Polygoni Multiflori Radix Praeparata polysaccharides enhance gut health and mitigate ischemic stroke by regulating SCFA and amino acid metabolism in gut microbiota by Lingyu Ruan, Zhennan Wang, Mengyun Zheng, Qi Zheng, Qing Qing, Hongyan Lin, Yuheng Tao, Liqun Wang, Junsong Wang, Wenhao Ge, Wenhao Ge

“…Neurological assessment, histopathology, and protein factors detection assessed PMP’s effectiveness. Further, 1H NMR based metabolomics and 16S rRNA gene sequencing examined gut microbiota metabolites and profiles, respectively, in order to elucidate the underlying mechanisms from the perspective of the gut-brain axis.ResultsPMP significantly improved the neurologic functions and reduced the cerebral infarction volume in MCAO/R rats. …”
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Component Composition and Antimicrobial Activity of CO2 Extract of Portulaca oleracea, Growing in the Territory of Kazakhstan by Meruyert I. Tleubayeva, Ubaidilla M. Datkhayev, Mereke Alimzhanova, Margarita Yu Ishmuratova, Nadezhda V. Korotetskaya, Raisa M. Abdullabekova, Elena V. Flisyuk, Nadezhda G. Gemejiyeva

“…This study showed that CO2 extract of Portulaca oleracea’s raw material contained biological active compounds exhibiting a significant antimicrobial effect.…”
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Whether the Indications for Reverse Shoulder Arthroplasty Should Continue to Be Expanded? A Systematic Review and Meta‐Analysis by Huankun Li, Hangsheng Bao, Zhidong Yang, Baijun Hu, Yaocheng Pan, Yi Wang, Jiayi Chen, Hongjun Chen, Bisheng Shen, Yonggen Zou

“…The minimum follow‐up period was 1 year, and a random‐effects model was utilized for data synthesis. Results A total of 45 studies were included in the meta‐analysis. …”
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A novel NFKB1 agonist remodels tumor microenvironment and activates dendritic cells to promote anti-tumor immunity in colorectal cancer by Ying Chen, Qiaoming Li, Zixiang Wang, Ling V. Sun, Steven X. Hou

“…Methods We conducted an in vivo chemical screen to identify F1929-1458, which is capable of eliciting an organism-wide response to destroy stem cell tumors in Drosophila. We then performed functional validation using a mouse colorectal cancer graft tumor model established with the CT26 cell line characterized by its high content of CSCs. …”
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Rapid Detection of Trace Toxicants in Blood Using Thermal Desorption Coupled to Continuous Atmospheric Pressure Interfaced Ion Trap Mass Spectrometry by Hui-wen RUAN, Gui-yun SONG, Zhi-gang FAN, Suo-suo YANG, Jian KANG, Lei HUA, Wei-guo WANG

“…Miniaturized ion trap mass spectrometers have characteristics of high working pressure, tandem-in-time mass spectrometry functions, and field-portable design, which represent a promising approach for rapid on-site detection and hold significant potential for supporting the diagnosis and treatment of acute poisoning. …”
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甘油二酯的降血脂及控制体质量作用机制研究进展Research progress on the mechanism of diacylglycerol on reducing blood lipid and controlling body weight by 施丽娜1，王亚群2，王明星2，王月华2，程芳园2，金俊1，金青哲1，吴港城1，王兴国1SHI Lina1，WANG Yaqun2，WANG Mingxing2，WANG Yuehua2，CHENG Fangyuan2， JIN Jun1，JIN Qingzhe1，WU Gangcheng1，WANG Xingguo1

“…In conclusion, based on the specific digestive and metabolic pathways of DAG and the regulation of lipid metabolism-related genes after DAG intake, DAG can effectively reduce the postprandial lipid level and the accumulation of body fat to achieve the effect of controlling body weight and improving or preventing the occurrence of obesity.…”
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A randomised controlled trial of amygdala fMRI-neurofeedback versus sham-feedback in borderline-personality disorder – systematic literature review and introduction to the BrainSTE... by Christian Paret, Miroslava Jindrová, Nikolaus Kleindienst, Judith Eck, Hester Breman, Michael Lührs, Beatrix Barth, Thomas Ethofer, Andreas J. Fallgatter, Rainer Goebel, Andreas Hoell, Denise Lockhofen, Annika S. Reinhold, Simon Maier, Swantje Matthies, Christoph Mulert, Christian Schönholz, Ludger Tebartz van Elst, Christian Schmahl

“…Hyperactivity of the amygdala is assumed to drive exaggerated emotional responses in BPD. Functional Magnetic Resonance Imaging (fMRI)-based neurofeedback is an endogenous neuromodulation method intended to address the imbalance of neural circuits and thus holds the potential as a treatment for BPD. …”
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Bridging viral hepatitis and liver cancer: Emerging concepts in pathogenesis and therapeutic innovation by Keyin Zheng, Aimin Jiang, Zhengrui Li, Li Chen, Kailai Li, Junyi Shen, Hank Z. H. Wong, Quan Cheng, Jian Zhang, Anqi Lin, Peng Luo

“…For HCV‐related HCC, we focus on exploring the following oncogenic mechanisms: oncogenic mechanisms of viral proteins, virus infection‐mediated metabolic disorders, functional dysregulation of immune cells in the microenvironment, and virus‐induced hepatic fibrosis. …”
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Double-layer membrane framework-based gold microelectrode for determination of natural labile copper in complex water environments by Xinyue Hu, Haitao Han, Shanshan Wang, Dawei Pan

“…Benefiting from the synergistic effects of the double-layer membrane framework, the so-designed LGL/Nafion functionalized μ-GE (LGL/Nafion/μ-GE) exhibited excellent detection performance for Cu, as well as anti-biofouling capability. …”
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Decellularized Matrix Scaffolds for Vascular Transplantation: Addressing Immunogenicity, Sterilization, and Current Strategies for Long-Term Storage by Yevhen V. Shevchenko, Tetiana I. Liadova, Fedir V. Hladkykh, Mariia S. Matvieienko, Mykola O. Chyzh, Roman R. Komorovsky

“…Decellularized tissue is receiving significant attention as a potential biological scaffold, as it retains the structure and functions of the extracellular matrix. The application of sterilization methods, such as gamma irradiation from Cobalt-60, ensures deep penetration and preservation of physical properties of the materials.…”
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Extracellular vesicles from different regions of the female reproductive tract promote spermatozoa motility and support capacitation by Camilla Fasoli, Elisa Giacomini, Valentina Pavone, Lisett Solano Narduche, Viviana Bonzi, Laura Privitera, Paolo Giardina, Ludovica Bartiromo, Matteo Schimberni, Luca Pagliardini, Enrico Papaleo, Massimo Candiani, Andrea Salonia, Riccardo Vago

“…Abstract Extracellular vesicles (EVs) have been proven to have a crucial role in intercellular communication and have attracted significant attention in the physiology of reproduction because of their multiple functions in physiological processes essential for reproduction including gametogenesis, fertilization and embryo-endometrial cross-talk. …”
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Influences of pH on Gelling and Digestion–Fermentation Properties of Fish Gelatin–Polysaccharide Hydrogels by Wanyi Sun, Qiuyu Lu, Jiajing Chen, Xinxin Fan, Shengnan Zhan, Wenge Yang, Tao Huang, Fulai Li

“…These findings provide valuable insights into the pH-responsive functional properties of FG-based hydrogels and their potential applications in designing novel food matrices with enhanced nutritional and probiotic attributes.…”
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Inoculation and co-inoculation of lettuce and arugula hydroponically influence nitrogen metabolism, plant growth, nutrient acquisition and photosynthesis by Carlos Eduardo da Silva Oliveira, Thaissa Julyanne Soares Sena Oliveira, Arshad Jalal, Guilherme Carlos Fernandes, Andréa de Castro Bastos, Andréa de Castro Bastos, Marcelo Rinaldi da Silva, Gabriela Rodrigues Sant’Ana, Jailson Vieira Aguilar, Liliane Santos de Camargos, Tiago Zoz, Marcelo Carvalho Minhoto Teixeira Filho

“…The objective of this study was to investigate the effects of single and combined inoculations of A. brasilense, B. subtilis and P. fluorescens on lettuce and arugula grown in a hydroponic system. …”
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Pervasive glycative stress links metabolic imbalance and muscle atrophy in early-onset Parkinson's disease by Natalia Prudente de Mello, Michelle Tamara Berger, Kim A. Lagerborg, Yingfei Yan, Jennifer Wettmarshausen, Susanne Keipert, Leopold Weidner, Janina Tokarz, Gabriele Möller, Stefano Ciciliot, Safal Walia, Yiming Cheng, Margarita Chudenkova, Anna Artati, Daniela Vogt Weisenhorn, Wolfgang Wurst, Jerzy Adamski, Roland Nilsson, Giovanni Cossu, Agnita Boon, Anneke Kievit, Wim Mandemakers, Vincenzo Bonifati, Mohit Jain, Martin Jastroch, Philippe Schmitt-Kopplin, Fabiana Perocchi, Kenneth Allen Dyar

“…We investigated metabolic consequences by combining classical metabolic phenotyping (body composition, glucose tolerance, indirect calorimetry, functional assays of isolated mitochondria) with metabolomics profiling of biospecimens from mice and PD patients. …”
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Integrative metabolomics and transcriptomics analysis of hippocampus reveals taurine metabolism and sphingolipid metabolism dysregulation associated with sleep deprivation-induced... by Ting Chen, Junke Jia, Chenyi Gao, Qi Zhong, Lijuan Tang, Xiaokai Sui, Shuang Li, Chang Chen, Zongze Zhang

“…Sleep deprivation is known to impair cognitive functions. In this study, we investigated the mechanisms underlying memory impairment induced by sleep deprivation through a combined metabolomic and transcriptomic analysis of hippocampus. …”
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Construction of a tumor mutational burden-derived LncRNA prognostic computational framework associated with therapy sensitivity in skin cutaneous melanoma by Gaohua Li, Tingting Wu, Heping Li, Chuzhong Wei, Yuanbo Sun, Pengcheng Gao, Xinlin Huang, Zining Liu, Jianwei Li, Yanan Wang, Guoxin Li, Lei Fan

“…Methods TILPI was developed using a combination of gene set variation analysis, differential expression analysis, and COX regression analysis. Additionally, functional experiments were conducted to validate the findings, focusing on the effects of STARD4-AS1 knockdown on SKCM tumor cell behavior. …”
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Microencapsulation of bioactive volatile compounds from MD2 pineapple peel Extract using spray-drying and foam-mat drying by Nur Liyana Nordin, Jamilah Bakar, Noranizan Mohd Adzahan, Ahmad Faizal Abdull Razis, Norsharina Ismail, Rabiha Sulaiman

“…Microcapsule powder from bioactive-rich extracts of cellulase-treated MD2 pineapple peel has the potential to be used in functional foods, nutraceuticals, pharmaceuticals, and cosmetics ingredients.…”
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Identifying Priority Areas for Planning Urban Green Infrastructure: A Fuzzy Artificial Intelligence-Based Framework by Leonardo Massato Nicacio Nomura, Adriano Bressane, Vitoria Valente Monteiro, Inara Vilas Boas de Oliveira, Graziele Ruas, Rogério Galante Negri, Alexandre Marco da Silva

“…The system’s modular structure, use of triangular membership functions, and incorporation of the gamma operator allow for adaptable prioritization across different planning horizons. …”
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Clinical and laboratory aspects of patients diagnosed with various inherited platelet disorders by Veysel Gök, Alper Ozcan, Fatma Türkan Mutlu, Ebru Yılmaz, Deniz Kocak Göl, Mustafa Ozay, Baver Demir, Hüseyin Taskiran, Hasan Bas, Mehmet Burak Mutlu, Muhammet Ensar Dogan, Atil Bisgin, Ido Somekh, Meino Rohlfs, Munis Dundar, Yusuf Ozkul, Christoph Klein, Musa Karakukcu, Ekrem Unal

“…Future research should focus on functional studies of novel mutations and refining treatment protocols to enhance care for this complex population.…”
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Vitamin D Supplementation in Selected Autoimmune Diseases by Monika Kamińska, Aleksandra Kozioł, Magdalena Agata Miernik-Skrzypczak, Natalia Dąbrowska, Adrian Uchto, Patrycja Karnas-Bogacka, Marta Katarzyna Malicka, Maria Jasiewicz, Katarzyna Moczyróg

“…There is a growing emphasis on investigating the effects of vitamin D supplementation both in the prevention of autoimmune diseases and in the course of existing diseases. …”
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