Cardiomyocyte‐Enriched USP20 Ameliorates Pathological Cardiac Hypertrophy by Targeting STAT3 Deubiquitination by Lingfeng Zhong, Shanshan Dai, Fan Yu, Guo‐Ping Shi, Qinyan Gong, Yucong Zhang, Jingsi Duan, Zhengyin Lou, Zhixuan Tang, Fuzhe Gong, Derong Chen, Liya Hou, Xinyang Hu, Jinghai Chen, Jian'an Wang, Deling Yin

“…Cleavage Under Targets and Tagmentation assay (CUT&Tag) sequencing is employed to identify downstream targets of signal transducer and activator of transcription 3 (STAT3). Functionally, USP20 deficiency exacerbates cardiac hypertrophy induced by either angiotensin II (Ang II) or transverse aortic constriction (TAC), whereas USP20 overexpression alleviates hypertrophic responses. …”
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Factor analysis, emotional experience and behavioral feedback of contemporary Chinese youth participating in short-term monasticism: a qualitative study based on the online questio... by Chao Liu, Chao Liu, Li-Jen Lin, Li-Jen Lin, Hao Chen, Hao Chen, Thu-Hua Liu, Thu-Hua Liu, Huang-Li Lin, Wen-Ko Chiou, Wen-Ko Chiou, Wen-Ko Chiou, Wen-Ko Chiou

“…Future research should explore the long-term effects of these practices and examine their applicability across different cultural contexts.…”
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Significant advances in plant-available and replenishable macro- and micronutrients with soil health-oriented conservation farming: Novel insights from a multi-site on-farm evaluat... by Christoph Rosinger, Katharina Maria Keiblinger, Luca Giuliano Bernardini, Dietmar Horn, Gereon Heller, Herbert Eigner, Hans-Peter Kaul, Sabine Huber, Orracha Sae-Tun, Gernot Bodner

“…While conservation farming practices are known to increase soil health and ecosystem functioning, little is known about their effect on nutrient availability. …”
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Identification of electromyographic patterns of bradykinesia in patients with Parkinson's disease by Nikita Kozulin, Anastasiya Migulina, Denis Mokrushin, Gurgen Soghoyan, Aleksandr Artemenko, Artur Biktimirov

“…Conclusions: The results show the effectiveness of using sEMG and the number of peaks corresponding to the moments of muscle activation to assess bradykinesia.…”
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Novel Insights and Genomic Characterization of Coral-Associated Microorganisms from Maldives Displaying Antimicrobial, Antioxidant, and UV-Protectant Activities by Fortunato Palma Esposito, Andrea López-Mobilia, Michael Tangherlini, Vincenza Casella, Alessandro Coppola, Giulia Varola, Laura Vitale, Gerardo Della Sala, Pietro Tedesco, Simone Montano, Davide Seveso, Paolo Galli, Daniela Coppola, Donatella de Pascale, Christian Galasso

“…Metabarcoding analysis has been widely utilized to study CAM diversity under various conditions but provides limited information on their functional roles. Therefore, cultivation of bacterial strains remains indispensable for validating ecological and biotechnological hypotheses. …”
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Optimization of Biomass Delignification by Extrusion and Analysis of Extrudate Characteristics by Delon Konan, Adama Ndao, Ekoun Koffi, Saïd Elkoun, Mathieu Robert, Denis Rodrigue, Kokou Adjallé

“…The structural changes included the disorganization of the most recalcitrant functional groups, reduction of particle sizes, increase of specific surface areas, and the appearance of microscopic roughness on the particles. …”
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The impacts of multiple anthropogenic environmental drivers on plant–soil feedbacks: A systematic review protocol by Menilek S. Beyene, Adriano N. Roberto, Arthur A. D. Broadbent, Irene Cordero, David Johnson, Marney E. Isaac, Ainara Leizeaga, Deon Lum, Christopher R. Taylor, Richard D. Bardgett, Marc W. Cadotte

“…Abstract Plant–soil feedbacks (PSFs) regulate plant growth, plant community dynamics and ecosystem functioning and are important for global biogeochemical cycles. …”
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Cognitive behavioural therapy and related interventions for sleep disorders in children and adults with autism spectrum disorder: protocol for a systematic review and meta-analysis by Bin Xiao, Yinan Wu, Yi Zhong, Yuxin Wu, Yutong Li, Qianyi Zhai, Youyou Ji, Ronglin Xu, Lanshu Zhou

“…These sleep problems, including prolonged sleep latency and fragmented sleep, affect more than half of autistic individuals, exacerbating functional impairments and diminishing quality of life. …”
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Periplakin Attenuates Liver Fibrosis via Reprogramming CD44Low Cells into CD44High Liver Progenitor CellsSummary by Lichao Zhang, Zhiyong Xiong, Zebin Chen, Meiyining Xu, Siyu Zhao, Xianzhi Liu, Kefeng Jiang, Yunyi Hu, Shurui Liu, Xi Sun, Zhongdao Wu, Jia Shen, Lifu F. Wang

“…Results: The expression of PPL is upregulated in fibrotic livers in human and mouse models of liver fibrosis. Functionally, we found that PPL overexpression significantly attenuated liver fibrosis. …”
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Neuronal CD47 induces behavioral alterations and ameliorates microglial synaptic pruning in wild-type and Alzheimer’s mouse models by Wenjie Hu, Mengting Chen, Yuxue Lin, Hui Zhang, Li Sun, Wei Shao, Yuping Ye, Yujie Cheng, Shanshan Zhou, Panpan Hu, Xingqi Wu, Yin Xu, Kai Wang

“…Mechanistically, CD47 protein acts as a potent ‘do not eat me’ signal, protecting synapses from phagocytosis by microglia. However, the functional role of the upregulated neuronal CD47 signal under both physiological and pathological conditions remains unclear. …”
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Research hotspots of irisin in the nervous system: a bibliometric study and visualization analysis via CiteSpace by Jiacheng Wang, Jiacheng Wang, Juan Liu, Juan Liu, Wei Pang, Wei Pang, Wei Pang, Xin Li, Xin Li, Xin Li, Xinping Huang, Shan Wang, Shan Wang, Chunxiao Nan, Chunxiao Nan

“…Cluster analysis showed that the research frontier hotspots in this field could focus on three main topics: the functional role and mechanism of irisin, pathological experimental research, and clinical disease research.ConclusionIn recent years, research on irisin in the nervous system has primarily centered on elucidating its neuronal regulatory mechanisms and neuroprotective effects, along with their potential applications in neurological disorders. …”
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Sustainable cementitious materials: A comprehensive review on rice husk biochar-Portland cement blends by Wei-Hsin Chen, Baron Joseph P. Magdaraog, Aristotle T. Ubando, Charles B. Felix, Kun-Yi Andrew Lin, Sheila Conejos

“…Findings reveal that up to 25 % RHB can be blended with PC without compromising functional strength. This addition can decrease the global warming potential of traditional PC by up to 88 %. …”
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Dietary Administration of Postbiotics from <i>Vibrio proteolyticus</i> DCF12.2 Enhanced Intestinal Integrity, Microbiota, and Immune Response in Juvenile Gilthead Seabream (<i>Spar... by Olivia Pérez-Gómez, Sonia Rohra-Benítez, Marta Domínguez-Maqueda, Isabel M. Cerezo, Alba Galafat, Eduardo Martínez-Manzanares, Juan Miguel Mancera, Francisco Javier Alarcón-López, Jorge García-Márquez, Miguel Ángel Moriñigo, Salvador Arijo

“…In this study, we evaluated the effects of postbiotics derived from <i>Vibrio proteolyticus</i> DCF12.2 on intestinal histology, microbiota composition, and the expression of genes related to epithelial integrity and inflammation in juvenile gilthead seabream (<i>Sparus aurata</i>). …”
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Multimodal sequencing of neoadjuvant nivolumab treatment in hepatocellular carcinoma reveals cellular and molecular immune landscape for drug response by Fanhong Zeng, Qingyang Zhang, Yu-Man Tsui, Huanhuan Ma, Lu Tian, Abdullah Husain, Jingyi Lu, Joyce Man-Fong Lee, Vanilla Xin Zhang, Po-Man Li, Gary Cheuk-Hang Cheung, Tan-To Cheung, Daniel Wai-Hung Ho, Irene Oi-Lin Ng

“…Our results also indicate a functional antagonism between tumor-associated macrophages (TAMs) and CD8 cells and their spatial separation. …”
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Applying the blended KTA-Sprint framework to a usability assessment of a digital health module for informal caregivers co-managing heart failure by Ting Xiong, Camila Benmessaoud, Kaylen J. Pfisterer, Noor El-Dassouki, Raima Lohani, Karen Young, Quynh Pham

“…Moreover, the KTA-Sprint framework effectively guided the design and evaluation process for the Caretown module. …”
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Metabolomic insights into the prebiotic and metabolic regulatory properties of ellagic acid and urolithins on probiotic-like bacteria in vitro by Yang Yang, Ke Wang, Jia-Chi Chiou, Danyue Zhao

“…However, little is known about polyphenol’s metabolic regulatory effects towards individual bacteria at the molecular level. …”
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Detecting Postural Instability in Parkinson&#x2019;s Disease From IMU-Based Objective Measures by Kendal Smith, Diego Torricelli, Miguel Gonzalez-Sanchez, Javier Ricardo Perez-Sanchez, Elisa Luque-Buzo, Francisco Grandas, Juan Miguel Marin, Jorge Andres Gomez-Garcia

“…Parkinson&#x2019;s Disease (PD) is a progressive neurological disorder that affects both motor and non-motor functions. A critical aspect of PD is postural instability, which is associated with a higher risk of falls and a significant decline in mobility. …”
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Vitamin D and depression in adults: A systematic review by Vlad Dionisie, Mihnea Alexandru Gaman, Cristina Anghele, Mihnea Costin Manea, Maria Gabriela Puiu, Iulia-Ioana Stanescu-Spinu, Octavian-Ilarian Baiu, Florian Antonescu, Mirela Manea, Adela Magdalena Ciobanu

“…Although the pathogenesis of depression remains far from fully understood, current research suggests a potential role for vitamin D due to its involvement in brain functioning. Moreover, vitamin D supplementation has shown promising results in the treatment of patients with depression. …”
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Identification of a novel nonsense mutation in α-galactosidase A that causes Fabry disease in a Chinese family by Yushi Peng, Meize Pan, Yuchen Wang, Zongrui Shen, Jian Xu, Fu Xiong, Hongbo Xiao, Yun Miao

“…Apoptosis was assessed in GLA mutant cell lines to confirm the functional effects. As a result, a new mutation, c.777_778del (p. …”
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Comparative study of the glucose and trehalose addition on the extenders for goat sperm liquid storage. by Md. Emtiaj Alam, Most. Shorifa Yeasmin, Dipak Kumar Das, Md. Shohidul Islam, Soshe Ahmed, Md. Hamidul Islam, Md. Akhtarul Islam, Md. Mostofa Kamal, Aurangazeb Kabir, Alam Khan, Md. Hakimul Haque, Md. Abdul Masum, Moizur Rahman, Mst. Ishrat Zerin Moni.

“…Objectives: The objective of this study was to assess the effects of varying glucose and trehalose concentrations on tris-citric acid-egg yolk-fructose (TCEF) diluents for the short-term cold storage of goat semen. …”
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