Bioactive manganese-decorated titanium implants for osteoporotic bone regeneration by Lei Wang, Chaoxi Yan, Fan Wang, Qiang Wang, Degang Huang, Xin Yang, Tao Ma, Pingbo Chen, Congming Li, Zhouzhou Zhang, Guoyang Wan, Xing Yang

“…Transcriptome sequencing revealed the significant regulatory functions of Mn2+, which upregulated the HIF-1 signaling pathway to enhance bone regeneration. …”
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Leveraging the integration of bioinformatics and machine learning to uncover common biomarkers and molecular pathways underlying diabetes and nephrolithiasis by Xudong Shen, Xudong Shen, Xudong Shen, Guoxiang Li, Guoxiang Li, Guoxiang Li, Junfeng Yao, Junfeng Yao, Junfeng Yao, Junping Yang, Xiaobo Ding, Xiaobo Ding, Xiaobo Ding, Zongyao Hao, Zongyao Hao, Zongyao Hao, Yan Chen, Yang Chen, Yang Chen, Yang Chen

“…After eliminating batch effects, we performed differential expression analysis and applied weighted gene co-expression network analysis (WGCNA) to investigate associations with 18 forms of cell death. …”
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Developing an efficient anticorrosive system through advanced modification of plasma-electrolyzed MgO with CeNiLDH complexed with V₂O₅ nanoparticles and (2E)-But-2-enedioic acid... by Mosab Kaseem, Ananda Repycha Safira, Mohammad Aadil, Talitha Tara Thanaa, Arash Fattah-alhosseini

“…These cloud-like structures, driven by enhanced absorption and robust hydrogen bonding throughout the hierarchical network, effectively suppress corrosion by delaying the movement of corrosive anions. …”
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Outcomes of Salvage Treatment After Primary Treatment for Renal Cell Cancer: A Systematic Review by Nicola Longo, Francesco Di Bello, Luigi Napolitano, Ernesto Di Mauro, Simone Morra, Giuliano Granata, Federico Polverino, Agostino Fraia, Gabriele Pezone, Roberto La Rocca, Claudia Collà Ruvolo, Gianluigi Califano, Massimiliano Creta

“…The aim of the current study is to summarize available evidence about the surgical, oncological, and functional outcomes of salvage renal options after previous treatments for RCC. …”
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A global systematic review of the remote sensing vegetation indices by Kai Yan, Si Gao, Guangjian Yan, Xuanlong Ma, Xiuzhi Chen, Peng Zhu, Jinhua Li, Sicong Gao, Jean-Philippe Gastellu-Etchegorry, Ranga B. Myneni, Qiao Wang

“…This study conducted a bibliometric review of VI-related literature in the web of science (WOS) database since 1986, examining current trends and issues in data sources, geographic areas, eco-functional areas, applications, and technical methods. …”
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Decreased mitochondrial transcription factor A and mitochondrial DNA copy number promote cyclin-dependent kinase inhibitor 1A expression and reduce tumorigenic properties of colore... by Jessika Buchwaldt, Tania Fritsch, Monika Hartmann, Hagen Roland Witzel, Michael Kloth, Wilfried Roth, Katrin E. Tagscherer, Nils Hartmann

“…Here, we investigated the effect of TFAM deficiency on mtDNA and tumorigenic properties in the human colorectal cancer cell line SW480. …”
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Antioxidant and Anti-Inflammatory Activities of Cutlassfish Head Peptone in RAW 264.7 Macrophages by Su-Jin Lee, Jeonghyeon Im, Svini Dileepa Marasinghe, Eunyoung Jo, Minthari Sakethanika Bandara, Youngdeuk Lee, Jaewon Lee, Gun-Hoo Park, Chulhong Oh

“…CP exhibited significant antioxidant effects, particularly in scavenging ABTS and DPPH radicals, as well as reducing oxidative stress markers and inflammatory responses in LPS-stimulated macrophages. …”
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Assembly of CCR5 with gp120 inhibits the HIV infectivity specifically in T cells by Joyce Appiah-Kubi, Yuan Yuzhe, Takeo Kuwata, Hiromi Terasawa, Perpetual Nyame, Wright Ofotsu Amesimeku, Md. Jakir Hossain, Shuzo Matsushita, Tomohiro Sawa, Yosuke Maeda, Shinji Harada, Keisuke Yusa, Kazuaki Monde

“…Abstract For the entry of R5 human immunodeficiency virus type 1 (HIV-1) into target cells, CCR5 functions as a coreceptor following the binding of the envelope glycoprotein gp120 to the receptor CD4. …”
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PKMYT1 kinase ameliorates cisplatin sensitivity in osteosarcoma by Binfeng Liu, Wei Li, Wenchao Zhang, Chengyao Feng, Lu Wan, Shasha He, Ruiling Xu, Zheng Fu, Zhongyue Liu, Haodong Xu, Xin Jin, Chao Tu, Zhihong Li

“…Subsequent analysis of patient-derived clinical specimens, along with in vitro functional assays, demonstrated that DDP treatment induces the activation of PKMYT1 in OS cells. …”
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Glioblastoma Cell Migration, Invasion and Vasculogenic Mimicry Downmodulated by Novel uPAcyclin Derivatives by Federica Santoro, Francesco Merlino, Diego Brancaccio, Iolanda Camerino, Stefania Belli, Amelia Cimmino, Paolo Grieco, Luca Colucci-D’Amato, Maria Patrizia Stoppelli, Paola Franco, Alfonso Carotenuto

“…These studies shed light on the functional relevance of single amino acid residues in uPAcyclin and lead to the identification of therapeutically interesting new variants as promising candidates for anti-GBM therapies.…”
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Persistent Activation of Sphingosine‐1‐Phosphate Receptor 1 by Phytosphingosine‐3,4‐Cyclic Phosphate Ameliorates Sepsis by Inhibiting Hyperinflammation and Vascular Hyperpermeabili... by Suhong Duan, Seung‐Gook Kim, Jiaying Bao, Hyung‐Jin Lim, Joon Woo Kim, Sung‐Il Yoon, Young Jun Park, Sanguk Yun, Kye‐Seong Kim, Hwa‐Ryung Song, Myeong Jun Choi, Myung‐Kwan Han

“…Here, we show that our newly synthesized phytosphingosine‐3,4‐cyclic phosphate (3,4‐cPP), a functional agonist of S1P receptor 1 (S1P1), exerts a strong protective effect against severe cecal ligation and puncture (CLP)‐induced sepsis. 3,4‐cPP persistently activates S1P1 without inducing internalization. 3,4‐cPP upregulates SIRT1 expression in macrophages and endothelial cells via S1P1 activation. …”
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ASPM mediates nuclear entrapment of FOXM1 via liquid-liquid phase separation to promote progression of hepatocarcinoma by Xunliang Jiang, Jun Liu, Ke Wang, Jianyong Sun, Huilong Yin, Yu Jiang, Yongkang Liu, Ningbo Wang, Xiaochen Ding, Pu Gao, Lin Li, Xiang Zhang, Jipeng Li, Rui Zhang

“…ChIP-sequencing data show ASPM and FOXM1 co-occupy the promoters of multiple genes to promote their transcription, enhancing FOXM1-driven oncogenic progression. In functional experiments, inhibition of ASPM suppresses tumor growth of HCC cells in vivo and in vitro, while overexpression of ASPM has opposite effects. …”
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Optimization Techniques for Physician Scheduling Problem: A Systematic Review of Recent Advancements and Future Directions by Norizal Abdullah, Masri Ayob, Meng Chun Lam, Nasser R. Sabar, Graham Kendall, Mohamad Khairulamirin Md Razali

“…Our study also extends the problem definition, constraints, evaluation functions, and the variants of PSP. We examine a wide range of optimization methodologies, including mathematical programming, heuristics, matheuristics, and machine learning, highlighting their strengths and limitations in addressing the multifaceted nature of PSP. …”
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GWAS and transcriptome analyses unravel ZmGRAS15 regulates drought tolerance and root elongation in maize by Dongmei Wang, Xuyang Liu, Guanhua He, Kailiang Wang, Yongxiang Li, Honghui Guan, Tianyu Wang, Dengfeng Zhang, Chunhui Li, Yu Li

“…However, due to the complexity of the maize genome and the multiplicity of drought tolerance mechanisms, identifying the genetic effects of drought tolerance remains great challenging. …”
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Nervonic acid alleviates radiation-induced early phase lung inflammation by targeting macrophages activation in mice by Chenlin Wang, Chenlin Wang, Yanan Wu, Yanan Wu, Chao Liu, Yang Li, Song Mi, Xiaofan Yang, Tong Liu, Yuanjing Tian, YingYing Zhang, Pingping Hu, Lili Qiao, Guodong Deng, Ning Liang, Jinyue Sun, Yan Zhang, Yan Zhang, Yan Zhang, Jiandong Zhang, Jiandong Zhang, Jiandong Zhang

“…NA can protect lung tissues against the toxic effects of ionizing radiation and is a new potential functional component for targeting macrophages.…”
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Determination of Main Bearing Dynamic Clearance in a Shield Tunneling Machine Through a Broadband PMUT Array with a Decreased Blind Area and High Accuracy by Guoxi Luo, Haoyu Zhang, Delai Liu, Wenyan Li, Min Li, Zhikang Li, Lin Sun, Ping Yang, Ryutaro Maeda, Libo Zhao

“…In addition, a specific ultrasound signal processing circuit with functions of transmitting, receiving, and processing ultrasonic waves was developed. …”
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CARDIAC RESYNCHRONIZATION THERAPY WITH OR WITHOUT AN IMPLANTABLE CARDIOVERTER DEFIBRILLATOR IN DIFFERENT GROUPS OF HEART FAILURE PATIENTS by Perisic Zoran, Kostic Tomislav, Ilic Stevan, Koracevic Goran, Djindjic Boris, Milic Dragan, Vladimir Mitov, Salinger Martinovic Sonja, Stanojevic Dragana, Golubovic Mladjan

“…Aim of the study was to examine the effects of different CRT devices in carefully selected heart failure patients during 1 year.Material and methods. …”
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Friend leukemia virus integration 1 is a predictor of poor prognosis of breast cancer and promotes metastasis and cancer stem cell properties of breast cancer cells by Xu Yan, Yu Yu, Lingyu Li, Naifei Chen, Wei Song, Hua He, Jie Dong, Xiangliang Liu, Jiuwei Cui

“…To further verify the effect of FLI‐1 in promoting the metastasis of TNBC, we performed a series of functional experiments in vitro and orthotopic xenograft experiments in the mammary fat pad of nude mice. …”
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Recovering bioactive compounds and antioxidant capacity of medium roasted spent coffee grounds through varied hydrothermal brewing cycles by Nur Maiyah, Soraya Kerdpiboon, Suriyan Supapvanich, William L. Kerr, Pongsert Sriprom, Natthaporn Chotigavin, Wanwimol Klaypradit, Tongchai Puttongsiri

“…This study investigated the effects of hydrothermal brewing cycles on the bioactive compounds and antioxidant capacity of medium roasted Arabica (A) and Robusta (R) SCGs. …”
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MSC-derived extracellular vesicles: Precision miRNA delivery for overcoming cancer therapy resistance by Ahsas Goyal, Muhammad Afzal, Kavita Goyal, Subbulakshmi Ganesan, Mukesh Kumari, S. Sunitha, Aniruddh Dash, Suman Saini, Mohit Rana, Gaurav Gupta, Haider Ali, Ling Shing Wong, Vinoth Kumarasamy, Vetriselvan Subramaniyan

“…Cancer remains a prominent worldwide health concern, presenting existing therapies with frequent difficulties, including major toxicity, limited effectiveness, and treatment resistance emergence. These issues highlight the necessity for novel and enhanced remedies. …”
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