei, Ruiyue Shi, Shaohui Tang, Yuqiang Nie, Yujie Liang, Jun Yao, Lisheng Wang, Defeng Li

“…Second, L. reuteri-CMVs were taken up by intestinal epithelial cells (IECs), elevated the expression of ZO-1, E-cadherin (Cdh1), and Occludin (Ocln), decreased intestinal permeability, and exerted protective effects on epithelial tight junction functionality. …”
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High-risk alcohol consumption is associated with mitochondrial damage-associated molecular patterns in people living with HIV by Shannon R. Gilstrap, Micheal D. Ho, Joanna M. Hobson, Dyan M. White-Gilliam, Khalid Freij, Michael A. Owens, Shameka L. Cody, S. Justin Thomas, Robert E. Sorge, Burel R. Goodin

“…These results suggest that the effects of alcohol consumption on mitochondrial damage and dysfunction may be exacerbated by HIV infection. …”
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Nanostructure-controlled Cu-doped MnO2 for ozone synergistic catalytic disinfection by JianGuo Huang, Rashid Khan, Chunhui Zhai, Xianting Ding, Li-Sha Zhang, Jin-Ming Wu, Zhizhen Ye

“…Existing disinfection techniques commonly suffer from secondary pollution and difficulty in achieving continuous disinfection while ensuring safety and effectiveness, particularly in crowded environments. …”
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Tranexamic acid impairs plasmin generation on human mesenchymal stem cells and derived membrane microvesicles, halting pericellular proteolysis by Ramy Abou Rjeily, Christina Mrad, Fatiha Z. El-Ghazouani, Florence Toti, Audrey Cras, Audrey Cras, Eduardo Angles-Cano

“…Pericellular proteolysis is a key mechanism mediating the aforementioned processes.AimThis study primarily aimed to define mechanistic pathways of plasmin formation and its consequences on MSC phenotype and functioning. We have also investigated the regulatory mechanisms mediated by PAI-1 and the ability of MSCs to shed microvesicles bearing the proteolytic machinery.MethodsHuman MSCs were derived from bone marrow or umbilical cord donors. …”
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Artificial intelligence and omics-based autoantibody profiling in dementia by Kazuki M. Matsuda, Yumi Umeda-Kameyama, Kazuhiro Iwadoh, Masashi Miyawaki, Mitsutaka Yakabe, Masaki Ishii, Sumito Ogawa, Masahiro Akishita, Masahiro Akishita, Shinichi Sato, Ayumi Yoshizaki

“…Future research should involve longitudinal observation in larger, diverse cohorts and functional studies to clarify autoantibodies' roles in dementia pathogenesis and their diagnostic and therapeutic potential.…”
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The Sm14+GLA-SE Recombinant Vaccine Against <i>Schistosoma mansoni</i> and <i>S. haematobium</i> in Adults and School Children: Phase II Clinical Trials in West Africa by Amadou Tidjani Ly, Doudou Diop, Modou Diop, Anne-Marie Schacht, Abdoulaye Mbengue, Rokhaya Diagne, Marieme Guisse, Jean-Pierre Dompnier, Carolina Messias, Rhea N. Coler, Celso R. Ramos, Jacques-Noël Tendeng, Seynabou Ndiaye, Miryam Marroquin-Quelopana, Juçara de Carvalho Parra, Tatiane dos Santos, Marília Sirianni dos Santos Almeida, Daniella Arêas Mendes-da-Cruz, Steven Reed, Wilson Savino, Gilles Riveau, Miriam Tendler

“…Methods: Participants were evaluated based on clinical assessments, laboratory tests (including hematologic and biochemical analyses of renal and hepatic functions), and immunological parameters (humoral and cellular responses) up to 12 months after the first vaccination dose in the Phase IIa trial and after 120 days in the Phase IIb trial. …”
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